Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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Evaluating the Efficacy and Safety of Icalcaprant in Subjects with Bipolar Depression
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Bipolar DepressionPurpose
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population.This study will assess how safe and effective Icalcaprant is in treating adult participants with bipolar I or II disorder.
Could this study be right for you?
- Diagnosed with Bipolar Disorder I or II
- Currently in a depressive episode
- Currently receiving treatment of a mood stabilizer
Age Range
18 - 65 years -
Research Study for Grave's Disease
Official Title A Phase 1, First-in-Human, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Intravenous and Subcutaneous Administration of MER511 in Adults With Graves’ DiseasePurpose
- To find out how safe the study drug is and how well people with Graves’ disease can handle taking one or more doses.
- To describe how the body absorbs, uses, and removes a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
- To check whether the body creates an immune response after a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
Could this study be right for you?
- Grave's disease diagnosis
- Taking methimazole or propylthiouracil
- Weigh at least 110 lbs
- Women of childbearing potential must agree to use contraceptive methods and avoid egg donation during the study; Men with partners of childbearing potential must agree to use a condom or abstinence and avoid sperm donation during the study
Age Range
18 - 55 years -
Men’s Health, Friendships and Relationships
Official Title Men Talking: How Do Men Discuss Health, Friendships, and Relationships?Purpose
The purpose of this study is to gain a better understanding of men’s friendships, relationships, and health-information seeking.
The study consists of a 60–90-minute interview at a location of the participant’s choosing.
Thank you for your time and assistance!
Could this study be right for you?
- 18 years and older
- assigned male at birth
- live in Columbus Metro Area
Age Range
18 years and up -
Kicking the Habit: A Research Study Testing the Buckeye Quit Stick
Official Title A Pilot/Feasibility Study of the Buckeye Quit Stick: A Novel Resource for Successful Tobacco CessationPurpose
The Buckeye Quit Stick is part of a research study to learn whether people are willing to use a handheld stick as a tool for the hand-mouth routine of smoking. It focuses on the hand-to-mouth habit by providing something to hold and use instead of a cigarette. The main goal of this study is to see if patients that plan to quit smoking will use this device and evaluate their experiences with the Buckeye Quit Stick.
Participants will also continue to receive national guidelines for smoking cessation support from the James Comprehensive Cancer Center Smoking Cessation Clinic. A participant is considered to have completed the research study when they complete all study visits or at approximately 6 months.Could this study be right for you?
- Must be 21 years of age or older
- Patient of the OSU Thoracic Clinics
- Suspected or confirmed lung cancer diagnosis
- Current self-reported smoker
Age Range
21 years and up -
Preserving Manual Wheelchair User Shoulder Health
Official Title Quantifying Musculoskeletal Adaptations to Manual Wheelchair Use Across the LifespanPurpose
Manual wheelchair use places high physical demands on the arms and shoulders, which can lead to pain and injury, especially with aging. This study aims to understand how wheelchair use affects shoulder anatomy and movement to improve prevention, early detection, and treatment of upper extremity pain and injury in manual wheelchair users.
Participation includes two in-person research sessions, each lasting about 60 minutes, conducted at the Martha Morehouse Medical Pavilion:
- MRI session to examine shoulder anatomy (no radiation involved)
- Movement analysis session to assess muscle activity and arm function during everyday tasks such as wheelchair propulsion and reaching
Sessions may be completed on the same day or on different days within one week.
Total study participation is approximately 2 hours.
Could this study be right for you?
- Adults (>18 years old) who are primary manual wheelchair users
- Must be able to safely participate in MRI and movement analysis
- Individuals who are pregnant or have MRI-incompatible metal implants are not eligible
Age Range
18 - 110 years -
CP-MOVES: Standing Intervention for Children with Motor Delays.
Official Title CP-MOVES: Complex rehabilitation technology enabled Physical activity for children with Motor delays Via telehealth in natural EnvironmentsPurpose
This study will examine physical activity, sleep, and quality of life in children with severe motor delays and their parents before and after an 8-week intervention using adaptive standers.
Parents with a child with severe motor delay will enroll with their child (up to 1 parent per child). Both parent and child will participate in one telehealth-supervised session per week and two unsupervised sessions per week. Both parent and child will wear activity trackers on the wrists and waist for 1 week before and 1 week after treatment in order to measure physical activity and sleep. Parents will also complete surveys on quality of life before and after treatment.
Could this study be right for you?
- Medical diagnosis causing motor delay
- Unable to stand independently
- A parent or primary caregiver able to enroll as a participant in the study
- Internet or cellular service to join telehealth sessions
- Live within 100 miles of Ohio State University or willing to travel to the lab for one visit
Age Range
1 - 6 years -
Living Well with Advanced Breast Cancer
Official Title Living Well with Advanced Breast CancerPurpose
The purpose of this study is to understand how patients with advanced breast cancer are using supportive care, what has helped them, what has been hard, and what kind of help they still need. Our goal is to learn from patients and caregivers about met and unmet survivorship care needs, including care that focuses on improving health and well-being of a person living with cancer.
Study participants would be asked to complete a brief survey on their demographics via phone or email. Participants will then complete a one-time interview with our study staff via zoom, phone call, or in person, depending on preference. During the interview, the study team will ask for feedback on patient and caregiver experience and needs regarding support services.
Total study participation is less than 2 hours and can be done remotely.
Could this study be right for you?
- Diagnosed with stage 4 metastatic breast cancer within the past 5 years
- A patient in the Medical Oncology Clinic at Stephanie Spielman Comprehensive Breast Center (SSCBC)
Age Range
18 - 110 years -
TBI and other Acquired Brain Injuries Study
Official Title Resource Mapping for Families of Children with Brain InjuryPurpose
The purpose of this study is to assess the family needs of children with a brain injury. We want to explore your experiences getting care, the barriers, and facilitators your family has faced in navigating and accessing services after hospital discharge, and your ongoing unmet needs.
Could this study be right for you?
- You are a primary care giver of a child that sustained a brain injury
- Your child was hospitalized for an overnight stay as a result of their brain injury
- Your child was 18 or younger when their brain injury occurred
- You speak English
Age Range
19 years and up -
Blocking Orexin Receptors to Help Treat Alcohol Addiction and Stress-Driven Drinking
Official Title OASIS - Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related DrinkingPurpose
This study will look at whether suvorexant can help treat alcohol use disorder, how it works, and who it works best for. Suvorexant is a medicine that blocks certain brain signals linked to wakefulness.
Your total participation time in this study will be approximately 9 weeks.
Could this study be right for you?
Inclusion Criteria:
- Age 18-65
- Participant is able to give informed consent
- Engage in heavy alcohol use defined as drinking ≥14 standard drinks per week if male and ≥7 standard drinks per week if female.
General - Exclusion Criteria
- Clinically significant medical or neurological condition (e.g., liver disease, narcolepsy, complex sleep behaviors, severe hepatic impairment, COPD, severe obstructive sleep apnea)
- Current or past DSM-5 diagnosis of mania, schizophrenia, psychosis
- Past suicide attempt within 3 years or presence of moderate suicidal ideation
- Engage in night-shift work
Age Range
18 - 65 years -
Improving Physical Ability and Cellular Senescence Elimination in HIV
Official Title Improving Physical Ability and Cellular Senescence Elimination in HIV (IPACE-HIV)Purpose
The purpose of this study is to evaluate the safety and tolerability of dasatinib and quercetin (D+Q) and efficacy of this regimen in improving physical function outcomes in people with HIV (PWH) who are frail or prefrail.
Could this study be right for you?
- People living with HIV ≥50 years diagnosed with HIV 10 or more years ago
- Currently on combination antiretroviral therapy
- Currently virologically suppressed
- Must meet FFP criteria & have 4-meter gait speed in the range of .5-1.2 m/sec
Age Range
50 years and up -
An Infusion Study for Patients with Newly Diagnosed Type 1 Diabetes
Official Title A randomized, double-blind, Phase 3 study to investigate efficacy and safety of teplizumab compared with placebo in participants 1 to 25 years of age with recently diagnosed Stage 3 Type 1 Diabetes (T1D)Purpose
This study is testing a medicine called teplizumab to see if it can help people aged 18 to 25 who were recently diagnosed with Type 1 Diabetes (T1D). The goal is to find out if teplizumab can protect the cells in the body that make insulin, which helps control blood sugar.
People with T1D usually lose these insulin-producing cells over time, and this study wants to see if teplizumab can slow down or stop that process. Everyone in the study will continue using insulin as usual, but some will also get teplizumab (or a placebo, which has no medicine) through IV infusions.
Researchers hope this treatment will:
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Help the body keep making some of its own insulin
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Reduce the amount of insulin people need to take
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Improve blood sugar control
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Lower the risk of very low blood sugar levels
The study will last about 84 weeks (a little over a year and a half), and participants will have regular checkups and tests to see how well the medicine works and how safe it is.
Could this study be right for you?
- Must be diagnosed with Type 1 Diabetes in the past 2 months
- Must have had a positive test for at least one Type 1 Diabetes antibody
- For female participants of childbearing potential - must use a contraception method (or abstinence)
Age Range
18 - 25 years -
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A Study to Evaluate Investigation Drug, BHV-7000, in Patients with Refractory Focal Onset Epilepsy
Official Title A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset EpilepsyPurpose
This research is being done to see the effectiveness and safety of a new drug called BHV-7000 as a possible treatment for focal seizures for patients who are taking anti-seizure medications (ASMs) and still experiencing seizures. Refractory focal epilepsy is when someone continues to have focal seizures despite treatment with ASMs or other treatments.
People who take part in this study will be randomly assigned to either study medication or a placebo, will participate for up to 5 months, and the study includes up to 7 in-person visits.
Could this study be right for you?
- Experiencing at least 4 or more observable focal seizures per month
- Taking at least 1 and up to 3 anti-seizure medications
- Do not have a history of cluster/repetitive seizures (which you were not able to individually count) in the past 6 months
- Between the ages of 18 to 75
Age Range
18 - 75 years