Official Title Immune Response in Adolescents

Purpose

Our goal in this study is to learn more about the immune system in adolescence and early adulthood. We are looking to enroll healthy children ages 12-18 years old.

Enrollment in the study will require 1 visit to Nationwide Children’s Hospital involving a blood draw and 2 nasal swabs.
The visit will take approximately 1- 1 ½ hour(s). We ask that the family brings a copy of the child’s immunization record to the visit.

Could this study be right for you?

Children will need to meet the following criteria to be in the study:

Inclusion Criteria:

• Parents/Legal guardian able and willing to sign informed consent and the child is willing to sign assent form for participation. All forms are in English.
• Healthy children, age 12-18 years old

Exclusion Criteria:

• Any chronic or congenital conditions that may potentially affect immune responses
• Cough, congestion, fever, rhinorrhea, rash and any other symptoms indicative of infection within the 2 weeks prior to enrollment sampling
• HIV, AIDS or other immunodeficiencies or any other condition that may affect their immune system
• Use of systemic steroids within 2 weeks prior to enrollment
• Immunization(s) within the last 30 days

Age Range

12 and up

Official Title ImproviNg The BrEast CaNcer Care DelivEry MoDel for Sex and Gender Minority Survivors (INTENDED for SGM)

Purpose

The long-term goal of this study is to improve decision quality and health-related outcomes for sexual gender minority (SGM) breast/chest cancer survivors. The goal is to evaluate important ways the current care model needs adjusted for SGM people, and how best to combine a socially important care model into clinical practice.

Survivors: Eligible participants will participate in a 90-minute focus group and online survey regarding your opinions about improving LGBTQ+ breast/chest cancer care.

Clinicians: Eligible participants will participate in a 30-minute interview and brief survey regarding your opinions about improving LGBTQ+ breast/chest cancer care.

Participation in this study will take no more than 1 hour and 30 minutes.

Could this study be right for you?

Survivors:

1. Self-identify as a member of the SGM community
2. Age ≥18 years at the time of signing the informed consent form
3. Breast/chest cancer survivor in active treatment or completed active treatment in the last 10 years (not including hormone therapy)
4. Be able to read and speak English
5. Have received care in the U.S.
6. Be able to participate in virtual meetings

Clinicians:

1. Physicians, advance practice providers, nurses, psychologists, social workers, therapists, technologists, and other trained clinical professionals
2. Provide care to individuals diagnosed with breast cancer in the U.S.
3. Be able to read and speak English
4. Be able to participate in virtual meetings

Age Range

18 and up

Official Title A Hybrid Effectiveness-Implementation Trial to Improve Safe Driving among Teen Drivers with Traffic Violations

Purpose

The purpose of this study is to test the effects of an in-vehicle driving feedback technology, with and without parent training, on parent-teen communications as well as teens' risky driving behaviors, unsafe driving behaviors, and subsequent traffic violations.

Could this study be right for you?

In order to be eligible:

• You must be 16-18 years of age
• Need a valid State of Ohio driver's license (no learner's permit)
• Proof of car insurance
• Must drive more than one hour per week

Age Range

16 and up

Official Title A Phase 2, double-blind, randomized, placebo-controlled study of nelotanserin versus placebo in patients with dementia with Lewy bodies (DLB) experiencing REM sleep behaviors (RBD)

Purpose

The purpose of this study is to evaluate the safety of the study drug called nelotanserin and to assess the effects of nelotanserin in those experiencing frequent REM sleep behavior disorders due to dementia with Lewy bodies. Nelotanserin (study drug) is an investigational product, which means that it has not been approved by the U.S. Food and Drug Administration (FDA) or the government health agencies of any other countries.

Could this study be right for you?

• Age: 50-85
• Diagnosis: probable dementia with Lewy bodies or Parkinson's disease dementia
• AND diagnosis of REM sleep behavior disorder (RBD) with frequent RBD episodes
• Must have a study partner willing to serve as a collateral informant for study assessments
• MMSE Score: greater than or equal to 18 (Mini Mental State Examination score to be explained by the coordinator)

Age Range

50 and up

Official Title Mechanisms of Negative Affectivity

Purpose

Symptoms related to depression and anxiety can affect a person’s daily life and relationships. Some research suggests that people with mood and anxiety disorders process information differently than people without these types of disorders.

The purpose of this study is to better understand the way the brain works in people who have depression and anxiety. Researchers hope their findings will lead to better ways to diagnose and treat mood and anxiety disorders in the future.

Participation involves an initial phone call and a 3 to 5 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan.

The 3rd and 4th visits (at 6 and 12 months) will include 1.5 to 3 hours of questionnaires and interviews each.

Following the scan, the 6-month follow-up, and the 12-month follow-up, participants will also complete daily online questionnaires for 7 days.

Could this study be right for you?

You may be eligible for this study if you are:

• 18-25 years of age
• Right-handed
• Currently experiencing symptoms of depression or anxiety (feeling down or depressed, anxious, nervous, or tense, having no interest in things you used to enjoy, or feeling hopeless)
• Not currently receiving treatment (psychiatric medications or therapy)
• No major medical problems (e.g., stroke, heart disease, high blood pressure, endocrine disorders, etc.)
• No history of neurological disorders (e.g., seizures, head injury, etc.)
• Normal vision, vision that is corrected to normal with glasses or contacts
• Willing and able to undergo fMRI scanning (not claustrophobic, no non-removable metal in your body)
• Not pregnant

Participation involves an initial phone call and a 3 to 5 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan.

The 3rd and 4th visits (at 6 and 12 months) will include 1.5 to 3 hours of questionnaires and interviews each.

Following the scan, the 6-month follow-up, and the 12-month follow-up, participants will also complete daily online questionnaires for 7 days.

Age Range

18 and up

Official Title Mechanisms of Self and Other Evaluation (MeSO Study)

Purpose

The purpose of this study is to better understand the way the brain works in people who have depression and people who have previously been depressed. We are also testing healthy subjects for comparison. We hope our findings will lead to better ways to diagnose and treat mood disorders in the future. Participation involves an initial phone call and a 2 to 4 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan. Two months after the scan, participants will complete daily online questionnaires for 7 days. This process is repeated 2 months later (4 months after the scan). 

Could this study be right for you?

You may be eligible for this study if you:

• Are between the ages of 18-40
• Are right-handed
• Do not have a history of neurological disorders (e.g., seizures, head injury, etc.)
• Do not have major medical problems (e.g., stroke, heart disease, high blood pressure, endocrine disorders, etc.)
• Have normal vision, vision that is corrected to normal with glasses or contacts
• Are willing and able to undergo fMRI scanning (not claustrophobic, no non-removable metal in your body)
• Are not pregnant

Age Range

18 and up

Official Title Adipocyte-T Cell Interactions Modulate Adipose Inflammation and Insulin Sensitivity Following Weight Gain

Purpose

The purpose of this research study is to better understand the role of fat tissue, how cells in fat tissue communicate, and determine what signals specific cells use to cause inflammation and insulin resistance during weight gain. This may help researchers better understand the process that happens in Type 2 Diabetes. As a result, through the course of six--nine weeks, participants will be asked to gain at least 10% of their starting body weight. A dietitian will meet with participants to give advice to help with meeting the study weight gain goals, as well as provide additional meal vouchers and supplemental shakes as needed. Following the study, participants will receive guidance how to lose the weight they've gained if they would like to do that.

Could this study be right for you?

You may be eligible if you:

• Are 18-60 years of age
• Are lean; Have a BMI 18-24.9 kg/m2 (*see link below for calculating your BMI -- Body Mass Index)
• Have healthy levels of cholesterol and triglycerides (These will be tested at screening)
• Are a non-smoker
• Are non-diabetic
• Are free of chronic illness
• Are not pregnant or breastfeeding

*Calculate your BMI

Exclusion Criteria:

• Fasting triglycerides > 150 mg/dL or nonfasting triglycerides ˃ 250 mg/dl
• LDL-Cholesterol level > 150 mg/dL
• Presence of significant anemia (hemoglobin <10.0 gm/dL)
• Currently or planning to take blood thinners
• Current smokers
• Have taken steroids or anti-inflammatory meds for >6 months in the last 6 months
• >10% body weight loss within 3 months of enrollment
• *Other exclusions may apply

Age Range

18 and up

Official Title Movement and Music Intervention for Individuals with Dementia

Purpose

There is some evidence that music based interventions may have a protective effect on the brain in those with dementia. There is also evidence that doing activities that engage the brain through music are beneficial. This study seeks to investigate the potential benefits of a music based intervention for individuals with dementia.

Could this study be right for you?

You may be eligible if you:

• Have a diagnosis of dementia (mild to moderate)
• Are age 60 and older
• Able to follow simple instructions

EXCLUSION CRITERIA:

• Unable to walk 10 feet unassisted
• Presence of bone disorder that impacts walking
• Presence of other neurologic diagnosis that impacts cognitive or motor function such as stroke, Parkinson disease or traumatic brain injury

Age Range

60 and up

Official Title CHILDHOOD ATROPINE FOR MYOPIA PROGRESSION (CHAMP): A 3-ARM RANDOMIZED, DOUBLE-MASKED, PLACEBO-CONTROLLED, PHASE 3 STUDY OF ATROPINE SULFATE OPHTHALMIC SOLUTION 0.01% AND 0.02%

Purpose

The purpose of the study is to determine if a daily eye drop will help slow the progression of nearsightedness in children.

Could this study be right for you?

Your child may be eligible for this study if he/she is:

• Ages 3-17
• Nearsighted

Participants will complete visits for follow-up (every 6 months) and to pick up study eye drops (every 3 months).

Please have your child’s current eye glasses prescription available when you call.

Age Range

3 and up

Official Title Development of Parent-Child Interactions

Purpose

This study will examine how a child’s hearing loss may affect the dynamics of parent-child interactions. The study will observe how normal-hearing and hearing-impaired child learn novel words during videotaped parent-child interactions.

Individual study visits may last 30-45 minutes, and there may be multiple study visits per year.

Could this study be right for you?

• Families with children 9 months to 6 years of age
• Children who do and do not have hearing loss may be eligible to participate in this study

Official Title Performance and Cognitive Changes Across Menstrual Phase

Purpose

This study will look at the influence of the hormonal changes that occur between the early-follicular and mid-luteal phases of the menstrual cycle on neurocognitive performance before and after an intense resistance workout in premenopausal, moderately active females. Additionally, this study will be determining the accuracy and usefulness of using a menstrual cycle tracking phone application in predicting menstruation and ovulation

Your participation in the study will last between 2 and 3 months dependent on where in your current menstrual cycle you are upon enrollment in the study. There are 6 total visits across the 2 to 3 month study duration.

Could this study be right for you?

The eligibility criteria are as follows:

1. Be between the ages of 18 and 35
2. Participate in at least 3 hours of planned physical activity per week
3. Able to squat 100% of your body weight
4. Able to bench press 70% of your body weight
5. Using non-hormonal contraceptives

Age Range

18 and up

Official Title Perinatal Arterial Stroke: The I-ACQUIRE Study

Purpose

Children who suffered a stroke before or shortly after being born that was caused by blockage of blood flow in an artery, it often results in the child showing some weakness on one side of their body.

With this study, we want to find out if a type of therapy may help children who have weakness on one side of their body due to perinatal arterial ischemic stroke, learn how to better use their weaker arm.

All children will be in the study for about 13 - 15 months. Some children may be in the study for a longer period, depending on which treatment they receive during Phase 1 of the study. The I-ACQUIRE therapy involves fun learning and play, self-help activities, and manipulating interesting toys and objects.

Could this study be right for you?

• Your child must be between the ages of 8 and 36 months old when beginning this study
• Your child must have suffered a perinatal arterial ischemic stroke
• Upper limb weakness
• Parents must be able to participate at least 1x/week for therapy and 40-60 minutes/day at home