• Visual acuity in the amblyopic eye between 20/40 and 20/200
• No previous treatment for amblyopia, including glasses or contact lenses
• Amblyopia (lazy eye) in one eye

• Current e-cigarette user (daily vaping for at least the past 3 months)
• 21-25 years old
• Normal weight (BMI < 25) or obese (BMI >30)
• Willing to attend 5 study visits to OSU over the course of 1 year
• Willing to abstain from all tobacco and nicotine for at least 12 hours prior to lab sessions
• No lung, heart, thyroid, or neuromuscular problems and no diabetes diagnosis
• Staying within the Columbus/Central Ohio region for the next year

Aerobically Trained: having a measured aerobic capacity in the 80th percentile according to age

Resistance Trained: able to squat 120% and bench press 60% of their body weight.

Unacclimatized: participants had not been consistently exposed to hot conditions (i.e., sauna, hot yoga, etc.) in the past 2 months.

• Near-sighted prescription between -1.00D and -6.00D
• Current correction with glasses, soft contact lenses, or overnight orthokeratology contact lenses
• Has been wearing current correction for 6 months or longer
• Good eye and overall health

• Nausea going on for more than 2 months
• 18 years or older
• Able to understand English
• Seen at OSU for their care
• Able to complete surveys online using either smart phone or computer

• Male and females aged 18 to 40 years old
• Normal/corrected vision and color vision
• Autistic participants must be verbal and have an IQ > 70

Inclusion Criteria

• Ages 25-80
• Have nonalcoholic fatty liver disease or something similar

Exclusion Criteria Include

• Unable to have an MRI scan
• Pregnancy 

• Male and females aged 18 years or older
• Resident of Franklin County
• Experienced at least one overdose in Franklin County, OH between January 2021 and December 2022
• You suspected your overdose was opioid-related or someone gave you Narcan
• Willing to discuss your overdose experience in a one-on-one interview
• Have access to a private room and an Internet connection, or able to travel to a local public library for the interview

Eligibility Criteria:

• 18-65 years old
• Generally medically and physically healthy
• Regular alcohol use

Exclusion Criteria:

• Diagnosis of bipolar disorder, schizophrenia, mania, or psychosis
• Currently pregnant or trying to become pregnant (female)
• Presence of ferrous-containing metal in the body
• Inability to tolerate enclosed spaces
   

Exclusion Criteria varies, please contact Study Coordinator for more information.

Eligibility Criteria: 

• African-American/Black children who are 4 years old 

• Male and Females aged 50 years or older
• Diagnosis of dementia due to Alzheimer's Disease/Diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer’s Disease
• A caregiver is available who has frequent contact with the subject, agrees to observe for adverse events, and will accompany the subject to all clinic visits for the duration of the protocol
• CT or MRI scans within 24 months prior to screening without evidence of an infection, infarction, or other focal 

Inclusion Criteria varies, please contact Study Coordinator for more information.

The below Exclusion Criteria apply to both the AD and MCI groups.

• Any significant neurological disease other than suspected incipient disease
• History of schizophrenia 
• History of systemic cancer within the past 18 months (non-metastatic skin cancers are acceptable).
• Any significant systemic illness or unstable medical conditions which could lead to difficulty complying with the protocol
• Use of any investigational drugs within thirty days or five half-lives, whichever is longer, prior to screening.

Exclusion Criteria varies, please contact Study Coordinator for more information. 

Inclusion Criteria:

To be eligible, an individual must meet all of the following inclusion criteria:

• Ability to read and understand English
• Provision of signed and dated informed consent form(s)
• Willing and able to receive study-related messages and survey links via email
• Willing and able to receive study-related phone calls
• Age 18 years old or older
• Low-back pain for at least 3 months and occurring on at least half the days in the past 6 months
• Contraindicated to no more than one of the study interventions at the time of eligibility assessment(s)
• Eligible to receive at least three of the four study interventions and willing to receive any intervention for which they are eligible
• A PEG score 4 or higher at two time points: 1) screening prior to the Run-in period and 2) screening prior to baseline (Visit 0)
• Willing and able to undergo required phenotyping
• Regular reliable access to an internet-enabled device such as a smart phone, tablet, or laptop computer

• Meet Run-in period engagement eligibility criteria:

  • Completion of two Run-in study information modules prior to period 1 randomization (Visit 0)
  • Response to at least 5 emails prior to period 1 randomization (Visit 0)
• Low-back pain more severe than pain in other parts of the body
• Available to complete the full study protocol (approximately 9 months)

Exclusion Criteria:

An individual who meets any of the following criteria will be excluded from participation in this study:

• Pregnant at the time of Visit 0 (Baseline)

• Affirmative participant response to any of the following conditions:

  • Progressive neurodegenerative disease
  • History of discitis osteomyelitis (spine infection) or spine tumor
  • History of ankylosing spondylitis, rheumatoid arthritis, polymyalgia rheumatica, psoriatic arthritis, or lupus
  • History of cauda equina syndrome or spinal radiculopathy with functional motor deficit (strength <4/5 on manual motor testing)
  • Diagnosis of any vertebral fracture in the last 6 months
  • Osteoporosis requiring pharmacologic treatment other than vitamin D, calcium supplements, or bisphosphonates.
  • History of any bone-related cancer or cancer that metastasized to the bone
  • Currently in treatment for any non-skin cancer or plan to start non-skin cancer treatment in the next 12 months
  • History of any non-skin cancer treatment in the last 24 months
  • Visual or hearing difficulties that would preclude participation
  • Uncontrolled drug/alcohol addiction
  • Individuals actively pursuing disability or workers compensation or involved in active personal injury-related litigation
  • Currently participating in another interventional pain study
• Any condition that, in the opinion of the investigator, would preclude the patient from being able to safely participate in in the trial