Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

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  • Reviewing and Evaluating Resources Related to Dizziness and Home Based Therapies

    Official Title

    Usability & Acceptability of a Patient-Oriented Educational Resource for Dizziness

    Purpose

    The purpose of this study is to look at a web-based tool on the topic of dizziness so that we can create resources for teaching patients about causes of dizziness and home-based therapies. We are recruiting patients with dizziness and/or general volunteers to review the web-based tool and then provide feedback which will then be used to help update requirements for the educational tool. This study will take about 20-30 minutes of your time to review a website and complete a survey. If you decide to also participate in the discussion, it will take about 20-30 more minutes.

    Could this study be right for you?

    - Participants must be 18 years or older - able to speak and read English at an eighth-grade level or above - be willing and able to participate

    Age Range

    18 and up
  • Rotator Cuff Study--For Those Who Require Surgical Treatment for Full Thickness Massive Tear

    Official Title

    A prospective, single blinded, multi-center, randomized, controlled, pivotal study to assess the safety and effectiveness of the InSpace™ device for treatment of full thickness Massive Rotator Cuff Tears

    Purpose

    This research study will evaluate a new device, InSpace, for use with a full thickness massive tear of rotator cuff (the group of connective tissues in the shoulder). The device is designed to allow smooth gliding of the bones in the shoulder during motion, which may allow rehabilitation exercises with less pain. The research study is being conducted to see whether the InSpace device is safe and effective for shoulder problems due to a full thickness massive rotator cuff tear.

    Could this study be right for you?

    1) Is male or female ≥ forty (40) years of age
    2) Positive diagnostic imaging by MRI within 9 months of enrollment of the index shoulder indicating a full thickness MRCT: measuring ≥ 5 cm in diameter (Cofield classification) and involving ≥ two tendons
    3) Functional deltoid muscle and preserved passive range of motion on physical examination
    4) Failed non-operative treatment of at least 4 months from the initial treatment to include one or all of the following: Oral analgesics, Anti-inflammatory medication (e.g., ibuprofen, naproxen), Corticosteroid injection(s), Physical therapy, Activity modification, or Rest (sling used)
    5) Must be able to read and understand the approved Informed Consent Form (written and oral)
    6) Must be in general good health (as determined by the Investigator) based on screening assessments and medical history
    7) Must be independent, ambulatory, and can comply with all post-operative evaluations and visits.

    Other details will be shared by the study coordinator.

    Age Range

    40 and up
  • Study to Assess the Efficacy and Safety of Adjunctive NBI-1065845 in Adults with Major Depressive Disorder (MDD) (SAVITRI)

    Official Title

    Study to Assess the Efficacy and Safety of Adjunctive NBI-1065845 in Adults with Major Depressive Disorder (MDD) (SAVITRI)

    Purpose

    The purpose of this study is to evaluate the effectiveness and safety of NBI-1065845 compared with placebo. In addition to the study drug, participants will continue their normal antidepressant medications. The main goal of this study is to examine the improving symptoms of depression.

    The duration of the study will last 14 weeks, including up to 4 weeks of screening, 8 weeks of study drug dosing, and a follow-up period of 2 weeks.

    Could this study be right for you?

    • Aged 18-65 years old
    • Have a diagnosis of Major Depressive Disorder (MDD)
    • Currently depressed
    • Poor response to antidepressant treatment

    Age Range

    18 and up
  • Studying a New Method to Evaluate Blood Flow in Patients with Peripheral Artery Disease (PAD)

    Official Title

    Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease

    Purpose

    The purpose of this study is to study a new method to evaluate blood flow to the calves and feet. We hope this information can help evaluate the effectiveness of treatments and predict clinical outcomes. Participants will be required to attend one (2 hr) session at Nationwide Children's Hospital.

    Could this study be right for you?

    -Diagnosis of Peripheral Arterial Disease (PAD) OR leg symptoms, such as muscle pain or cramping AND/OR foot wound that has required medical consultation Healthy volunteers - must be at least 40 years of age - no history of cardiovascular disease (including high blood pressure) - no history of diabetes mellitus - non-smoker - normal BMI

    Age Range

    40 and up
  • Studying the Effects Nitrous Oxide (Laughing Gas) Has on Aggression

    Official Title

    Nitrous Oxide and Cortico-Limbic Function in Aggression (Laughing Gas Study or LGS).

    Purpose

    The purpose of this study is to see how laughing gas (nitrous oxide) changes brain activity in study participants with and without “anger issues”. Brain activity is measured by Magnetic Resonance Imaging.

    The length of time you will be involved in this study will be 4-8 weeks.

    Could this study be right for you?

    - You are a medically healthy man or woman
    - You are between the ages of 21 and 55 years of age
    - Do not abuse alcohol or other drugs
    - With a current history of “anger issues”
    - Able to complete study sessions during the week

    Age Range

    21 and up
  • The ARCADIA Study -- A medication study for prevention of recurrent ischemic stroke

    Official Title

    AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke (ARCADIA)

    Purpose

    The purpose of this research study is to compare the effects (good and bad) of apixaban with the effects (good and bad) of aspirin in patients with unexplained strokes and atrial cardiopathy to see which is better at prevention of future strokes.

    Could this study be right for you?

    - You are at least 45 years old
    - Clinical diagnosis of ischemic stroke* of unknown cause (ESUS or cryptogenic) in the last 120 days
    - Underwent an echocardiogram as part of your stroke work up
    - No history of atrial fibrillation (irregular heartbeat)
    - No known allergy or intolerance to aspirin or apixaban

    *An “ischemic” stroke is an injury to the brain caused by a blocked blood vessel supplying the brain.

    Age Range

    45 and up
  • The Brain Exercise Study

    Official Title

    Strategies for the Development of Social Cognitive Training for Impulsive Aggression (Brain Exercise Study or BES).

    Purpose

    The purpose of this study is to see if brain exercise done on the computer can reduce aggression in those with “anger issues”. The study is a six-week clinical trial using selected brain exercises versus other computer-based exercises.

    Could this study be right for you?

    - Medically healthy man or woman - You are between 21 and 55 years of age - With a current history of “anger issues” - You have regular access to a computer and a smart phone

    Age Range

    21 and up
  • The EASE Study

    Official Title

    A STUDY TO EVALUATE THE SAFETY AND EFFICACY OF THE MATERNA PREP DEVICE IN REDUCING PELVIC MUSCLE INJURIES DURING VAGINAL DELIVERY

    Purpose

    This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery.

    Could this study be right for you?

    You may be eligible for this study if you: 1. Are scheduled for vaginal birth. 2. Are pregnant with a single fetus. 3. Haven't given birth previously, or had a previous pregnancy terminated within 24 weeks gestation. 4. Are willing to comply with the protocol required follow-up visits. 5. Are able and willing to provide written informed consent prior to enrollment. 6. Are 18 years of age or older at time of consent. You will be ineligible for this study if you: 1. Have a high likelihood of less than 1 hour of potential device dilation time after you arrive at the hospital. 2. Have a need for or is planning a Caesarean-section. 3. Begin labor with less than 36 weeks gestation. 4. Have a neurological disorder that could cause pelvic floor dysfunction, such as multiple sclerosis or spinal cord injury 5. Have a collagen-associated disorder that affects tissue elasticity, such as scleroderma or Ehlers-Danlos syndrome 6. Have a localized (genital tract) or systemic infection. 7. Have had prior surgical procedures to the vaginal anatomy which could lead to pelvic floor dysfunction, such as pelvic fractures or pelvic soft tissue injuries 8. Have any general health condition or systemic disease that may represent, in the opinion of the investigator, a potential increased risk associated with device use or pregnancy. 9. Have placenta previa or vasa previa. 10. Have a known significant chromosomal or structural fetal anomalies. 11. Have a category 2 and/or 3 fetal tracing that is unresolved.

    Age Range

    18 and up
  • The Family Risk Study

    Official Title

    Parental History of Suicidal Behavior and Early Markers of Risk in Pre-pubescent Youth

    Purpose

    The purpose of this study is to learn what factors may be related to suicide attempt(s) in children (ages 6 - 9) that have a parental history of suicidal behavior in hopes that this information will help prevent and treat self-harm behavior in youth at high risk.

    Both parents and children will complete questionnaires, interview questions, and a family discussion in addition to problem solving tasks and computer games.

    There are multiple study visits. The first will last about 2.5 to 3 hours and all other appointments will occur annually from your first appointment. Due to COVID-19, families will have the option to conduct annual follow-up appointments via telephone. These annual telephone visits will last approximately 30-45 minutes. If the annual visit is conducted in-person, it will last 1.5 to 2.5 hours.

    Could this study be right for you?

    - Parents and children must be able to read and understand English fluently
    - Child is 6 to 9 years of age
    - Meet other criteria (e.g., no traumatic brain injury) for the study

    Age Range

    6 and up
  • The Ohio State Lupus, Vasculitis and Glomerulonephritis Registry

    Official Title

    The Ohio State Lupus, Vasculitis and Glomerulonephritis Registry

    Purpose

    The purpose of the OSU Lupus and Vasculitis Registry is to obtain clinical and laboratory information about lupus and vasculitis and glomerulonephritis.

    Could this study be right for you?

    Patients at the Ohio State University Rheumatology and Lupus Clinic with one of the following diagnoses who are ages 18 years of age and older:
    - Systemic lupus erythematosus
    - Discoid lupus
    - Mixed connective tissue disorder
    - Undifferentiated connective tissue disorder
    - Wegener’s granulomatosus
    - Microscopic polyangiitis
    - Henoch-Schonlien Purpura
    - Takayasu’s arteritis
    - Giant cell/temporal arteritis
    - Churg-Strauss vasculitis
    - Other vasculitides
    - IgA nephropathy
    - Anti-GBM GN
    - Membranous GN
    - Minimal Change Disease
    - Focal Segmental Glomerulosclerosis

    Age Range

    18 and up
  • The REGENERATE Study - A study to evaluate the effectiveness and safety of a medication (Obeticholic Acid) for those with NASH (nonalcoholic steatohepatitis)

    Official Title

    A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects with Nonalcoholic Steatohepatitis

    Purpose

    This research study is for those who have nonalcoholic steatohepatitis (NASH) (meaning your liver is swollen and damaged because of a buildup of fat in your liver) and some liver fibrosis (which is damaged and scarred liver tissue). Because of your condition, you may be eligible for a research study on an investigational drug for your condition. The Regenerate Study will assess the safety and effectiveness of the investigational medication obeticholic acid (OCA) compared to placebo in delaying specific medical conditions or health related issues that can occur in patients with nonalcoholic steatohepatitis (NASH) (meaning your liver is swollen and damaged because of a buildup of fat in your liver) and some liver fibrosis (which is damaged and scarred liver tissue).

    Could this study be right for you?

    - Age 18 or older
    - Diagnosed with Stage 2 or 3 NASH (nonalcoholic steatohepatitis--meaning your liver is swollen and damaged because of a buildup of fat in your liver) and some liver fibrosis (which is damaged and scarred liver tissue).

    If you are eligible and decide to take part in this research study, you will need to complete 1 or 2 screening visits to see if you are eligible to participate in the study. Once the study doctor determines you can participate in the study, you will be asked to come back to the clinic 8 times (for the Month 0 [Day 1] Visit, the Month 1 Visit, the Month 3 Visit, and then every 3 months) for the first 18 months you are in the study and then 2 times per year (every 6 months) for each additional year you are in the study.

    Age Range

    18 and up
  • The Spine Project

    Official Title

    The Spine Phenome Project

    Purpose

    This study is designed to capture information about your spine. We will collect information from wearable sensors while you move your low back and neck. We will also collect a series of questionnaires and information from your medical record that related to your spine health. We want to compare the health history and motion capabilities of participants with healthy spines to participants with back and neck pain disorders. We believe that capturing and analyzing this information together will advance our understanding of low back and neck disorders and help develop healthcare applications, tools, or devices that improve the way we prevent, evaluate, and treat spine disorders. You will complete up to 8 visits and participate in the study for up to 5 years.

    Could this study be right for you?

    To participate, you must meet the following criteria: -Age 18-80 -Able to speak, read, and understand English -Able to stand for 20 minutes Please let us know if you have any of the following as you may not be eligible to participate (not a complete list): -Currently pregnant -Currently seeing or planning to see a medical provider for low back or neck pain -History of chronic low back or neck pain lasting longer than 3 months -Severe back or spine curvature (example – scoliosis) -Current condition requiring a back brace -History of spine surgery -History of brain or spine cancer -Open wounds on back or neck -Current spine infection

    Age Range

    18 and up