Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study About Recovery After ACL Reconstruction (RARE)

    Official Title
    Disability after ACL Reconstruction: Development of an Alternative Model of Care
    Purpose

    The anterior cruciate ligament (ACL) in your knee can be injured and treated with an ACL reconstruction surgery. An ACL reconstruction may impact function, muscle strength, the way you move, and knee joint health. However, outcomes at 2 years after ACL reconstructions in young persons are not well-understood. Findings from this study will provide information regarding the clinical, function, muscle strength, and movement patterns after ACL injury and reconstruction to help inform physicians and physical therapists who work with these patients.

    Could this study be right for you?

    You may be eligible if:

    1. You are between the ages of 16-35 years old
    2. 2 years (+/- 8 months) status post ACL Reconstruction
    3. Regularly participated in physical activity prior to their ACL injury

    Age Range
    16 and up
  • A Study Comparing Upadacitinib to Dupilumab in Adult Subjects with Moderate to Severe Atopic Dermatitis

    Official Title
    M16-046: A Phase 3b Multicenter, Randomized, Double-Blind, Double-Dummy, Active Controlled Study Comparing the Safety and Efficacy of Upadacitinib to Dupilumab in Adult Subjects with Moderate to Severe Atopic Dermatitis
    Purpose

    The purpose of this study is to compare the effectiveness and safety of upadacitinib (ABT-494) versus dupilumab for the treatment of adult subjects (18-75 years of age) with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

    Could this study be right for you?

    - Subject must have chronic Atopic Dermatitis (AD) with onset at least 3 years prior to study participation - Subject must have > or = 10% body surface area involvement of atopic dermatitis - Subject must have had inadequate response to topical corticosteroids or topical calcineurin inhibitors within the past 6 months - OR documented systemic treatment for AD within the past 6 months - OR for whom topical treatments are otherwise medically inadvisable - No prior exposure to any JAK inhibitor ( eg. ruxolitinib, tofacitinib, baricitinib, upadacitinib, PF-04965842, and filgotinib) - No prior exposure to dupilumab

    Age Range
    18 and up
  • A Study Evaluating Alcohol Use and Anger

    Official Title
    Aggression and Social-Emotional Information Processing: Neural Correlates During Alcohol Intoxication (Columbus Brain Activity Study or CBA)
    Purpose

    The purpose of this study is to see how alcohol changes brain activity in different groups of study participants who currently drink at least 10 drinks a week and who have (or do not have) “anger issues”. Brain activity will be measured by Magnetic Resonance Imaging (MRI). Total time you will be in the research study will be for about 4-8 weeks from your initial visit.

    Could this study be right for you?

    - Healthy men and women 21-55 years of age - Drink on a regular basis (~ 10 alcoholic beverages per week) - With a current history of "anger issues" - Able to complete study sessions during the week

    Age Range
    21 and up
  • A Study Evaluating Cognition, Insulin Resistance and Omega-3s (RACIR O-3) in Breast Cancer Survivors

    Official Title
    Remote assessment of cognition, insulin resistance and omega-3s (RACIR O-3) in breast cancer survivors
    Purpose

    We are studying the relationships between cognitive function, insulin resistance, and omega-3 fatty acids in the blood and from the diet among breast cancer survivors and women without a history of cancer diagnoses. We hope to learn more about how to potentially protect breast cancer patients from uncomfortable mental changes during and after treatment for breast cancer, such as “chemo brain”.

    This is a completely remote study, meaning all study tasks can be completed from the comfort of home. Enrolled participants will complete several online surveys and questionnaires, a Zoom video call for additional assessments, and will be sent materials to complete finger-stick blood sample collections from the comfort of home over a period of 3-4 weeks.

    The information we gain from this research study will help us design a future clinical trial to test if dietary interventions can help reduce or prevent cognitive changes like chemo brain in breast cancer patients.

    Could this study be right for you?

    - Accepts healthy volunteers - YES
    - Females
    - Age 45-75 years
    - Post-menopausal (at least 12 months no menses)
    - Stage I-III Breast Cancer diagnosis
    - 1-4 years post initial breast cancer diagnosis
    - No diagnosis of diabetes
    - English speaking

    Age Range
    45 and up
  • A Study Evaluating Occupational Therapy Interventions for Children with Autism Spectrum Disorders

    Official Title
    Characterizing Occupational Therapy Intervention for Children with Autism Spectrum Disorders
    Purpose

    We are actively recruiting typically developing children (ages 6 – 13 years) to participate in a new study looking at attention and sensory processing. In this study, we are investigating what occupational therapy practitioners are doing during therapy for children with autism and to see the effect of occupational therapy on brainwaves and behavior. We will identify differences in brainwaves in children with and without autism. You and your child will be asked to schedule one visit to the EEG lab at Ohio State University. Your visit will last about 2.5 hours and include an hour of EEG testing and one hour of paper-pencil game-like activities measuring attention. We need parent consent, and the parent/guardian will complete assessments about their child as well.

    Could this study be right for you?

    - Children with no autism or any other medical diagnosis - Your child is between 6 - 13 years of age

    Age Range
    6 and up
  • A Study Evaluationg Decision-making for Young Adults, Older Adults, and Adults with Early Alzheimer’s Disease and Mild Cognitive Impairment

    Official Title
    Modeling Cognition and Aging
    Purpose

    The goal of this study is to develop models to better understand decision-making for young adults, older adults, and adults with early Alzheimer’s disease and Mild Cognitive Impairment.

    This study involves making simple decisions (such as “are there more blue dots or more yellow dots?”) on a computer. Healthy volunteers will also complete basic tasks such as solving puzzles, questionnaires involving numbers, and will be asked to provide basic demographic and health information.

    Could this study be right for you?

    You may be eligible for this study if:

    - You are ages 18-25 OR
    - You are age 60-90 and have NOT been diagnosed with a memory disorder OR
    - You are age 60-90 and HAVE been diagnosed with either Mild Cognitive Impairment OR mild Alzheimer's disease
    - You are a native English speaker
    - You are able to see a computer screen and use hands on keyboard/screen

    Age Range
    18 and up
  • A study for children with nearsightedness

    Official Title
    The Chaperone Study: A multi-center, double-masked, randomized, placebo-controlled, phase III study of the safety and efficacy of atropine 0.1% and 0.01% ophthalmic solutions administered with a microdose dispenser for the reduction of pediatric myopia progression
    Purpose

    Is your child nearsighted?

    Nearsightedness, or myopia, is a condition that results in blurry vision when looking at distant objects.

    Myopia happens when the eyeball grows too long or the cornea (the clear front cover of the eye) is too curved.
    As a result, light entering the eye is not focused correctly. While glasses and contact lenses can help a person with myopia see clearly, they do not address the underlying stretching of the eye.

    Myopia detected in young children tends to increase through the school years . As myopia progresses, it can increase the risk of retinal detachment, cataracts, myopia maculopathy and even blindness. To date, FDA has not approved any drug therapies for reducing myopia progression.

    This is why researchers are working to develop new medications and technologies that may help children and teens with this condition. The CHAPERONE Study is a research study testing the safety and effectiveness of microdosed atropine eye solution to see if it slows the progression of myopia in children.

    Could this study be right for you?

    - Is your child between 3-12 years old?
    - Does your child need glasses to see distant objects?
    - Is your child able to go to periodic visits at the study clinic to check his/her vision and overall eye health over a 4-year period (11 scheduled visits will be required)?
    - Are you available to speak with study staff by phone periodically between your child’s clinic visits to review your child’s experience using study medication?

    This study is not for children who have:
    - Used atropine or other myopia drug therapies
    - Had prior eye surgery
    - A systemic disease or condition that can affect their vision

    Age Range
    3 and up
  • A Study for New Moms about Pelvic Floor Disorders

    Official Title
    Pelvic Floor Disorders in the First Year After Childbirth: (PEACH Study)
    Purpose

    The goal of this study is to learn more about problems with urine or stool control, prolapse (feeling or seeing a vaginal bulge), and pain with sex, all which can affect mothers after delivery when they are most busy with their newborn.

    If you join this study, you will complete a series of online surveys over a period of 12 months. The surveys will ask about urine and stool control, pelvic issues, and sexual issues. Each survey will take about 5-10 minutes.

    Could this study be right for you?

    You may be eligible if upon reading this, you:

    - Have given birth within the last 10 days at The Ohio State University Wexner Medical Center
    - Are 18 years of age or older
    - Recently had a full term vaginal delivery of one baby
    - Able to speak and read English

    Age Range
    18 and up
  • A Study for Night Shift Workers

    Official Title
    Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)
    Purpose

    This research study aims to determine the effects of a noninvasive form of brain stimulation on alertness for night shift workers.

    Could this study be right for you?

    • You are age 18 to 65
    • You are currently working the night shift at least 3x/week
    • You are suffering from sleepiness at work
    • You do not have significant heart and lung problems
    • You work within the Columbus, OH area

    Age Range
    18 and up
  • A study for those undergoing MLF Surgery

    Official Title
    SIJ Stabilization in Long Fusion to the Pelvis: Randomized Controlled Trial
    Purpose

    To determine whether placement of iFuse-3D across the ssacroiliac joint (SIJ) in the Bedrock configuration provides
    clinical and/or radiographic benefits in patients undergoing multilevel spine fusion (MLF) surgery with fixation to the pelvis

    Could this study be right for you?

    You may be eligible for this study if you are:
    1. Age 21-75 at time of screening
    2. Scheduled for multilevel (4 or more levels) spinal fusion surgery with planned fixation to the pelvis using S2AI screws
    3. Patient has the necessary mental capacity to participate and is physically able to comply with study protocol requirements

    Exclusion Criteria
    1. The reason for your multilevel spine fusion surgery is any of the following:
    a. Congenital neuromuscular disease
    b. Prior pelvic fixation (already have S2AI or iliac bolts in place, current surgery indicated to revise this hardware)
    c. Grade IV spondylolisthesis
    2. Prior sacroiliac joint fusion/fixation on either side
    3. Presence of spinal cord stimulator
    4. Presence of severe hip pain that could impair functional and quality of life improvement from complex spine surgery
    5. Surgeon plans to use iliac screw for pelvic fixation
    6. Severe osteoporosis
    7. Known allergy to titanium or titanium alloys
    8. Current local or systemic infection that raises the risk of surgery
    9. Currently receiving or seeking short- or long-term worker's compensation and/or currently involved in injury litigation related to the SIJ or low back pain.
    10. Currently pregnant or planning pregnancy in the next 2 years
    11. Known or suspected drug or alcohol abuse
    12. Fibromyalgia

    Age Range
    21 and up
  • A Study for Those with Chronic Pancreatitis

    Official Title
    A PHASE 1, SINGLE DOSE PK AND SAFETY STUDY WITH NI-03 FOLLOWED BY A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP DOSE-RANGING STUDY TO EVALUATE THE SAFETY AND EFFICACY OF NI-03 COMPARED TO PLACEBO IN SUBJECTS WITH CHRONIC PANCREATITIS
    Purpose

    The purpose of this study is to learn if a study drug called NI-03 (also known as Camostat) can help people with chronic pancreatitis. We want to find out what effects, good or bad, the study drug has on the disease. It has been approved in Japan and has been available by prescription for the treatment of the acute pain associated with chronic pancreatitis. The study drug will not be approved for sale in the United States until tests from studies like this one show that it is safe and effective.

    Could this study be right for you?

    -You are between the ages of 18-80
    -You have a diagnosis of chronic pancreatitis
    -For males: documented surgical sterilization, sexual abstinence, or agreed upon means of contraception from screening until 28 days after final dose of study medication is required
    -For females: documented surgical sterilization, sexual abstinence, postmenopausal status for at least 1 year, or agreed upon means of contraception from screening until 28 days after final dose of study medication is required

    Age Range
    18 and up
  • A Study for Those with Chronic Pancreatitis - The PROCEED Study

    Official Title
    Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies PROCEED Study)
    Purpose

    This study is done for researchers to understand pancreatitis and learn how the disease progresses naturally over time.

    From the results of this study, researchers hope to develop some lab tests to support early diagnosis of chronic pancreatitis and to also discover any genetic factors that may affect your chances of developing chronic pancreatitis. The results of this study may also provide information that will open opportunities for new drug discovery.

    Could this study be right for you?

    • You have a history of acute or chronic pancreatitis OR
    • You have experienced pain in your abdomen that a doctor has suggested could be due to pancreatitis
    • You are between the ages of 18 and 75

    Age Range
    18 and up