Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study About Recovery After ACL Reconstruction (RARE)

    Official Title
    Disability after ACL Reconstruction: Development of an Alternative Model of Care
    Purpose

    The anterior cruciate ligament (ACL) in your knee can be injured and treated with an ACL reconstruction surgery. An ACL reconstruction may impact function, muscle strength, the way you move, and knee joint health. However, outcomes at 2 years after ACL reconstructions in young persons are not well-understood. Findings from this study will provide information regarding the clinical, function, muscle strength, and movement patterns after ACL injury and reconstruction to help inform physicians and physical therapists who work with these patients.

    Could this study be right for you?

    You may be eligible if:

    1. You are between the ages of 16-35 years old
    2. 2 years (+/- 8 months) status post ACL Reconstruction
    3. Regularly participated in physical activity prior to their ACL injury

    Age Range
    16 and up
  • A Study about Tools to Assess Mental Health for Youth with Intellectual Disabilities and Their Caregivers

    Official Title
    Development and Validation of a Diagnostic Interview to Assess Psychopathology in Youths with Intellectual Disabilities
    Purpose

    This study will help researchers to learn more about mental health for youth with intellectual disabilities. The purpose of our study is to develop a diagnostic interview to assess mental health issues in youths with Intellectual Disabilities. The instrument would address a significant need and allow for more accurate estimation of mental disorders in the Intellectual Disabilities population.

    We are recruiting youths with Intellectual Disabilities aged 14-21, and their caregivers as well. Each participant would take part in one individual session of approximately 60-90 minutes (with breaks) at the Ohio State University Nisonger Center. Youths will be asked to respond to a set of interview questions about mental health, including providing feedback on a set of illustrations related to the interview questions about emotions, feelings, and behaviors. Parents or caregivers will be asked to provide feedback on the interview questions asked of youth.

    Could this study be right for you?

    You may be eligible to participate in the study if you are:
    --14 to 21 years old AND have been diagnosed with an Intellectual Disability

    Youths will be asked to respond to a set of interview questions about mental health, including providing feedback on a set of illustrations related to the interview questions about emotions, feelings, and behaviors. Parents or caregivers will be asked to provide feedback on the interview questions asked of youth.

    Age Range
    14 and up
  • A Study After Roux-en-Y Gastric Bypass Surgery

    Official Title
    The colorectal cancer risk paradox after Roux-en-Y gastric bypass surgery and weight regain: Interplay and mechanistic insights into the role of the gut microbiome and lipidomics
    Purpose

    This study is being done to find out if certain stool microbiota (tiny microorganisms such as bacteria) and blood fat metabolism particles that are linked to colon cancer are increased in patients following bariatric (weight loss) surgery. We are also attempting to identify if stool microbiota and fat metabolism is linked to successful weight loss after bariatric surgery which in turn can impact the risk of cancer.

    This study requires only one telehealth study visit followed by an at-home stool collection and optional blood work.

    Could this study be right for you?

    - Are between 18 and 75 years of age
    - Have had Gastric Sleeve or Roux-en-y within 1-10 years
    - Willing to collect and send to our lab a stool sample
    - Have NO personal or family history of colorectal cancer, precancerous polyps, inflammatory bowel disease, immune suppression diarrhea, cirrhosis, or an active complication of your bariatric surgery

    Age Range
    18 and up
  • A Study Comparing Upadacitinib to Dupilumab in Adult Subjects with Moderate to Severe Atopic Dermatitis

    Official Title
    M16-046: A Phase 3b Multicenter, Randomized, Double-Blind, Double-Dummy, Active Controlled Study Comparing the Safety and Efficacy of Upadacitinib to Dupilumab in Adult Subjects with Moderate to Severe Atopic Dermatitis
    Purpose

    The purpose of this study is to compare the effectiveness and safety of upadacitinib (ABT-494) versus dupilumab for the treatment of adult subjects (18-75 years of age) with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

    Could this study be right for you?

    - Subject must have chronic Atopic Dermatitis (AD) with onset at least 3 years prior to study participation
    - Subject must have > or = 10% body surface area involvement of atopic dermatitis
    - Subject must have had inadequate response to topical corticosteroids or topical calcineurin inhibitors within the past 6 months
    - OR documented systemic treatment for AD within the past 6 months
    - OR for whom topical treatments are otherwise medically inadvisable
    - No prior exposure to any JAK inhibitor ( eg. ruxolitinib, tofacitinib, baricitinib, upadacitinib,
    PF-04965842, and filgotinib)
    - No prior exposure to dupilumab

    Age Range
    18 and up
  • A Study Evaluating Alcohol Use and Anger

    Official Title
    Aggression and Social-Emotional Information Processing: Neural Correlates During Alcohol Intoxication (Columbus Brain Activity Study or CBA)
    Purpose

    The purpose of this study is to see how alcohol changes brain activity in different groups of study participants who currently drink at least 10 drinks a week and who have (or do not have) “anger issues”. Brain activity will be measured by Magnetic Resonance Imaging (MRI).

    Total time you will be in the research study will be for about 4-8 weeks from your initial visit.

    Could this study be right for you?

    - Healthy men and women 21-55 years of age
    - Drink on a regular basis (~ 10 alcoholic beverages per week)
    - With a current history of "anger issues"
    - Able to complete study sessions during the week

    Age Range
    21 and up
  • A Study Evaluating Brain Development and Behavior in Children

    Official Title
    Exploring the Connectivity and Functional Organization of the Child Brain
    Purpose

    The purpose of the study is to investigate how the brain develops and how it leads to our own unique behavior later on in life. We are studying children as they start school and learn new skills, and following up with them as they grow.

    Children will perform computer based tasks such as seeing colorful faces, objects, and scenes, watching or listening to stimuli and making a response (e.g., button or verbal response), or move areas of his/her body (e.g., tapping his/her fingers) while we monitor their brain activity using functional Magnetic Resonance Imaging (fMRI). We may also monitor the participant’s eye position with a special eye-tracking camera so that we can assess where the participants are looking during the tasks.

    The total length of the study will be between 3 and 5 hours, including up to 3 hours outside the MRI scanner and 2 hours in the scanner. Because the purpose of this study is to track development in each individual across time, we will ask you if you would like to participate in subsequent scan sessions as your child gets older.

    Could this study be right for you?

    - Children ages 3-15 years of age
    - Born at greater than 37 weeks or to term
    - no family history of mental illness
    - No alcohol or drug use
    - normal vision and hearing
    - Native English speakers

    Age Range
    3 and up
  • A Study Evaluating Cognition, Insulin Resistance and Omega-3s (RACIR O-3) in Breast Cancer Survivors

    Official Title
    Remote assessment of cognition, insulin resistance and omega-3s (RACIR O-3) in breast cancer survivors
    Purpose

    We are studying the relationships between cognitive function, insulin resistance, and omega-3 fatty acids in the blood and from the diet among breast cancer survivors and women without a history of cancer diagnoses. We hope to learn more about how to potentially protect breast cancer patients from uncomfortable mental changes during and after treatment for breast cancer, such as “chemo brain”.

    This is a completely remote study, meaning all study tasks can be completed from the comfort of home. Enrolled participants will complete several online surveys and questionnaires, a Zoom video call for additional assessments, and will be sent materials to complete finger-stick blood sample collections from the comfort of home over a period of 3-4 weeks.

    The information we gain from this research study will help us design a future clinical trial to test if dietary interventions can help reduce or prevent cognitive changes like chemo brain in breast cancer patients.

    Could this study be right for you?

    - Accepts healthy volunteers - YES
    - Females
    - Age 45-75 years
    - Post-menopausal (at least 12 months no menses)
    - Stage I-III Breast Cancer diagnosis
    - 1-4 years post initial breast cancer diagnosis
    - No diagnosis of diabetes
    - English speaking

    Age Range
    45 and up
  • A Study Evaluating How Heart Disease Affects School Readiness in Children

    Official Title
    Preschool Study of Congenital Heart Outcomes of Learning and Readiness (p-SCHOLAR)
    Purpose

    The purpose of the p-SCHOLAR study is to learn about how congenital heart disease (CHD) might be related to school readiness and development in young children.

    This is a single-study visit that will last approximately 3 hours and take place at Nationwide Children's Hospital.

    During the 3-hour study visit, we will measure the child's thinking skills, knowledge of letters and numbers, and their behavior. We will also ask the caregiver to complete a set of surveys and a short interview about the child.

    If the child is enrolled in a preschool or another educational program, their teacher will have the opportunity to participate in the study as well.

    Could this study be right for you?

    - Legal guardians and their child aged 4 or 5 years old
    - Children who have not yet started kindergarten
    - Children with no history of congenital heart defects (CHD), traumatic brain injury (TBI), or genetic conditions known to affect cognition
    - Children with no severe hearing or vision impairments
    - Children born full term (gestational age ≥ 37 weeks)
    - Children and caregivers fluent in English

    Age Range
    4 and up
  • A Study Evaluating Ketorolac Dosing and Pain Management After C-section Delivery

    Official Title
    Dosing of Ketorolac Impacts post-cesarean paiN manaGement (KING): A Randomized Controlled Trial
    Purpose

    The purpose of this study is to compare the use of morphine milligram equivalents (MME) in the first 24 hours of post-op C-Section delivery in patients getting a single dose of 30 mg ketorolac injected through the vein vs. 60 mg ketorolac injected through the vein in the operating room after the end of surgery.

    Participation in this study starts from enrollment until being discharged from the hospital.

    Could this study be right for you?

    INCLUSION:
    • Pregnant women aged between 18 to 45 years old
    • C-Section as the planned delivery process
    • Regional anesthesia (Spinal, Epidural, Combined Spinal Epidural)
    EXCLUSION:
    • Known allergy or adverse reaction to NSAIDs, aspirin, or ketorolac
    • Patients with peptic ulcer disease, preexisting kidney or liver disease
    • Patients with bleeding problem
    • Acute or chronic pain disorder
    • General anesthesia
    • Opioid use disorder
    • Emergent Cesarean delivery
    • Active asthma
    • Patients weighing <50 kg

    Age Range
    18 and up
  • A Study Evaluating Occupational Therapy Interventions for Children with Autism Spectrum Disorders

    Official Title
    Characterizing Occupational Therapy Intervention for Children with Autism Spectrum Disorders
    Purpose

    We are actively recruiting typically developing children (ages 6 – 13 years) to participate in a new study looking at attention and sensory processing. In this study, we are investigating what occupational therapy practitioners are doing during therapy for children with autism and to see the effect of occupational therapy on brainwaves and behavior. We will identify differences in brainwaves in children with and without autism.

    You and your child will be asked to schedule one visit to the EEG lab at Ohio State University. Your visit will last about 2.5 hours and include an hour of EEG testing and one hour of paper-pencil game-like activities measuring attention.

    We need parent consent, and the parent/guardian will complete assessments about their child as well.

    Could this study be right for you?

    - Children with no autism or any other medical diagnosis
    - Your child is between 6 - 13 years of age

    Age Range
    6 and up
  • A Study Evaluating Treatment for Intrahepatic Cholestasis of Pregnancy (ICP) - A liver disorder that can develop in pregnancy

    Official Title
    A Phase 2a/2b Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in Adult Women with Intrahepatic Cholestasis of Pregnancy and Elevated Serum Bile Acid Concentrations (OHANA)
    Purpose

    The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment intrahepatic cholestasis of pregnancy (ICP).

    Depending upon how many weeks pregnant you are when you are screened at the first study visit, study participation could last up to 27 weeks

    Could this study be right for you?

    Inclusion Criteria:
    • Females aged 18 to 45 years old
    • Viable pregnancy of 20 weeks 0 days above
    • Diagnosis of intrahepatic cholestasis of pregnancy (ICP)
    • Willing and able to not use of any of the following for the duration of the study: statins, rifampin, bile acid sequestrants (e.g., cholestyramine), peroxisome proliferator-activated receptor (PPAR) agonists/fibrate drugs (e.g., fenofibrate, bezafibrate), S-adenosyl methionine.

    Exclusion Criteria:
    • Presence of triplets or higher multiple gestation
    • Breastfeeding
    • Alcohol use disorder or substance abuse within 12 months
    • Known diagnosis of HIV infection or HIV antibody positivity

    Exclusion Criteria varies, please contact Study Coordinator for more information.

    Age Range
    18 and up
  • A Study Evaluationg Decision-making for Young Adults, Older Adults, and Adults with Early Alzheimer’s Disease and Mild Cognitive Impairment

    Official Title
    Modeling Cognition and Aging
    Purpose

    The goal of this study is to develop models to better understand decision-making for young adults, older adults, and adults with early Alzheimer’s disease and Mild Cognitive Impairment.

    This study involves making simple decisions (such as “are there more blue dots or more yellow dots?”) on a computer. Healthy volunteers will also complete basic tasks such as solving puzzles, questionnaires involving numbers, and will be asked to provide basic demographic and health information.

    Could this study be right for you?

    You may be eligible for this study if:

    - You are ages 18-25 OR
    - You are age 60-90 and have NOT been diagnosed with a memory disorder OR
    - You are age 60-90 and HAVE been diagnosed with either Mild Cognitive Impairment OR mild Alzheimer's disease
    - You are a native English speaker
    - You are able to see a computer screen and use hands on keyboard/screen

    Age Range
    18 and up