Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study to Evaluate the Safety of REL-1017, A Study Drug Used to Treat Major Depressive Disorder (MDD)

    Official Title
    Safety of REL-1017 for Major Depressive Disorder (RELIANCE-OLS)
    Purpose

    This is a 1-year open-label study to access the safety of REL-1017, a study medication, once daily as a workable treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug for the duration of the treatment period.

    This study will last 13 months and you will come to the study site at least 15 times over this period. This will include 1 final visit about 1 month after you stop taking the study drug.

    Could this study be right for you?

    • Aged 18-65 years old
    • Diagnosed with Major Depressive Disorder (MDD)
    • Currently depressed
    • Taking or having taken between 1 and 3 antidepressants for the current episode of depression

    Age Range
    18 and up
  • A Study to Evaluate Upadacitinib Along with Topical Corticosteroids on Teens and Adults with Atopic Dermatitis (eczema)

    Official Title
    M16-047: A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Combination with Topical Corticosteroids on Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis
    Purpose

    The purpose of this study is to compare the effectiveness and safety of Upadacitinib (ABT-494) to placebo (pill without any active substance that looks like upadacitinib) in combination with topical corticosteroids for adolescents (12-17 years of age) and adults (18-75 years of age with moderate to severe atopic dermatitis (AD).

    Could this study be right for you?

    - Adolescent subjects must weigh more than 40 kg (88 lb)
    - Subject must be in good general health (other than Atopic Dermatitis)
    - Subject must have chronic Atopic Dermatitis (AD) with onset of symptoms at least 3 years before first dose of study medication
    - Subject must have documented history of inadequate response to topical corticosteroids (TCS), topical calcineurin inhibitor (TCI), or systemic treatment for AD within 6 months prior to first dose of study medication
    - Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study and for 30 days after last dose of the study drug.
    - No history of drug or alcohol abuse in the 6 months prior to receiving the first dose of study medication

    Age Range
    12 and up
  • A Study to Examine Atropine for the Reduction of Nearsightedness (The CHAPERONE Study)

    Official Title
    Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)
    Purpose

    The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness.

    Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends.

    This study will take place over a 4-year time period.

    Could this study be right for you?

    · Children aged 3 to < 13 years old.

    · No previous use of medications related to myopia control.

    · Glasses and/or contact lens prescription between -1.00 and -6.00 diopters.

    Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility

    Age Range
    3 and up
  • A Study to Examine How Art Reduces Stress in People Who Suffer from Chronic Digestive Issues (ART-GUT study)

    Official Title
    Art to promote Reduction in stress, Truncate severity of Gastrointestinal symptoms Understand its role in Therapy (ART-GUT study)
    Purpose

    The purpose of this study is to evaluate whether group-art sessions can reduce stress, improve sleep quality, improve quality of life and decrease severity of digestive symptoms in participants who suffer from chronic digestive issues. Participants will meet virtually once per week for 1.5 hour sessions, via Zoom, and will be provided with art supplies.

    The start date will be determined by the date the 1st session starts for a given group. Thus participants can be in the study for up to 14 weeks.

    Could this study be right for you?

    • Male or females aged 18 years or older
    • Suffer from Chronic Digestive Symptoms
    • Willing to meet virtually once per week for 1.5 hour group sessions

    Age Range
    18 and up
  • A Study to Examine Pragmatic Evaluation of Events and Benefits of Lipid-lowering in Older Adults (PREVENTABLE)

    Official Title
    PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE)
    Purpose

    The purpose of this study is to evaluate the use of statins to possibly prevent Mild Cognitive Intervention (MCI) or dementia, along with the prevention of physical disability and cardiovascular disease in older adults.

    Your participation in this study will last up to 5 years.

    Could this study be right for you?

    • Male and females older than 75 years older
    • No history of heart attack, stroke, revascularization (restore blood flow) or obstructive heart disease where a statin was prescribed
    • No heart failure hospitalization or statin use within the last 12 months
    • No history or current evidence of dementia
    • No condition/situation that would prevent the use of a statin
    • No major hearing or visual impairment

    Age Range
    75 and up
  • A Study to Examine Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's Disease

    Official Title
    Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's Disease
    Purpose

    The purpose of this study is to examine how men and women with and without dementia might perceive and respond to pain or discomfort.

    Participants may complete various questionnaires by phone or video conferencing once a week for up to 8 weeks with an optional MRI screening.

    Could this study be right for you?

    • Men and women aged 60 years or older
    • Dementia or memory issues

    Participants and their caregiver (if applicable) may complete only 1 day of the study, or they may complete as many as they would like for up to 8 days total.

    Age Range
    60 and up
  • A Study to Examine the Early Development of Attention, Learning, and Memory During Childhood

    Official Title
    A multi-year study of learning during childhood
    Purpose

    The purpose of this study is to investigate the early development of attention, learning, and memory.

    The duration of the study will last over 4 years.

    Participation in this study includes 4, 90-minute-long visits to the lab per year. During these 90-minute-long visits, your child will play 2-3 computerized games, designed to assess different aspects of their cognitive ability.

    Could this study be right for you?

    Children aged 4 years old only; children must be 4 years old at their initial visit to participate.

    Age Range
    4 and up
  • A Study to Examine the Effects of Movies on Children's Behavior

    Official Title
    Media Violence and Gun Violence
    Purpose

    Researchers want to examine the effects of movies on children aged 8 - 12 years. If your child joins this study, they will watch a 1-minute safety video at home and answer a short survey. At-home activities should take less than 20 minutes. Next, they will come to OSU campus for the lab part (parking is paid, mask wearing is required) with a same aged peer or sibling. There they will watch a movie clip for 20 minutes (rated PG) and afterwards be placed in a room containing toys and games that they can play with for another 20 minutes. The children will be videotaped so we can see what they do. Participation in the lab portion will take 50 – 60 minutes.

    Could this study be right for you?

    - Participants in the study will be children aged 8 - 12 years old - In order to participate in this study, your child must bring another child 8 - 12 years old. If you don't have two children within this age range, your child can bring a friend or relative.

    Age Range
    8 and up
  • A Study to Help Improve Symptoms of Gastroparesis (BREATHE)

    Official Title
    Breathing Reduces Enteric symptoms and Anxiety promoting Therapeutic Healing Experience (BREATHE) – A Randomized Clinical Trial in Patients with Symptoms of Gastroparesis
    Purpose

    The purpose of this research study is to see if practicing mindful breathing daily can reduce stress, improve sleep
    and possibly improve symptoms in patients with Gastroparesis.

    Gastroparesis is a condition characterized by symptoms such as nausea, vomiting, feeling excessively full after eating a little bit, bloating and abdominal pain. One or more of these symptoms can be present in a given patient.

    Your participation throughout the study will last 6 weeks.

    Could this study be right for you?

    • At least 18 years of age
    • Able to read and understand English
    • Has symptoms of gastroparesis for at least 6 months (gastric emptying study is NOT required for inclusion)

    Age Range
    18 and up
  • A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression

    Official Title
    A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
    Purpose

    This study is being done to see if the study drug, called BI 1358894, compared to a drug called quetiapine, may help people with Major Depressive Disorder (MDD) who do not progress when taking an antidepressant medication alone. This study will help to gain information for providing better or new possible treatments for people in the future.

    This study will take place over a period of 13 weeks and have about 8 visits to the study center and 2 that will be done by phone.

    Could this study be right for you?

    • Aged 18-65 years old
    • Diagnosed with Major Depressive Disorder (MDD)
    • Currently depressed
    • Taking an antidepressant

    Age Range
    18 and up
  • A Study to Understand How Medications Can Affect Prediabetes in African Americans

    Official Title
    The Role of the Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose Metabolism among African Americans: Pilot Study
    Purpose

    The purpose of this study is to find out if taking one medication Diovan (valsartan) or a combination of two medications (valsartan and sacubatril) in one pill called Entresto, will improve prediabetes in Blacks /African Americans over the course of 6 months. We will also look for changes in blood pressure and blood vessel stiffness throughout the course of the study in order to better understand how these medications may impact prediabetes.

    Could this study be right for you?

    Inclusion Criteria: - African American aged 18-65 years old - History of impaired fasting glucose - Impaired glucose tolerance - A1c 5.7-6.4% or other risk factors for diabetes Exclusion Criteria: - Type 2 diabetes - Systolic blood pressure greater than 150/100 or medications to lower your blood pressure - Systolic blood pressure less than 100/60 - Steroid use - Hyperkalemia (high potassium levels)

    Age Range
    18 and up
  • A Study Using the Medication Ferumoxytol to Develop an Enhanced MRI Test

    Official Title
    Development and Testing of Ferumoxytol-enhanced MRI Protocol in Healthy Subjects
    Purpose

    This study is being done to develop a Magnetic resonance imaging (MRI) test that provides better-quality whole-heart pictures. MRI is a non-invasive machine that collects detailed pictures inside your body.

    Healthy volunteers will be tested in the MRI scanner while being given a dose of a medicine called Ferumoxytol into an IV (intravenous catheter) that will be placed in your arm or hand. Ferumoxytol is a medicine usually used in patients with iron deficiencies and has recently been used as an alternative to other MRI contrast agents and has successfully been applied in adult and pediatric patient populations.

    Could this study be right for you?

    Inclusion:
    • Males and females ages 18 years and older
    • No history of cardiovascular disease

    Exclusion:
    • Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:
    • Reactions to MRI including metallic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, coronary artery stent, neurostimulator, any other medical metallic implant
    • History of cardiovascular disease or uncontrolled high blood pressure
    • Claustrophobia
    • Inability to lie flat for up to 1 hour
    • Weight exceeding 300 pounds
    • Pregnancy

    Age Range
    18 and up