Official Title

A Multi-Actor Examination of Gestational Diabetes Mellitus (GDM)

Purpose

This study aims to examine the experience of people who have been diagnosed or are currently living with gestational diabetes, including how they manage and make sense of their diagnosis. 

Could this study be right for you?

• Aged 18 years or older
• Must live in the state of Ohio
• Must be currently pregnant and have been diagnosed with gestational diabetes OR must have been diagnosed with gestational diabetes during a recent pregnancy (within the last 12 months)

Age Range

18 years and up

Official Title

ExaStim Upper Limb Pivotal Clinical Validation Study

Purpose

The purpose of this study is to evaluate the safety and effectiveness of ExaStim® transcutaneous spinal stimulation on upper extremity function when applied in combination with physical therapy (PT) and/or occupational therapy (OT).

Participants will be randomized to the stimulation group or a control group. Outcomes will include sensory, motor, and functional tests, as well as questionnaires.

Could this study be right for you?

• Aged 22 years or older
• Traumatic chronic spinal cord injury
• Level of injury between C2-T2
• No active implanted medical device for electrical stimulation
• No Botox for 3 months
• Have a chronic, traumatic SCI (chronic is >12 months since injury, or 6 months if unchanged symptoms)
• Has some, but limited upper extremity function
• BMI <40
• Cannot be pregnant

 

Age Range

22 years and up

Official Title

Treatment of Stress and Anxiety in mild cognitive impairment (MCI)/Mild Alzheimer's Disease and related dementias (ADRD) and their care partners: A Randomized Controlled Trial

Purpose

The purpose of this study is to assess the impact of a treatment on anxiety and stress in individuals with memory concerns and those already with a diagnosis of Mild Cognitive Impairment (MCI), Mild Alzheimer's Disease and related dementias. 

Could this study be right for you?

The primary participant must:
· Be at least 60 years of age
· Have a “care-partner” that is willing to participate in the full program (such as a spouse, child or a good friend)
· NOT have a terminal illness or severe motor impairment
· Be able to use a computer and smartphone and read English at the 6th grade level

The care partner must:
· Be at least 18 years of age
· Be able to use a computer and smartphone and read English at the 6th grade level

Age Range

60 - 99 years

Official Title

Dilated Wavefront versus Non-Dilated Wavefront for Metric-Optimized Refraction Procedure for Individuals with Down Syndrome

Purpose

The purpose of this study is to examine whether we can use an instrument that measures how the eye focuses light to determine the best glasses prescription.

Could this study be right for you?

• Children with Down syndrome age 5 to 17 years
• Able to do vision tests by naming or matching shapes or letters
• Able to look at lights for short periods of time
• No nystagmus (uncontrolled eye movements when trying to look at things)
• Safe to dilate the eyes - we will screen medical history, eye health, and allergies to determine this
• No scars on the front of the eye
• No cataracts
• No eye diseases like glaucoma or retinal problems

Age Range

5 - 17 years

Official Title

Collecting information to understand cancer survivors’ preference for alternative nicotine-tobacco products

Purpose

The purpose of this study is to understand how cancer survivors view the risks and benefits of nicotine and tobacco products.

The duration of the study will last two hours. 

 

 

 

Could this study be right for you?

• At least 21 years old
• Cancer survivor
• Currently smoking combustible tobacco
• Access to an email address and a phone, tablet, or computer with internet access
• Currently using electronic nicotine delivery systems (e-cigarettes, vape pens, e-hookah, etc.) OR interested in trying them in the future

Age Range

21 years and up

Official Title

A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)

Purpose

The purpose of this study is to see if benralizumab (biologic drug), given as injections under the skin, can help control your Hypereosinophilic Syndrome (HES) better if it is added to available standard of care HES medications which you may be currently taking. 

HES (Hypereosinophilic Syndrome) is a disease characterized by high levels of eosinophils (a particular type of white blood cell) in your blood and a build-up of eosinophils in some organs and tissues (like skin, heart, lungs, intestines or others) causing their dysfunction.

The duration of the study will last 18 months.

Could this study be right for you?

 

• Eosinophil (a type of white blood cells) count ≥ 1000 cells/μL at screening
• Documented diagnosis of Hypereosinophilic Syndrome (HES)
• History of persistent eosinophilia >1500 cells/μL (at least 2 examinations, interval ≥1 month)
• End organ manifestations attributable to the eosinophilia

Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information.

Age Range

18 years and up

Official Title

Retirement from contact sports after concussion

Purpose

The purpose of this study is to learn about the experiences of children and young adults after they stop playing contact sports due to concussion.

Could this study be right for you?

• Male and females aged 14-22 years old
• Retired from contact sports due to prior concussion

Additionally, a parent may participate if their child enrolls. 

Age Range

14 - 22 years

Official Title

Improving emergency care and outcomes of immune-related adverse events: The immune related emergency disposition index (irEDI)

Purpose

The purpose of this study is to learn more about how to best care for patients who have immune-related side effects and have received treatment with an immune checkpoint inhibitor. 

The duration of this study is 30 days. 

Could this study be right for you?

• Must speak English and/or Spanish
• Diagnosis of cancer (excluding non-melanoma skin cancer)
• Last immunotherapy received within 90 days of study enrollment

Age Range

18 years and up

Official Title

Effect of Glucose Fluctuations on Atrial Fibrillation Burden among Patients with Diabetes Mellitus and Paroxysmal Atrial Fibrillation or Recent Atrial Fibrillation Ablation

Purpose

The purpose of this study is to examine the effects of glucose levels on atrial fibrillation episodes in people with diabetes and history of atrial fibrillation.

The duration of the study lasts 6 months. 

Could this study be right for you?

• Participants diagnosed with type 2 diabetes mellitus
• Body mass index between 25 and 45 kg/m2
• Insulin use at least 10 units per day or more than 1 glucose lowering medication with a hemoglobin A1c greater than 7%
• ICM placement
• Paroxysmal atrial fibrillation (irregular heartbeat that goes back to normal after a week) or atrial fibrillation ablation (procedure to treat irregular heartbeat) within 30 days

Age Range

40 - 79 years

Official Title

Retirement from Contact Sports after Concussion

Purpose

The purpose of this study is to understand the experiences of children and young adults after medical retirement from contact sports due to concussion(s).

Participants and their parent(s) will complete online questionnaires (about 10 minutes) at the time of enrollment. You will then be scheduled for an interview (about 30 minutes) by video meeting or phone.

Could this study be right for you?

• Children and young adults who have retired from contact sports or other high-risk activities (i.e. dirt bike riding, downhill skiing...) due to prior concussion.  
• Parents may participate if their child enrolls.

Age Range

14 - 22 years

Official Title

A Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, and Effectiveness of CIN-107 for the Management of Blood Pressure in Patients with Primary Aldosteronism

Purpose

The purpose of this study is to see how the study drug CIN-107 works in managing blood pressure in patients with primary aldosteronism (PA), a hormone disorder which causes your body to produce too much of the hormone aldosterone.

The duration of this study is 74 weeks. 

Could this study be right for you?

• Diagnosis of primary aldosteronism (PA)
• Taking an MRA to control BP, such as Spironolactone or Eplerenone, or not yet taking an MRA

Age Range

18 and up

Official Title

Safety, Tolerability, and Outcomes of Velpatasvir/SofosbuviR in Treatment of Chronic Hepatitis C Virus during Pregnancy (STORC), pregnant woman

Purpose

This study involves evaluating a medication for hepatitis C in pregnant women. 

If you are a pregnant woman with chronic hepatitis C and you join the study, you are consenting to enroll yourself and your baby after he/she is born.

Maternal participants will have 7 visits over approximately 7 months. Infant participants have four visits over approximately the first year of life.

Could this study be right for you?

(This is not a complete list)  

- Must be  18 - 45 years of age

- Chronic HCV infection of at least 6 months

- Singleton pregnancy at 20 + 0 to 30 + 0 weeks’ gestation

- Documented negative Hepatitis B testing for current infection (negative HBsAg test) prior to enrollment

- If living with HIV, must be on antiretroviral therapy

 

Exclusion Criteria (not a complete list)

- Plans to relocate away from the study site area in the next 16 months and unable/unwilling to return for study visits

- History of cirrhosis

- Known fetal chromosomal abnormality prior to enrollment

Age Range

18 - 45