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Search Studies

Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

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Found 111 results. Displaying page 4 of 10.
  • Ohio Mood Disorder Registry and Repository

    Official Title Ohio Mood Disorder Registry and Repository

    Purpose

    Mood disorders like Major Depressive Disorder and Bipolar Disorder can be chronic, recurrent illnesses. Our treatments to date can help many people but are often trial and error, and continuity and access to care form major barriers. Our purpose is to create a research registry and repository of individuals with mood disorders who are willing to provide clinical data yearly, and who are willing to be contacted to participate in current and future studies of mood disorders.

    Could this study be right for you?

    Inclusion Criteria

    • 8-70 years of age.
    • Fluency or advanced conversational English abilities, by self-report.
    • Eligible individuals will have a history of two or more mood disorder episodes (depression events of at least 2 weeks meeting 5 of the criteria for major depressive disorder).

    Exclusion Criteria

    • Head injury with loss of consciousness of five minutes or greater.
    • Hospitalization for drug-related concerns.
    • Evidence of intellectual disability.
    • Diagnosis of a developmental condition like autism spectrum disorder.
    • Evidence of psychosis outside of a mood episode (e.g., schizophrenia).
    • Hospitalization or infusion for eating condition.

    Age Range

    8 - 70 years
  • A Study Examining Cochlear Implant Surgery

    Purpose

    This study aims at preserving residual hearing and assessing outcomes in cochlear implant patients.

    Could this study be right for you?

    • Sensorineural hearing loss in both ears acquired after birth
    • Better hearing in the low frequencies in the ear to be implanted
    • Severe to profound hearing loss in the mid-to-high frequencies in the ear to be implanted
    • English-speaking

    Inclusion Criteria varies, please contact Study Coordinator. 

    Age Range

    18 - 79 years
  • A Study About Aromatic L-Amino Acid Decarboxylase Deficiency (AADC) in Pediatric Patients

    Official Title A Single-Stage, Adaptive, Open-Label Dose Escalation Safety Study of Adeno-Associated Virus Encoding Human Aromatic L-Amino Acid Decarboxylase (AAV2-hAADC) Administered by MR- guided Infusion into the Midbrain in Pediatric Patients with AADC Deficiency

    Purpose

    The overall objective of this study is to determine the safety and efficacy of AAV2-hAADC delivered to the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) in children with aromatic L-amino acid decarboxylase (AADC) deficiency, and to see if there is a demonstration of effective restoration of AADC function by assays of CSF neurotransmitter metabolites and F-DOPA PET imaging, as allowed by subject’s ability to travel to undergo follow-up visits.

    Could this study be right for you?

    Inclusion Criteria

    • Diagnosis of AADC deficiency from genetic test and CSF/blood enzyme test
    • Failed to derive adequate benefit from standard medical therapy as judged by presence of residual oculugyric crises and developmental delay.
    • Documented history of motor developmental delay, with inability to walk independently without support by age 18 months.
    • Both parents (or legal guardians) must give their consent for their child’s participation in the study unless (i.) one parent is deceased, unknown or incompetent; (ii.) one parent is not reasonably available; or (iii.) one parent has responsibility for the care and custody of the child.

    Inclusion Criteria varies, please contact Study Coordinator for more information.

    Exclusion Criteria

    • Presence of other significant medical or neurological conditions that would create an unacceptable operative or anesthetic risk.
    • Previous stereotactic neurosurgery.
    • Coagulopathy, or need for ongoing anticoagulant therapy.
    • Receipt of any investigational agent within 60 days prior to Baseline and during study participation.

    Exclusion Criteria varies, please contact Study Coordinator for more information.

    Age Range

    2 years and up
  • Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy

    Official Title Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy

    Purpose

    The purpose of this study is to determine whether spinal cord stimulation (SCS) will reduce pain in patients with painful Diabetic Peripheral Neuropathy (DPN).

    Could this study be right for you?

    Inclusion Criteria:

    • Over 18 years old
    • Diagnosis of diabetic peripheral neuropathy refractory to treatment with gabapentin or pregabalin and at least 1 other class of analgesic
    • Diagnosis of medically refractory pain secondary to diabetic neuropathy
    • Presence of pain for 12 months

    Exclusion Criteria:

    • Severe medical comorbidities that, in the opinion of the surgeon, exclude the patient from surgical intervention
    • Spinal disease with severe spinal stenosis or spinal cord compression in the region of the proposed spinal cord stimulator lead placement
    • Coagulopathy that cannot be corrected
    • Unable to discontinue blood thinning medications

    Inclusion and Exclusion Criteria varies, please contact Study Coordinator.

    Age Range

    18 years and up
  • Diabetic Foot Ulcer Study

    Official Title Concurrent optical and magnetic stimulation (COMS) for treatment of refractory diabetic foot ulcer; a prospective randomized, sham-controlled, double-blinded, pivotal clinical trial

    Purpose

    The purpose of this study is to evaluate the safety and effectiveness of the treatment with the COMS One device in subjects with refractory diabetic foot ulcers (DFUs). 

    The duration of this study will last up to 28 weeks. 

    Could this study be right for you?

    Inclusion

    • Male and females aged 22 to 90 years old 
    • Able to understand and sign the informed consent form (ICF) and comply with requirements set in the protocol including trial visits, trial treatment and dressing regimens and compliance with required offloading device (if applicable)
    • Type 1 or Type 2 diabetes mellitus

    Exclusion

    • Known pregnancy or lactating
    • Active skin cancer, a history of skin cancer or any other localized cancer, precancerous lesions or large moles in the areas to be treated
       

    Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information. 

    Age Range

    22 - 90 years
  • A Study for those with Treatment Resistant Epilepsy & Anxiety

    Official Title An open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound unilateral thalamotomy for patients with treatment-refractory focal onset epilepsy and comorbid anxiety

    Purpose

    The purpose of the study is to learn more about whether an ultrasound treatment for epilepsy and anxiety is safe and effective.

    Could this study be right for you?

    • Age: 18-65 years old
    • Treatment resistant Epilepsy (focal or partial-onset seizures)
    • ≥ 3 seizures/month
    • Moderate-to-severe Anxiety

     

     

    Age Range

    18 - 65 years
  • A Study Investigating a Medicine to Improve Social Communication in Adolescents and Adults with Autism Spectrum Disorder (ASD).

    Official Title MapLight Study (IRIS Clinical Trial)

    Purpose

    The purpose of this study is to investigate a medication intended to improve social communication in adolescents and adults with ASD.

    Could this study be right for you?

    • Have an autism diagnosis or suspect you have an autism diagnosis
    • Have a caregiver or study partner willing to enroll in the study with you

    Age Range

    18 - 45 years
  • PROMISE

    Official Title PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life (PROMISE)

    Purpose

    The purpose of this study is to find out more about how health and exposures during pregnancy, such as having an infection, diet and growth may impact later risk of islet autoimmunity in the
    child. We are also interested in finding out more about why having a father or sibling with type 1 diabetes increases risk of autoimmunity in the child than having a mother with type 1 diabetes.

    Could this study be right for you?

    Inclusion:

    • Pregnant women:
      • who is between 8-24 weeks gestation with a singleton pregnancy
      • have had type 1 diabetes for at least 12 months, or the father of the baby or a full sibling of the baby has type 1 diabetes
      • is 18 years of age or older
      • is willing to have blood collected and to complete questionnaires about prenatal exposures once per trimester during their pregnancy (up to 3 visits) and up to 12 weeks after they deliver their baby
      • is willing to have their baby screened for genetic risk for type 1 diabetes, to complete online questionnaires, and to have their child followed for measurement of islet autoimmunity according to the determined risk for type 1 diabetes, through 5-7 years of age.
        • If low risk, two screenings: the first at 2 years of age and the second between 5-7 years of age
        • If high risk, five screenings: every six months through 2 years of age, and one between 5-7 years of age

    The father of the baby will also be asked to complete one visit during pregnancy but it is not mandatory.

    Exclusion:

    • Multiple Gestation pregnancy
    • Mother unable to consent due to intellectual impairment
    • Fetus with known medical issue that would affect study participation
    • Surrogate / gestational mothers who are not biologically related to offspring they are carrying

    Age Range

    18 years and up
  • Research Study on Light Sensitivity after Head Injury

    Official Title Effect of Fixation Training with Colored Light Targets on Traumatic Brain Injury-Associated Photophobia

    Purpose

    Researchers at The Ohio State University College of Optometry are seeking individuals with a recent history of head trauma who are experiencing light sensitivity. The goal of this study is to determine if daily 20 minute fixation training sessions using a colored (red or blue) light target affects symptoms of light sensitivity, or alters other measurements of the eyes and vision including pupil response.  

    This study will involve attending five 1-2 hour study visits, occurring every 1.5 months for 6 months. Study visits will include answering questions about eye and health history, completing surveys, reading letters on an eye chart, having the pupils measured in response to flashes of light, measuring the side vision, measuring eye alignment and in some cases focusing ability. Outside of the study visits, participants will also complete daily 20 minute fixation training sessions for 6 months using a colored (red or blue) light target, completed at home between study visits.

    Could this study be right for you?

    • Must be 18 to 80 years old
    • Experienced a head injury 3 or more months ago
    • Current symptoms of light sensitivity
    • Be healthy and have good eye health

    Age Range

    18 - 80 years
  • Healthy Diet Study

    Official Title A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fraction

    Purpose

    The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with heart failure and diabetes or pre-diabetes or metabolic syndrome.

     

    Could this study be right for you?

    • Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
    • NYHA class I – III for at least 3 months.
    • Ejection fraction ≥50% by biplane 2D, or 3D echo, or CMR.
    • Echo findings of abnormal or indeterminant diastolic function or RHC data: At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg. Pulmonary vascular resistance (PVR) < 3 Wood Units.
    • Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
    • Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
    • Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
    • Ability to participate in exercise treadmill testing.
    • Ability to sign written consent.

    Exclusions:

    • Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
    • Known allergy or sensitivity to gadolinium-based contrast agents.
    • Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
    • Other metallic implants/aneurysm clips that are contraindicated in MRI.
    • Claustrophobia
    • History of severe kidney disease of eGFR < 30 ml/kg/1.73m2.

    Exclusion Criteria varies, please contact Study Coordinator.

    Age Range

    18 - 80 years
  • Breathing Training Program for Breast Cancer Survivors with Obesity

    Official Title Reducing exercise intolerance through inspiratory muscle training in obese breast cancer survivors (IMOCS)

    Purpose

    The purpose of this study is to better understand why some survivors of breast cancer have difficulty exercising. We also want to learn if breathing exercises can make it easier to tolerate exercise. 

    Could this study be right for you?

    • Breast Cancer Survivor
    • Completed treatment within 6 months–5 years
    • Have obesity, defined as body mass index between 30-50 kg/m2
    • Can exercise independently

    Age Range

    18 years and up
  • Brains, Emotion Regulation and Adolescent Moods (BEAM) Study

    Official Title Neurodevelopmental Mechanisms Underlying the Onset of Depression among At-Risk Youth: The Role of Dysregulation in the Negative Valence System

    Purpose

    The purpose of this study is to test whether changes in the way in which we react and respond to emotional or stressful information represent a risk factor for depression in kids of mothers with and without depression. Findings from the study have the potential to decrease the high rates of depression observed in children of depressed mothers.  

    Could this study be right for you?

    You may be eligible for this study if:

    • Are 18-65 years old and female.
    • Have a biological child who is between 9 and 14 years of age.
    • Have a history of major depressive disorder