Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • Young Women’s Health Study

    Official Title
    An Intervention Study about Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease
    Purpose

    Researchers at Nationwide Children’s Hospital are seeking volunteers to be a part of a study looking at how to best screen for bleeding disorders in young women.

    Participants will be asked to undergo a finger prick blood test and complete questionnaires. If their survey answers suggest they have heavy menses or abnormal bleeding, they will also be asked to have a blood draw on the same day.

    Could this study be right for you?
    • Are 9 to 21 years old
    • Have had your first menstrual cycle
    Age Range
    9 - 21
  • A Study to Examine if a Foot Stool can Make it Easier for People with Constipation to have a Bowel Movement (FASED Study)

    Official Title
    FASED (Footstool in Alleviating Symptoms of Evacuation Disorder)
    Purpose

    The purpose of this research study is to see if using a footstool can make it easier to have bowel movements in patients who suffer from chronic constipation. The participants will be given a free footstool to use. They will be asked to keep a record of their bowel symptoms and answer some surveys about their symptoms on a phone or computer. 

    You will be in the study for approximately 12 weeks. This includes 2 weeks before you start using the footstool, followed by 8 weeks where you will be using the footstool and up to 2 weeks to complete your initial and final surveys. 

    Could this study be right for you?
    • At least 18 years old 

    • Able to understand English 

    • Symptoms such as feeling incompletely empty after a bowel movement, needing to strain a lot when having a bowel movement or needing to use maneuvers such as rocking one's body back and forth or using their finger to remove stool. 

     

    Age Range
    18 - 99
  • Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and Obesity

    Official Title
    Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and Obesity
    Purpose

    The purpose of this study is to lower the rate of type 2 diabetes in rural Appalachia youth due to obesity and/or being overweight. Our long-term goal is to improve the health of underserved, high-risk youth.

    This study will test the effectiveness of the Mentored Planning to be Active + Family on physical activity outcomes and health outcomes among rural Appalachian middle school aged youth suffering from either overweight or obesity.

    We have local high school-aged teen mentors work closely with middle school youth to increase social support, self-efficacy, and self-regulation skills to sustain physical activity and improve health before the children enter high school.

    The peer mentoring is followed by a 6-month family reinforcement program.

    Some parents will provide child assessment data of perceived child physical activity behaviors and child health.

     

    Could this study be right for you?
    • Child has access to a computer or tablet device at home for virtual mentoring sessions/meetings
    • Child suffers from overweight or obesity - does not need to be under the care of a health care professional for this condition
    • Child and Parent able to participate read English at a 4th grade level. 
    • Family not expected to move from rural Appalachia within the 18 months. 
    Age Range
    12 - 13
  • Cardiovascular Effects of Ketone Ester Ingestion

    Official Title
    Cardiovascular Effects of Acute Ketone Ester Ingestion in Healthy Adults
    Purpose

    This study is intended to evaluate the effects of a drink supplement on heart function and health in healthy adults after consuming a ketone ester (KE) supplement drink compared to a placebo drink.

    You will undergo an MRI exam for this study. You will also receive six blood draws in total, from an IV catheter set at the beginning of the study. 

    The duration of this study will comprise a single visit and will last no longer than 4 hours. 

    Could this study be right for you?

    Inclusion:

    • Able to comply with study requirements as well as pre-test requirements
    • BMI between 18 and 30 kg/m2
    • Body weight > 150lbs

    Exclusion:

    Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:

    • Pregnancy 
    • Allergies to components in the test products, including milk protein, and not lactose intolerant
    • History of alcoholism (previous 2 years)
    • Taking prescriptive medications or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
    • Current smoker
    • Contraindications to MRI including cardiac pacemaker or defibrillator, brain aneurysm clips, neuro-stimulator, the presence of any magnetic metal in the body or claustrophobia

    Exclusion Criteria varies, please contact Study Coordinator for more information. 

    Age Range
    18 - 65
  • "What do physicians know about intellectual disability?" Getting information to design better medical training

    Official Title
    "What do physicians know about intellectual disability?" Getting information to design better medical training
    Purpose

    The purpose of this study is to explore the physicians’ knowledge of intellectual disabilities (ID) and their medical training and practice. The information resulting from this study will help to design adequate interventions and training programs for medical students and physicians aimed to improve their ID knowledge and the health care services provided to patients with ID. This is an observational cross-sectional study of physicians in the US using an anonymous online survey. The entire survey has 156 items and will require 15-20 minutes to complete.

    Could this study be right for you?

    - You are an American medical resident, an attending physician, or a medical educator in any type of medical specialization, and - You have or do not have experience with patients with intellectual disabilities

    Age Range
    24 and up
  • A Distracted Driving Study for iPhone and Android Phone Users-- Ages 18 - 20

    Official Title
    Distracted Driving Study--A phone app to reduce cell phone usage among young drivers
    Purpose

    This is a study is being done to find out if a phone app reduces calling and texting while driving among young drivers.

    Could this study be right for you?

    - 18-20 years old
    - Use an iPhone or Android smartphone
    - Have a full driver’s license that allows unsupervised driving at all times
    - Have a car that they are exclusive access to (primary driver, do not share the car)
    - Car is insured for liability during crashes
    - Driver uses the car more than 2 days a week on average
    - Are a US citizen

    Age Range
    18 and up
  • A Medication study for Children with Major Depressive Disorder (Ages 7 -17)

    Official Title
    A Double-blind, Placebo- and Active-controlled Evaluation of the Safety and Efficacy of Levomilnacipran ER in Pediatric Patients 7-17 Years With Major Depressive Disorder
    Purpose

    The purpose of this research study is to evaluate the drug Levomilnacipran extended-release to see how well the drug works, observe the side effects, and how well tolerated it is compared to placebo in pediatric patients with major depressive disorder.

    Could this study be right for you?

    Your child may be eligible if:
    • be between 7 and 17 years of age
    • give their assent (a simplified version of this consent form that your child will sign)
    • have a diagnosis of Major Depressive Disorder
    • meet all of the additional relevant inclusion criteria
    • understand the study instructions, and be willing and able to follow these instructions

    Exclusion Criteria:
    • Your child will not be able to take part in the study if she is pregnant, nursing, or planning a pregnancy
    • Your child will not be able to take part in this study if he/she takes any illegal substances

    Age Range
    7 and up
  • A Medication Study for Individuals with Alport Syndrome (AS) and Primary Steroid-Resistant Focal Segmental (FSGS)

    Official Title
    A multicenter, randomized, double-blind, parallel group, placebo-controlled study to assess safety, tolerability, pharmacokinetics and pharmacodynamics of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis.
    Purpose

    The overall objective is to investigate to investigate how safe, how well tolerated, and how effective R3R01 is in treating uncontrolled proteinuria in patients with Alport syndrome and steroid-resistant Focal Segmental Glomerulosclerosis. All eligible participants will be enrolled to receive R3R01 over a treatment period of 12 weeks. The study will consist of 3 periods, including a screening period of 3 weeks, a treatment period of 12 weeks, and a follow up of period of 12 weeks.

    Could this study be right for you?

    You may be eligible to participate if: • You are aged 18 years or older • Female patients and female partners of male patients willing to not become pregnant for the duration of the study • Have not had an organ transplant and/or on a organ transplant list • Have high protein in urine Alport Syndrome (AS) specific: • Have X-linked AS and autosomal recessive AS • Confirmed diagnosis of AS be genetic testing or kidney biopsy • Do not have another kidney disease FSGS specific: • Not older than 75 years of age • Primary Focal segmental glomerulosclerosis (FSGS) (not caused by other condition) that is confirmed by kidney biopsy or documentation of genetic mutation • Steroid-resistance: previous steroid treatment without remission

    Age Range
    18 and up
  • A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)

    Official Title
    A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)
    Purpose

    The purpose of this study is to examine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

    The duration of the study will consist over a 5 year period. You will visit the study site approximately 23 times after your implant surgery.

    Could this study be right for you?

    • Aged 18 years or older
    • Must be in a major depressive episode (MDD or bipolar disorder) for ≥ two years or have at least had four episodes of depression including the current episode
    • Patients depressive illness meets a minimum criteria of four prior failed treatments of adequate dose and duration

    Age Range
    18 and up
  • A Registry for Those with Hypophosphatasia (HPP)

    Official Title
    AN OBSERVATIONAL, LONGITUDINAL, PROSPECTIVE, LONG-TERM REGISTRY OF PATIENTS WITH HYPOPHOSPHATASIA
    Purpose

    The purpose of this registry is to collect information about Hypophosphatasia (HPP), a rare bone disorder characterized by the abnormal development of bones and teeth. This long-term registry will collect and store patient medical information, and other related information to use in medical research. the registry may help researchers better understand the condition and learn more about patients who have HPP. This data may help other people with HPP in the future.

    Could this study be right for you?

    - 18 years of age or older
    - Been diagnosed with Hypophosphatasia (HPP)- a rare genetic disorder characterized by the abnormal development of bones and teeth.
    - Not participating in another Alexion-sponsored clinical trial

    Age Range
    18 and up
  • A Study About Brain Activity and Suicide Prevention Strategies

    Official Title
    Neural Mechanisms and Predictors of an Ultra-Brief Suicide Prevention Strategy
    Purpose

    This research study will look at how patterns of brain activity influence thoughts and behaviors. This research is being done to better explain why people have thoughts about suicide and how different suicide prevention strategies impact brain responses to emotional information.

    Could this study be right for you?

    Eligibility Criteria includes:
    - 18-65 years old
    - generally medically and physically healthy
    - current suicidal ideation and intent OR no lifetime history of DSM-5 disorder, no lifetime suicidal intent or lifetime suicide attempts
    (partial list of inclusion criteria)

    Exclusion Criteria:
    - Diagnosis of bipolar disorder, schizophrenia, mania, or psychosis
    - Currently pregnant (positive pregnancy test), or trying to become pregnant (female)
    - Presence of ferrous-containing metal in the body
    - Inability to tolerate enclosed spaces
    (partial list of exclusion criteria)

    Age Range
    18 and up
  • A Study about Fitness, Aging, and Stress in People with Traumatic Brain Injury

    Official Title
    Fitness, Aging, Stress & TBI Exposure Repository (FASTER)
    Purpose

    The purpose this study is to examine how individual differences in health changes (muscle strength, blood pressure) and behavioral changes (sleep, physical activity) impact memory, attention, and the brain. We study these relationships in among a variety of older adults, including those with a history of concussion, traumatic brain injury (TBI), and posttraumatic stress disorder (PTSD). The long-term goal of this project is to identify modifiable factors that exacerbate or protect from age-related cognitive decline.

    Could this study be right for you?

    Eligibility Criteria: • Aged 18 years and older • Speak English • History of concussion, traumatic brain injury, and/or posttraumatic stress disorder • Must have primary care physician

    Age Range
    18 and up