Official Title A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients (NOVA-II)

Purpose

Hand-Foot Skin Reaction (HFSR) is a common adverse event induced by Vascular Endothelial Growth Receptor Inhibitor (VEGFRi) treatment in cancer patients. The main purpose of this study is to evaluate the safety and efficacy of OQL011 compared to vehicle ointment in treating patients with moderate to severe VEGFRi-associated HFSR. This study will also identify an optimal dosage for Phase III study and explore the pharmacokinetics profile of OQL011 in HFSR patients.

Could this study be right for you?

• Patient must be age 18 years of age or older.
• Patient must have a confirmed cancer diagnosis for which VEGFRi treatment is indicated, and must be currently under VEGFRi-based anti-cancer therapy with stable dosage for ≥ 1 week.
• Patient on pain medications is allowed provided they have been on stable dosage in the past 1 week and is going to continue at the same dosage.

Age Range

18 and up

Official Title A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients with Severe or Very Severe Alopecia Areata (JAHO)

Purpose

The main reason for you to take part in this study is not to treat you for your condition but to help in answering the following research questions:
• Whether baricitinib is better than placebo in the treatment of patients with severe alopecia areata (AA)
• The safety of baricitinib and any side effects you may have when you take it.

Could this study be right for you?

• Are at least 18 years and ≤60 years for males (≤70 years of age for females) at the time of informed consent
• Are able to read, understand, and give documented (electronic or paper signature) informed consent
• Current AA episode of more than 6 months’ duration and hair loss encompassing ≥50% of the scalp
• No spontaneous improvement over the past 6 months

Age Range

18 and up

Official Title A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy (SLEEP)

Purpose

The purpose of this study is to understand how Continuous Positive Airway Pressure (CPAP)
for mild to moderate sleep apnea may affect hypertensive disorders of pregnancy and other
complications of pregnancy such as gestational diabetes.

Could this study be right for you?

1. No prior delivery at or after 20 weeks 0 days of gestation
2. Pregnancy with only one fetus
3. Gestational age at randomization between 14 weeks 0 days and 21 weeks 6 days
4. Diagnosis with mild to moderate OSA as defined by an AHI score ≥ 5 and <30

Age Range

18 and up

Official Title The influence of receiving real-time visual feedback on breathing during treadmill running to exhaustion

Purpose

The purpose of this research is to assess if receiving real-time visual feedback on your breathing pattern during a run has any influence on time to exhaustion.

The feedback will be provided through animations on a screen placed in front of the treadmill that open and close as the chest and abdomen expand and contract. Research has shown that you want the chest and abdomen to expand and contract at the same time to achieve the most efficient breathing possible, meaning you will want the animations to open and close at the same time.

The ultimate objective is to see if this feedback allowed the participant to last longer until reaching their exhaustion point.

Could this study be right for you?

• Healthy adults who run 5 to 20 miles per week
• Have NOT been injured while running in the past six months
• Have NOT been medically diagnosed with breathing deficiencies
• must be age 18 or older

Those who are interested in participating will be directed to complete a survey, found at go.osu.edu/RunningAndBreathing, to ensure that they meet the previously mentioned criteria.

Age Range

18 and up

Official Title Relationship Dynamics in Families of Children with ADHD and Their Opposite-Sex Siblings

Purpose

This study is being done to better understand relationship dynamics between children with ADHD, their siblings, and their parents. Our goal is to better understand how differences in family dynamics affect children with ADHD. Participants will be asked to fill out several self-report questionnaires and engage in a family conflict task. During several tasks, participants will have various physiological measures (e.g., heart rate, breathing rate, etc.) taken using electrodes placed on their body. Results of this study will be used to develop other studies and to inform future treatment and prevention programs.

Could this study be right for you?

We are recruiting children between 8 and 10 years old with an opposite sex sibling. In order to participate, families must meet the following criteria:

• Mothers must be willing to participate
• They must have a child between ages 8 and 10
• That child must have a sibling of the opposite sex that is within 2 years of their age

Age Range

6 and up

Official Title Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of a Plant Polyphenol for COVID-19

Purpose

The purpose of this trial is to determine whether a commercially available dietary supplement may decrease the severity of patients with early COVID-19

Could this study be right for you?

Inclusion Criteria:

• Outpatients who test positive for infection with SARS-CoV-2
• Age 45 years and older
• Experiencing COVID 19 symptoms for 7 days or less, OR 72 hours of new respiratory symptoms
• Patient must have access to the internet or a smartphone to complete surveys
• English-speaking patients

Age Range

45 and up

Official Title Microdosed Atropine for the Reduction of Pediatric Myopia Progression (The CHAPERONE Study)

Purpose

The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness. Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends. This study will take place over a 4-year time period.

Could this study be right for you?

• Children aged 3 to < 13 years old.
• No previous use of medications related to myopia control.
• Glasses and/or contact lens prescription between -1.00 and -6.00 diopters.

Interested guardians who believe their child may be eligible should contact study coordinators to further determine eligibility.

Age Range

3 and up

Official Title Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimer's Disease

Purpose

The purpose of this study is to examine how men and women with and without dementia might perceive and respond to pain or discomfort.

Participants may complete various questionnaires by phone or video conferencing once a week for up to 8 weeks with an optional MRI screening.

Could this study be right for you?

• Men and women aged 60 years or older
• Dementia or memory issues

Participants and their caregiver (if applicable) may complete only 1 day of the study, or they may complete as many as they would like for up to 8 days total.

Age Range

60 and up

Official Title A multi-year study of learning during childhood

Purpose

The purpose of this study is to investigate the early development of attention, learning, and memory.

The duration of the study will last over 4 years.

Participation in this study includes 4, 90-minute-long visits to the lab per year. During these 90-minute-long visits, your child will play 2-3 computerized games, designed to assess different aspects of their cognitive ability.

Could this study be right for you?

Children aged 4 years old only; children must be 4 years old at their initial visit to participate.

Age Range

4 and up

Official Title Breathing Reduces Enteric symptoms and Anxiety promoting Therapeutic Healing Experience (BREATHE) – A Randomized Clinical Trial in Patients with Symptoms of Gastroparesis

Purpose

The purpose of this research study is to see if practicing mindful breathing daily can reduce stress, improve sleep
and possibly improve symptoms in patients with Gastroparesis.

Gastroparesis is a condition characterized by symptoms such as nausea, vomiting, feeling excessively full after eating a little bit, bloating and abdominal pain. One or more of these symptoms can be present in a given patient.

Your participation throughout the study will last 6 weeks.

Could this study be right for you?

• At least 18 years of age
• Able to read and understand English
• Has symptoms of gastroparesis for at least 6 months (gastric emptying study is NOT required for inclusion)

Age Range

18 and up

Official Title Development and Testing of Ferumoxytol-enhanced MRI Protocol in Healthy Subjects

Purpose

This study is being done to develop a Magnetic resonance imaging (MRI) test that provides better-quality whole-heart pictures. MRI is a non-invasive machine that collects detailed pictures inside your body. Healthy volunteers will be tested in the MRI scanner while being given a dose of a medicine called Ferumoxytol into an IV (intravenous catheter) that will be placed in your arm or hand. Ferumoxytol is a medicine usually used in patients with iron deficiencies and has recently been used as an alternative to other MRI contrast agents and has successfully been applied in adult and pediatric patient populations.

Could this study be right for you?

Inclusion:

• Males and females ages 18 years and older
• No history of cardiovascular disease

Exclusion:

• Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:
• Reactions to MRI including metallic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, coronary artery stent, neurostimulator, any other medical metallic implant
• History of cardiovascular disease or uncontrolled high blood pressure
• Claustrophobia
• Inability to lie flat for up to 1 hour
• Weight exceeding 300 pounds
• Pregnancy

Age Range

18 and up

Official Title A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir® System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis (SPRAY-CB)

Purpose

The purpose of this study is to determine the safety and effectiveness of a device called the RejuvenAir® System, developed for patients with chronic bronchitis. The primary objective of this trial is to demonstrate the safety and effectiveness of the RejuvenAir® System for the treatment of adult subjects with a diagnosis of CB defined as COPD with classic 3 months of cough and sputum production for a minimum of 2 years who demonstrate ongoing symptoms of cough and significant mucus production. You will be in the study for approximately 36 months, including the screening period.

Could this study be right for you?

Inclusion Criteria:

1. Males and females 40-80 years of age
2. Must demonstrate daily cough and significant mucus production
3. Have had a diagnosis of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) for a minimum of two years. (CB is defined clinically as chronic productive cough for 3 months in each of 2 successive years in a patient in whom other causes of productive cough have been excluded)
4. Smoking history of at least 10 pack years
5. Non-smoking for a minimum of 2 months prior to consent and agrees to continue not smoking for the duration of the study

Exclusion Criteria:

1. Have had an acute pulmonary infection, exacerbation or pneumonia requiring medical treatment (with antibiotics and/or steroids) within 4 weeks prior of initially planned study bronchoscopy
2. Diagnosis of Asthma
3. You have had any type of transplant procedure
4. Use e-cigarettes, vaping or inhaled substances not prescribed by a physician RejuvenAir® System
5. You are pregnant, nursing, or planning to get pregnant during study

* This is not a complete list of either inclusion or exclusion criteria

Age Range

40 and up