Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • SOAR (State of Ohio Adversity and Resilience) Brain Health Study

    Official Title
    State of Ohio Adversity and Resilience Study (SOAR)- Deep Phenotyping
    Purpose

    The purpose of this study is to develop effective mental health and preventing suicide and substance use disorder, we must better understand risks, which lead to mental illness, and resilience, which allows us to grow even in presence of adversity. This study is looking at how people live and how they deal with distress, depression or drugs and alcohol in Ohio. Family members living in Ohio are asked to participate.

    Could this study be right for you?

    Eligibility:

    Inclusion criteria:

    • Adults, age 18-72, and adolescents, age 12-17.

    Exclusion criteria:

    • Inability to functionally communicate in English.
    • Unwilling/unable to sign informed consent or assent document or obtain parental authorization from a parent or legal guardian (subjects <18 years old).
    • Inability to understand/follow instructions for study procedures.
    • Participants without at least 1 other family member who is willing to participate
      • The definition of family member is subjective to the participant and may not be a blood relative.
    Age Range
    12 - 72 years
  • A Study about how the Menthol Cigarette Ban impacts the African American community

    Official Title
    Assessing the Impact of an FDA Ban on Menthol Cigarettes on Tobacco-Related Health Disparities in African American Smokers
    Purpose

    The main reason this study is being done is to assess the impact of the FDA’s (and Columbus) menthol ban on African American (AA) communities. This information will provide the Food and Drug Administration (FDA) with needed information on the impact of a menthol ban on the population most affected by such a policy. The study will focus on collecting survey data on AA menthol smokers’ perception of a menthol ban, their awareness/accessibility to quitting support, and their willingness to enroll in a future study.

    Could this study be right for you?

    All participants must be self-identified AAs and then sorted into the following categories:

    • A Current Menthol smoker is defined as someone who regularly smokes menthol cigarette smokers, at least 5 cigs/day for > 1 year.
    • A Former menthol smoker is defined as someone who quit menthol cigarette smoking for >6 months, who previously smoked >5 cigs/day for >1 year.
    • Never-smoker is defined as someone who smoked < 100 cigs in their lifetime (CDC definition) and none for >1 year.

    Additional eligibility criteria include:

    (1) between 21 and 50 years old; (2) access to a smartphone or email, and (3) reading and speaking English.

    Age Range
    21 - 50 years
  • Ohio Mood Disorder Registry and Repository

    Official Title
    Ohio Mood Disorder Registry and Repository
    Purpose

    Mood disorders like Major Depressive Disorder and Bipolar Disorder can be chronic, recurrent illnesses. Our treatments to date can help many people but are often trial and error, and continuity and access to care form major barriers. Our purpose is to create a research registry and repository of individuals with mood disorders who are willing to provide clinical data yearly, and who are willing to be contacted to participate in current and future studies of mood disorders.

    Could this study be right for you?

    Inclusion Criteria

    • 8-70 years of age.
    • Fluency or advanced conversational English abilities, by self-report.
    • Eligible individuals will have a history of two or more mood disorder episodes (depression events of at least 2 weeks meeting 5 of the criteria for major depressive disorder).

    Exclusion Criteria

    • Head injury with loss of consciousness of five minutes or greater.
    • Hospitalization for drug-related concerns.
    • Evidence of intellectual disability.
    • Diagnosis of a developmental condition like autism spectrum disorder.
    • Evidence of psychosis outside of a mood episode (e.g., schizophrenia).
    • Hospitalization or infusion for eating condition.
    Age Range
    8 - 70 years
  • A Study Examining Cochlear Implant Surgery

    Purpose

    This study aims at preserving residual hearing and assessing outcomes in cochlear implant patients.

    Could this study be right for you?

    · Sensorineural hearing loss in both ears acquired after birth

    · Better hearing in the low frequencies in the ear to be implanted

    · Severe to profound hearing loss in the mid-to-high frequencies in the ear to be implanted

    · English-speaking

    Inclusion Criteria varies, please contact Study Coordinator. 

    Age Range
    18 - 79 years
  • A Study About Aromatic L-Amino Acid Decarboxylase Deficiency (AADC) in Pediatric Patients

    Official Title
    A Single-Stage, Adaptive, Open-Label Dose Escalation Safety Study of Adeno-Associated Virus Encoding Human Aromatic L-Amino Acid Decarboxylase (AAV2-hAADC) Administered by MR- guided Infusion into the Midbrain in Pediatric Patients with AADC Deficiency
    Purpose

    The overall objective of this study is to determine the safety and efficacy of AAV2-hAADC delivered to the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) in children with aromatic L-amino acid decarboxylase (AADC) deficiency, and to see if there is a demonstration of effective restoration of AADC function by assays of CSF neurotransmitter metabolites and F-DOPA PET imaging, as allowed by subject’s ability to travel to undergo follow-up visits.

    Could this study be right for you?

    Inclusion Criteria

    • Diagnosis of AADC deficiency from genetic test and CSF/blood enzyme test
    • Failed to derive adequate benefit from standard medical therapy as judged by presence of residual oculugyric crises and developmental delay.
    • Documented history of motor developmental delay, with inability to walk independently without support by age 18 months.
    • Both parents (or legal guardians) must give their consent for their child’s participation in the study parents unless (i.) one parent is deceased, unknown or incompetent; (ii.) one parent is not reasonably available; or (iii.) one parent has responsibility for the care and custody of the child.

    Inclusion Criteria varies, please contact Study Coordinator for more information.

    Exclusion Criteria

    • Presence of other significant medical or neurological conditions that would create an unacceptable operative or anesthetic risk.
    • Previous stereotactic neurosurgery.
    • Coagulopathy, or need for ongoing anticoagulant therapy.
    • Receipt of any investigational agent within 60 days prior to Baseline and during study participation.

    Exclusion Criteria varies, please contact Study Coordinator for more information. 

    Age Range
    2 years and up
  • Interview Study for Caregivers of Older Adults with Memory Problems

    Official Title
    CareNet: An Interactive Digital Tool to Assess Informal Caregiving Networks of Older Adults with Dementia
    Purpose

    We are interested in understanding the dynamics of caregiving when multiple caregivers are involved in caring for an older adult with memory problems. We would like to interview the primary caregiver in a brief one-time interview about their thoughts and experiences in providing care for an older adult with memory problems. 

    Could this study be right for you?

    Participants must be:

    • An unpaid caregiver of an older adult with memory loss problems
      • The older adult must be 65 years or older
      • The older adult must not live in a residential care/assisted living facility
    • Able to identify at least one other unpaid caregiver for the older adult with memory loss problems
    • Able to communicate in English
    Age Range
    18 years and up
  • Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy

    Official Title
    Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy
    Purpose

    The purpose of this study is to determine whether spinal cord stimulation (SCS) will reduce pain in patients with painful Diabetic Peripheral Neuropathy (DPN).

    Could this study be right for you?

     

    Inclusion Criteria:

    • Over 18 years old
    • Diagnosis of diabetic peripheral neuropathy refractory to treatment with gabapentin or pregabalin and at least 1 other class of analgesic
    • Diagnosis of medically refractory pain secondary to diabetic neuropathy
    • Presence of pain for 12 months

    Exclusion Criteria:

    • Severe medical comorbidities that, in the opinion of the surgeon, exclude the patient from surgical intervention
    • Spinal disease with severe spinal stenosis or spinal cord compression in the region of the proposed spinal cord stimulator lead placement
    • Coagulopathy that cannot be corrected
    • Unable to discontinue blood thinning medications

    Inclusion and Exclusion Criteria varies, please contact Study Coordinator. 

    Age Range
    18 years and up
  • Diabetic Foot Ulcer Study

    Official Title
    Concurrent optical and magnetic stimulation (COMS) for treatment of refractory diabetic foot ulcer; a prospective randomized, sham-controlled, double-blinded, pivotal clinical trial
    Purpose

    The purpose of this study is to evaluate the safety and effectiveness of the treatment with the COMS One device in subjects with refractory diabetic foot ulcers (DFUs). 

    The duration of this study will last up to 28 weeks. 

    Could this study be right for you?

    Inclusion

    • Male and females aged 22 to 90 years old 
    • Able to understand and sign the informed consent form (ICF) and comply with requirements set in the protocol including trial visits, trial treatment and dressing regimens and compliance with required offloading device (if applicable)
    • Type 1 or Type 2 diabetes mellitus

    Exclusion

    • Known pregnancy or lactating
    • Active skin cancer, a history of skin cancer or any other localized cancer, precancerous lesions or large moles in the areas to be treated
       

    Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information. 

    Age Range
    22 - 90 years
  • Share your Experience: Exploring Gastrointestinal Symptoms and Food Struggles

    Official Title
    In Their Own Words: A Qualitative Exploration of Food Insecurity in the Lives of Patients with Gastrointestinal Disorders
    Purpose

    The purpose of this study is to better understand the daily food- and nutrition-related experiences of people with GI symptoms through a virtual interview. 

    There has been very little research on how food challenges affect those with GI symptoms and conditions.

    We think you may have valuable insights, Your Voice Matters! 

     

     

     

     

     

     

     

    Could this study be right for you?
    • 18 + years old 
    • Have experienced any level of food-related concerns within the past 12+ months 
    • Living with GI symptoms and/or diagnosed GI condition 
    Age Range
    18 years and up
  • A Study for those with Treatment Resistant Epilepsy & Anxiety

    Official Title
    An open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound unilateral thalamotomy for patients with treatment-refractory focal onset epilepsy and comorbid anxiety
    Purpose

    The purpose of the study is to learn more about whether an ultrasound treatment for epilepsy and anxiety is safe and effective.

    Could this study be right for you?
    • Age: 18-65 years old
    • Treatment resistant Epilepsy (focal or partial-onset seizures)
    • ≥ 3 seizures/month
    • Moderate-to-severe Anxiety

     

     

    Age Range
    18 - 65 years
  • A Study Evaluating How Dietary Fat Affects Cognition

    Official Title
    Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study: Dietary Fat Quality and Cognitive Impairment
    Purpose

    The purpose of the EFFECT Study is to determine how dietary fats influence cognitive (mental) function in adults.

     

    During the 7-week study participants will

    • Consume one study food per day for a total of 3 weeks
    • Have their blood drawn
    • Have their body weight and shape measured
    • Complete cognitive tests
    • Fill out questionnaires
    • Complete diet and physical activity recalls
    Could this study be right for you?
    • Feel your memory or concentration is not as good as you'd like it to be
    • Are overweight
    • Do NOT have diabetes
    • Do NOT have dementia or Alzheimer's
    • Do NOT have food allergies 
    • Are NOT pregnant or nursing an infant
    Age Range
    40 - 75 years
  • Variations in Ketone Metabolism

    Official Title
    Strategies to Augment Ketosis- Variations in Ketone Metabolism
    Purpose

    This study is being done to see how individuals respond to a ketone ester (KE) across different age groups and health statuses. With the ketogenic diet becoming more popular, research on ketones (a molecule created when fat is broken down in the body) has grown as well. 

    These findings will be used to help develop future research studies and help others to pick the right doses of ketone supplement.

    Could this study be right for you?
    • Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction 

    • Have NOT experienced >10% weight loss in the last 6 months 

    • Do NOT currently consume a low carbohydrate diet 

    • Do NOT consume alcohol more than 3 drinks/daily or 14 drinks/weekly 

    • Do NOT suffer from food allergies or gastrointestinal disorders 

    Age Range
    20 - 70 years