Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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Research Study on the Biomechanics of Total Knee Replacements
Official Title Biomechanical Metrics of Movement Relative to Total Knee ArthroplastyPurpose
This study aims to understand how a total knee replacement surgery (TKR) affects muscle function and movement in the lower body. It focuses on four key areas:
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Examining how TKR changes the way muscles work in the lower body.
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Exploring how these muscle changes relate to the forces people experience when walking and doing daily activities after surgery.
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Connecting muscle function to how well patients feel and move after TKR.
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Identifying different types of TKR patients based on their physical traits, movement patterns, and medical history to see how they compare.
Could this study be right for you?
- Must be scheduled to receive a total knee replacement within the next 2 months
- Have a body mass index (BMI) < 40
- Do not require the use of a cane or other assistive device when walking, climbing stairs, and getting up from a chair
Exclusion criteria varies; please contact Study Coordinator for more information
Age Range
18 years and up -
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Impacts of Ketone Esters on Exercise and Heart Health in Type 2 Diabetics
Official Title Effects of Acute and Chronic Ketone Ester Consumption on Exercise Tolerance and Cardiac Function in Subjects with DiabetesPurpose
This placebo-controlled study is being done to evaluate the effects of a ketone ester drink on exercise performance and heart health in a group of subjects diagnosed with type 2 diabetes.
Could this study be right for you?
There are additional exclusion criteria, study staff will screen fully before enrollment.
Age Range
18 - 80 years -
Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial Disease (PAD)
Official Title Radiotracer Imaging of Lower Extremity Skeletal Muscle Perfusion in Patients with Peripheral Arterial DiseasePurpose
The purpose of this study is to look at a new method to evaluate blood flow to the calves and feet.
Peripheral Artery Disease (PAD) patient outcomes will be evaluated for up to 12 months after their revascularization procedure to assess how early changes in SPECT-derived foot perfusion relate to rates of diabetic wound healing and limb salvage. Outcomes will be specifically evaluated at 3, 6, 9, and 12 months after revascularization at the time of their follow-up clinic visits to the OSU Comprehensive Wound Center at OSU Hospital East. Primary outcomes of interest will be 1) changes in wound size and healing, 2) minor or major amputations of the lower extremity, and 3) any subsequent interventional procedures, such as balloon angioplasty, stenting, or surgical bypass.
Could this study be right for you?
Heathly Volunteers with out previous cardiovascular disease
Or
PAD
Age Range
18 years and up -
Effect of Diet and Electrical Stimulation Exercise on Blood Pressure Control in Spinal Cord Injury
Official Title Lifestyle solutions to postprandial hypotension in spinal cord injuryPurpose
To test if a low-glycemic diet and electrical stimulation of leg muscles can improve blood pressure control after eating.
Could this study be right for you?
- Spinal cord injury sustained at least 1-year ago
- Level of injury between C4 and T10
- Use of wheelchair for majority of daily activities
Age Range
18 years and up -
Making Colorectal Cancer Screening Simple and Accessible Through Technology
Official Title Digital Transformation of CRC Screening: Revolutionizing Access and Saving LivesPurpose
The purpose of this study is to conduct usability testing to evaluate ease of use and overall user experience of a website designed to promote colorectal (CRC) awareness and screening uptake among adults 45-64.
Could this study be right for you?
Inclusion Criteria: Eligible participants will 1) be between the ages of 45-64, 2) at average risk for CRC and 3) from diverse racial/ethnic and socioeconomic backgrounds
Those who are ineligible fall under the following categories:
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Age: Individuals outside the age range of 45-64 will be excluded
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Pregnancy Status: Pregnant individuals will be excluded from the study. since CRC screening is not recommended for pregnant individuals
Age Range
45 - 64 years -
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Does the amount of nicotine in filtered little cigars impact health and smoking habits?
Official Title LOWFLC Study: Addiction potential of low nicotine filtered little cigarsPurpose
Researchers from The Ohio State University are recruiting adult users of little cigars and cigarillos to help improve understanding of the products’ health impact.
Could this study be right for you?
- Current smoker
- No significant health problems
Age Range
21 - 75 years -
A Study for Reducing Alcohol Use During MOUD (Phase Two)
Official Title Brief Digitally Enhanced Intervention for Managing Emotional Pain and Reducing Alcohol Use during Medication for OUD (Phase Two)Purpose
This study is being done to further examine and improve how a brief clinical treatment intervention may reduce alcohol use among patients engaged in medication for opioid use disorder (MOUD) treatment.
The length of the study is approximately 10 weeks and will include two on-campus lab visits at Ohio State's Medical Campus, daily surveys via a smartphone app (surveys 3 times a day for ~21 days), three treatment sessions (completed online or in-person), and follow-up questionnaires (completed online). The total time commitment of the study is 11 hours and 6 minutes.
Could this study be right for you?
Inclusion Criteria:
- engaged in MOUD treatment (for at least one month)
- alcohol consumption (within the past 12 months)
- age 18 or older
- access to a smart phone
(partial list of inclusion criteria)
Exclusion Criteria:
- diagnosis of psychosis or bipolar I
- currently pregnant (positive pregnancy test)
(partial list of exclusion criteria)
Age Range
18 years and up -
A Depression Study Examining the Effects of Lumateperone in Treatment-Resistant Depression
Official Title A Randomized, Double-Blind, Placebo-controlled Multicenter Study to Assess the
Efficacy and Safety of Lumateperone as Adjunctive Therapy in the Treatment of
Patients with Major Depressive DisorderPurpose
Depression is one of the most common mental health issues worldwide. Many people with major depressive disorder (MDD) take antidepressant medications that do not provide enough of a response to ease their depressive symptoms.
The primary objective of this study is to evaluate the benefit of Lumateperone 42 mg administered once daily compared with placebo as adjunctive treatment to antidepressant therapy (ADT) in patients with Major Depressive Disorder (MDD) who have an inadequate response to ongoing ADT.
Could this study be right for you?
You may be able to take part if you:
• are 18–65 years of age
• have a confirmed diagnosis of Major Depressive Disorder (MDD)
• feel that your current antidepressant medication is not working well
• Has tried 2 or more antidepressant medication in the current episode of depression
Other criteria will need to be met to confirm your eligibility for this study.
Age Range
18 - 65 years -
Comparing Adults with Knee Osteoarthritis to Healthy Controls: A Study on Brain Activation
Official Title The KOBRA Study: The Effects of Knee Osteoarthritis on Brain ActivationPurpose
The purpose of this study is to assess changes in brain activation and processing in those with right knee osteoarthritis compared to healthy controls.
Could this study be right for you?
- Either two healthy knees OR those with right knee pain from a diagnosis of right knee osteoarthritis with a healthy left knee
- No metal implants that prevent you from having an MRI
- No foot/ankle/leg/hip surgeries in the past year
- No neurologic conditions
- No conditions that prevent athletic participation or maximal effort exercise
- Able to provide informed consent
- Speak and read English
Age Range
45 - 70 years -
Understanding How Children Learn and Organize Words
Official Title The Development of Semantic OrganizationPurpose
We are currently in the process of conducting a 5-year National Institutes of Health-funded longitudinal study on semantic and language development, specifically focusing on how children learn new words and understand their meanings. Our goal is to not only examine language learning but also how these processes evolve as children grow.
In this study, we will follow two hundred 4-year-old junior scientists as they participate in fun, interactive word-learning and language activities. Over the course of the study, participants will visit our lab twice a year, each lasting around 60-90 minutes (including breaks), to engage in a series of playful games with a research assistant designed to explore how children comprehend and retain new vocabulary. Additionally, your child will have the opportunity to wear a LENA recorder—a small, wearable device that tracks the number of words your child hears throughout the day, similar to a Fitbit but for words!
Could this study be right for you?
- Child must be monolingual
- Not born premature
- No developmental delays
- Can give a verbal response
- Normal to corrected vision
Age Range
4 - 4 years -
Sensory Processing in Autism
Official Title Neural Biomarkers of Sensory Symptoms in AutismPurpose
The purpose of this study is to understand sensory processing in children on the autism spectrum, Using EEG, we will look at brainwaves while children play different computer games. We will also have children play some paper-pencil games during their visit to our lab. We hope to better understand sensory experiences and support autistic people in ways that celebrate their unique strengths.
Could this study be right for you?
Inclusion criteria for the autism group are
- Diagnosis of autism from a licensed psychologist based on the Autism Diagnostic Interview-Revised or the Autism Diagnostic Observation Schedule (ADOS),
- Aged 8 - 12 years old
- Normal/corrected vision/hearing, and IQ > 65. 19 Children taking stimulant medications will be included in the study but will be required to be off medication for 24 (for short-acting preparations) to 48 h (long-acting preparations) prior to the visit
Inclusion criteria for the age-matched TD control group include:
- No concerns/diagnoses of any neurodevelopmental, learning, or mental health conditions
Age Range
8 - 12 years -
A First-in-human Study of a New Gene Therapy (AMT-260) in Adults with Unilateral Refractory Mesial Temporal Lobe Epilepsy (MTLE)
Official Title A Multi-center, Phase 1/2a, First-in-human (FIH) Study Investigating the Safety, Tolerability, and Efficacy of AMT-260 in Adults with Unilateral Refractory Mesial Temporal Lobe Epilepsy (MTLE) Administered via Magnetic Resonance Imaging (MRI)-guided Convection-enhanced Delivery (CED)Purpose
You are being invited to participate in a study about mesial temporal lobe epilepsy (MTLE) on only 1 side (unilateral) of the brain that has not responded to medication (refractory).
The study will test AMT-260, which is a new gene therapy under investigation for use in treating people like you with MTLE. It is not yet approved as a drug for treating MTLE. It can only be used in a study like this one. This is the first time this gene therapy will be used in humans. It has previously been studied in animals.
AMT-260 is a gene therapy designed to reduce the electrical signals between nerve cells (neurons) in the parts of your brain where nerve cells are abnormally connected. This reduces the extra electrical signals that happen at the same time and is intended to reduce your seizure activity.
The overall goals of this study are:
- To observe whether participants have any side effects from AMT-260 or from the procedure to deliver AMT-260 into the brain and how well participants tolerate any side effects that may occur.
- To measure if participants have changes in:
- frequency of their seizures
- how their seizures affect their life
- how the human body takes up and removes AMT-260
- To find the best dose of AMT-260 for future participants to ensure clinical benefit with minimal or no side effects.
Could this study be right for you?
Adult, 18-65 years of age, inclusive, capable of giving informed consent.
Written informed consent is given freely after the nature of the study has been explained to the participant and the completion of data disclosure.
Willingness to undergo necessary surgical procedures.
Diagnosis of unilateral refractory MTLE for ≥360 days, confirmed by an Epilepsy Monitoring Unit.Additional Eligibility Criteria to be assessed by neurosurgery team, and as described in the study protocol.
Age Range
18 - 65 years