Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study for Those With Hip Impingement

    Official Title
    Physical Activity and Pain Patterns in Individuals with Femoroacetabular Impingement Syndrome
    Purpose

    Femoroacetabular impingement syndrome (FAIS), also known as hip impingement, is the most common reason for hip pain in young, active adults. It often causes pain with simple daily tasks like walking and squatting, but most often limits sports and physical activity participation. It is possible that way in which people move may increase their risk for FAIS. It is also possible that different activity patterns cause continued pain in those with FAIS. In order to develop effective rehabilitation programs, we need to figure out if there are patterns of activity (or inactivity) that contribute to pain in individuals with FAIS.

    Could this study be right for you?

    Inclusion Criteria:
    Individuals ages 18-40 years with documentation of medical diagnosis of FAIS, with or without labral pathology and who meet the following criteria:
    1. Complaints of hip joint pain, catching, or stiffness with prolonged sitting or standing, walking, squatting, pivoting/twisting, AND
    2. Pain reproduced with at least one of three provocative tests: (1) hip flexion with adduction and internal rotation (FADIR), or (2) hip flexion with abduction and external rotation (FABER), or (3) resisted straight leg raise.

    Exclusion Criteria:
    Any of the following conditions or surgical history:
    1. Previous history of hip surgery, including previous arthroscopy or open procedure on hip, including periacetabular osteotomy (PAO)
    2. Medical diagnosis of slipped capital femoral epiphysis, hip dysplasia, Legg-Calve-Perthes disease, osteonecrosis, or fracture
    3. History of hip dislocation
    4. Medical diagnosis of bilateral FAIS AND is unable to identify a more symptomatic side
    5. History of other lower extremity or spine injury or surgery that required continued care of a medical provider in the previous two years (conditions may have altered activity participation beyond that of the participant’s current hip pain)

    Age Range
    18 and up
  • A Study for those with Type 2 Diabetes AND Depression

    Official Title
    Mindfulness-based cognitive therapy for comorbid depression and type 2 diabetes
    Purpose

    The aim of this study is to improve mood and diabetes-related outcomes for those with type 2 diabetes mellitus (T2DM) AND symptoms of depression. The present study will examine the effect of mindfulness-based cognitive therapy (MBCT) on symptoms of depression and diabetes.

    Your participation in this study will last 8 weeks.

    Could this study be right for you?

    You may qualify if:
    • You are between the ages 18-75
    • You have type 2 diabetes
    • You are feeling symptoms of depression

    Age Range
    18 and up
  • A Study for Those With Type 2 Diabetes AND Who Are Experiencing Food Insecurity

    Official Title
    Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)
    Purpose

    The purpose of this study is to improve hemoglobin A1c levels in patients with type 2 diabetes experiencing food insecurity.

    The study will examine the effects of a produce referral program alone and in combination with other interventions. Our research is designed to develop a deeper understanding of how to provide patients with type 2 diabetes that are experiencing food insecurity with the resources, skills, and education to manage their health and social needs.

    Could this study be right for you?

    Inclusion Criteria:
    - Age 18 years and older
    - Type 2 diabetes based on American Diabetes Association Criteria
    - Hemoglobin A1c level > 7.5%
    - Worried about running out of food before you have money to buy more

    Exclusion Criteria:
    - Pregnant

  • A Study of DBS-Expert system used during Deep Brain Stimulation For Parkinson's Disease

    Official Title
    DBS-Expert: Automated Deep Brain Stimulation Programming Using Functional Mapping Phase II
    Purpose

    Deep Brain Stimulation (DBS) surgery is FDA approved for the treatment of Parkinson's Disease. The purpose of this study is to examine a technology (DBS-Expert system) that uses objective measurements to guide DBS programming. The DBS-Expert system analyzes motion data and provides recommendations to the physician or healthcare professional regarding DBS programming settings.

    Could this study be right for you?

    You may be eligible if you:
    * Over the age of 18
    * Able and willing to provide informed consent
    * Clinical diagnosis of idiopathic Parkinson's Disease
    * Implanted Boston Scientific DBS system

    Exclusion Criteria

    * You are currently participating in any study with an investigational medicinal product (IMP) or investigational device.

    Age Range
    18 and up
  • A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression

    Official Title
    A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression
    Purpose

    The purpose of this study is to see if esketamine nasal spray alone is effective as a medication to improve depressive symptoms in adults with treatment-resistant depression when compared with placebo nasal spray.

    The duration of the study consists up to a maximum of 24 weeks.

    Could this study be right for you?

    • Aged 18 years or older
    • Must have had no response (less than 25% improvement) to at least 2 oral antidepressant treatments in the current episode of depression

    Age Range
    18 and up
  • A Study of Milestones to Advance Language Learning

    Official Title
    SMALL Talk: Study of Milestones to Advance Language Learning
    Purpose

    The goal of this study is to identify early risk for developmental language disorder (DLD) among young, low-income children, and to determine how caregiver and child chronic stress and interaction quality interact to disrupt language growth among these children. The long-term objective is to identify pathways through which early family situations and the conditions of poverty disrupt early language paths among low-income children and contribute to heightened rates of DLD.

    Could this study be right for you?

    Inclusion criteria are:
    - have a child that is 9 months or younger
    - child resides in a low-income household, using some sort of government assistance or using the 200% threshold from the Department of Health and Human Services based on annual household income and number of persons in home

    Exclusion criteria:
    - Children who are multiple births, preterm (<35 weeks), and have profound or severe disabilities will be excluded, with the latter including congenital blindness, deafness, Down syndrome and other frank neurological deficits.

  • A study on language impairment following a stroke

    Official Title
    Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response
    Purpose

    This NIH-funded project will investigate patient-specific factors that may influence response to therapy for language impairment after stroke, or aphasia. Results from this work will assist with better estimation of prognosis for stroke survivors with aphasia, which could empower patients and families to make more informed health care decisions about how to pursue the most appropriate rehabilitation services based on their unique characteristics, such as genetics, cognitive skills, and brain structure after stroke.

    Could this study be right for you?

    Participants must meet the following criteria:
    - Native English speaker
    - Able to have an MRI
    - Had only one stroke (in the left hemisphere of the brain)

    Age Range
    18 and up
  • A Study on the Prediction of Preterm Birth

    Official Title
    Elastography and the Prediction of Preterm Birth Using E‐cervix
    Purpose

    This study will assess the use of elastography ultrasound using E‐cervix technology in the prediction of preterm birth before 37 weeks of their pregnancy in women with a history of preterm birth.

    Could this study be right for you?

    You may be eligible if you are :
    * Pregnant women between the ages of 18‐50 years of age
    * Scheduled for a routine anatomy ultrasound and cervical length measurement between 18‐24 weeks gestation.
    * Prior preterm birth not induced between 16 weeks and 36 weeks of pregnancy
    * Currently pregnant with one child

    Exclusion Criteria
    * Women with a cervical cerclage in place
    * Women pregnant with multiples

    Age Range
    18 and up
  • A study on the role of spirituality and faith during cancer treatment

    Official Title
    Patient perceptions about the role of spirituality and faith during cancer treatment
    Purpose

    The purpose of the current study is to characterize the perspectives of cancer patients who have undergone a cancer-directed surgery on the role of spirituality and/or religion during their cancer journey in order to better define the desired access to related resources during cancer care. Results from this study will inform future research aimed at addressing patient-centered spirituality/faith needs of cancer patients.

    If you are interested in participating in this study, please contact Elizabeth Palmer <a href="mailto:elizabeth.palmer@osumc.edu&quot; target="_blank">elizabeth.palmer@osumc.edu</a>

    Could this study be right for you?

    If you’ve had or will have surgery to treat a cancer diagnosis, you can help researchers at Ohio State examine how patient spirituality and/or religion influences the cancer journey by taking an online survey.

    Participants should be:
    • Over 18 years old.
    • Diagnosed with cancer (all types).
    • At least four months past the initial cancer diagnosis.
    • Underwent or will receive a surgical procedure related to their cancer
    • Able read and write in the English language.

    Age Range
    18 and up
  • A study to assess the safety and efficacy of IV ganaxolone as an additional treatment for status epilepticus (RESET Study)

    Official Title
    A study to optimize the dosing regimen and assess safety and efficacy of IV ganaxolone as adjuvant therapy for established status epilepticus
    Purpose

    The purpose of the RESET study is to determine the safety and effectiveness of ganaxolone (an investigational medicine) when administered in addition to current medicines used to treat prolonged seizures.

    Could this study be right for you?

    Inclusion Criteria (not a complete list):

    - Males or females of at least 18 years of age
    - You must have received benzodiazepines before or after arrival to the Emergency Department for generalized
    convulsive seizures lasting > 5 minutes

    Exclusion Criteria (not a complete list):

    - Intubated or "to be" intubated
    - A known allergy or sensitivity to progesterone or allopregnanolone medications/supplements
    - Status Epilepticus is due to acute anoxic brain injury, cardiac arrest, acute trauma, hyper-/hypo- glycemia
    - Known or suspected pregnancy

    Age Range
    18 and up
  • A Study to Compare Medications in Patients with Advanced Parkinson's Disease

    Official Title
    A Randomized, Double-Blind, Double-Dummy, Active-Controlled Study Comparing the Efficacy, Safety and Tolerability of ABBV-951 to Oral Carbidopa/Levodopa in Advanced Parkinson's Disease Patients
    Purpose

    The purpose of this study is to find out how well ABBV-951 works to control Parkinson's disease symptoms compared to oral Carbidopa (CD)/Levodopa (LD). The study is also seeking to test whether ABBV-951 is well tolerated in patients with Parkinson's disease.

    Could this study be right for you?

    1. Male or female, age 30 or older
    2. Has not received deep brain stimulation, Carbidopa (CD)/Levodopa (LD) enteral suspension, or any other Parkinson's Disease (PD) medication as continuous daily infusion
    3. Subject does not have a history of significant skin conditions or disorders
    4. Subject does not have a recent (within 6 months before screening) history of drug or alcohol abuse
    5) Subject does not have a history or presence of psychotic episodes
    6) Subject does not have other clinically significant unstable medical conditions
    7) Subject must have a diagnosis of levodopa-responsive idiopathic PD

    * other eligibility criteria to be discussed/reviewed with the study team

    Age Range
    30 and up
  • A Study to Evaluate a Medication Used in Treating Hand-Foot Skin Reaction (HFSR) in Cancer Patients (NOVA-II)

    Official Title
    A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients (NOVA-II)
    Purpose

    Hand-Foot Skin Reaction (HFSR) is a common adverse event induced by Vascular Endothelial Growth Receptor Inhibitor (VEGFRi) treatment in cancer patients. The main purpose of this study is to evaluate the safety and efficacy of OQL011 compared to vehicle ointment in treating patients with moderate to severe VEGFRi-associated HFSR. This study will also identify an optimal dosage for Phase III study and explore the pharmacokinetics profile of OQL011 in HFSR patients.

    Could this study be right for you?

    - Patient must be age 18 years of age or older.
    - Patient must have a confirmed cancer diagnosis for which VEGFRi treatment is indicated, and must be currently under VEGFRi-based anti-cancer therapy with stable dosage for ≥ 1 week.
    - Patient on pain medications is allowed provided they have been on stable dosage in the past 1 week and is going to continue at the same dosage.

    Age Range
    18 and up