Healthy Volunteers

Official Title

Development of Patient-Reported Outcome Measures for Children with Concussion-Related and Non-Concussion-Related Non-Strabismic Binocular Vision, Accommodative and Visual Tracking Problems: Phase 1

Purpose

The purpose of this study is to assist in development of a new quality of life survey that can be used to learn more about how eye teaming, focusing ability and eye movement problems affect a child’s life.

Could this study be right for you?

• Children experiencing eye teaming, focusing, and eye movement problems (with recent concussion or non-concussed)
• Children with amblyopia (lazy eye) are excluded

Age Range

8 - 17 years

Official Title

AMBLYOPIA TREATMENT STUDY (ATS22): A Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles plus Patching for Amblyopia in Children 3 to <13 Years Old

Purpose

The purpose of this study is to evaluate if treating amblyopia (lazy eye) with glasses and patching at the same time improves vision as well as treating amblyopia first with glasses and then with patching, if needed.

Could this study be right for you?

• Visual acuity in the amblyopic eye between 20/40 and 20/200
• No previous treatment for amblyopia, including glasses or contact lenses
• Amblyopia (lazy eye) in one eye

Age Range

3 - 12

Official Title

Assessing Responses to Exercise in the Heat in Trained Women

Purpose

The purpose of this research study is to conduct exercise in hot and neutral environments on women who are aerobically trained and resistance trained to characterize and compare responses across physiologic, perceptual, and neurocognitive domains. Our rationale for this investigation is that its completion would provide evidence as to how women of different fitness backgrounds respond to exercise in the heat and how that response is different from exercising in thermoneutral conditions to better describe how the female body tolerates exercise in the heat with implications for those in recreation, competitive sports, and occupation that expands to emergency and military services.

Could this study be right for you?

Aerobically Trained: having a measured aerobic capacity in the 80th percentile according to age

Resistance Trained: able to squat 120% and bench press 60% of their body weight.

Unacclimatized: participants had not been consistently exposed to hot conditions (i.e., sauna, hot yoga, etc.) in the past 2 months.

Age Range

18 - 35

Official Title

Visual Search Strategy in Neurodivergent Populations

Purpose

The purpose of this study is to evaluate if people with autism are different from typical people in the way they pay attention and look for things. They use a special test called the Adaptive Choice Visual Search task to see how people search for things in a picture. In this study, we want to know if people with autism do better or worse than typical people and if they use different strategies to find things. We want to understand why some people with autism are better at paying attention when they look at things.

Could this study be right for you?

• Male and females aged 18 to 40 years old
• Normal/corrected vision and color vision
• Autistic participants must be verbal and have an IQ > 70

Age Range

18 - 40

Official Title

Ontogenesis of Categorization; Linking development, mechanisms, and biology

Purpose

The purpose of this study is to investigate the early development of attention, learning, and memory during childhood. Participation in this study includes 4, 90-minute-long visits to the lab per year. During these visits, your child will play 2-3 fun, computerized games. These games are designed to assess various aspects of their cognitive ability. 

The duration of the study will last 4 years.

Could this study be right for you?

Eligibility Criteria: 

• African-American/Black children who are 4 years old 

Age Range

4 - 4

Official Title

An Intervention Study about Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease

Purpose

Researchers at Nationwide Children’s Hospital are seeking volunteers to be a part of a study looking at how to best screen for bleeding disorders in young women.

Participants will be asked to undergo a finger prick blood test and complete questionnaires. If their survey answers suggest they have heavy menses or abnormal bleeding, they will also be asked to have a blood draw on the same day.

Could this study be right for you?

• Are 9 to 21 years old
• Have had your first menstrual cycle

Age Range

9 - 21

Official Title

Cardiovascular Effects of Acute Ketone Ester Ingestion in Healthy Adults

Purpose

This study is intended to evaluate the effects of a drink supplement on heart function and health in healthy adults after consuming a ketone ester (KE) supplement drink compared to a placebo drink.

You will undergo an MRI exam for this study. You will also receive six blood draws in total, from an IV catheter set at the beginning of the study. 

The duration of this study will comprise a single visit and will last no longer than 4 hours. 

Could this study be right for you?

Inclusion:

• Able to comply with study requirements as well as pre-test requirements
• BMI between 18 and 30 kg/m2
• Body weight > 150lbs

Exclusion:

Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:

• Pregnancy 
• Allergies to components in the test products, including milk protein, and not lactose intolerant
• History of alcoholism (previous 2 years)
• Taking prescriptive medications or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
• Current smoker
• Contraindications to MRI including cardiac pacemaker or defibrillator, brain aneurysm clips, neuro-stimulator, the presence of any magnetic metal in the body or claustrophobia

Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range

18 - 65

Official Title

Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)

Purpose

The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness. Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends. This study will take place over a 4-year time period.

Could this study be right for you?

· Children aged 3 to < 13 years old. · No previous use of medications related to myopia control. · Glasses and/or contact lens prescription between -1.00 and -6.00 diopters. Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility

Age Range

3 and up

Official Title

Fitness, Aging, Stress & TBI Exposure Repository (FASTER)

Purpose

The purpose this study is to examine how individual differences in health changes (muscle strength, blood pressure) and behavioral changes (sleep, physical activity) impact memory, attention, and the brain. We study these relationships in among a variety of older adults, including those with a history of concussion, traumatic brain injury (TBI), and posttraumatic stress disorder (PTSD). The long-term goal of this project is to identify modifiable factors that exacerbate or protect from age-related cognitive decline.

Could this study be right for you?

Eligibility Criteria: • Aged 18 years and older • Speak English • History of concussion, traumatic brain injury, and/or posttraumatic stress disorder • Must have primary care physician

Age Range

18 and up

Official Title

Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease

Purpose

The purpose of this study is to study a new method to evaluate blood flow to the calves and feet. We hope this information can help evaluate the effectiveness of treatments and predict clinical outcomes. Participants will be required to attend one (2 hr) session at Nationwide Children's Hospital.

Could this study be right for you?

-Diagnosis of Peripheral Arterial Disease (PAD) OR leg symptoms, such as muscle pain or cramping AND/OR foot wound that has required medical consultation Healthy volunteers - must be at least 40 years of age - no history of cardiovascular disease (including high blood pressure) - no history of diabetes mellitus - non-smoker - normal BMI

Age Range

40 and up