Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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A Study Utilizing Functional Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery
Official Title Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor SurgeryPurpose
The goal of this study is to understand if there are any changes to the connections between the cells in the brain before and after the ultrasound surgery for the treatment of Essential Tremor. This will be done by comparing patients who have had ultrasound surgery and Essential Tremor with healthy individuals. This study may help us to better target the tremor region in the brain during the ultrasound surgery.
Could this study be right for you?
- You must be between the ages of 40 and 85
- Willing to have MRI imaging of the brain
Age Range
40 and up -
A treatment study for chondral lesion in your knee
Official Title Evaluation of the efficacy of radiofrequency-based debridement vs. mechanical debridement for the treatment of articular cartilage lesions.Purpose
The purpose of this study is to evaluate 2 different treatments, Mechanical Debridement (i.e., a mechanical shaver that removes areas of damaged tissue) and Radiofrequency Debridement (i.e., electrical energy that removes areas of damaged tissue), used to treat the chondral lesion in your knee.
Could this study be right for you?
You may be eligible for this study if you:
- Are 18 - 50 years of age
- Suspected chondral damage in the following locations where debridement is indicated:
- Medial femoral condyle
- Lateral femoral condyle
- Trochlea
- Patella
- 1 or more chondral lesion(s) as noted on MRI
Exclusion:
- Previous chondral treatment in the same compartment (prior debridement and lavage performed more than three months prior to baseline are acceptable)
- Pregnant and/or intending to become pregnant during this study period
Age Range
18 and up -
A Treatment Study For COPD
Official Title A Multicenter, Randomized, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira™ Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD)Purpose
The purpose of this research study is to evaluate the safety and efficacy of the Nuvaira System, which is made by Nuvaira, Inc., for Targeted Lung Denervation (TLD) Therapy.
The primary purpose of conducting this study is to see if TLD Therapy in addition to optimal medical care (daily breathing medications you have been prescribed by your doctor) is better at reducing a moderate or severe worsening of symptoms (known as an COPD flare-ups or exacerbations) and related hospitalizations than optimal medical care (daily breathing medications you have been prescribed by your doctor) alone.
Could this study be right for you?
Inclusion Criteria:
- Between 40 and 75 years of age
- Non-smoking for a minimum of 2 months prior to consent and agrees to not smoke for the duration of the study
- Diagnosis of COPD with 30% ≤ FEV1 <60% of predicted and FEV1/FVC <70% (post-bronchodilator)
- SpO2 of at least 89% on room air at the time of screening
- Has a documented history of having minimally been taking a regular respiratory maintenance medication for at least 12 months at the time of consent; medications will be reviewed by study team
- If you have participated in a formal pulmonary rehabilitation program recently, program completion should have occurred more than 3 months prior to consent; if in a maintenance program, you will agree to continue your current program through your 12-month follow-up visit;
- Additional criteria will be reviewed by the study team
Involvement in this study will last approximately 62 months.
Age Range
40 and up -
Abbott DBS (Deep Brain Stimulation) Registry
Official Title ABT-CIP-10300: Abbott DBS Registry of Outcomes for Indications over Time (ADROIT)Purpose
The purpose of this study is to collect information and evaluate outcomes for Abbott Deep Brain Stimulation (DBS) systems that are approved and sold in your country.
In order to evaluate how the DBS system performs, data will be collected before, during and after DBS implant when you visit the study doctor. The data collected will include information on your movements, feelings, daily activities, and DBS program settings.
The information gathered in this study will add to the understanding of treatment options for future patients receiving DBS.
Could this study be right for you?
Inclusion Criteria:
- You are scheduled for a new implant or IPG device replacement surgery with a market-released Abbott DBS system within 3 months
Exclusion Criteria:
- You are currently enrolled or plan to enroll in another study that may alter the results of this clinical investigation
- You have another disease, conditions, or other medical, social, or psychological conditions that could limit your ability to participate in the clinical investigation or to satisfy follow-up requirements
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Adult Eye Tracking Study
Official Title Comprehensive Protocol for Cognitive Development ResearchPurpose
The purpose of this study is to better understand learning, memory and attention development from childhood to adulthood using eye-tracking techniques.
This study will include one lab visit which will take place on Ohio State's main campus and will last approximately 40-60 minutes.
Could this study be right for you?
Eligibility Criteria:
- Must be 18 and 35 years of age
- Have normal or corrected to normal vision
Age Range
18 and up -
Adults Helping Adults With Immune Diseases
Official Title Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validationPurpose
A test for healthy adults from 19 - 75 years old to develop normal values for interpretation of immunological tests in adults with disorders of the immune system.
Voluntary participation involves blood draw at Nationwide Children's hospital. Qualified participants would be eligible to provide a sample every 2 months (not more than 6 times per year).
Could this study be right for you?
If you are:
- An adult 19 years of age or older
- Healthy with no significant medical diagnoses
- Have no chronic conditions that can affect results of immunological studies
- Not on any medication known to alter immune status or function
- Have not undergone recent surgery, chemotherapy, radiation or transplantation
- Non-smoker
- Body mass index (BMI) in healthy range
- No infections within last 2 months
Age Range
19 and up -
An Observational Study to Evaluate Lung Health in Young Adults
Official Title [American Lung Association (ALA)] Lung Health Cohort (LHC) StudyPurpose
The purpose of this study is to examine why some people have better lung function than others as young adults during the period of peak lung health (ages 25 to 35 years old). The long-term goal of this study is to come up with ideas about how to promote the best possible lung function in young adults.
Participation in this study will be 4.5 years.
Could this study be right for you?
Inclusion Criteria:
- Men and women aged 25-35 years old at time of examination
- Able to read and understand English or Spanish
- Have a social security number
Exclusion Criteria:
- Severe asthma or other chronic lung disease
- Diagnosed cardiovascular disease
- History of cancer other than non-melanoma skin cancer
- Currently pregnant
Age Range
25 and up -
Child Categorization Study
Official Title The Ontogenesis of Categorization (Children age 4)Purpose
The purpose of the study is to investigate the early development of attention, learning and memory; this is a multi-year study.
All sessions will take approximately 60-120 minutes to complete. This study will be conducted in our lab, and mandated OSU COVID safety protocol will be followed.
Could this study be right for you?
- Children who are 4 years old
- Have normal or corrected to normal vision
Age Range
4 and up -
Child Memory Study
Official Title Cognitive Development (Children 4-9 yrs old)Purpose
The purpose of this study is to understand how children sort new information using simple memory exercises with animated computer games.
All sessions will take approximately 25-45 minutes to complete. Participating children will play memory games on our touchscreens and computers. For on-campus sessions, mandated OSU COVID safety precautions will be followed.
Could this study be right for you?
- Children ages 4-9 years old
Age Range
4 and up -
Children Helping Children With Immune Diseases
Official Title Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validationPurpose
This study uses healthy children from newborns to 18 years old to help understand immune disorders. This study will compare healthy children and teens to children and teens with disorders of the immune system.
Volunteers will visit Nationwide Children's Hospital (NCH) for a blood draw either one time or not more than once every three months.
Could this study be right for you?
If your child is:
- Newborn to 18 years of age
- Healthy with no significant medical diagnoses
- Has no chronic medical conditions that can affect results of immunological studies
- Is not on any medication known to alter immune status or function
- Has not undergone recent surgery, chemotherapy, radiation or transplantation
- Has had no infections within the last 2 months
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Cognition and Brain Circuitry
Official Title Cognition and Brain CircuitryPurpose
The purpose of the study is to look at how our brain networks interact for different mental functions and how individual differences in brain structure and function determines individual differences in behavior. During this study, we use magnetic resonance imaging methods: functional magnetic resonance imaging (fMRI) and diffusion weighted imaging (DWI). Functional MRI (fMRI) and DWI are typical imaging methods that use a strong magnetic field and radio waves to make pictures of your body. The total length of the study will be between 3 and 4 hours, including up to 2 hours outside the MRI scanner and 2 hours in the scanner.
Could this study be right for you?
- Healthy adults between 18-40 years of age
- Have normal or corrected-to-normal vision
Age Range
18 and up -
Decision Making Among Couples Concerning "Permanent/Irreversible" Birth Control
Official Title Couple Dynamics Surrounding Contraceptive SterilizationPurpose
This study aims to understand people’s experiences with contraceptive sterilization (such as tubal ligations or vasectomies).
The purpose of this study is to better understand how adults decide to use sterilization as
their main form of birth control. By examining sterilization decisions, this study will
provide a better understanding of how individuals describe and explain their decision
making process.In this study we are interested in learning how people discuss these decisions with their partner, as
well as everyday interactions with their partner, other forms of birth control, and attitudes
about gender more generally.Could this study be right for you?
- Ages 21-55
- Have used tubal ligation or vasectomy as primary contraception, WITHIN the last five (5) years
Participants will be asked to answer a series of questions regarding their experience with sterilization. Interviews will be digitally recorded by audiotape and will remain confidential. The duration of the interview will last approximately one hour to one hour and thirty minutes.
Age Range
21 and up