Search Studies

Official Title Decision-Making Abilities and Testamentary Capacity Among Older Adults

Purpose

The overall goal of this research is to examine factors such as social resources, personality characteristics, and neurocognitive functioning in relation to decision-making abilities testamentary capacity among healthy older adults.

Another purpose of this research study is to evaluate the impact of Problem-Solving Treatment-Primary Care (PST-PC), a cognitive-behavioral therapeutic approach, on decision making among healthy older adults. PST-PC involves a seven-step model, in which participants identify problems to be solved, discuss and evaluate different resolutions to reach desired goals; create action plans to accomplish determined goals; and evaluate their effectiveness in resolving designated problems.

We will compare the effectiveness of PST-PC on individuals who will not receive any intervention.

A no treatment control group of older adult participants will also be recruited to compare the effectiveness of PST-PC to individuals who do not receive the intervention. This no treatment control group will composed of participants who do not receive the PST-PC sessions.

Could this study be right for you?

Inclusion Criteria:
-adults aged 65 and older
- Must be independently-living and community-dwelling
- Participants must be willing to undergo a health interview to rule out outstanding medical and psychiatric conditions
- Adequate sensory abilities

Exclusion Criteria:

- A history of psychiatric illness necessitating inpatient treatment
- Participants with self-reported depression and/or anxiety exceeding mild levels of clinical severity

Age Range

65 and up

Official Title An Examination of the Diet Quality of Children Low Income Children from 3-5 Years of Age

Purpose

To determine dietary patterns and calculate dietary quality of young children enrolled in child care centers, WIC, and other places that serve parents and young children; and to identify the most significant cultural, social, and economic factors influencing the dietary and eating patterns of these children.

The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.

Could this study be right for you?

- Parents and/or caregivers must be at least 18 years of age
- Each household must qualify as low income status
- Each parent/caregiver must be fluent in English
- Each child must not have a medical condition requiring diet modifications
- Each child must be 3-5 years old

Age Range

3 and up

Official Title An Examination of the Diet Quality of Low-Income Children from Birth to 6 Months Old.

Purpose

The purpose of the research is to determine the dietary patterns and calculate the dietary quality of infants and enrolled in childcare centers, WIC, and other places that serve parents of young children; and to identify the most significant cultural, social, and economic factors influencing the dietary and feeding patterns of these children.

The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.

Could this study be right for you?

- Parents or caregivers must be at least 18 years of age
- Each parent/caregiver must be fluent in English
- Each household must qualify as low income status based on the number of people in the household
- Children must be within 0-6 months of age
- Children must not have any medical condition requiring a modified diet

Official Title An Examination of the Diet Quality of Low-Income Children 6-24 months old

Purpose

The purpose of the research is to determine the dietary patterns and calculate the dietary quality of children 6 to 24 months of age and enrolled in childcare centers, WIC, and other places that serve parents of young children; and to identify the most important cultural, social, and economic factors influencing the dietary and feeding patterns of these children. The total amount of time you will be asked to volunteer for this study is 2 hours and 10 minutes.

Could this study be right for you?

- Parent or caregiver of a child 6 to 24 months old - Receiving WIC, SNAP, or similar benefits - Live in Franklin County, Ohio

Age Range

18 and up

Official Title Mobile Health App as a Cardiotoxicity Symptom Logging Tool: Feasibility Pilot Study

Purpose

To evaluate the cardio-oncology patient population’s experience with using smart-phone technology as a part of self-management with their care through features such as symptom logging and education. Eligible patients will be asked to participate in a 30-minute virtual interview and/or a 60-minute virtual design or usability session to discuss their thoughts on a mobile app for cardio-oncology patients.

Could this study be right for you?

- English-speaking - Prior cancer diagnosis - Currently undergoing a cancer regimen that includes a targeted, biologic, radiation, and/or immune-based therapy (ex. TKIs and/or ICIs). - No pregnant females - No prisoners

Age Range

18 and up

Official Title Neural Mechanisms of Mindfulness-based Cognitive Therapy (MBCT) for Posttraumatic Stress Disorder (PTSD) and COVID Pandemic-related Stress

Purpose

The purpose of this study is to better understand how Mindfulness-based Mind-Body therapies work to help people with Posttraumatic Stress and Stress and Anxiety related to the COVID Pandemic. We want to learn more about how these treatments work so we can put together better treatments for people with PTSD and stress or worry. Time in the study altogether is generally about 16-18 weeks

Could this study be right for you?

For those suffering from PTSD: - Must be between 18 – 72 years of age - Must have current clinically significant symptoms of PTSD - Must be able to come to OSU Columbus campus for fMRI brain scan - Must be appropriate for group therapy Eligibility for those with Pandemic Stress: - Must be between 18 – 72 years of age - Must have current stress related to the pandemic - Must reside in selected zip codes / under-resourced areas in central Ohio (areas with high levels of residents with incomes near the poverty line) - Must be able to come to OSU Columbus campus for fMRI brain scan - Must be appropriate for group therapy - May have up to moderate depression and/or anxiety

Age Range

18 and up

Official Title Trauma and Neurobiological Threat Reactivity as Risk Factors for Alcohol Abuse in Youth

Purpose

This research study will look at how brain and behavioral responses to emotional prompts relate to future behaviors. This research is being done to better understand risk factors and behavior change in adolescents. The total time that you will be involved in this study is 15 hours including 4 in-person visits and online follow-up forms every 3-months for 2 years.

Could this study be right for you?

Eligibility Criteria includes: - 16-19 years old - No history of alcohol use disorder - History of Interpersonal Trauma - Voluntarily consumed at least 1 prior alcoholic beverage (partial list of inclusion criteria) Exclusion Criteria - Currently pregnant (positive pregnancy test), or trying to become pregnant (women) - Lifetime history of any substance use disorder (partial list of exclusion criteria)

Age Range

16 and up

Official Title A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in people with Depression

Purpose

The purpose of this study is to see if a new drug (BI 1358894), taken in addition to a current antidepressant, is useful and safe for treating patients with Major Depressive Disorder.

You will be in this study approximately 13 weeks and have about 8 visits to the study center. You will also have about 2 visits that will be done by phone.

Could this study be right for you?

Inclusion criteria:
- Between the ages of 18 and 65
- Currently taking an antidepressant
- Currently experiencing symptoms of depression

Age Range

18 and up

Official Title Determining the Optimal Treatment Intensity for Children with Language Impairment

Purpose

The purpose of the study is to determine the amount of speech-language intervention children need to make improvements.

We hope to identify the appropriate amount of intervention needed as well as the point at which adding more intervention is no longer beneficial.

Participation in this study will last for approximately 10 weeks with one 2 hour session before the book reading intervention, one 2 hour session after the book reading intervention and a 6-month follow up.

Could this study be right for you?

Inclusion Criteria:

• Your child is between the ages of 5 and 6 years 11 months old
• Has received a primary diagnosis of a Language Impairment with vocabulary deficits
• Receives Speech and Language services through their school
• Primarily communicates in English

Age Range

5 and up

Official Title Healthy New Albany: Breast Cancer Project

Purpose

Determine the feasibility of delivering a community-based, lifestyle weight management intervention in producing meaningful improvements in weight loss and relevant clinical and patient-reported outcomes in Breast Cancer survivors.

Could this study be right for you?

Female breast cancer survivor within 60 months after cessation of active treatment. Overweight/Obese (BMI > 25). Ability to understand and willing to sign a written informed consent. Willing and physically able to participate in physical activity. Obtain physician consent via primary care physician and/or treating oncologist.

Age Range

30 and up

Official Title Hepatitis C Virus Immunity in Women and Children

Purpose

This is a study to find out how pregnancy affects a mother’s immune system. (The “immune system” is the part of the body that fights germs.) This study is also to find out why some babies who are exposed to infections during pregnancy get infected and others do not.

To do this project we need to study some women and babies who are infected with the hepatitis C virus and others who are not. This will allow us to compare their immune systems.

Could this study be right for you?

You may be eligible to participate if you are:

PREGNANCY COHORT eligibility criteria:
1) Pregnant (enrollment preferably during 1st or 2nd trimester, but may occur as late as the delivery hospitalization)
2) HCV-RNA positive (#150) or HCV-RNA negative (#50)
3) Willing and able to attend all study visits

Exclusion criteria for mothers:
1) Inability to provide informed consent
2) Incarceration

Inclusion criteria for infants:
1) Child born to study mother

Exclusion criteria for infants:
1) In custody of county children’s services (Enrolled infants who are temporarily in custody of children’s services will not have further study blood draws, but lab results from blood tests ordered by their pediatrician may be followed to monitor the outcome of their HCV exposure. Infants who are later placed back in the custody of their mother or relative may be re-enrolled.)

NON-PREGNANCY COHORT eligibility criteria:
1) Willing and able to attend all study visits

Exclusion criteria:
1) Currently pregnant
2) Inability to provide informed consent
3) Incarceration

Official Title Immune Response in Adolescents

Purpose

Our goal in this study is to learn more about the immune system in adolescence and early adulthood. We are looking to enroll healthy children ages 12-18 years old.

Enrollment in the study will require 1 visit to Nationwide Children’s Hospital involving a blood draw and 2 nasal swabs.
The visit will take approximately 1- 1 ½ hour(s). We ask that the family brings a copy of the child’s immunization record to the visit.

Could this study be right for you?

Children will need to meet the following criteria to be in the study:

Inclusion Criteria:
· Parents/Legal guardian able and willing to sign informed consent and the child is willing to sign assent form for participation. All forms are in English.
· Healthy children, age 12-18 years old

Exclusion Criteria:
· Any chronic or congenital conditions that may potentially affect immune responses
· Cough, congestion, fever, rhinorrhea, rash and any other symptoms indicative of infection within the 2 weeks prior to enrollment sampling
· HIV, AIDS or other immunodeficiencies or any other condition that may affect their immune system
· Use of systemic steroids within 2 weeks prior to enrollment
· Immunization(s) within the last 30 days

Age Range

12 and up