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Search Studies

Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

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Found 111 results. Displaying page 8 of 10.
  • A Study to Evaluate the Safety and Effectiveness of a Dietary Supplement Used in Treating COVID-19

    Official Title Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of a Plant Polyphenol for COVID-19

    Purpose

    The purpose of this trial is to determine whether a commercially available dietary supplement may decrease the severity of patients with early COVID-19

    Could this study be right for you?

    Inclusion Criteria:

    • Outpatients who test positive for infection with SARS-CoV-2
    • Age 45 years and older
    • Experiencing COVID 19 symptoms for 7 days or less, OR 72 hours of new respiratory symptoms
    • Patient must have access to the internet or a smartphone to complete surveys
    • English-speaking patients

    Age Range

    45 and up
  • A Study to Examine Atropine for the Reduction of Nearsightedness (The CHAPERONE Study)

    Official Title Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)

    Purpose

    The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness. Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends. This study will take place over a 4-year time period.

    Could this study be right for you?

    • Children aged 3 to < 13 years old.
    • No previous use of medications related to myopia control.
    • Glasses and/or contact lens prescription between -1.00 and -6.00 diopters.

    Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility.

    Age Range

    3 and up
  • A Study to Help Improve Symptoms of Gastroparesis (BREATHE)

    Official Title Breathing Reduces Enteric symptoms and Anxiety promoting Therapeutic Healing Experience (BREATHE) – A Randomized Clinical Trial in Patients with Symptoms of Gastroparesis

    Purpose

    The purpose of this research study is to see if practicing mindful breathing daily can reduce stress, improve sleep
    and possibly improve symptoms in patients with Gastroparesis.

    Gastroparesis is a condition characterized by symptoms such as nausea, vomiting, feeling excessively full after eating a little bit, bloating and abdominal pain. One or more of these symptoms can be present in a given patient.

    Your participation throughout the study will last 6 weeks.

    Could this study be right for you?

    • At least 18 years of age
    • Able to read and understand English
    • Has symptoms of gastroparesis for at least 6 months (gastric emptying study is NOT required for inclusion)

    Age Range

    18 and up
  • A Study Using the RejuvenAir® System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis (SPRAY-CB)

    Official Title A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir® System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis (SPRAY-CB)

    Purpose

    The purpose of this study is to determine the safety and effectiveness of a device called the RejuvenAir® System, developed for patients with chronic bronchitis. The primary objective of this trial is to demonstrate the safety and effectiveness of the RejuvenAir® System for the treatment of adult subjects with a diagnosis of CB defined as COPD with classic 3 months of cough and sputum production for a minimum of 2 years who demonstrate ongoing symptoms of cough and significant mucus production. You will be in the study for approximately 36 months, including the screening period.

    Could this study be right for you?

    Inclusion Criteria:

    1. Males and females 40-80 years of age
    2. Must demonstrate daily cough and significant mucus production
    3. Have had a diagnosis of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) for a minimum of two years. (CB is defined clinically as chronic productive cough for 3 months in each of 2 successive years in a patient in whom other causes of productive cough have been excluded)
    4. Smoking history of at least 10 pack years
    5. Non-smoking for a minimum of 2 months prior to consent and agrees to continue not smoking for the duration of the study

    Exclusion Criteria:

    1. Have had an acute pulmonary infection, exacerbation or pneumonia requiring medical treatment (with antibiotics and/or steroids) within 4 weeks prior of initially planned study bronchoscopy
    2. Diagnosis of Asthma
    3. You have had any type of transplant procedure
    4. Use e-cigarettes, vaping or inhaled substances not prescribed by a physician RejuvenAir® System
    5. You are pregnant, nursing, or planning to get pregnant during study

    * This is not a complete list of either inclusion or exclusion criteria

    Age Range

    40 and up
  • A treatment study for chondral lesion in your knee

    Official Title Evaluation of the efficacy of radiofrequency-based debridement vs. mechanical debridement for the treatment of articular cartilage lesions.

    Purpose

    The purpose of this study is to evaluate 2 different treatments, Mechanical Debridement (i.e., a mechanical shaver that removes areas of damaged tissue) and Radiofrequency Debridement (i.e., electrical energy that removes areas of damaged tissue), used to treat the chondral lesion in your knee.

    Could this study be right for you?

    You may be eligible for this study if you:

    • Are 18 - 50 years of age
    • Suspected chondral damage in the following locations where debridement is indicated:
      • Medial femoral condyle
      • Lateral femoral condyle
      • Trochlea
      • Patella
    • 1 or more chondral lesion(s) as noted on MRI

    Exclusion:

    • Previous chondral treatment in the same compartment (prior debridement and lavage performed more than three months prior to baseline are acceptable)
    • Pregnant and/or intending to become pregnant during this study period

    Age Range

    18 and up
  • A Treatment Study For COPD

    Official Title A Multicenter, Randomized, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira™ Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD)

    Purpose

    The purpose of this research study is to evaluate the safety and efficacy of the Nuvaira System, which is made by Nuvaira, Inc., for Targeted Lung Denervation (TLD) Therapy.

    The primary purpose of conducting this study is to see if TLD Therapy in addition to optimal medical care (daily breathing medications you have been prescribed by your doctor) is better at reducing a moderate or severe worsening of symptoms (known as an COPD flare-ups or exacerbations) and related hospitalizations than optimal medical care (daily breathing medications you have been prescribed by your doctor) alone.

    Could this study be right for you?

    Inclusion Criteria:

    • Between 40 and 75 years of age
    • Non-smoking for a minimum of 2 months prior to consent and agrees to not smoke for the duration of the study
    • Diagnosis of COPD with 30% ≤ FEV1 <60% of predicted and FEV1/FVC <70% (post-bronchodilator)
    • SpO2 of at least 89% on room air at the time of screening
    • Has a documented history of having minimally been taking a regular respiratory maintenance medication for at least 12 months at the time of consent; medications will be reviewed by study team
    • If you have participated in a formal pulmonary rehabilitation program recently, program completion should have occurred more than 3 months prior to consent; if in a maintenance program, you will agree to continue your current program through your 12-month follow-up visit;
    • Additional criteria will be reviewed by the study team

    Involvement in this study will last approximately 62 months.

    Age Range

    40 and up
  • Abbott DBS (Deep Brain Stimulation) Registry

    Official Title ABT-CIP-10300: Abbott DBS Registry of Outcomes for Indications over Time (ADROIT)

    Purpose

    The purpose of this study is to collect information and evaluate outcomes for Abbott Deep Brain Stimulation (DBS) systems that are approved and sold in your country.

    In order to evaluate how the DBS system performs, data will be collected before, during and after DBS implant when you visit the study doctor. The data collected will include information on your movements, feelings, daily activities, and DBS program settings.

    The information gathered in this study will add to the understanding of treatment options for future patients receiving DBS.

    Could this study be right for you?

    Inclusion Criteria:

    • You are scheduled for a new implant or IPG device replacement surgery with a market-released Abbott DBS system within 3 months

    Exclusion Criteria:

    • You are currently enrolled or plan to enroll in another study that may alter the results of this clinical investigation
    • You have another disease, conditions, or other medical, social, or psychological conditions that could limit your ability to participate in the clinical investigation or to satisfy follow-up requirements
  • Adults Helping Adults With Immune Diseases

    Official Title Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation

    Purpose

    A test for healthy adults from 19 - 75 years old to develop normal values for interpretation of immunological tests in adults with disorders of the immune system.

    Voluntary participation involves blood draw at Nationwide Children's hospital. Qualified participants would be eligible to provide a sample every 2 months (not more than 6 times per year).

    Could this study be right for you?

    If you are:

    • An adult 19 years of age or older
    • Healthy with no significant medical diagnoses
    • Have no chronic conditions that can affect results of immunological studies
    • Not on any medication known to alter immune status or function
    • Have not undergone recent surgery, chemotherapy, radiation or transplantation
    • Non-smoker
    • Body mass index (BMI) in healthy range
    • No infections within last 2 months

    Age Range

    19 and up
  • An Intervention Study for Subjects with Palmoplantar Pustulosis

    Official Title ANB019-003: A Phase II, Randomized, Placebo-controlled, Double-blind, Multiple Dose Study to Evaluate the Efficacy and Safety of ANB019 in Subjects with Palmoplantar Pustulosis

    Purpose

    This study is being done to assess the effects of the experimental study drug (ANB019) in patients with PPP.

    Could this study be right for you?

    • Must have a clinical diagnosis of PPP for at least 6 months prior to screening
    • Must have active pustules on palms and/or soles of feet
    • BMI must be within the range of 18-36 kg/m2
    • Subjects must be in otherwise good health
    • Must not have any suspected autoimmune disorder or immune deficiency
    • No major surgeries in the past 4 weeks
    • No history of malignancy in the past 5 years
    • No history of drug, alcohol, or other substance abuse

    Age Range

    18 and up
  • An Observational Study to Examine School Transition after Traumatic Brain Injury

    Official Title STATBI: School Transitions after Traumatic Brain Injury

    Purpose

    The purpose of this study is to understand the best ways to help students return to school after brain injury of any severity. This is important to study because finding the best ways to help students go back to school right after brain injury, and over time, can help improve student success and recovery.

    Your participation in the study would take place when you/your child begins the study and then at 3 months, 6 months, 12 months, 2 years (if applicable) and 3 years (if applicable) after the study starts.

    Could this study be right for you?

    • Students aged 5 to 18 years old
    • In kindergarten through 12th grade
    • Must Speak English
    • Traumatic Brain Injury (TBI) of any severity
    • Parent/caregiver is willing to share medical and academic information with the research team (all study activities are virtual/remote)

    Age Range

    5 and up
  • Children Helping Children With Immune Diseases

    Official Title Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation

    Purpose

    This study uses healthy children from newborns to 18 years old to help understand immune disorders. This study will compare healthy children and teens to children and teens with disorders of the immune system.

    Volunteers will visit Nationwide Children's Hospital (NCH) for a blood draw either one time or not more than once every three months.

    Could this study be right for you?

    If your child is:

    • Newborn to 18 years of age
    • Healthy with no significant medical diagnoses
    • Has no chronic medical conditions that can affect results of immunological studies
    • Is not on any medication known to alter immune status or function
    • Has not undergone recent surgery, chemotherapy, radiation or transplantation
    • Has had no infections within the last 2 months
  • Cognition and Brain Circuitry

    Official Title Cognition and Brain Circuitry

    Purpose

    The purpose of the study is to look at how our brain networks interact for different mental functions and how individual differences in brain structure and function determines individual differences in behavior. During this study, we use magnetic resonance imaging methods: functional magnetic resonance imaging (fMRI) and diffusion weighted imaging (DWI). Functional MRI (fMRI) and DWI are typical imaging methods that use a strong magnetic field and radio waves to make pictures of your body. The total length of the study will be between 3 and 4 hours, including up to 2 hours outside the MRI scanner and 2 hours in the scanner.

    Could this study be right for you?

    • Healthy adults between 18-40 years of age
    • Have normal or corrected-to-normal vision

    Age Range

    18 and up