Official Title MIND-TNBC - Pilot study of a MIND diet intervention in women undergoing active treatment for triple negative breast cancer

Purpose

A research team at The Ohio State University in Columbus, OH, is recruiting participants for a remote study of diet and cognition among breast cancer patients.

Enrolled participants will be randomized to receive a personalized 12-week nutrition intervention for cognitive health with a registered dietitian-nutritionist or a 12-week general healthy lifestyle program and will complete all study visits remotely. Participants will be contacted 6 months after the intervention for data collection.

Could this study be right for you?

• Female
• Recently diagnosed with stage II-III triple-negative breast cancer
• Have just started, or soon will start systemic therapy (e.g. chemotherapy, targeted or immune therapies)
• English speaking

 

Age Range

40 - 65 years

Contact Information

Remote

Cindy Conway

conway.113@osu.edu

Official Title A randomized, double-blind, placebo-controlled, parallel group, pilot study to evaluate the effect of a ketone ester on muscle and immune function in older men and women who are at risk for strength and mobility decline

Purpose

The purpose of this study is to measure the effect of 20 weeks of Ketone Ester consumption on a composite score of vigor-frailty in older adults who are at risk for mobility and strength decline and to investigate the effect of 20 weeks of Ketone Ester consumption on additional physical function measures, cognitive and immune function, muscle metabolism, safety, tolerability, gut microbiome, and quality of life in older adults who are at risk for mobility and strength decline. 

Could this study be right for you?

65 years of age or older

• living independently
• English speaking and able to understand study procedures and provide Informed Consent
• women must be post menopause
• ambulatory and able to pass the walk speed criteria at screening            
• minimum body weight of 50kgs (110 lbs.) at time of screening
• able to fast and abstain from alcohol, cannabis products and not exercise for 10 hours prior to study visits
• maintain current diet, exercise, medication and supplement use
• must not have a known allergy, intolerance, or sensitivity to any soy or milk protein
• must not be under active surveillance or treatment for cancer
• has not followed a ketogenic diet or used any ketone products within 30 days of screening or at anytime during the study period
• does not work night shifts or shifts that do not allow for a consistent meal schedule during the day
• does not take any immunosuppressive medications,  weight loss medications or supplements, chronic antibiotic usage or receiving chemotherapy
• must not adhere to any extreme dietary habits, including intermittent fasting, Atkins, vegan, high protein low carbohydrate
• must not be a heavy alcohol drinker (women 8 drinks or more per week; men 15 drinks or more per week)
• must not have uncontrolled elevated cholesterol upon results of screening laboratory results

Age Range

65 - 99 years

Contact Information

Ohio State University, PAES

Kemba Johnson

kemba.johnson@osumc.edu

614-293-3041

Official Title A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy

Purpose

This research is being done to see the effectiveness and safety of a new drug called BHV-7000 as a possible treatment for focal seizures for patients who are taking anti-seizure medications (ASMs) and still experiencing seizures. Refractory focal epilepsy is when someone continues to have focal seizures despite treatment with ASMs or other treatments.

People who take part in this study will be randomly assigned to either study medication or a placebo, will participate for up to 5 months, and the study includes up to 7 in-person visits.

Could this study be right for you?

1. Experiencing at least 4 or more observable focal seizures per month
2. Taking at least 1 and up to 3 anti-seizure medications
3. Do not have a history of cluster/repetitive seizures (which you were not able to individually count) in the past 6 months
4. Between the ages of 18 to 75

Age Range

18 - 75 years

Contact Information

300 W 10th Ave, Columbus, OH, 43210

Emily Huber

emily.huber@osumc.edu

614-814-1120

Official Title A Randomized, Double-blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Purpose

In this research study a study drug named XEN1101 is being tested for the treatment of seizures. The main purpose of this study is to determine if XEN1101 can reduce the seizure frequency and if it is safe to use.  People who take part in this study will be randomly assigned to either study medication or a placebo, will participate for up to 5 months, and includes up to 7 in-person visits.

Could this study be right for you?

1. Experiencing at least 3 PGTCS in an 8-week period
2. Have tried at least 2 anti-seizure medications without success
3. Do not have a history of cluster/repetitive seizures (which you were not able to individually count) in the past 12 months
4. 18 years old and up

Age Range

18 years and up

Contact Information

300 W 10th Ave, Columbus, OH, 43210

Emily Huber

emily.huber@osumc.edu

614-814-1120

Official Title Sex Differences in Alcohol Use: Neural and Hormonal Influences

Purpose

The goal of the study is to gain a better understanding of how hormonal fluctuation across the female menstrual cycle impact brain activity and associated drinking behaviors.

Participation includes:
•    One orientation session (2 hours)
•    Three brain imaging (fMRI)/alcohol and saline administration sessions (7 hours each)
•    Six follow-up online surveys (30 mins each)
•    Two follow-up sessions (1 hour each)

The total time commitment of the study is 28 hours over the course of 21 months.

Could this study be right for you?

1. Age: 21–26 years old (must bring proof of age to Orientation, e.g., driver’s license or passport)
2. In good health, as confirmed by responses to the Screening Interview
3. No contraindications for fMRI (e.g., no metal in the body, as confirmed by MRI screening form)
4. Reports typical weekly alcohol consumption 
5. No current or past treatment for a drug or alcohol use disorder
6. Not currently pregnant, breastfeeding, or planning to become in the next 3 months (women only)
7. Regular menstrual cycles (women only)
8. No use  of hormonal contraception or plans to begin use within the next 3 months (women only)

Age Range

21 - 26 years

Contact Information

Center for Neuroimaging, Neurophenotyping, Neurocomputation, and Neuromodulation (C4N); 1960 Kenny Rd, Columbus, OH 43210

Noah Dray

Noah.Dray@osumc.edu

Official Title Pain Sensitivity and Endogenous Pain Modulation in Autistic Adults (R21)

Purpose

The purpose of this project is to study how pain may differ in adults with or without autism. Our goal is to study whether or not pain is experienced or felt differently in autistic adults compared to non-autistic adults.

Participants will be screened by phone. After meeting the initial screening criteria, the study visit will be scheduled. Participants can expect one study visit lasting 2-3 hours with time built in for breaks.

Could this study be right for you?

• Not currently on any daily pain medications

Age Range

30 - 70 years

Contact Information

Ankita Patel

patel.3386@osu.edu

614-292-3381

Official Title Linking Age, Balance, Vestibular Function, and Falls

Purpose

The purpose of this study is to learn how aging in different sensory systems, including the vestibular system (that portion of the inner ear that measures both motion and orientation of the head), influences maintaining balance while standing and walking, and contributes to fall risk. 

Could this study be right for you?

• Must be able to stand
• No leg or foot amputations
• No lower limb braces
• Not currently feeling dizzy/lightheaded
• Not currently pregnant by self-report
  • Due to potentially nauseogenic nature of some motions and to protect fetus and mother, pregnant women will also be excluded from this study
• Weight <= 275 pounds
• No past or current history of:
  • Severe head trauma or traumatic brain injury
  • Any vestibular disorder (e.g., Meniere’s Disease, Vestibular Migraine, Unresolved BPPV/BPPN, Vestibular hypofunction, except that due to aging, PPPD) as assessed using clinical diagnostic tests described in proposal
  • History of seizures
  • Neurologic illness or conditions known to impact vestibular or balance function(e.g., stroke, neurodegenerative disorders, demyelinating illness)
  • Major psychiatric (e.g., panic disorder, psychosis, etc.) disorder
  • Any of the following eye diseases or conditions: amblyopia (or “lazy eye”) or history of amblyopia, diagnosis of age-related macular degeneration, retina dystrophy, glaucoma, cataracts, or any other eye condition that limits vision to worse than 20/40
  • Recent (<6 months) orthopedic injuries of the lower extremities (e.g., plantar fasciitis, ankle, knee or hip injury, back strain/herniated disc, …).
  • Upper extremity injuries requiring current sling immobilization
  • Recent surgery
  • Any other severe health problem (heart disease, pulmonary disease, cancer, etc.).
  • Vision in both eyes must be better than 20/40 with best correction
  • Outer and/or middle ear pathologies
  • Otologic pathologies or diagnoses (e.g. Meniere’s disease, otosclerosis, conductive or mixed hearing losses)
• Must be able to walk unassisted for 30 minutes
• No current use of ambulatory assistive devices
• Normal hearing bilaterally, air conduction pure-tone thresholds ≤ 25 dB HL at all octave frequencies between 250 and 8000 Hz
• Bilaterally, symmetric sensorineural hearing loss with four-frequency pure-tone average (500, 1000, 2000, 4000) less than 71 dB HL
• If interested, please go to go.osu.edu/vestibular to be screened for eligibility

Age Range

18 - 89 years

Contact Information

OSU Bevis Hall, 1080 Carmack Rd, Columbus, OH 43210

John Oas

oas01@osumc.edu

Official Title Fostering Agricultural Relationships and Meaning - Thriving on Kinship (FARM-TOK)

Purpose

The purpose of this study is to understand how well and how accepted a phone-based intervention for loneliness works for people in rural or farming/agricultural areas. The goal of this intervention is to reduce loneliness and improve mental well-being. 

Could this study be right for you?

Inclusion criteria 

• Understand English
• Reside in an agricultural area in Ohio 
• Experiencing loneliness or social isolation 

Exclusion Criteria 

• Limited mental competency/not able to give informed consent 
• Non-English Speaking 
• Diagnosis of neurological disorder or Bipolar I
• Current psychotic diagnosis
• Suicidal or homicidal intent indicating need for hospitalization or treatment (as determined by clinical interviewer)

Age Range

18 years and up

Contact Information

Taylor Sabbagh

taylor.sabbagh@osumc.edu

614-814-1545

Official Title The Foods and Oils to Repair Correct and Enhance Strength (FORCES) Study: Determining the effect of dietary oils on muscle function, strength and mass

Purpose

The purpose of the FORCES Study is to determine how dietary oils effect muscle function, strength and mass in older adults who feel their muscle function and strength has declined with age.

During this 27-week study participants will

•  Consume ~2.5 tsp of oil each day through foods

• Complete muscle function and strength testing

• Have their blood drawn

• Have their body weight and composition measured

• Have an MRI scan of your legs, if able

• Fill out questionnaires

• Collect a small amount of muscle tissue from the leg (muscle biopsy

Could this study be right for you?

Feel your muscle function, strength or mass as decreased with age

Do NOT have food allergies 

Are not taking any weight loss medications or following a weight loss program

Age Range

65 - 80 years

Contact Information

The Ohio State University Columbus Campus

Rachel Cole

belurylabstudies@osu.edu

614-247-8235

Official Title Learning Interactions Made for Everyone (LIME)

Purpose

This study will examine activities of caregivers and their preschool aged child over a 12-week period. Caregivers will track learning activities with their child over the 12-weeks. Some participants will be asked to engage in additional learning activities with their child. Researchers will conduct assessments with the child before and after the 12-week program, as well as brief follow-ups 3-, 6-, and 12- months after completion. The total duration of participation in this study is up to 24 hours. The study will identify strategies in home-based learning activities and inform development of interventions to improve school readiness among children.

Could this study be right for you?

Child is minimally verbal in English.

Caregiver understands enough English to understand intervention materials.

Child does not have a severe intellectual disability.

Caregiver and child reside in the greater Columbus area.

Age Range

42 - 57 months

Contact Information

Columbus, Ohio

Eileen Donnally

donnally.7@osu.edu

614-247-5897

Official Title Phase I Study of the Safety and Feasibility of a Ketogenic Dietary Intervention to Improve Response to Immunotherapy

Purpose

This study will look at if a ketogenic diet (KD) can help treatment work better in patients with metastatic melanoma or metastatic kidney cancer. People who take part in the study will be randomly assigned to either continue eating their usual diet or trying the KD diet for 24 weeks. Participants will have blood and stool samples collected during the study. They will also test their sugar by doing daily glucose fingers sticks. Participants may be paid up to $200 for taking part in the study.

Could this study be right for you?

1. Patients with metastatic melanoma receiving first-line treatment with immunotherapy or Patients with metastatic renal cell cancer receiving first line treatment with immunotherapy.
2. Willing to give three stool samples
3. Willing to participate in a ketogenic diet (KD)

Age Range

18 years and up

Contact Information

The Ohio State University

Helena Gastier

_JOC-NTresearch_@osumc.edu

614-257-3434

Official Title The Knowledge and Perceptions of Gen Zs Regarding the Dietary Guidelines for Americans

Purpose

1. Use ideas from Social Cognitive Theory to describe Gen Zs regarding the Dietary Guidelines for Americans (DGA) 2020 to 2025
2. Explain what Gen Z knows and believes regarding the MyPlate recommendations for healthy eating related to:

• Filling half their plate with fruit and vegetables
• Filling one-quarter of their plate with lean protein, and varying the sources of protein
• Filling one-quarter of their plate with grains, making half of the grains whole grains

3. To describe the associations between demographic variables (ethnicity, education, household income, and home environment) and Gen Zs perceptions and knowledge of the DGA

Could this study be right for you?

18 to 28 years old

Live in the US

English speaker

Have access to a device that supports Zoom

Age Range

18 - 28 years

Contact Information

United States

Livia Schorn or Rhea Umrani

umrani.2@buckeyemail.osu.edu; schorn.5@buckeyemail.osu.edu

614-814-0866