Official Title Determining the Optimal Treatment Intensity for Children with Language Impairment

Purpose

The purpose of the study is to determine the amount of speech-language intervention children need to make improvements.

We hope to identify the appropriate amount of intervention needed as well as the point at which adding more intervention is no longer beneficial.

Participation in this study will last for approximately 10 weeks with one 2 hour session before the book reading intervention, one 2 hour session after the book reading intervention and a 6-month follow up.

Could this study be right for you?

Inclusion Criteria:

• Your child is between the ages of 5 and 6 years 11 months old
• Has received a primary diagnosis of a Language Impairment with vocabulary deficits
• Receives Speech and Language services through their school
• Primarily communicates in English

Age Range

5 and up

Official Title Healthy New Albany: Breast Cancer Project

Purpose

Determine the feasibility of delivering a community-based, lifestyle weight management intervention in producing meaningful improvements in weight loss and relevant clinical and patient-reported outcomes in Breast Cancer survivors.

Could this study be right for you?

• Female breast cancer survivor within 60 months after cessation of active treatment.
• Overweight/Obese (BMI > 25).
• Ability to understand and willing to sign a written informed consent.
• Willing and physically able to participate in physical activity.
• Obtain physician consent via primary care physician and/or treating oncologist.

Age Range

30 and up

Official Title Hepatitis C Virus Immunity in Women and Children

Purpose

This is a study to find out how pregnancy affects a mother’s immune system. (The “immune system” is the part of the body that fights germs.) This study is also to find out why some babies who are exposed to infections during pregnancy get infected and others do not.

To do this project we need to study some women and babies who are infected with the hepatitis C virus and others who are not. This will allow us to compare their immune systems.

Could this study be right for you?

You may be eligible to participate if you are:

PREGNANCY COHORT eligibility criteria:

1. Pregnant (enrollment preferably during 1st or 2nd trimester, but may occur as late as the delivery hospitalization)
2. HCV-RNA positive (#150) or HCV-RNA negative (#50)
3. Willing and able to attend all study visits

Exclusion criteria for mothers:

1. Inability to provide informed consent
2. Incarceration

Inclusion criteria for infants:

1. Child born to study mother

Exclusion criteria for infants:

1. In custody of county children’s services (Enrolled infants who are temporarily in custody of children’s services will not have further study blood draws, but lab results from blood tests ordered by their pediatrician may be followed to monitor the outcome of their HCV exposure. Infants who are later placed back in the custody of their mother or relative may be re-enrolled.)

NON-PREGNANCY COHORT eligibility criteria:

1. Willing and able to attend all study visits

Exclusion criteria:

1. Currently pregnant
2. Inability to provide informed consent
3. Incarceration

Official Title Immune Response in Adolescents

Purpose

Our goal in this study is to learn more about the immune system in adolescence and early adulthood. We are looking to enroll healthy children ages 12-18 years old.

Enrollment in the study will require 1 visit to Nationwide Children’s Hospital involving a blood draw and 2 nasal swabs.
The visit will take approximately 1- 1 ½ hour(s). We ask that the family brings a copy of the child’s immunization record to the visit.

Could this study be right for you?

Children will need to meet the following criteria to be in the study:

Inclusion Criteria:

• Parents/Legal guardian able and willing to sign informed consent and the child is willing to sign assent form for participation. All forms are in English.
• Healthy children, age 12-18 years old

Exclusion Criteria:

• Any chronic or congenital conditions that may potentially affect immune responses
• Cough, congestion, fever, rhinorrhea, rash and any other symptoms indicative of infection within the 2 weeks prior to enrollment sampling
• HIV, AIDS or other immunodeficiencies or any other condition that may affect their immune system
• Use of systemic steroids within 2 weeks prior to enrollment
• Immunization(s) within the last 30 days

Age Range

12 and up

Official Title ImproviNg The BrEast CaNcer Care DelivEry MoDel for Sex and Gender Minority Survivors (INTENDED for SGM)

Purpose

The long-term goal of this study is to improve decision quality and health-related outcomes for sexual gender minority (SGM) breast/chest cancer survivors. The goal is to evaluate important ways the current care model needs adjusted for SGM people, and how best to combine a socially important care model into clinical practice.

Survivors: Eligible participants will participate in a 90-minute focus group and online survey regarding your opinions about improving LGBTQ+ breast/chest cancer care.

Clinicians: Eligible participants will participate in a 30-minute interview and brief survey regarding your opinions about improving LGBTQ+ breast/chest cancer care.

Participation in this study will take no more than 1 hour and 30 minutes.

Could this study be right for you?

Survivors:

1. Self-identify as a member of the SGM community
2. Age ≥18 years at the time of signing the informed consent form
3. Breast/chest cancer survivor in active treatment or completed active treatment in the last 10 years (not including hormone therapy)
4. Be able to read and speak English
5. Have received care in the U.S.
6. Be able to participate in virtual meetings

Clinicians:

1. Physicians, advance practice providers, nurses, psychologists, social workers, therapists, technologists, and other trained clinical professionals
2. Provide care to individuals diagnosed with breast cancer in the U.S.
3. Be able to read and speak English
4. Be able to participate in virtual meetings

Age Range

18 and up

Official Title A Hybrid Effectiveness-Implementation Trial to Improve Safe Driving among Teen Drivers with Traffic Violations

Purpose

The purpose of this study is to test the effects of an in-vehicle driving feedback technology, with and without parent training, on parent-teen communications as well as teens' risky driving behaviors, unsafe driving behaviors, and subsequent traffic violations.

Could this study be right for you?

In order to be eligible:

• You must be 16-18 years of age
• Need a valid State of Ohio driver's license (no learner's permit)
• Proof of car insurance
• Must drive more than one hour per week

Age Range

16 and up

Official Title A Phase 2, double-blind, randomized, placebo-controlled study of nelotanserin versus placebo in patients with dementia with Lewy bodies (DLB) experiencing REM sleep behaviors (RBD)

Purpose

The purpose of this study is to evaluate the safety of the study drug called nelotanserin and to assess the effects of nelotanserin in those experiencing frequent REM sleep behavior disorders due to dementia with Lewy bodies. Nelotanserin (study drug) is an investigational product, which means that it has not been approved by the U.S. Food and Drug Administration (FDA) or the government health agencies of any other countries.

Could this study be right for you?

• Age: 50-85
• Diagnosis: probable dementia with Lewy bodies or Parkinson's disease dementia
• AND diagnosis of REM sleep behavior disorder (RBD) with frequent RBD episodes
• Must have a study partner willing to serve as a collateral informant for study assessments
• MMSE Score: greater than or equal to 18 (Mini Mental State Examination score to be explained by the coordinator)

Age Range

50 and up

Official Title Mechanisms of Negative Affectivity

Purpose

Symptoms related to depression and anxiety can affect a person’s daily life and relationships. Some research suggests that people with mood and anxiety disorders process information differently than people without these types of disorders.

The purpose of this study is to better understand the way the brain works in people who have depression and anxiety. Researchers hope their findings will lead to better ways to diagnose and treat mood and anxiety disorders in the future.

Participation involves an initial phone call and a 3 to 5 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan.

The 3rd and 4th visits (at 6 and 12 months) will include 1.5 to 3 hours of questionnaires and interviews each.

Following the scan, the 6-month follow-up, and the 12-month follow-up, participants will also complete daily online questionnaires for 7 days.

Could this study be right for you?

You may be eligible for this study if you are:

• 18-25 years of age
• Right-handed
• Currently experiencing symptoms of depression or anxiety (feeling down or depressed, anxious, nervous, or tense, having no interest in things you used to enjoy, or feeling hopeless)
• Not currently receiving treatment (psychiatric medications or therapy)
• No major medical problems (e.g., stroke, heart disease, high blood pressure, endocrine disorders, etc.)
• No history of neurological disorders (e.g., seizures, head injury, etc.)
• Normal vision, vision that is corrected to normal with glasses or contacts
• Willing and able to undergo fMRI scanning (not claustrophobic, no non-removable metal in your body)
• Not pregnant

Participation involves an initial phone call and a 3 to 5 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan.

The 3rd and 4th visits (at 6 and 12 months) will include 1.5 to 3 hours of questionnaires and interviews each.

Following the scan, the 6-month follow-up, and the 12-month follow-up, participants will also complete daily online questionnaires for 7 days.

Age Range

18 and up

Official Title Mechanisms of Self and Other Evaluation (MeSO Study)

Purpose

The purpose of this study is to better understand the way the brain works in people who have depression and people who have previously been depressed. We are also testing healthy subjects for comparison. We hope our findings will lead to better ways to diagnose and treat mood disorders in the future. Participation involves an initial phone call and a 2 to 4 hour visit to find out if you are eligible. This visit will include completing questionnaires and interviews. If eligible, participants will have a second 3-5 hour visit for an MRI scan. Two months after the scan, participants will complete daily online questionnaires for 7 days. This process is repeated 2 months later (4 months after the scan). 

Could this study be right for you?

You may be eligible for this study if you:

• Are between the ages of 18-40
• Are right-handed
• Do not have a history of neurological disorders (e.g., seizures, head injury, etc.)
• Do not have major medical problems (e.g., stroke, heart disease, high blood pressure, endocrine disorders, etc.)
• Have normal vision, vision that is corrected to normal with glasses or contacts
• Are willing and able to undergo fMRI scanning (not claustrophobic, no non-removable metal in your body)
• Are not pregnant

Age Range

18 and up

Official Title Adipocyte-T Cell Interactions Modulate Adipose Inflammation and Insulin Sensitivity Following Weight Gain

Purpose

The purpose of this research study is to better understand the role of fat tissue, how cells in fat tissue communicate, and determine what signals specific cells use to cause inflammation and insulin resistance during weight gain. This may help researchers better understand the process that happens in Type 2 Diabetes. As a result, through the course of six--nine weeks, participants will be asked to gain at least 10% of their starting body weight. A dietitian will meet with participants to give advice to help with meeting the study weight gain goals, as well as provide additional meal vouchers and supplemental shakes as needed. Following the study, participants will receive guidance how to lose the weight they've gained if they would like to do that.

Could this study be right for you?

You may be eligible if you:

• Are 18-60 years of age
• Are lean; Have a BMI 18-24.9 kg/m2 (*see link below for calculating your BMI -- Body Mass Index)
• Have healthy levels of cholesterol and triglycerides (These will be tested at screening)
• Are a non-smoker
• Are non-diabetic
• Are free of chronic illness
• Are not pregnant or breastfeeding

*Calculate your BMI

Exclusion Criteria:

• Fasting triglycerides > 150 mg/dL or nonfasting triglycerides ˃ 250 mg/dl
• LDL-Cholesterol level > 150 mg/dL
• Presence of significant anemia (hemoglobin <10.0 gm/dL)
• Currently or planning to take blood thinners
• Current smokers
• Have taken steroids or anti-inflammatory meds for >6 months in the last 6 months
• >10% body weight loss within 3 months of enrollment
• *Other exclusions may apply

Age Range

18 and up

Official Title Movement and Music Intervention for Individuals with Dementia

Purpose

There is some evidence that music based interventions may have a protective effect on the brain in those with dementia. There is also evidence that doing activities that engage the brain through music are beneficial. This study seeks to investigate the potential benefits of a music based intervention for individuals with dementia.

Could this study be right for you?

You may be eligible if you:

• Have a diagnosis of dementia (mild to moderate)
• Are age 60 and older
• Able to follow simple instructions

EXCLUSION CRITERIA:

• Unable to walk 10 feet unassisted
• Presence of bone disorder that impacts walking
• Presence of other neurologic diagnosis that impacts cognitive or motor function such as stroke, Parkinson disease or traumatic brain injury

Age Range

60 and up

Official Title CHILDHOOD ATROPINE FOR MYOPIA PROGRESSION (CHAMP): A 3-ARM RANDOMIZED, DOUBLE-MASKED, PLACEBO-CONTROLLED, PHASE 3 STUDY OF ATROPINE SULFATE OPHTHALMIC SOLUTION 0.01% AND 0.02%

Purpose

The purpose of the study is to determine if a daily eye drop will help slow the progression of nearsightedness in children.

Could this study be right for you?

Your child may be eligible for this study if he/she is:

• Ages 3-17
• Nearsighted

Participants will complete visits for follow-up (every 6 months) and to pick up study eye drops (every 3 months).

Please have your child’s current eye glasses prescription available when you call.

Age Range

3 and up