Official Title Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)

Purpose

The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness. Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends. This study will take place over a 4-year time period.

Could this study be right for you?

• Children aged 3 to < 13 years old.
• No previous use of medications related to myopia control.
• Glasses and/or contact lens prescription between -1.00 and -6.00 diopters.

Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility.

Age Range

3 and up

Official Title Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's Disease

Purpose

The purpose of this study is to examine how men and women with and without dementia might perceive and respond to pain or discomfort.

Participants may complete various questionnaires by phone or video conferencing once a week for up to 8 weeks with an optional MRI screening.

Could this study be right for you?

• Men and women aged 60 years or older
• Dementia or memory issues

Participants and their caregiver (if applicable) may complete only 1 day of the study, or they may complete as many as they would like for up to 8 days total.

Age Range

60 and up

Official Title A multi-year study of learning during childhood

Purpose

The purpose of this study is to investigate the early development of attention, learning, and memory.

The duration of the study will last over 4 years.

Participation in this study includes 4, 90-minute-long visits to the lab per year. During these 90-minute-long visits, your child will play 2-3 computerized games, designed to assess different aspects of their cognitive ability.

Could this study be right for you?

Children aged 4 years old only; children must be 4 years old at their initial visit to participate.

Age Range

4 and up

Official Title Breathing Reduces Enteric symptoms and Anxiety promoting Therapeutic Healing Experience (BREATHE) – A Randomized Clinical Trial in Patients with Symptoms of Gastroparesis

Purpose

The purpose of this research study is to see if practicing mindful breathing daily can reduce stress, improve sleep
and possibly improve symptoms in patients with Gastroparesis.

Gastroparesis is a condition characterized by symptoms such as nausea, vomiting, feeling excessively full after eating a little bit, bloating and abdominal pain. One or more of these symptoms can be present in a given patient.

Your participation throughout the study will last 6 weeks.

Could this study be right for you?

• At least 18 years of age
• Able to read and understand English
• Has symptoms of gastroparesis for at least 6 months (gastric emptying study is NOT required for inclusion)

Age Range

18 and up

Official Title A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir® System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis (SPRAY-CB)

Purpose

The purpose of this study is to determine the safety and effectiveness of a device called the RejuvenAir® System, developed for patients with chronic bronchitis. The primary objective of this trial is to demonstrate the safety and effectiveness of the RejuvenAir® System for the treatment of adult subjects with a diagnosis of CB defined as COPD with classic 3 months of cough and sputum production for a minimum of 2 years who demonstrate ongoing symptoms of cough and significant mucus production. You will be in the study for approximately 36 months, including the screening period.

Could this study be right for you?

Inclusion Criteria:

1. Males and females 40-80 years of age
2. Must demonstrate daily cough and significant mucus production
3. Have had a diagnosis of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) for a minimum of two years. (CB is defined clinically as chronic productive cough for 3 months in each of 2 successive years in a patient in whom other causes of productive cough have been excluded)
4. Smoking history of at least 10 pack years
5. Non-smoking for a minimum of 2 months prior to consent and agrees to continue not smoking for the duration of the study

Exclusion Criteria:

1. Have had an acute pulmonary infection, exacerbation or pneumonia requiring medical treatment (with antibiotics and/or steroids) within 4 weeks prior of initially planned study bronchoscopy
2. Diagnosis of Asthma
3. You have had any type of transplant procedure
4. Use e-cigarettes, vaping or inhaled substances not prescribed by a physician RejuvenAir® System
5. You are pregnant, nursing, or planning to get pregnant during study

* This is not a complete list of either inclusion or exclusion criteria

Age Range

40 and up

Official Title Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery

Purpose

The goal of this study is to understand if there are any changes to the connections between the cells in the brain before and after the ultrasound surgery for the treatment of Essential Tremor. This will be done by comparing patients who have had ultrasound surgery and Essential Tremor with healthy individuals. This study may help us to better target the tremor region in the brain during the ultrasound surgery.

Could this study be right for you?

• You must be between the ages of 40 and 85
• Willing to have MRI imaging of the brain

Age Range

40 and up

Official Title Evaluation of the efficacy of radiofrequency-based debridement vs. mechanical debridement for the treatment of articular cartilage lesions.

Purpose

The purpose of this study is to evaluate 2 different treatments, Mechanical Debridement (i.e., a mechanical shaver that removes areas of damaged tissue) and Radiofrequency Debridement (i.e., electrical energy that removes areas of damaged tissue), used to treat the chondral lesion in your knee.

Could this study be right for you?

You may be eligible for this study if you:

• Are 18 - 50 years of age
• Suspected chondral damage in the following locations where debridement is indicated:
  • Medial femoral condyle
  • Lateral femoral condyle
  • Trochlea
  • Patella
• 1 or more chondral lesion(s) as noted on MRI

Exclusion:

• Previous chondral treatment in the same compartment (prior debridement and lavage performed more than three months prior to baseline are acceptable)
• Pregnant and/or intending to become pregnant during this study period

Age Range

18 and up

Official Title A Multicenter, Randomized, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira™ Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD)

Purpose

The purpose of this research study is to evaluate the safety and efficacy of the Nuvaira System, which is made by Nuvaira, Inc., for Targeted Lung Denervation (TLD) Therapy.

The primary purpose of conducting this study is to see if TLD Therapy in addition to optimal medical care (daily breathing medications you have been prescribed by your doctor) is better at reducing a moderate or severe worsening of symptoms (known as an COPD flare-ups or exacerbations) and related hospitalizations than optimal medical care (daily breathing medications you have been prescribed by your doctor) alone.

Could this study be right for you?

Inclusion Criteria:

• Between 40 and 75 years of age
• Non-smoking for a minimum of 2 months prior to consent and agrees to not smoke for the duration of the study
• Diagnosis of COPD with 30% ≤ FEV1 <60% of predicted and FEV1/FVC <70% (post-bronchodilator)
• SpO2 of at least 89% on room air at the time of screening
• Has a documented history of having minimally been taking a regular respiratory maintenance medication for at least 12 months at the time of consent; medications will be reviewed by study team
• If you have participated in a formal pulmonary rehabilitation program recently, program completion should have occurred more than 3 months prior to consent; if in a maintenance program, you will agree to continue your current program through your 12-month follow-up visit;
• Additional criteria will be reviewed by the study team

Involvement in this study will last approximately 62 months.

Age Range

40 and up

Official Title ABT-CIP-10300: Abbott DBS Registry of Outcomes for Indications over Time (ADROIT)

Purpose

The purpose of this study is to collect information and evaluate outcomes for Abbott Deep Brain Stimulation (DBS) systems that are approved and sold in your country.

In order to evaluate how the DBS system performs, data will be collected before, during and after DBS implant when you visit the study doctor. The data collected will include information on your movements, feelings, daily activities, and DBS program settings.

The information gathered in this study will add to the understanding of treatment options for future patients receiving DBS.

Could this study be right for you?

Inclusion Criteria:

• You are scheduled for a new implant or IPG device replacement surgery with a market-released Abbott DBS system within 3 months

Exclusion Criteria:

• You are currently enrolled or plan to enroll in another study that may alter the results of this clinical investigation
• You have another disease, conditions, or other medical, social, or psychological conditions that could limit your ability to participate in the clinical investigation or to satisfy follow-up requirements

Official Title Comprehensive Protocol for Cognitive Development Research

Purpose

The purpose of this study is to better understand learning, memory and attention development from childhood to adulthood using eye-tracking techniques.

This study will include one lab visit which will take place on Ohio State's main campus and will last approximately 40-60 minutes.

Could this study be right for you?

Eligibility Criteria:

• Must be 18 and 35 years of age
• Have normal or corrected to normal vision

Age Range

18 and up

Official Title Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation

Purpose

A test for healthy adults from 19 - 75 years old to develop normal values for interpretation of immunological tests in adults with disorders of the immune system.

Voluntary participation involves blood draw at Nationwide Children's hospital. Qualified participants would be eligible to provide a sample every 2 months (not more than 6 times per year).

Could this study be right for you?

If you are:

• An adult 19 years of age or older
• Healthy with no significant medical diagnoses
• Have no chronic conditions that can affect results of immunological studies
• Not on any medication known to alter immune status or function
• Have not undergone recent surgery, chemotherapy, radiation or transplantation
• Non-smoker
• Body mass index (BMI) in healthy range
• No infections within last 2 months

Age Range

19 and up

Official Title [American Lung Association (ALA)] Lung Health Cohort (LHC) Study

Purpose

The purpose of this study is to examine why some people have better lung function than others as young adults during the period of peak lung health (ages 25 to 35 years old). The long-term goal of this study is to come up with ideas about how to promote the best possible lung function in young adults.

Participation in this study will be 4.5 years.

Could this study be right for you?

Inclusion Criteria:

• Men and women aged 25-35 years old at time of examination
• Able to read and understand English or Spanish
• Have a social security number

Exclusion Criteria:

• Severe asthma or other chronic lung disease
• Diagnosed cardiovascular disease
• History of cancer other than non-melanoma skin cancer
• Currently pregnant

Age Range

25 and up