Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • Experiences, attitudes, and practices of firearms among women gun owners in New Jersey and Ohio

    Official Title
    Experiences, attitudes, and practices of firearms among women gun owners in New Jersey and Ohio
    Purpose

    The purpose of this study is to better understand experiences, attitudes, and practices of women gun owners in New Jersey and Ohio to ultimately improve understanding of factors that may influence suicide prevention strategies. 

    Could this study be right for you?
    • Be at least 18 years old 
    • Identify as female 
    • Own at least one handgun 
    • Live in either New Jersey or Ohio 
    • Use an Internet-connected device with a webcam
    Age Range
    18 - 99
  • "What do physicians know about intellectual disability?" Getting information to design better medical training

    Official Title
    "What do physicians know about intellectual disability?" Getting information to design better medical training
    Purpose

    The purpose of this study is to explore the physicians’ knowledge of intellectual disabilities (ID) and their medical training and practice. The information resulting from this study will help to design adequate interventions and training programs for medical students and physicians aimed to improve their ID knowledge and the health care services provided to patients with ID.

    This is an observational cross-sectional study of physicians in the US using an anonymous online survey. The entire survey has 156 items and will require 15-20 minutes to complete.

    Could this study be right for you?

    - You are an American medical resident, an attending physician, or a medical educator in any type of medical specialization, and

    - You have or do not have experience with patients with intellectual disabilities

    Age Range
    24 and up
  • A Medication study for Children with Major Depressive Disorder (Ages 7 -17)

    Official Title
    A Double-blind, Placebo- and Active-controlled Evaluation of the Safety and Efficacy of Levomilnacipran ER in Pediatric Patients 7-17 Years With Major Depressive Disorder
    Purpose

    The purpose of this research study is to evaluate the drug Levomilnacipran extended-release to see how well the drug works, observe the side effects, and how well tolerated it is compared to placebo in pediatric patients with major depressive disorder.

    Could this study be right for you?

    Your child may be eligible if:
    • be between 7 and 17 years of age
    • give their assent (a simplified version of this consent form that your child will sign)
    • have a diagnosis of Major Depressive Disorder
    • meet all of the additional relevant inclusion criteria
    • understand the study instructions, and be willing and able to follow these instructions

    Exclusion Criteria:
    • Your child will not be able to take part in the study if she is pregnant, nursing, or planning a pregnancy
    • Your child will not be able to take part in this study if he/she takes any illegal substances

    Age Range
    7 and up
  • A Medication Study for Individuals with Alport Syndrome (AS) and Primary Steroid-Resistant Focal Segmental (FSGS)

    Official Title
    A multicenter, randomized, double-blind, parallel group, placebo-controlled study to assess safety, tolerability, pharmacokinetics and pharmacodynamics of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis.
    Purpose

    The overall objective is to investigate to investigate how safe, how well tolerated, and how effective R3R01 is in treating uncontrolled proteinuria in patients with Alport syndrome and steroid-resistant Focal Segmental Glomerulosclerosis.

    All eligible participants will be enrolled to receive R3R01 over a treatment period of 12 weeks. The study will consist of 3 periods, including a screening period of 3 weeks, a treatment period of 12 weeks, and a follow up of period of 12 weeks.

    Could this study be right for you?

    You may be eligible to participate if:
    • You are aged 18 years or older
    • Female patients and female partners of male patients willing to not become pregnant for the duration of the study
    • Have not had an organ transplant and/or on a organ transplant list
    • Have high protein in urine

    Alport Syndrome (AS) specific:
    • Have X-linked AS and autosomal recessive AS
    • Confirmed diagnosis of AS be genetic testing or kidney biopsy
    • Do not have another kidney disease

    FSGS specific:
    • Not older than 75 years of age
    • Primary Focal segmental glomerulosclerosis (FSGS) (not caused by other condition) that is confirmed by kidney biopsy or documentation of genetic mutation
    • Steroid-resistance: previous steroid treatment without remission

    Age Range
    18 and up
  • A Physical Activity Study for Post-Kidney Transplant Patients

    Official Title
    Increasing Activity Post-Kidney Transplant with SystemCHANGE TM
    Purpose

    The purpose of this study is to determine the best way to help people that have had a kidney transplant perform daily physical activity. Currently, we do not know the best way to help people who have had a kidney transplant to remember to perform regular physical activity. This study will help us explore how to promote routine daily physical activity

    Could this study be right for you?

    • You are at least 60 years of age
    • You have had a kidney transplant and are not on dialysis
    • You own a smartphone
    • You have the ability to secure a device similar to a watch to your wrist
    • You do not use assistive devices for walking
    • You are not currently hospitalized

    Age Range
    60 and up
  • A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)

    Official Title
    A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)
    Purpose

    The purpose of this study is to examine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

    The duration of the study will consist over a 5 year period. You will visit the study site approximately 23 times after your implant surgery.

    Could this study be right for you?

    • Aged 18 years or older
    • Must be in a major depressive episode (MDD or bipolar disorder) for ≥ two years or have at least had four episodes of depression including the current episode
    • Patients depressive illness meets a minimum criteria of four prior failed treatments of adequate dose and duration

    Age Range
    18 and up
  • A Registry for Those with Hypophosphatasia (HPP)

    Official Title
    AN OBSERVATIONAL, LONGITUDINAL, PROSPECTIVE, LONG-TERM REGISTRY OF PATIENTS WITH HYPOPHOSPHATASIA
    Purpose

    The purpose of this registry is to collect information about Hypophosphatasia (HPP), a rare bone disorder characterized by the abnormal development of bones and teeth. This long-term registry will collect and store patient medical information, and other related information to use in medical research. the registry may help researchers better understand the condition and learn more about patients who have HPP. This data may help other people with HPP in the future.

    Could this study be right for you?

    - 18 years of age or older
    - Been diagnosed with Hypophosphatasia (HPP)- a rare genetic disorder characterized by the abnormal development of bones and teeth.
    - Not participating in another Alexion-sponsored clinical trial

    Age Range
    18 and up
  • A Study about Non-Invasive Bioelectronic Treatment After C-Section Deliveries (ELECTRON)

    Official Title
    Non-invasive bioELEctroniC treatment foR pOst-cesareaN (ELECTRON)
    Purpose

    The overall goal of this study is to examine whether after a C-Section delivery, the use of non-invasive bioelectronic treatment (treating women with devices that balance electrical signaling in the nervous system) will help improve pain management and reduce inpatient postoperative opioid use.

    Your participation in this study will last 6 weeks. You will be asked to complete a series of questions at the end of your enrollment.

    Could this study be right for you?

    Inclusion Criteria:
    • Women aged 18 years or older
    • English Speaking
    • Cesarean (C-Section) delivery
    • Recently given birth to singleton, or twin gestation
    Exclusion Criteria:
    • Combined vaginal/cesarean deliveries
    • Fetal or neonatal death prior to randomization
    • Inability to complete all three non-invasive bioelectronic treatment during inpatient stay as assessed by research staff
    • Participation in another intervention study that influences the primary outcome in this trial

    Age Range
    18 and up
  • A Study about Pain Sensitivity and Unpleasantness in People with Alzheimer's Disease and Cancer

    Official Title
    Pain Sensitivity and Unpleasantness in People with Alzheimer's Disease and Cancer
    Purpose

    The purpose of this study is to examine how men and women with dementia and/or cancer might process and respond to pain or discomfort.

    Participants may complete various questionnaires by phone or video conferencing once a week for up to 7 weeks with one optional in-person session.

    Could this study be right for you?

    • Men and women aged 60 years or older
    • Dementia or memory issues
    • Cancer (any type excluding brain cancer)
    • Dementia or memory issues and cancer (any type excluding brain cancer)

    Age Range
    60 and up
  • A Study About Recovery After ACL Reconstruction (RARE)

    Official Title
    Disability after ACL Reconstruction: Development of an Alternative Model of Care
    Purpose

    The anterior cruciate ligament (ACL) in your knee can be injured and treated with an ACL reconstruction surgery. An ACL reconstruction may impact function, muscle strength, the way you move, and knee joint health. However, outcomes at 2 years after ACL reconstructions in young persons are not well-understood. Findings from this study will provide information regarding the clinical, function, muscle strength, and movement patterns after ACL injury and reconstruction to help inform physicians and physical therapists who work with these patients.

    Could this study be right for you?

    You may be eligible if:

    1. You are between the ages of 16-35 years old
    2. 2 years (+/- 8 months) status post ACL Reconstruction
    3. Regularly participated in physical activity prior to their ACL injury

    Age Range
    16 and up
  • A Study about Tools to Assess Mental Health for Youth with Intellectual Disabilities and Their Caregivers

    Official Title
    Development and Validation of a Diagnostic Interview to Assess Psychopathology in Youths with Intellectual Disabilities
    Purpose

    This study will help researchers to learn more about mental health for youth with intellectual disabilities. The purpose of our study is to develop a diagnostic interview to assess mental health issues in youths with Intellectual Disabilities. The instrument would address a significant need and allow for more accurate estimation of mental disorders in the Intellectual Disabilities population.

    We are recruiting youths with Intellectual Disabilities aged 14-21, and their caregivers as well. Each participant would take part in one individual session of approximately 60-90 minutes (with breaks) at the Ohio State University Nisonger Center. Youths will be asked to respond to a set of interview questions about mental health, including providing feedback on a set of illustrations related to the interview questions about emotions, feelings, and behaviors. Parents or caregivers will be asked to provide feedback on the interview questions asked of youth.

    Could this study be right for you?

    You may be eligible to participate in the study if you are:
    --14 to 21 years old AND have been diagnosed with an Intellectual Disability

    Youths will be asked to respond to a set of interview questions about mental health, including providing feedback on a set of illustrations related to the interview questions about emotions, feelings, and behaviors. Parents or caregivers will be asked to provide feedback on the interview questions asked of youth.

    Age Range
    14 and up
  • A Study After Roux-en-Y Gastric Bypass Surgery

    Official Title
    The colorectal cancer risk paradox after Roux-en-Y gastric bypass surgery and weight regain: Interplay and mechanistic insights into the role of the gut microbiome and lipidomics
    Purpose

    This study is being done to find out if certain stool microbiota (tiny microorganisms such as bacteria) and blood fat metabolism particles that are linked to colon cancer are increased in patients following bariatric (weight loss) surgery. We are also attempting to identify if stool microbiota and fat metabolism is linked to successful weight loss after bariatric surgery which in turn can impact the risk of cancer.

    This study requires only one telehealth study visit followed by an at-home stool collection and optional blood work.

    Could this study be right for you?

    - Are between 18 and 75 years of age
    - Have had Gastric Sleeve or Roux-en-y within 1-10 years
    - Willing to collect and send to our lab a stool sample
    - Have NO personal or family history of colorectal cancer, precancerous polyps, inflammatory bowel disease, immune suppression diarrhea, cirrhosis, or an active complication of your bariatric surgery

    Age Range
    18 and up