Official Title MapLight Study (IRIS Clinical Trial)

Purpose

The purpose of this study is to investigate a medication intended to improve social communication in adolescents and adults with ASD.

Could this study be right for you?

• Have an autism diagnosis or suspect you have an autism diagnosis
• Have a caregiver or study partner willing to enroll in the study with you

Age Range

18 - 45 years

Official Title PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life (PROMISE)

Purpose

The purpose of this study is to find out more about how health and exposures during pregnancy, such as having an infection, diet and growth may impact later risk of islet autoimmunity in the
child. We are also interested in finding out more about why having a father or sibling with type 1 diabetes increases risk of autoimmunity in the child than having a mother with type 1 diabetes.

Could this study be right for you?

Inclusion:

• Pregnant women:
  • who is between 8-24 weeks gestation with a singleton pregnancy
  • have had type 1 diabetes for at least 12 months, or the father of the baby or a full sibling of the baby has type 1 diabetes
  • is 18 years of age or older
  • is willing to have blood collected and to complete questionnaires about prenatal exposures once per trimester during their pregnancy (up to 3 visits) and up to 12 weeks after they deliver their baby
  • is willing to have their baby screened for genetic risk for type 1 diabetes, to complete online questionnaires, and to have their child followed for measurement of islet autoimmunity according to the determined risk for type 1 diabetes, through 5-7 years of age.
    • If low risk, two screenings: the first at 2 years of age and the second between 5-7 years of age
    • If high risk, five screenings: every six months through 2 years of age, and one between 5-7 years of age

The father of the baby will also be asked to complete one visit during pregnancy but it is not mandatory.

Exclusion:

• Multiple Gestation pregnancy
• Mother unable to consent due to intellectual impairment
• Fetus with known medical issue that would affect study participation
• Surrogate / gestational mothers who are not biologically related to offspring they are carrying

Age Range

18 years and up

Official Title Effect of Fixation Training with Colored Light Targets on Traumatic Brain Injury-Associated Photophobia

Purpose

Researchers at The Ohio State University College of Optometry are seeking individuals with a recent history of head trauma who are experiencing light sensitivity. The goal of this study is to determine if daily 20 minute fixation training sessions using a colored (red or blue) light target affects symptoms of light sensitivity, or alters other measurements of the eyes and vision including pupil response.  

This study will involve attending five 1-2 hour study visits, occurring every 1.5 months for 6 months. Study visits will include answering questions about eye and health history, completing surveys, reading letters on an eye chart, having the pupils measured in response to flashes of light, measuring the side vision, measuring eye alignment and in some cases focusing ability. Outside of the study visits, participants will also complete daily 20 minute fixation training sessions for 6 months using a colored (red or blue) light target, completed at home between study visits.

Could this study be right for you?

• Must be 18 to 80 years old
• Experienced a head injury 3 or more months ago
• Current symptoms of light sensitivity
• Be healthy and have good eye health

Age Range

18 - 80 years

Official Title A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fraction

Purpose

The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with heart failure and diabetes or pre-diabetes or metabolic syndrome.

 

Could this study be right for you?

• Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
• NYHA class I – III for at least 3 months.
• Ejection fraction ≥50% by biplane 2D, or 3D echo, or CMR.
• Echo findings of abnormal or indeterminant diastolic function or RHC data: At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg. Pulmonary vascular resistance (PVR) < 3 Wood Units.
• Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
• Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
• Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
• Ability to participate in exercise treadmill testing.
• Ability to sign written consent.

Exclusions:

• Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
• Known allergy or sensitivity to gadolinium-based contrast agents.
• Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
• Other metallic implants/aneurysm clips that are contraindicated in MRI.
• Claustrophobia
• History of severe kidney disease of eGFR < 30 ml/kg/1.73m2.

Exclusion Criteria varies, please contact Study Coordinator.

Age Range

18 - 80 years

Official Title Reducing exercise intolerance through inspiratory muscle training in obese breast cancer survivors (IMOCS)

Purpose

The purpose of this study is to better understand why some survivors of breast cancer have difficulty exercising. We also want to learn if breathing exercises can make it easier to tolerate exercise. 

Could this study be right for you?

• Breast Cancer Survivor
• Completed treatment within 6 months–5 years
• Have obesity, defined as body mass index between 30-50 kg/m2
• Can exercise independently

Age Range

18 years and up

Official Title Neurodevelopmental Mechanisms Underlying the Onset of Depression among At-Risk Youth: The Role of Dysregulation in the Negative Valence System

Purpose

The purpose of this study is to test whether changes in the way in which we react and respond to emotional or stressful information represent a risk factor for depression in kids of mothers with and without depression. Findings from the study have the potential to decrease the high rates of depression observed in children of depressed mothers.  

Could this study be right for you?

You may be eligible for this study if:

• Are 18-65 years old and female.
• Have a biological child who is between 9 and 14 years of age.
• Have a history of major depressive disorder

Official Title ExaStim Upper Limb Pivotal Clinical Validation Study

Purpose

The purpose of this study is to evaluate the safety and effectiveness of ExaStim® transcutaneous spinal stimulation on upper extremity function when applied in combination with physical therapy (PT) and/or occupational therapy (OT).

Participants will be randomized to the stimulation group or a control group. Outcomes will include sensory, motor, and functional tests, as well as questionnaires.

Could this study be right for you?

• Aged 22 years or older
• Traumatic chronic spinal cord injury
• Level of injury between C2-T2
• No active implanted medical device for electrical stimulation
• No Botox for 3 months
• Have a chronic, traumatic SCI (chronic is >12 months since injury, or 6 months if unchanged symptoms)
• Has some, but limited upper extremity function
• BMI <40
• Cannot be pregnant

Age Range

22 years and up

Official Title Treatment of Stress and Anxiety in mild cognitive impairment (MCI)/Mild Alzheimer's Disease and related dementias (ADRD) and their care partners: A Randomized Controlled Trial

Purpose

The purpose of this study is to assess the impact of a treatment on anxiety and stress in individuals with memory concerns and those already with a diagnosis of Mild Cognitive Impairment (MCI), Mild Alzheimer's Disease and related dementias. 

Could this study be right for you?

The primary participant must:

• Be at least 60 years of age
• Have a “care-partner” that is willing to participate in the full program (such as a spouse, child or a good friend)
• NOT have a terminal illness or severe motor impairment
• Be able to use a computer and smartphone and read English at the 6th grade level

The care partner must:

• Be at least 18 years of age
• Be able to use a computer and smartphone and read English at the 6th grade level

Age Range

60 - 99 years

Official Title Dilated Wavefront versus Non-Dilated Wavefront for Metric-Optimized Refraction Procedure for Individuals with Down Syndrome

Purpose

The purpose of this study is to examine whether we can use an instrument that measures how the eye focuses light to determine the best glasses prescription.

Could this study be right for you?

• Children with Down syndrome age 5 to 17 years
• Able to do vision tests by naming or matching shapes or letters
• Able to look at lights for short periods of time
• No nystagmus (uncontrolled eye movements when trying to look at things)
• Safe to dilate the eyes - we will screen medical history, eye health, and allergies to determine this
• No scars on the front of the eye
• No cataracts
• No eye diseases like glaucoma or retinal problems

Age Range

5 - 17 years

Official Title A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)

Purpose

The purpose of this study is to see if benralizumab (biologic drug), given as injections under the skin, can help control your Hypereosinophilic Syndrome (HES) better if it is added to available standard of care HES medications which you may be currently taking. 

HES (Hypereosinophilic Syndrome) is a disease characterized by high levels of eosinophils (a particular type of white blood cell) in your blood and a build-up of eosinophils in some organs and tissues (like skin, heart, lungs, intestines or others) causing their dysfunction.

The duration of the study will last 18 months.

Could this study be right for you?

• Eosinophil (a type of white blood cells) count ≥ 1000 cells/μL at screening
• Documented diagnosis of Hypereosinophilic Syndrome (HES)
• History of persistent eosinophilia >1500 cells/μL (at least 2 examinations, interval ≥1 month)
• End organ manifestations attributable to the eosinophilia

Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information.

Age Range

18 years and up

Official Title Retirement from contact sports after concussion

Purpose

The purpose of this study is to learn about the experiences of children and young adults after they stop playing contact sports due to concussion.

Could this study be right for you?

• Male and females aged 14-22 years old
• Retired from contact sports due to prior concussion

Additionally, a parent may participate if their child enrolls.

Age Range

14 - 22 years

Official Title Retirement from Contact Sports after Concussion

Purpose

The purpose of this study is to understand the experiences of children and young adults after medical retirement from contact sports due to concussion(s).

Participants and their parent(s) will complete online questionnaires (about 10 minutes) at the time of enrollment. You will then be scheduled for an interview (about 30 minutes) by video meeting or phone.

Could this study be right for you?

• Children and young adults who have retired from contact sports or other high-risk activities (i.e. dirt bike riding, downhill skiing...) due to prior concussion.  
• Parents may participate if their child enrolls.

Age Range

14 - 22 years