Official Title

In Their Own Words: A Qualitative Exploration of Food Insecurity in the Lives of Patients with Gastrointestinal Disorders

Purpose

The purpose of this study is to better understand the daily food- and nutrition-related experiences of people with GI symptoms through a virtual interview. 

There has been very little research on how food challenges affect those with GI symptoms and conditions.

We think you may have valuable insights, Your Voice Matters! 

 

 

 

 

 

 

 

Could this study be right for you?

• 18 + years old 
• Have experienced any level of food-related concerns within the past 12+ months 
• Living with GI symptoms and/or diagnosed GI condition 

Age Range

18 years and up

Official Title

An open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound unilateral thalamotomy for patients with treatment-refractory focal onset epilepsy and comorbid anxiety

Purpose

The purpose of the study is to learn more about whether an ultrasound treatment for epilepsy and anxiety is safe and effective.

Could this study be right for you?

• Age: 18-65 years old
• Treatment resistant Epilepsy (focal or partial-onset seizures)
• ≥ 3 seizures/month
• Moderate-to-severe Anxiety

 

 

Age Range

18 - 65 years

Official Title

Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study: Dietary Fat Quality and Cognitive Impairment

Purpose

The purpose of the EFFECT Study is to determine how dietary fats influence cognitive (mental) function in adults.

 

During the 7-week study participants will

• Consume one study food per day for a total of 3 weeks
• Have their blood drawn
• Have their body weight and shape measured
• Complete cognitive tests
• Fill out questionnaires
• Complete diet and physical activity recalls

Could this study be right for you?

• Feel your memory or concentration is not as good as you'd like it to be
• Are overweight
• Do NOT have diabetes
• Do NOT have dementia or Alzheimer's
• Do NOT have food allergies 
• Are NOT pregnant or nursing an infant

Age Range

40 - 75 years

Official Title

MapLight Study (IRIS Clinical Trial)

Purpose

The purpose of this study is to investigate a medication intended to improve social communication in adolescents and adults with ASD.

Could this study be right for you?

• Have an autism diagnosis or suspect you have an autism diagnosis
• Have a caregiver or study partner willing to enroll in the study with you

Age Range

18 - 45 years

Official Title

Pippa Fitness Pessary Device Effectiveness and Safety Study

Purpose

The purpose of this study is to demonstrate the effectiveness and safety of the Pippa Fitness Pessary (device) when self-administered and used in a home environment.
 

Could this study be right for you?

. Be a female 18 years or older
· Live in or near Columbus, Ohio
· Consistently leak during light exercise
· Have no prior vaginal surgery

 

Age Range

18 years and up

Official Title

PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life (PROMISE)

Purpose

The purpose of this study is to find out more about how health and exposures during pregnancy, such as having an infection, diet and growth may impact later risk of islet autoimmunity in the
child. We are also interested in finding out more about why having a father or sibling with type 1 diabetes increases risk of autoimmunity in the child than having a mother with type 1 diabetes.

Could this study be right for you?

Inclusion:
Pregnant women:
- who is between 8-24 weeks gestation with a singleton pregnancy
- have had type 1 diabetes for at least 12 months, or the father of the baby or a full sibling of the baby has type 1 diabetes
- is 18 years of age or older
- is willing to have blood collected and to complete questionnaires about prenatal exposures once per trimester during their pregnancy (up to 3 visits) and up to 12
weeks after they deliver their baby
- is willing to have their baby screened for genetic risk for type 1 diabetes, to complete online questionnaires, and to have their child followed for measurement
of islet autoimmunity according to the determined risk for type 1 diabetes, through 5-7 years of age.
o If low risk, two screenings: the first at 2 years of age and the second between 5-7 years of age
o If high risk, five screenings: every six months through 2 years of age, and one between 5-7 years of age

The father of the baby will also be asked to complete one visit during pregnancy but it is not mandatory.

Exclusion:
- Multiple Gestation pregnancy
- Mother unable to consent due to intellectual impairment
- Fetus with known medical issue that would affect study participation
- Surrogate / gestational mothers who are not biologically related to offspring they are carrying

Age Range

18 years and up

Official Title

Effect of Fixation Training with Colored Light Targets on Traumatic Brain Injury-Associated Photophobia

Purpose

Researchers at The Ohio State University College of Optometry are seeking individuals with a recent history of head trauma who are experiencing light sensitivity. The goal of this study is to determine if daily 20 minute fixation training sessions using a colored (red or blue) light target affects symptoms of light sensitivity, or alters other measurements of the eyes and vision including pupil response.  

This study will involve attending five 1-2 hour study visits, occurring every 1.5 months for 6 months. Study visits will include answering questions about eye and health history, completing surveys, reading letters on an eye chart, having the pupils measured in response to flashes of light, measuring the side vision, measuring eye alignment and in some cases focusing ability. Outside of the study visits, participants will also complete daily 20 minute fixation training sessions for 6 months using a colored (red or blue) light target, completed at home between study visits.

Could this study be right for you?

• Must be 18 to 80 years old
• Experienced a head injury 3 or more months ago
• Current symptoms of light sensitivity
• Be healthy and have good eye health 

Age Range

18 - 80 years

Official Title

A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fraction

Purpose

The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with heart failure and diabetes or pre-diabetes or metabolic syndrome.

 

Could this study be right for you?

• Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
• NYHA class I – III for at least 3 months.
• Ejection fraction ≥50% by biplane 2D, or 3D echo, or CMR
• Echo findings of abnormal or indeterminant diastolic function or RHC data:  At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg.  pulmonary vascular resistance (PVR) < 3 Wood Units.
• Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
• Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
• Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
• Ability to participate in exercise treadmill testing.
• Ability to sign written consent.

Exclusions:

•  Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
•  Known allergy or sensitivity to gadolinium-based contrast agents.           
• Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
• Other metallic implants/aneurysm clips that are contraindicated in MRI.           
• Claustrophobia
• History of severe kidney disease of eGFR<30 ml/kg/1.73m2.

 

Exclusion Criteria varies, please contact Study Coordinator. 

Age Range

18 - 80 years

Official Title

Reducing exercise intolerance through inspiratory muscle training in obese breast cancer survivors (IMOCS)

Purpose

The purpose of this study is to better understand why some survivors of breast cancer have difficulty exercising. We also want to learn if breathing exercises can make it easier to tolerate exercise. 

Could this study be right for you?

• Breast Cancer Survivor
• Completed treatment within 6 months–5 years
• Have obesity, defined as body mass index between 30-50 kg/m2
• Can exercise independently

Age Range

18 years and up

Official Title

A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Efficacy and Safety Study of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa

Purpose

The purpose of this study is to evaluate the efficacy of povorcitinib.

Could this study be right for you?

• Subject must have a diagnosis of hidradenitis suppurativa for at least 3 months prior to study visit 
• Subject must have at least 5 active HS spots in 2 different body areas 
• Subject must have tried an oral or injected medication for HS with little to no improvement 
• Subject must be in good general health with no history of tuberculosis, heart disease, cancer, HIV, hepatitis B or C, or blood clots 
• Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study 

Age Range

18 years and up

Official Title

Two Birds with One Stone: Impact of A Low Glycemic Index Diet on Postprandial Hypotension and Glucose Metabolism in Individuals with Spinal Cord Injury (FIP)

Purpose

The purpose of this study is to examine the effect of a short-term low glycemic index diet on blood pressure and blood sugar control after eating.

Could this study be right for you?

• Adults aged 18-65 years old
• Chronic spinal cord injury
• Level of injury between C4 and L2

Age Range

18 - 65 years

Official Title

Neurodevelopmental Mechanisms Underlying the Onset of Depression among At-Risk Youth: The Role of Dysregulation in the Negative Valence System

Purpose

The purpose of this study is to test whether changes in the way in which we react and respond to emotional or stressful information represent a risk factor for depression in kids of mothers with and without depression. Findings from the study have the potential to decrease the high rates of depression observed in children of depressed mothers.  

Could this study be right for you?

You may be eligible for this study if:

• You are 18-65 years old and female.
• You have a biological child who is between 9 and 14 years of age.