Official Title Development of Parent-Child Interactions

Purpose

This study will examine how a child’s hearing loss may affect the dynamics of parent-child interactions. The study will observe how normal-hearing and hearing-impaired child learn novel words during videotaped parent-child interactions.

Individual study visits may last 30-45 minutes, and there may be multiple study visits per year.

Could this study be right for you?

• Families with children 9 months to 6 years of age
• Children who do and do not have hearing loss may be eligible to participate in this study

Official Title Performance and Cognitive Changes Across Menstrual Phase

Purpose

This study will look at the influence of the hormonal changes that occur between the early-follicular and mid-luteal phases of the menstrual cycle on neurocognitive performance before and after an intense resistance workout in premenopausal, moderately active females. Additionally, this study will be determining the accuracy and usefulness of using a menstrual cycle tracking phone application in predicting menstruation and ovulation

Your participation in the study will last between 2 and 3 months dependent on where in your current menstrual cycle you are upon enrollment in the study. There are 6 total visits across the 2 to 3 month study duration.

Could this study be right for you?

The eligibility criteria are as follows:

1. Be between the ages of 18 and 35
2. Participate in at least 3 hours of planned physical activity per week
3. Able to squat 100% of your body weight
4. Able to bench press 70% of your body weight
5. Using non-hormonal contraceptives

Age Range

18 and up

Official Title Perinatal Arterial Stroke: The I-ACQUIRE Study

Purpose

Children who suffered a stroke before or shortly after being born that was caused by blockage of blood flow in an artery, it often results in the child showing some weakness on one side of their body.

With this study, we want to find out if a type of therapy may help children who have weakness on one side of their body due to perinatal arterial ischemic stroke, learn how to better use their weaker arm.

All children will be in the study for about 13 - 15 months. Some children may be in the study for a longer period, depending on which treatment they receive during Phase 1 of the study. The I-ACQUIRE therapy involves fun learning and play, self-help activities, and manipulating interesting toys and objects.

Could this study be right for you?

• Your child must be between the ages of 8 and 36 months old when beginning this study
• Your child must have suffered a perinatal arterial ischemic stroke
• Upper limb weakness
• Parents must be able to participate at least 1x/week for therapy and 40-60 minutes/day at home

Official Title Shoulder Surgery Outcomes Registry

Purpose

This registry will collect outcomes data of patients undergoing shoulder surgery with Dr. Jonathan Barlow or Dr. Julie Bishop. The purpose of this registry is to provide a way to collect and store data for patients undergoing shoulder surgery to support the conduct of future research in an effort to improve patient outcomes.

Could this study be right for you?

• A patient undergoing surgery with Dr Jonathan Barlow or Dr Julie Bishop (will be asked to enroll once the clinical decision has been made to proceed with surgery)
• 18 to 89 years old
• Able to provide consent

Age Range

18 and up

Official Title Usability & Acceptability of a Patient-Oriented Educational Resource for Dizziness

Purpose

The purpose of this study is to look at a web-based tool on the topic of dizziness so that we can create resources for teaching patients about causes of dizziness and home-based therapies. We are recruiting patients with dizziness and/or general volunteers to review the web-based tool and then provide feedback which will then be used to help update requirements for the educational tool. This study will take about 20-30 minutes of your time to review a website and complete a survey. If you decide to also participate in the discussion, it will take about 20-30 more minutes.

Could this study be right for you?

• Participants must be 18 years or older
• Able to speak and read English at an eighth-grade level or above
• Be willing and able to participate

Age Range

18 and up

Official Title A prospective, single blinded, multi-center, randomized, controlled, pivotal study to assess the safety and effectiveness of the InSpace™ device for treatment of full thickness Massive Rotator Cuff Tears

Purpose

This research study will evaluate a new device, InSpace, for use with a full thickness massive tear of rotator cuff (the group of connective tissues in the shoulder). The device is designed to allow smooth gliding of the bones in the shoulder during motion, which may allow rehabilitation exercises with less pain. The research study is being conducted to see whether the InSpace device is safe and effective for shoulder problems due to a full thickness massive rotator cuff tear.

Could this study be right for you?

1. Is male or female ≥ forty (40) years of age
2. Positive diagnostic imaging by MRI within 9 months of enrollment of the index shoulder indicating a full thickness MRCT: measuring ≥ 5 cm in diameter (Cofield classification) and involving ≥ two tendons
3. Functional deltoid muscle and preserved passive range of motion on physical examination
4. Failed non-operative treatment of at least 4 months from the initial treatment to include one or all of the following: Oral analgesics, Anti-inflammatory medication (e.g., ibuprofen, naproxen), Corticosteroid injection(s), Physical therapy, Activity modification, or Rest (sling used)
5. Must be able to read and understand the approved Informed Consent Form (written and oral)
6. Must be in general good health (as determined by the Investigator) based on screening assessments and medical history
7. Must be independent, ambulatory, and can comply with all post-operative evaluations and visits.

Other details will be shared by the study coordinator.

Age Range

40 and up

Official Title Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease

Purpose

The purpose of this study is to study a new method to evaluate blood flow to the calves and feet. We hope this information can help evaluate the effectiveness of treatments and predict clinical outcomes. Participants will be required to attend one (2 hr) session at Nationwide Children's Hospital.

Could this study be right for you?

-Diagnosis of Peripheral Arterial Disease (PAD) OR leg symptoms, such as muscle pain or cramping AND/OR foot wound that has required medical consultation

• Healthy volunteers must:
• Be at least 40 years of age
• Have no history of cardiovascular disease (including high blood pressure)
• Have no history of diabetes mellitus
• Be a non-smoker
• Have normal BMI

Age Range

40 and up

Official Title Nitrous Oxide and Cortico-Limbic Function in Aggression (Laughing Gas Study or LGS).

Purpose

The purpose of this study is to see how laughing gas (nitrous oxide) changes brain activity in study participants with and without “anger issues”. Brain activity is measured by Magnetic Resonance Imaging.

The length of time you will be involved in this study will be 4-8 weeks.

Could this study be right for you?

• You are a medically healthy man or woman
• You are between the ages of 21 and 55 years of age
• Do not abuse alcohol or other drugs
• With a current history of “anger issues”
• Able to complete study sessions during the week

Age Range

21 and up

Official Title AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke (ARCADIA)

Purpose

The purpose of this research study is to compare the effects (good and bad) of apixaban with the effects (good and bad) of aspirin in patients with unexplained strokes and atrial cardiopathy to see which is better at prevention of future strokes.

Could this study be right for you?

• You are at least 45 years old
• Clinical diagnosis of ischemic stroke* of unknown cause (ESUS or cryptogenic) in the last 120 days
• Underwent an echocardiogram as part of your stroke work up
• No history of atrial fibrillation (irregular heartbeat)
• No known allergy or intolerance to aspirin or apixaban

*An “ischemic” stroke is an injury to the brain caused by a blocked blood vessel supplying the brain.

Age Range

45 and up

Official Title Strategies for the Development of Social Cognitive Training for Impulsive Aggression (Brain Exercise Study or BES).

Purpose

The purpose of this study is to see if brain exercise done on the computer can reduce aggression in those with “anger issues”. The study is a six-week clinical trial using selected brain exercises versus other computer-based exercises.

Could this study be right for you?

• Medically healthy man or woman
• You are between 21 and 55 years of age
• With a current history of “anger issues”
• You have regular access to a computer and a smart phone

Age Range

21 and up

Official Title A STUDY TO EVALUATE THE SAFETY AND EFFICACY OF THE MATERNA PREP DEVICE IN REDUCING PELVIC MUSCLE INJURIES DURING VAGINAL DELIVERY

Purpose

This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery.

Could this study be right for you?

You may be eligible for this study if you:

1. Are scheduled for vaginal birth.
2. Are pregnant with a single fetus.
3. Haven't given birth previously, or had a previous pregnancy terminated within 24 weeks gestation.
4. Are willing to comply with the protocol required follow-up visits.
5. Are able and willing to provide written informed consent prior to enrollment.
6. Are 18 years of age or older at time of consent.

You will be ineligible for this study if you:

1. Have a high likelihood of less than 1 hour of potential device dilation time after you arrive at the hospital.
2. Have a need for or is planning a Caesarean-section.
3. Begin labor with less than 36 weeks gestation.
4. Have a neurological disorder that could cause pelvic floor dysfunction, such as multiple sclerosis or spinal cord injury.
5. Have a collagen-associated disorder that affects tissue elasticity, such as scleroderma or Ehlers-Danlos syndrome.
6. Have a localized (genital tract) or systemic infection.
7. Have had prior surgical procedures to the vaginal anatomy which could lead to pelvic floor dysfunction, such as pelvic fractures or pelvic soft tissue injuries.
8. Have any general health condition or systemic disease that may represent, in the opinion of the investigator, a potential increased risk associated with device use or pregnancy.
9. Have placenta previa or vasa previa.
10. Have a known significant chromosomal or structural fetal anomalies.
11. Have a category 2 and/or 3 fetal tracing that is unresolved.

Age Range

18 and up

Official Title Parental History of Suicidal Behavior and Early Markers of Risk in Pre-pubescent Youth

Purpose

The purpose of this study is to learn what factors may be related to suicide attempt(s) in children (ages 6 - 9) that have a parental history of suicidal behavior in hopes that this information will help prevent and treat self-harm behavior in youth at high risk.

Both parents and children will complete questionnaires, interview questions, and a family discussion in addition to problem solving tasks and computer games.

There are multiple study visits. The first will last about 2.5 to 3 hours and all other appointments will occur annually from your first appointment. Due to COVID-19, families will have the option to conduct annual follow-up appointments via telephone. These annual telephone visits will last approximately 30-45 minutes. If the annual visit is conducted in-person, it will last 1.5 to 2.5 hours.

Could this study be right for you?

• Parents and children must be able to read and understand English fluently
• Child is 6 to 9 years of age
• Meet other criteria (e.g., no traumatic brain injury) for the study

Age Range

6 and up