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An Investigational New Drug for the Treatment of Alzheimer’s Disease
Official Title A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Escalating Doses of LH-001 in Healthy SubjectsPurpose
The purpose of this study is to evaluate the safety and tolerability of an investigational new drug in healthy participants aged 18-60 years.
Could this study be right for you?
- In good health and BMI (ratio of body weight to height) between 18-29.9 kg/m2
- Willing to participate in various research assessments including blood collection, urine collection, electrocardiogram, and vital signs
- Willing to stay overnight (~30 hours) in the OSU Hospital Clinical Research Center
- If sexually active, willing to utilize highly effective birth control during the study period
- Not currently pregnant or breast-feeding
- No significant medical condition involving any major organs (heart, lung, liver, brain, or endocrine)
- No to any of the following: alcohol or substance abuse, spleen problems, or drug hypersensitivity
- No history of or undergoing treatment for: major psychiatric illness, seizures, or autoimmune disease
- Not currently taking immunosuppressive drugs
- No active Hepatitis B, Hepatitis C, or HIV
- No cancer history within 5 years (squamous and basal cell skin cancer excluded)
Age Range
18 - 60 years -
MOMI Study
Official Title The mom and infant outcomes (MOMI) study: A trial of perinatal outpatient delivery systemsPurpose
To improve our ability to provide the best possible care to every mom and infant, we are testing two different models of primary care during the first year after childbirth.
Could this study be right for you?
- You may qualify if you’re currently pregnant – AND – you’ve ever had high blood pressure, diabetes, depression, or anxiety, including during pregnancy.
If you participate, you’ll be randomly assigned to an Ohio State location that delivers one of two models of care. Providers at all locations can help you manage your health, but the models differ in several ways.
- You’ll complete three study visits with surveys, several measurements, and blood and hair sampling. We’ll collect cord blood and review medical records.
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Bisexual Health and Relationships Project
Official Title Bisexual Health and Relationships ProjectPurpose
The purpose of this study is to better understand the health behaviors and health outcomes for married bisexual people.
Could this study be right for you?
Our study examines the health of married Bi+ (defined as bisexual, pansexual, queer, etc.) people. We are interviewing both Bi+ individuals and their partners over Zoom. We are specifically looking to speak with:
- Bi+ men married to men
- Bi+ people of color of any gender
Age Range
35 - 65 years -
Sleep Restriction and Ketone Supplements
Official Title Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction (STAK-Sleep)Purpose
To examine if drinking a ketone supplement, twice a day, can improve brain, digital shooting, and physical performance during short-term sleep restriction (4 nights, 50% of normal sleep).
Could this study be right for you?
- Healthy
- Age: 18 - 40 years old
- BMI: 20-35 kg/m2
- No diagnosed sleep disorders
- Not consuming a ketogenic diet
Age Range
18 - 40 years -
Neurodevelopmental Effects of Youth Tackle Football
Official Title Understanding the Neurodevelopmental Effects of Youth Tackle Football ParticipationPurpose
In this study we are aiming to identify risk factors for higher exposure to football-related neurotrauma in youth tackle football players and to determine the effects of football-related neurotrauma exposure on neurodevelopment in children with no previous tackle football participation.
For this specific posting, we are looking for boys ages 8-12 who are non-athletes or athletes who play non-contact sports to serve as control subjects for our fMRI study.
Could this study be right for you?
We are looking for boys ages 8-12 who are either non-athletes or do not participate in any contact sports.
- Boys must have no metal implanted in the body
- Have no prior history of head trauma
- Have no serious health or mental health diagnoses
- Must not have a fear of enclosed spaces
Age Range
8 - 12 years -
Exploring the Development of the Infant and Fetal Brain
Official Title Exploring the Connectivity and Functional Organization of the Infant BrainPurpose
The purpose of the study is to investigate how the brain that we are each born with leads to our own unique behavior later in life, and the similarities and differences between maternal and child brains. We are studying infants prenatally and postnatally, following up with them as they grow and develop, and studying their mothers to understand how similar/different they are to their child.
Could this study be right for you?
- Infants under 3 years of age, and pregnant persons who are at least 20 weeks pregnant
- All participants must have no metal implanted in the body
- Have no significant health conditions or history of serious mental illness
- Not suffer from a (fear of enclosed spaces)
- Pregnancies must be without complication.
Age Range
Up to 40 years -
A Study Evaluating How Alcohol Affects Thinking and Decision Making
Official Title Impulsivity Domains and Subjective ResponsePurpose
The purpose of this study is to examine the degree to which different ways of thinking and decision making – measured using computer tasks and questionnaire – relate to how people feel after a dose of alcohol. By doing this study, we hope to learn about the relationships between decision making and responses to alcohol.
Could this study be right for you?
Inclusion criteria include:
- Ages 21-25
- English language Fluency
Exclusion criteria include:
- Any serious medical problems (i.e., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, gastrointestinal disorders, abnormal kidney function)
- Body weight < 110 or > 210 pounds
- Current medical or psychiatric condition requiring medication for which alcohol consumption is contraindicated
- Lifetime history of schizophrenia or other psychotic disorder
- Substance Use Disorder other than alcohol
Exclusion Criteria varies, please contact Study Coordinator.
Age Range
21 - 25 years -
PREVENTABLE
Official Title PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adultsPurpose
The purpose of PREVENTABLE is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability, or heart disease. The duration of the study will last 5 years.
Could this study be right for you?
Inclusion Criteria:
- Community-dwelling adults
- Age ≥75 years
- English or Spanish as primary language
Exclusion Criteria:
- Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
- Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
- Dementia (clinically evident or previously diagnosed)
- Dependence in any Katz Basic Activities of Daily Living [ADL] (with the exception of urinary or bowel continence)
- Severe hearing impairment (preventing phone follow up)
- Unable to talk (preventing phone follow up)
Exclusion Criteria varies, please contact Study Coordinator for more information.
Age Range
75 years and up -
The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience
Official Title The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase ResiliencePurpose
The purpose of this study is to improve the sense of hope and build resilience through creating one’s Tree of Hope. This study is being done because we see that today’s environment is quite stressful and this can lead to people feeling less hopeful in their present and the future.
Could this study be right for you?
- At least 18 years old
- Able to read and understand English
- Healthy people and patients will be eligible for this research study
- Participants will be eligible even if they are not seen at OSU for their care.
- We will not abstract any data from electronic health records. Patients will complete a survey that asks them questions about their health conditions
Exclusion Criteria
- Any physical or mental condition that the principal investigator considers as impacting the ability of the patient to participate in the research study. Examples include visual or hearing impairment, arthritis, weakness or other medical problem that impairs their ability to write.
Age Range
18 years and up -
A Study for Active Military Service Members (or recently served); Examining Uncertainty, Health, and Home Safety Practices
Official Title Uncertainty and Firearms: Obtaining Secure Storage (UFOS)Purpose
The purpose of this study is to examine whether fear of uncertainty plays a role in home safety practices among firearm owners who are currently or have recently served in the U.S. military.
Could this study be right for you?
- Currently serving in any Branch or Component of the U.S. military, or were discharged from the U.S. military within the past 90 days
- 18 years or older
- Own at least one firearm located in your home or vehicle
- Are able to speak and understand the English language
- Have an Apple or Android smartphone
Age Range
18 - 99 years