Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study to Evaluate an Investigational Drug (NLY01)Treatment to be used in Early-Stage Parkinson’s Disease

    Official Title
    Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of 36 Weeks of Treatment with NLY01 in Early-stage Parkinson’s Disease
    Purpose

    This research is studying a new drug, NLY01, in a large number of persons to learn about its effects in people with early-stage Parkinson’s disease (PD). Researchers want to know whether NLY01 helps lessen symptoms and signs of early PD, as well as slow the progression of the disease.

    You will have a 2 in 3 chance of receiving NLY01 and a 1 in 3 chance of receiving a placebo, sterile salt water that looks like NLY01 but does not contain the study drug.

    The total amount of time for you to be in the study will be approximately 45 to 54 weeks.

    Could this study be right for you?

    Inclusion:
    - Man or woman, at least 30 to 80 years old
    - Have early-stage Parkinson's disease
    - Not be on any current treatments for PD
    - If of reproductive potential, willing and able to use a highly effective form of birth control during the study and for 30 days following last dose of study material

    * Other criteria for eligibility apply

    Exclusion:
    - Diagnosis of secondary or atypical parkinsonism
    - Onset of any parkinsonian motor sign or symptom >5 years before Screening Visit
    - Previous surgical procedure for PD
    - Clinically significant medical, surgical, psychiatric, or laboratory abnormality
    - Has an ECG or clinical evidence of potentially unstable heart disease
    - Medical or recreational use of marijuana or THC-containing compounds within 3 months of the Screening Visit

    * Other criteria for exclusion apply

    Age Range
    30 and up
  • A Study to Evaluate an Investigational Drug (tavapadon) as a Possible Treatment in Early Parkinson’s Disease

    Official Title
    A PHASE 3, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP, 27-WEEK TRIAL TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF TWO FIXED DOSES OF TAVAPADON IN EARLY PARKINSON’S DISEASE (TEMPO-1 TRIAL)
    Purpose

    The main purpose of this study is to learn how well tavapadon (the study drug) works as a possible treatment for Parkinson’s disease and how safe the study drug is. The target dose range of tavapadon being studied is 5 to 15 mg once daily.

    If you choose to participate in this study, you may receive the study drug, or you may receive placebo. A placebo is an inactive material, such as a sugar pill, that looks like the study drug but does not contain any active study drug. Researchers use a placebo to see if the study drug works better or is safer than taking nothing.
    You will be in this study for approximately 35 weeks, which includes a screening visit and safety follow up, and you will need to come to the study center at least 11 times over this period.

    Could this study be right for you?

    You may be eligible if you:
    • Are Between the ages of 40 to 80 years
    • Are willing to practice effective birth control, or remain abstinent during the trial and for 4 weeks after the last dose of trial if you are a sexually active man or woman of childbearing potential
    • Were diagnosed more than 3 years ago
    • Willing and able to not use any PD medications that are not permitted by the protocol (including dopaminergic agents) throughout participation in the trial.

    You will be excluded if you:
    • Have a history or clinical features consistent with essential tremor, atypical or secondary parkinsonian syndrome (including, but not limited to, progressive supranuclear palsy, multiple system atrophy, cortico-basal degeneration, or drug-induced or post-stroke parkinsonism).
    • Have had previous surgical intervention (eg, deep brain stimulation) for PD or for whom such a procedure is planned or anticipated during the trial period.
    • Have hypertension.
    • Have previously participated in any tavapadon trial, including this trial, and received IMP.
    • Have received treatment with any other investigational drug within 60 days before signing the ICF.

    Age Range
    40 and up
  • A Study to Evaluate Baricitinib in Adults with Severe or Very Severe Alopecia Areata

    Official Title
    A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients with Severe or Very Severe Alopecia Areata (JAHO)
    Purpose

    The main reason for you to take part in this study is not to treat you for your condition but to help in answering the following research questions:
    • Whether baricitinib is better than placebo in the treatment of patients with severe alopecia areata (AA)
    • The safety of baricitinib and any side effects you may have when you take it.

    Could this study be right for you?

    - Are at least 18 years and ≤60 years for males (≤70 years of age for females) at
    the time of informed consent

    - Are able to read, understand, and give documented (electronic or paper
    signature) informed consent

    - Current AA episode of more than 6 months’ duration and hair loss
    encompassing ≥50% of the scalp

    - No spontaneous improvement over the past 6 months

    Age Range
    18 and up
  • A Study to Evaluate Brexpiprazole in the Maintenance Treatment of Adults with Major Depressive Disorder (MDD)

    Official Title
    A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of Brexpiprazole as Adjunctive Therapy in the Maintenance Treatment of Adults with Major Depressive Disorder
    Purpose

    Brexpiprazole is a medication being studied as a possible treatment for adjunctive treatment for Major Depressive Disorder (MDD). The reason for this study is to find out about the potential benefits and safety of Brexpiprazole.

    Could this study be right for you?

    Inclusion criteria:
    - Between the ages of 18 and 65
    - Currently depressed
    - Currently taking an antidepressant
    - Have tried at least 2 antidepressant medications

    Age Range
    18 and up
  • A Study to Evaluate Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

    Official Title
    A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy (SLEEP)
    Purpose

    The purpose of this study is to understand how Continuous Positive Airway Pressure (CPAP)
    for mild to moderate sleep apnea may affect hypertensive disorders of pregnancy and other
    complications of pregnancy such as gestational diabetes.

    Could this study be right for you?

    1. No prior delivery at or after 20 weeks 0 days of gestation
    2. Pregnancy with only one fetus
    3. Gestational age at randomization between 14 weeks 0 days and 21 weeks 6 days
    4. Diagnosis with mild to moderate OSA as defined by an AHI score ≥ 5 and <30

    Age Range
    18 and up
  • A Study to Evaluate E-Cigarette Nicotine Form, Concentration, and Flavor Among Youth

    Official Title
    Evaluating E-Cigarette Nicotine Form, Concentration, and Flavor Among Youth
    Purpose

    The purpose of this study is to examine the influence of nicotine form, concentration, and e-liquid flavor on youth vaping as well as the heart and lung effects associated with this behavior. You will be asked to attend 9 vaping sessions at The Ohio State University.

    Your participation in this study will last up to 6 months.

    Could this study be right for you?

    • Male or females aged 21-25 years old
    • Current E-Cigarette user
    • Able to attend 9 vaping sessions at The Ohio State University

    Age Range
    21 and up
  • A Study to Evaluate Long-Acting Antiretroviral Therapy in Non-adherent HIV-Infected Individuals

    Official Title
    A5359; A Phase III Study to Evaluate Long-Acting Antiretroviral Therapy in Non-adherent HIV-Infected Individuals
    Purpose

    This study is investigating if Long-Acting (LA) Injectable HIV-medications will be more successful for people who are non-adherent to their HIV medications than oral standard of care regimens. To be eligible to receive LA ART, participants will need to attain virologic suppression through adherence to an oral regimen first.

    Could this study be right for you?

    • Be between 18 - 75 years of age
    • Previously prescribed ART for at least 6 months
    • Screening HIV RNA is greater than 200 copies
    • Women must not be pregnant, planning to become pregnant, or breastfeeding. Women who can become pregnant must agree to use 1 form of effective birth control
    • Evidence of non-adherence to previous HIV medications

    Age Range
    18 and up
  • A Study to Evaluate the Effectiveness and Safety of NBI-1065846 (TERPIS)

    Official Title
    Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDD (TERPSIS)
    Purpose

    To evaluate the efficacy and safety of study drug NBI-1065846, used as adjunctive treatment to oral antidepressant medication(s), compared with a placebo when treating symptoms of anhedonia.

    Could this study be right for you?

    • Aged 18-65 years old
    • Diagnosis of MDD
    • Currently on stable dose of at least one antidepressant
    • Experiencing anhedonia (low interest, decreased enjoyment)

    Age Range
    18 and up
  • A Study to Evaluate the Safety and Effectiveness of a Dietary Supplement Used in Treating COVID-19

    Official Title
    Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of a Plant Polyphenol for COVID-19
    Purpose

    The purpose of this trial is to determine whether a commercially available dietary supplement may decrease the severity of patients with early COVID-19

    Could this study be right for you?

    Inclusion Criteria:

    - Outpatients who test positive for infection with SARS-CoV-2
    - Age 45 years and older
    - Experiencing COVID 19 symptoms for 7 days or less,
    OR 72 hours of new respiratory symptoms
    - Patient must have access to the internet or a smartphone to complete surveys
    - English-speaking patients

    Age Range
    45 and up
  • A Study to Evaluate the Safety of REL-1017, A Study Drug Used to Treat Major Depressive Disorder (MDD)

    Official Title
    Safety of REL-1017 for Major Depressive Disorder (RELIANCE-OLS)
    Purpose

    This is a 1-year open-label study to access the safety of REL-1017, a study medication, once daily as a workable treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug for the duration of the treatment period.

    This study will last 13 months and you will come to the study site at least 15 times over this period. This will include 1 final visit about 1 month after you stop taking the study drug.

    Could this study be right for you?

    • Aged 18-65 years old
    • Diagnosed with Major Depressive Disorder (MDD)
    • Currently depressed
    • Taking or having taken between 1 and 3 antidepressants for the current episode of depression

    Age Range
    18 and up
  • A Study to Evaluate Upadacitinib Along with Topical Corticosteroids on Teens and Adults with Atopic Dermatitis (eczema)

    Official Title
    M16-047: A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Combination with Topical Corticosteroids on Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis
    Purpose

    The purpose of this study is to compare the effectiveness and safety of Upadacitinib (ABT-494) to placebo (pill without any active substance that looks like upadacitinib) in combination with topical corticosteroids for adolescents (12-17 years of age) and adults (18-75 years of age with moderate to severe atopic dermatitis (AD).

    Could this study be right for you?

    - Adolescent subjects must weigh more than 40 kg (88 lb)
    - Subject must be in good general health (other than Atopic Dermatitis)
    - Subject must have chronic Atopic Dermatitis (AD) with onset of symptoms at least 3 years before first dose of study medication
    - Subject must have documented history of inadequate response to topical corticosteroids (TCS), topical calcineurin inhibitor (TCI), or systemic treatment for AD within 6 months prior to first dose of study medication
    - Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study and for 30 days after last dose of the study drug.
    - No history of drug or alcohol abuse in the 6 months prior to receiving the first dose of study medication

    Age Range
    12 and up
  • A Study to Examine Atropine for the Reduction of Nearsightedness (The CHAPERONE Study)

    Official Title
    Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)
    Purpose

    The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness.

    Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends.

    This study will take place over a 4-year time period.

    Could this study be right for you?

    · Children aged 3 to < 13 years old.

    · No previous use of medications related to myopia control.

    · Glasses and/or contact lens prescription between -1.00 and -6.00 diopters.

    Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility

    Age Range
    3 and up