Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study for those with COPD and Chronic Bronchitis

    Official Title
    A Clinical Evaluation of the RheOx Bronchial Rheoplasty System for the Treatment of the Symptoms of Chronic Bronchitis in Adult Patients with COPD
    Purpose

    RheOx (Gala Therapeutics, Inc.) is an investigational device designed to reduce cough and mucus production through a minimally-invasive procedure. The procedure is performed through a bronchoscope, a thin flexible tube that is inserted through the mouth into the lungs. Once in place, RheOx delivers short bursts of electrical energy to the inner walls of the bronchi, eliminating the mucus-producing cells. Over the next several days, new cells grow and produce less mucus. The right lung is treated first, followed by treatment of the left lung about 1 month later.

    RheOx has been studied in three clinical trials and has shown a significant improvement in quality of life and a reduction in cough and mucus at 12 months.

    Could this study be right for you?

    You may be eligible if:
    -You are at least 35 years of age.
    -Have chronic bronchitis, defined as productive cough for three months in each of two successive years, whereas other causes of productive cough have been ruled out
    -You are receiving guideline directed pharmacotherapy which includes one or more long acting bronchodilator (LAMA, LABA) with or without an inhaled corticosteroid for at least 8 weeks prior to randomization
    -You have a cigarette smoking history of at least ten pack years.
    -Other criteria that will be reviewed by the study team

    You will not be eligible if you have:
    - A known unresolved lower respiratory tract infection (e.g., pneumonia, mycobacterium avium-intracellulare infection (MAI), fungus, tuberculosis).
    - A steroid-dependent condition requiring more than 10 mg of oral corticosteroid per day.
    - Any implantable electronic device (e.g., pacemaker, cardioverter defibrillator, neuro-stimulation devices).
    - A history of arrhythmia within past two years which includes tachy-atrial arrhythmias, any ventricular tachy-arrhythmias, or sinus bradycardia with heart rate less than 45 beats per minute.
    - Unresolved lung cancer.
    - A pulmonary nodule or cavity that in the judgement of the Primary investigator may require intervention during the course of the study.
    - Had prior lung surgery, such as lung transplant, LVRS, lobectomy, lung implant/prosthesis, metal airway stent, valves, coils or bullectomy. Prior pneumothorax without lung resection, pleural procedures without surgery, or segmentectomy are acceptable.
    - Asthma based on Global Initiative for Asthma (GINA) criteria.
    - Smoked (including tobacco, marijuana, e-cigarettes, vaping, etc.) within the last 6 months.
    - Unable to walk over 238 feet in 6 minutes.
    - Uncontrolled GERD.
    - Had prior severe respiratory infection with SARS-CoV-2 (COVID-19) that required ICU support with non-invasive and/or invasive mechanical ventilation.
    - A known allergy to nickel.
    - Other criteria will be reviewed by the study team

    Age Range
    35 and up
  • A Study for Those with Diabetic Macular Edema--The BOULEVARD Study

    Official Title
    A PHASE 3, DOUBLE-MASKED, RANDOMIZED STUDY OF THE EFFICACY AND SAFETY OF INTRAVITREAL AFLIBERCEPT INJECTION IN PATIENTS WITH MODERATELY SEVERE TO SEVERE NONPROLIFERATIVE DIABETIC RETINOPATHY
    Purpose

    The purpose of this 28-week study to investigate the effects and safety of a medication in participants with Center Involving Diabetic Macular Edema (CI-DME). .

    Could this study be right for you?

    - 18 years and older - Macular edema associated with diabetic retinopathy (DR) - Diagnosis of diabetes mellitus (DM)

    Age Range
    18 and up
  • A Study for those with Type 2 Diabetes AND Depression

    Official Title
    Mindfulness-based cognitive therapy for comorbid depression and type 2 diabetes
    Purpose

    The aim of this study is to improve mood and diabetes-related outcomes for those with type 2 diabetes mellitus (T2DM) AND symptoms of depression. The present study will examine the effect of mindfulness-based cognitive therapy (MBCT) on symptoms of depression and diabetes.

    Your participation in this study will last 8 weeks.

    Could this study be right for you?

    You may qualify if:
    • You are between the ages 18-75
    • You have type 2 diabetes
    • You are feeling symptoms of depression

    Age Range
    18 and up
  • A Study for Those With Type 2 Diabetes AND Who Are Experiencing Food Insecurity

    Official Title
    Linking Education, Produce Provision, and Community Referrals to Improve Diabetes Care (LINK)
    Purpose

    The purpose of this study is to improve hemoglobin A1c levels in patients with type 2 diabetes experiencing food insecurity.

    The study will examine the effects of a produce referral program alone and in combination with other interventions. Our research is designed to develop a deeper understanding of how to provide patients with type 2 diabetes that are experiencing food insecurity with the resources, skills, and education to manage their health and social needs.

    Could this study be right for you?

    Inclusion Criteria:
    - Age 18 years and older
    - Type 2 diabetes based on American Diabetes Association Criteria
    - Hemoglobin A1c level > 7.5%
    - Worried about running out of food before you have money to buy more

    Exclusion Criteria:
    - Pregnant

  • A Study of DBS-Expert system used during Deep Brain Stimulation For Parkinson's Disease

    Official Title
    DBS-Expert: Automated Deep Brain Stimulation Programming Using Functional Mapping Phase II
    Purpose

    Deep Brain Stimulation (DBS) surgery is FDA approved for the treatment of Parkinson's Disease. The purpose of this study is to examine a technology (DBS-Expert system) that uses objective measurements to guide DBS programming. The DBS-Expert system analyzes motion data and provides recommendations to the physician or healthcare professional regarding DBS programming settings.

    Could this study be right for you?

    You may be eligible if you:
    * Over the age of 18
    * Able and willing to provide informed consent
    * Clinical diagnosis of idiopathic Parkinson's Disease
    * Implanted Boston Scientific DBS system

    Exclusion Criteria

    * You are currently participating in any study with an investigational medicinal product (IMP) or investigational device.

    Age Range
    18 and up
  • A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression

    Official Title
    A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression
    Purpose

    The purpose of this study is to see if esketamine nasal spray alone is effective as a medication to improve depressive symptoms in adults with treatment-resistant depression when compared with placebo nasal spray.

    The duration of the study consists up to a maximum of 24 weeks.

    Could this study be right for you?

    • Aged 18 years or older
    • Must have had no response (less than 25% improvement) to at least 2 oral antidepressant treatments in the current episode of depression

    Age Range
    18 and up
  • A Study of Milestones to Advance Language Learning

    Official Title
    SMALL Talk: Study of Milestones to Advance Language Learning
    Purpose

    The goal of this study is to identify early risk for developmental language disorder (DLD) among young, low-income children, and to determine how caregiver and child chronic stress and interaction quality interact to disrupt language growth among these children. The long-term objective is to identify pathways through which early family situations and the conditions of poverty disrupt early language paths among low-income children and contribute to heightened rates of DLD.

    Could this study be right for you?

    Inclusion criteria are: - have a child that is 9 months or younger - child resides in a low-income household, using some sort of government assistance or using the 200% threshold from the Department of Health and Human Services based on annual household income and number of persons in home Exclusion criteria: - Children who are multiple births, preterm (<35 weeks), and have profound or severe disabilities will be excluded, with the latter including congenital blindness, deafness, Down syndrome and other frank neurological deficits.

  • A Study of Mobile Health (mHealth), Breast Disease, and Lifestyle Modification

    Official Title
    Mobile Health (mHealth), Breast Disease, and Lifestyle Modification: Developing a Grounded Theory
    Purpose

    The purpose of this study is to understand breast cancer survivors use of mobile health (mHealth) apps for lifestyle behavior change - eating a healthier diet, exercising more, dealing with stress, & stopping smoking. Interviews will last approximately 60 - 90 minutes.

    Could this study be right for you?

    - You have a diagnosis of breast disease or are a breast cancer survivor.
    - You are age 18 or older
    - You are a female

    Age Range
    18 and up
  • A study on language impairment following a stroke

    Official Title
    Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response
    Purpose

    This NIH-funded project will investigate patient-specific factors that may influence response to therapy for language impairment after stroke, or aphasia. Results from this work will assist with better estimation of prognosis for stroke survivors with aphasia, which could empower patients and families to make more informed health care decisions about how to pursue the most appropriate rehabilitation services based on their unique characteristics, such as genetics, cognitive skills, and brain structure after stroke.

    Could this study be right for you?

    Participants must meet the following criteria:
    - Native English speaker
    - Able to have an MRI
    - Had only one stroke (in the left hemisphere of the brain)

    Age Range
    18 and up
  • A Study on the Role of Spirituality and Faith during Cancer Treatment

    Official Title
    Patient perceptions about the role of spirituality and faith during cancer treatment
    Purpose

    The purpose of the current study is to characterize the perspectives of cancer patients who have undergone a cancer-directed surgery on the role of spirituality and/or religion during their cancer journey in order to better define the desired access to related resources during cancer care. Results from this study will inform future research aimed at addressing patient-centered spirituality/faith needs of cancer patients.

    Could this study be right for you?

    If you’ve had or will have surgery to treat a cancer diagnosis, you can help researchers at Ohio State examine how patient spirituality and/or religion influences the cancer journey by taking an online survey.

    Participants should be:

    • Over 18 years old.

    • Diagnosed with cancer (all types).

    • At least four months past the initial cancer diagnosis.

    • Underwent or will receive a surgical procedure related to their cancer

    • Able read and write in the English language.

    Age Range
    18 and up
  • A Study to Compare Medications in Patients with Advanced Parkinson's Disease

    Official Title
    A Randomized, Double-Blind, Double-Dummy, Active-Controlled Study Comparing the Efficacy, Safety and Tolerability of ABBV-951 to Oral Carbidopa/Levodopa in Advanced Parkinson's Disease Patients
    Purpose

    The purpose of this study is to find out how well ABBV-951 works to control Parkinson's disease symptoms compared to oral Carbidopa (CD)/Levodopa (LD). The study is also seeking to test whether ABBV-951 is well tolerated in patients with Parkinson's disease.

    Could this study be right for you?

    1. Male or female, age 30 or older
    2. Has not received deep brain stimulation, Carbidopa (CD)/Levodopa (LD) enteral suspension, or any other Parkinson's Disease (PD) medication as continuous daily infusion
    3. Subject does not have a history of significant skin conditions or disorders
    4. Subject does not have a recent (within 6 months before screening) history of drug or alcohol abuse
    5) Subject does not have a history or presence of psychotic episodes
    6) Subject does not have other clinically significant unstable medical conditions
    7) Subject must have a diagnosis of levodopa-responsive idiopathic PD

    * other eligibility criteria to be discussed/reviewed with the study team

    Age Range
    30 and up
  • A Study to Evaluate a Medication Used in Treating Hand-Foot Skin Reaction (HFSR) in Cancer Patients (NOVA-II)

    Official Title
    A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients (NOVA-II)
    Purpose

    Hand-Foot Skin Reaction (HFSR) is a common adverse event induced by Vascular Endothelial Growth Receptor Inhibitor (VEGFRi) treatment in cancer patients. The main purpose of this study is to evaluate the safety and efficacy of OQL011 compared to vehicle ointment in treating patients with moderate to severe VEGFRi-associated HFSR. This study will also identify an optimal dosage for Phase III study and explore the pharmacokinetics profile of OQL011 in HFSR patients.

    Could this study be right for you?

    - Patient must be age 18 years of age or older. - Patient must have a confirmed cancer diagnosis for which VEGFRi treatment is indicated, and must be currently under VEGFRi-based anti-cancer therapy with stable dosage for ≥ 1 week. - Patient on pain medications is allowed provided they have been on stable dosage in the past 1 week and is going to continue at the same dosage.

    Age Range
    18 and up