Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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Nutrition Security Survey for Individuals Living with Spinal Cord Injury in Ohio
Official Title The prevalence of nutrition insecurity across Ohio targeting individuals with spinal cord injury (SCI) who live in urban and rural areasPurpose
The purpose of this study is for researchers at OSU to gather information on nutrition security for individuals with spinal cord injury living in Ohio.
If you agree to participate in this study, you will be asked to answer questions about your current socioeconomic situation as well as questions about your health including details regarding your spinal cord injury. You will then be directed to a 4-question survey asking about your experience with food in the last 12 months. You can fill out all these questions online, over the phone, or in-person, depending on your preference.
You will only be asked to complete the survey once. Answering all the questions including the survey should take less than 10 minutes to complete.
Could this study be right for you?
- Age 18 and older
- Diagnosis of Spinal Cord Injury
- Currently living in Ohio
Age Range
18 years and up -
A First-in-human Study of a New Gene Therapy (AMT-260) in Adults with Unilateral Refractory Mesial Temporal Lobe Epilepsy (MTLE)
Official Title A Multi-center, Phase 1/2a, First-in-human (FIH) Study Investigating the Safety, Tolerability, and Efficacy of AMT-260 in Adults with Unilateral Refractory Mesial Temporal Lobe Epilepsy (MTLE) Administered via Magnetic Resonance Imaging (MRI)-guided Convection-enhanced Delivery (CED)Purpose
You are being invited to participate in a study about mesial temporal lobe epilepsy (MTLE) on only 1 side (unilateral) of the brain that has not responded to medication (refractory).
The study will test AMT-260, which is a new gene therapy under investigation for use in treating people like you with MTLE. It is not yet approved as a drug for treating MTLE. It can only be used in a study like this one. This is the first time this gene therapy will be used in humans. It has previously been studied in animals.
AMT-260 is a gene therapy designed to reduce the electrical signals between nerve cells (neurons) in the parts of your brain where nerve cells are abnormally connected. This reduces the extra electrical signals that happen at the same time and is intended to reduce your seizure activity.
The overall goals of this study are:
- To observe whether participants have any side effects from AMT-260 or from the procedure to deliver AMT-260 into the brain and how well participants tolerate any side effects that may occur.
- To measure if participants have changes in:
- frequency of their seizures
- how their seizures affect their life
- how the human body takes up and removes AMT-260
- To find the best dose of AMT-260 for future participants to ensure clinical benefit with minimal or no side effects.
Could this study be right for you?
Adult, 18-65 years of age, inclusive, capable of giving informed consent.
Written informed consent is given freely after the nature of the study has been explained to the participant and the completion of data disclosure.
Willingness to undergo necessary surgical procedures.
Diagnosis of unilateral refractory MTLE for ≥360 days, confirmed by an Epilepsy Monitoring Unit.Additional Eligibility Criteria to be assessed by neurosurgery team, and as described in the study protocol.
Age Range
18 - 65 years -
Teen Depression Study
Official Title Developing Rumination-Focused Treatment to Reduce Risk for Depression Recurrence (RDR) in Adolescence (RuMeChange)Purpose
We are conducting a study looking at how therapy strategies can help teenagers stay healthy, reduce rumination, or overthinking and worrying, and prevent depression relapse. If eligible, the teenager would complete assessments which include clinical interviews over Zoom, surveys, cognitive testing, and an MRI.
A parent/guardian is required to enroll in the study and will complete questionnaires and a clinical interview as well.
Could this study be right for you?
Inclusion Criteria:
- 14-17 years of age at enrollment
- Youth assent and parent consent
Exclusion Criteria:
- Metal braces, tattoos with metal
- Claustrophobia
- Current pregnancy
Age Range
14 - 17 years -
Evaluation of the Estimated Specificity of the T-SPOT®.TB test for the detection of Tuberculosis infection
Official Title Evaluation of the Estimated Specificity of the T-SPOT®.TB test for the detection of Tuberculosis infectionPurpose
The purpose of this study is to determine the estimated accurateness of the T-SPOT.TB test, with a target of >95% preciseness for the finding of TB infection.
Your participation will involve completing an online or over the phone screening and a one-time blood sample collection of 10mL (2 teaspoons). The study visit should take about 30 minutes.
Could this study be right for you?
- 18 years of age and older
- Able to provide Informed Consent
- Have no symptoms nor suspicion of TB
- Live in low endemic area for TB
- Have NO medical record of TB, and not currently or previously diagnosed with TB
- NOT Pregnant
- Has NOT been born in or spent three weeks or more cumulatively in any WHO List of high TB burden countries
- Has NOT spent time, worked in a prison, a homeless shelter or a facility for respiratory healthcare
- Has NOT been in close contact with someone previously diagnosed with TB
- Has NOT worked with M. Tuberculosis (Mycobacterium Tuberculosis)
Your participation will involve completing an online or over the phone screening and a one-time blood sample collection of 10mL (2 teaspoons).
Age Range
18 - 90 years -
A Study to Evaluate Lutikizumab in Adults with Moderate to Severe Hidradenitis Suppurativa
Official Title A Phase 3 Multicenter, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lutikizumab in Adult and Adolescent Subjects with Moderate to Severe Hidradenitis SuppurativaPurpose
The purpose of this study is to evaluate the efficacy of lutikizumab
Could this study be right for you?
- Subject must have a diagnosis of moderate to severe hidradenitis suppurativa (HS) for at least 6 months with lesions in 2 distinct areas
- Subject must have tried a 12-week (about 3 months) trial of oral antibiotics with inadequate improvement
- Subject must be in good general health with no history of tuberculosis, HIV, or hepatitis B or C
- Subject must have no recent history (within 6 months) of significant medical conditions such as a heart attack or stroke
- Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study
Age Range
18 years and up -
A Study to Evaluate Vilobelimab for the Treatment of Ulcerative Pyoderma Gangrenosum
Official Title A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Adaptive Phase III Trial To Investigate Efficacy And Safety Of Viobelimab In The Treatment Of Ulcerative Pyoderma GangrenosumPurpose
This study aims to find out if a new investigational drug, vilobelimab (also called IFX-1) is safe and effective in treating pyoderma gangrenosum.
The study will measure if the study drug closes the ulcers of your skin. It will also measure if the study drug improves the severity of your disease (according to the study doctor and according to you) and if it improves your pain and your quality of life.
Could this study be right for you?
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Investigator confirmed clinical diagnosis of ulcerative pyoderma gangrenosum (PG).
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Minimum of 1 PG ulcer (other than peristomal) which qualifies as the target ulcer
- Area of at least 5 cm2 at screening and baseline
- Circulated by intact skin
- Evaluable by at least 2-dimensional measurement
Age Range
18 years and up -
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Spironolactone Versus Doxycycline for the Treatment Acne in Women
Official Title A Randomized, Double-Blind, Multi-Center Comparative Effectiveness Study Of Spironolactone Versus Doxycycline Hyclate For The Treatment Of Acne In WomenPurpose
To determine whether spironolactone is non-inferior to the oral tetracycline-class antibiotic doxycycline hyclate in the treatment of acne in women
Could this study be right for you?
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Assigned female at birth
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Acne defined as at least 10 inflammatory papules or pustules
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Not currently pregnant or planning to become pregnant
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Willing to attest to abstinence or some form of contraception for the duration of the study (4 months). Approved options of birth control to use during the study include:
- Hormonal contraception (for example, birth control pills, injection, implant, transdermal patch, vaginal ring)
- Intrauterine device (IUD)
- Tubal ligation (tying your tubes)
- Partner with a vasectomy
- Male or female condom with spermicide
- Diaphragm with spermicide
- Cervical cap contraceptive sponge with spermicide
Age Range
16 - 40 years -
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A Study to Evaluate Minoxidil for Treatment of Hair Loss in Patients with Breast Cancer on Endocrine Therapy
Official Title A Pilot Trial of Topical vs Oral Minoxidil for Treatment of Endocrine Therapy-Induced Alopecia in Breast Cancer PatientsPurpose
The purpose of this study is to evaluate the efficacy of minoxidil.
Could this study be right for you?
- Subjects must have a diagnosis of breast cancer stages I-IV
- Subjects must have hair loss while on endocrine therapy (i.e., tamoxifen or an aromatase inhibitor such as anastrozole)
- Subjects must not be on chemotherapy or have been on chemotherapy within 2 years
- Subjects must not have tried oral or topical minoxidil or spironolactone previously
- Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study
Age Range
18 - 70 years -
A Study to Evaluate Anifrolumab in Adults with Active Subacute or Chronic Cutaneous Lupus Erythematosus
Official Title A Multicenter Randomized, Double-blind, Placebo-controlled, Phase III Study to Evaluate the Efficacy and Safety of Anifrolumab in Adults with Chronic and/or Subacute Cutaneous Lupus Erythematosus who are Refractory and/or Intolerant to Antimalarial TherapyPurpose
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Subject must have a diagnosis of cutaneous lupus erythematosus
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Subject must have tried antimalarial treatment (i.e., hydroxychloroquine, quinacrine, or chloroquine) for at least 12 weeks (about 3 months) or was unable to tolerate antimalarial treatment due to side effects
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Subject must be in good general health with no history of tuberculosis, cancer, HIV, or hepatitis B or C
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Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study
Could this study be right for you?
- Subject must have a diagnosis of cutaneous lupus erythematosus
- Subject must have tried antimalarial treatment (i.e., hydroxychloroquine, quinacrine, or chloroquine) for at least 12 weeks (about 3 months) or was unable to tolerate antimalarial treatment due to side effects
- Subject must be in good general health with no history of tuberculosis, cancer, HIV, or hepatitis B or C
- Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study
Age Range
18 - 70 years -
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Creating Culturally Responsive Early Childhood Programs: Hearing from Parents about what they want
Official Title An Examination of Culturally Responsive, Inclusive, and Socially Just Practices Parent FeedbackPurpose
The research study will examine parents’ - or a child’s primary caregiver - perspectives on an online professional development (PD) training for teachers, targeting early care and education (ECE) teachers’ use of culturally responsive, inclusive, and socially just practices. Parents of young children will be recruited to review the online PD course and complete surveys about the course. A subset of participants will participate in a focus group to share their feedback on the course.
Could this study be right for you?
Parent or caregiver to a child who:
- Is between 3 and 5 years old
- Is identified as Black/African American
- Attends a center-based early care and education program (pre-kindergarten, Head Start, child care, preschool, etc.)
Age Range
17 - 99 years -
Hand-eye Coordination Measurements
Official Title Visuomotor skills assessed with different sports vision-related devicesPurpose
The purpose of this project is to determine whether performance correlates between different hand-eye coordination testing and training devices. Two of these devices require the participant to push lighted buttons on a wall-mounted board as fast as possible. The other device requires the participant to push a button at the same time that a (simulated) approaching object arrives.
Could this study be right for you?
- Visual acuity of 20/20 in each eye
- Stereoacuity (depth perception) of 60 seconds of arc
- No eye turn (strabismus) in left, right, or straight ahead gaze
Age Range
18 - 40 years -
Social Abilities and Aging Study
Official Title Progression of Social Cognitive Deficits in Mid- and Late-Life Schizophrenia Spectrum DisordersPurpose
This research is being done to investigate the effects of age on social cognition in schizophrenia spectrum disorder. The study also hopes to examine potential neural bases of social cognition. The findings of the research will help develop effective treatment strategies by identifying who, when, and how to intervene.
Could this study be right for you?
Patients:
- Diagnosis of a schizophrenia spectrum disorder (includes schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, schizophreniform disorder, unspecified or other-specified psychotic disorders)
Healthy Controls:
- No history of any psychotic disorder
- No psychiatric diagnosis in the last 5 years
- Not taking psychotropic medication
Age Range
35 - 75 years