Cardiovascular Effects of Ketone Ester Ingestion
This study is intended to evaluate the effects of a drink supplement on heart function and health in healthy adults after consuming a ketone ester (KE) supplement drink compared to a placebo drink.
You will undergo an MRI exam for this study. You will also receive six blood draws in total, from an IV catheter set at the beginning of the study.
The duration of this study will comprise a single visit and will last no longer than 4 hours.
Inclusion:
- Able to comply with study requirements as well as pre-test requirements
- BMI between 18 and 30 kg/m2
- Body weight > 150lbs
Exclusion:
Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:
- Pregnancy
- Allergies to components in the test products, including milk protein, and not lactose intolerant
- History of alcoholism (previous 2 years)
- Taking prescriptive medications or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
- Current smoker
- Contraindications to MRI including cardiac pacemaker or defibrillator, brain aneurysm clips, neuro-stimulator, the presence of any magnetic metal in the body or claustrophobia
Exclusion Criteria varies, please contact Study Coordinator for more information.
A Study to Evaluate E-Cigarette Nicotine Form, Concentration, and Flavor Among Youth
The purpose of this study is to examine the influence of nicotine form, concentration, and e-liquid flavor on youth vaping as well as the heart and lung effects associated with this behavior. You will be asked to attend 9 vaping sessions at The Ohio State University.
Your participation in this study will last up to 6 months.
• Male or females aged 21-25 years old
• Current E-Cigarette user
• Able to attend 9 vaping sessions at The Ohio State University
A Study to Examine Pragmatic Evaluation of Events and Benefits of Lipid-lowering in Older Adults (PREVENTABLE)
The purpose of this study is to evaluate the use of statins to possibly prevent Mild Cognitive Intervention (MCI) or dementia, along with the prevention of physical disability and cardiovascular disease in older adults. Your participation in this study will last up to 5 years.
• Male and females older than 75 years older • No history of heart attack, stroke, revascularization (restore blood flow) or obstructive heart disease where a statin was prescribed • No heart failure hospitalization or statin use within the last 12 months • No history or current evidence of dementia • No condition/situation that would prevent the use of a statin • No major hearing or visual impairment
A Study to Examine Atropine for the Reduction of Nearsightedness (The CHAPERONE Study)
The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness. Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends. This study will take place over a 4-year time period.
· Children aged 3 to < 13 years old. · No previous use of medications related to myopia control. · Glasses and/or contact lens prescription between -1.00 and -6.00 diopters. Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility
A Study about Fitness, Aging, and Stress in People with Traumatic Brain Injury
The purpose this study is to examine how individual differences in health changes (muscle strength, blood pressure) and behavioral changes (sleep, physical activity) impact memory, attention, and the brain. We study these relationships in among a variety of older adults, including those with a history of concussion, traumatic brain injury (TBI), and posttraumatic stress disorder (PTSD). The long-term goal of this project is to identify modifiable factors that exacerbate or protect from age-related cognitive decline.
Eligibility Criteria: • Aged 18 years and older • Speak English • History of concussion, traumatic brain injury, and/or posttraumatic stress disorder • Must have primary care physician
Fertility and Contraception Among African Immigrants in the United States
The purpose of the study is to learn about how African immigrants make decisions about childbearing, both individually and as a couple, the role of modern contraception in helping them achieve their fertility desires and the effect of migration on their childbearing desires.
- Nigerian immigrant men and women of reproductive age (18-45 years) and,
- Are in a relationship (dating, engaged or married)
Studying a New Method to Evaluate Blood Flow in Patients with Peripheral Artery Disease (PAD)
The purpose of this study is to study a new method to evaluate blood flow to the calves and feet. We hope this information can help evaluate the effectiveness of treatments and predict clinical outcomes. Participants will be required to attend one (2 hr) session at Nationwide Children's Hospital.
-Diagnosis of Peripheral Arterial Disease (PAD) OR leg symptoms, such as muscle pain or cramping AND/OR foot wound that has required medical consultation Healthy volunteers - must be at least 40 years of age - no history of cardiovascular disease (including high blood pressure) - no history of diabetes mellitus - non-smoker - normal BMI
A Study Evaluating Cognition, Insulin Resistance and Omega-3s (RACIR O-3) in Breast Cancer Survivors
We are studying the relationships between cognitive function, insulin resistance, and omega-3 fatty acids in the blood and from the diet among breast cancer survivors and women without a history of cancer diagnoses. We hope to learn more about how to potentially protect breast cancer patients from uncomfortable mental changes during and after treatment for breast cancer, such as “chemo brain”.
This is a completely remote study, meaning all study tasks can be completed from the comfort of home. Enrolled participants will complete several online surveys and questionnaires, a Zoom video call for additional assessments, and will be sent materials to complete finger-stick blood sample collections from the comfort of home over a period of 3-4 weeks.
The information we gain from this research study will help us design a future clinical trial to test if dietary interventions can help reduce or prevent cognitive changes like chemo brain in breast cancer patients.
- Accepts healthy volunteers - YES
- Females
- Age 45-75 years
- Post-menopausal (at least 12 months no menses)
- Stage I-III Breast Cancer diagnosis
- 1-4 years post initial breast cancer diagnosis
- No diagnosis of diabetes
- English speaking
A Study Evaluating Occupational Therapy Interventions for Children with Autism Spectrum Disorders
We are actively recruiting typically developing children (ages 6 – 13 years) to participate in a new study looking at attention and sensory processing. In this study, we are investigating what occupational therapy practitioners are doing during therapy for children with autism and to see the effect of occupational therapy on brainwaves and behavior. We will identify differences in brainwaves in children with and without autism. You and your child will be asked to schedule one visit to the EEG lab at Ohio State University. Your visit will last about 2.5 hours and include an hour of EEG testing and one hour of paper-pencil game-like activities measuring attention. We need parent consent, and the parent/guardian will complete assessments about their child as well.
- Children with no autism or any other medical diagnosis - Your child is between 6 - 13 years of age
MeSo Study
The purpose of this study is to better understand the way the brain works in people who have depression and people who have previously been depressed. We are also testing healthy subjects for comparison. We hope our findings will lead to better ways to diagnose and treat mood disorders in the future. Participation involves an initial phone call and a 2 to 4 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan. Two months after the scan, participants will complete daily online questionnaires for 7 days. This process is repeated 2 months later (4 months after the scan).
You may be eligible for this study if you: • Are between the ages of 18-40 • Are right-handed • Do not have a history of neurological disorders (e.g., seizures, head injury, etc.) • Do not have major medical problems (e.g., stroke, heart disease, high blood pressure, endocrine disorders, etc.) • Have normal vision, vision that is corrected to normal with glasses or contacts • Are willing and able to undergo fMRI scanning (not claustrophobic, no non-removable metal in your body) • Are not pregnant