An Intervention Study to Examine the Effects of Knee Brace Stiffness on Muscle Control following Total Knee Replacement

Official Title
Effects of Knee Brace Stiffness on Muscle Control following Total Knee Replacement
Purpose

The purpose of this study is to determine the effects of various knee braces on how you walk.

Participation in this study consists of 1 session lasting 2-3 hours. During testing, you will walk on a treadmill during several trials, each lasting 2-5 minutes. While walking, you will wear a knee brace, motion capture markers, and muscle activation sensors.

Could this study be right for you?

Knee Replacement participants:

· Men and women aged 45-89 years old

· Can walk for 45 minutes without stopping

· Received a TKR (total knee replacement) in the last 2 years

Healthy participants:

· Men and women aged 45-89 years old

· Can walk for 45 minutes without stopping

· No history of lower limb surgery

Exclusion criteria:

· Lower extremity surgeries (other than knee replacement);

· Spine pain

· Scoliosis

· Known pregnancy

Exclusion criteria varies, please contact Study Coordinator for more information.

Age Range
45 and up

A Study About Hip Pain in Active Young Adults

Official Title
Hip Muscle Strength, Muscle Activation Patterns, and Joint Contact Forces in Individuals with Femoroacetabular Impingement Syndrome
Purpose

Femoroacetabular impingement syndrome (FAIS), also known as hip impingement, is the most common cause of debilitating hip pain in young, active adults. FAIS is a movement-related syndrome defined by bony structure, clinical signs, and symptoms.

The purpose of this study is to better understand how muscle strength and timing of muscle activation contribute function and symptoms in hip impingement.  

You will be in the study for one day. The time involved in the clinical exam, laboratory testing session, and surveys will take a maximum of 2-3 hours. 

Could this study be right for you?

Inclusion Criteria:

1. Individuals ages 16-40 years with documentation of medical diagnosis of FAIS
2. Complaints of hip joint pain, catching, or stiffness with prolonged sitting or standing, walking, squatting, pivoting/twisting, AND 
3. Pain reproduced with certain hip movements

Exclusion Criteria:

Any of the following conditions or surgical history: 
1. Pregnancy 
2. Previous history of hip surgery
3. History of hip dislocation 
4. History of other lower extremity or spine injury or surgery that required continued care of a medical provider in the previous two years

Age Range
16 and up

A Study for Those With Hip Impingement

Official Title
Physical Activity and Pain Patterns in Individuals with Femoroacetabular Impingement Syndrome
Purpose

Femoroacetabular impingement syndrome (FAIS), also known as hip impingement, is the most common reason for hip pain in young, active adults. It often causes pain with simple daily tasks like walking and squatting, but most often limits sports and physical activity participation. It is possible that way in which people move may increase their risk for FAIS. It is also possible that different activity patterns cause continued pain in those with FAIS. In order to develop effective rehabilitation programs, we need to figure out if there are patterns of activity (or inactivity) that contribute to pain in individuals with FAIS.

Could this study be right for you?

Inclusion Criteria:
Individuals ages 18-40 years with documentation of medical diagnosis of FAIS, with or without labral pathology and who meet the following criteria:
1. Complaints of hip joint pain, catching, or stiffness with prolonged sitting or standing, walking, squatting, pivoting/twisting, AND
2. Pain reproduced with at least one of three provocative tests: (1) hip flexion with adduction and internal rotation (FADIR), or (2) hip flexion with abduction and external rotation (FABER), or (3) resisted straight leg raise.

Exclusion Criteria:
Any of the following conditions or surgical history:
1. Previous history of hip surgery, including previous arthroscopy or open procedure on hip, including periacetabular osteotomy (PAO)
2. Medical diagnosis of slipped capital femoral epiphysis, hip dysplasia, Legg-Calve-Perthes disease, osteonecrosis, or fracture
3. History of hip dislocation
4. Medical diagnosis of bilateral FAIS AND is unable to identify a more symptomatic side
5. History of other lower extremity or spine injury or surgery that required continued care of a medical provider in the previous two years (conditions may have altered activity participation beyond that of the participant’s current hip pain)

Age Range
18 and up

A study for those undergoing MLF Surgery

Official Title
SIJ Stabilization in Long Fusion to the Pelvis: Randomized Controlled Trial
Purpose

To determine whether placement of iFuse-3D across the ssacroiliac joint (SIJ) in the Bedrock configuration provides
clinical and/or radiographic benefits in patients undergoing multilevel spine fusion (MLF) surgery with fixation to the pelvis

Could this study be right for you?

You may be eligible for this study if you are:
1. Age 21-75 at time of screening
2. Scheduled for multilevel (4 or more levels) spinal fusion surgery with planned fixation to the pelvis using S2AI screws
3. Patient has the necessary mental capacity to participate and is physically able to comply with study protocol requirements

Exclusion Criteria
1. The reason for your multilevel spine fusion surgery is any of the following:
a. Congenital neuromuscular disease
b. Prior pelvic fixation (already have S2AI or iliac bolts in place, current surgery indicated to revise this hardware)
c. Grade IV spondylolisthesis
2. Prior sacroiliac joint fusion/fixation on either side
3. Presence of spinal cord stimulator
4. Presence of severe hip pain that could impair functional and quality of life improvement from complex spine surgery
5. Surgeon plans to use iliac screw for pelvic fixation
6. Severe osteoporosis
7. Known allergy to titanium or titanium alloys
8. Current local or systemic infection that raises the risk of surgery
9. Currently receiving or seeking short- or long-term worker's compensation and/or currently involved in injury litigation related to the SIJ or low back pain.
10. Currently pregnant or planning pregnancy in the next 2 years
11. Known or suspected drug or alcohol abuse
12. Fibromyalgia

Age Range
21 and up

A treatment study for chondral lesion in your knee

Official Title
Evaluation of the efficacy of radiofrequency-based debridement vs. mechanical debridement for the treatment of articular cartilage lesions.
Purpose

The purpose of this study is to evaluate 2 different treatments, Mechanical Debridement (i.e., a mechanical shaver that removes areas of damaged tissue) and Radiofrequency Debridement (i.e., electrical energy that removes areas of damaged tissue), used to treat the chondral lesion in your knee.

Could this study be right for you?

You may be eligible for this study if you:
• Are 18 - 50 years of age
• Suspected chondral damage in the following locations where debridement is indicated:
o Medial femoral condyle
o Lateral femoral condyle
o Trochlea
o Patella
• 1 or more chondral lesion(s) as noted on MRI

Exclusion:
• Previous chondral treatment in the same compartment (prior debridement and lavage performed more than three months prior to baseline are acceptable)
• Pregnant and/or intending to become pregnant during this study period

Age Range
18 and up

A Study About Recovery After ACL Reconstruction (RARE)

Official Title
Disability after ACL Reconstruction: Development of an Alternative Model of Care
Purpose

The anterior cruciate ligament (ACL) in your knee can be injured and treated with an ACL reconstruction surgery. An ACL reconstruction may impact function, muscle strength, the way you move, and knee joint health. However, outcomes at 2 years after ACL reconstructions in young persons are not well-understood. Findings from this study will provide information regarding the clinical, function, muscle strength, and movement patterns after ACL injury and reconstruction to help inform physicians and physical therapists who work with these patients.

Could this study be right for you?

You may be eligible if:

1. You are between the ages of 16-35 years old
2. 2 years (+/- 8 months) status post ACL Reconstruction
3. Regularly participated in physical activity prior to their ACL injury

Age Range
16 and up

A Treatment Study for Subchondroplasty® Procedure in the Hip

Official Title
A Longitudinal Outcomes Study of the Subchondroplasty® Procedure in the Hip
Purpose

To collect outcomes data for patients undergoing the Subchondroplasty® (SCP®) Procedure in the hip. Outcomes to be assessed include medication usage, pain, function, activity levels and patient satisfaction.

Could this study be right for you?

Eligibility Criteria
• 18 years of age or older
• Subchondral bone defect(s) in the hip (femoral head, femoral neck and/or acetabulum) has been confirmed via MRI or x-ray.
• Other requirements reviewed by the physician.

Exclusion Criteria:
• Collapse of the subchondral bone

Age Range
18 and up

A Treatment Study for Damaged Knee Cartilage Requiring Repair-- Hyalofast with BMAC

Official Title
A prospective, randomized, active treatment-controlled, evaluator-blinded (radiologist reviewer and physician evaluator) multicenter study to establish the superiority of a hyaluronan-based scaffold (Hyalofast®) with autologous bone marrow aspirate concentrate (BMAC) in the treatment of articular knee cartilage defect lesions in comparison to control (microfracture treatment)
Purpose

The purpose of this research study is to evaluate an investigational procedure for treatment of damage to the cartilage in your knee, also called a defect or lesion, which requires repair. If eligible, you will receive one of two possible arthoscophy procedures. You may be assigned to receive the study procedure to implant Hyalofast® scaffold in your knee together with cells from your own bone marrow, called Bone Marrow Aspirate Concentrate, or BMAC. Bone marrow is the substance found inside your bones that among other things helps to make blood cells. The other possible procedure is called Microfracture and is one of the current standard of care options to treat your condition.

Could this study be right for you?

-Ages 18 to 60.
-Patient’s body mass index (BMI) is <35 kg/m2
-Patient has a symptomatic lesion of the femoral condyle (medial and/or lateral) or femoral trochlea that is between 1--6 cm2 on screening images confirmed by the independent radiologist
-Patient is using only nonsteroidal anti-inflammatory drugs or acetaminophen/paracetamol during the month before signing the informed consent form to treat knee pain
-Patient is willing to use other pain medication rather than NSAIDS for 6 months post-surgery (e.g. acetaminophen, or narcotic analgesics, if prescribed). Post-surgical use of aspirin for clot prevention is acceptable.
-Patient is willing to restrict pain medication after 6 months post-surgery to NSAIDs or acetaminophen/paracetamol only through the end of the trial
-No history of previous microfracture or other cartilage repair procedure on study knee
-Not currently pregnant or expecting to become pregnant in the next 12 months
-No diagnosis of advanced osteoarthritis

Age Range
18 and up

Rheumatology Biorepository-- For Healthy Volunteers AND those with Autoimmune and Rheumatic Disorders

Official Title
The Ohio State University Rheumatology and Immunology Biorepository
Purpose

This study is being done to provide resources for future studies involving autoimmune and rheumatic disorders, such as systemic lupus erythematosus, rheumatoid arthritis, osteoarthritis, Sjogren’s syndrome, vasculitis, and undifferentiated connective tissue diseases. The samples and data collected will be stored and used in the future to learn more about rheumatic and autoimmune disorders. Healthy volunteers are also being recruited.

Could this study be right for you?

- 18 years of age or older

If you decide to participate in this study, you will be asked to provide some samples*.
The samples you can provide for this study could be any or all of the following:
• Blood (up to approximately 10 tablespoons)
• Urine
• Stool
• Saliva (approximately 2 teaspoons)
• Skin biopsy
• Oral mucosa biopsy
• Medical waste (such as skin or synovial fluid)

*You can choose which types of samples you would like to provide.

Age Range
18 and up

Follow-up Study for Those Who Have Undergone (or Will Undergo) the Subchondroplasty (SCP) Knee Procedure

Official Title
KNEE CREATIONS SCP® OBSERVATIONAL COHORT FOLLOW-UP STUDY
Purpose

A study for those who will (have undergone) the Subchondroplasty (SCP) procedure for their knee. SCP is a procedure performed on subjects who have bone marrow lesions(BMLs). BMLs are subchondral defects in the bone, also called Insufficiency Fractures. This follow-up study will collect information on the short- and long-term safety and effectiveness of the SCP procedure.

Could this study be right for you?

- 18 years of age or older
- Considered to be a candidate for SCP procedure by your surgeon
- Have agreed to undergo the SCP procedure or has already undergone the procedure
- Willing and able to sign a written consent form
- Has the ability and the willingness to contribute follow-up outcome data

Age Range
18 and up