This is a 1-year open-label study to access the safety of REL-1017, a study medication, once daily as a workable treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug for the duration of the treatment period.

This study will last 13 months and you will come to the study site at least 15 times over this period. This will include 1 final visit about 1 month after you stop taking the study drug.

The purpose of this study is to compare the effectiveness and safety of Upadacitinib (ABT-494) to placebo (pill without any active substance that looks like upadacitinib) in combination with topical corticosteroids for adolescents (12-17 years of age) and adults (18-75 years of age with moderate to severe atopic dermatitis (AD).

The purpose of this study to test the safety and effectiveness of atropine 0.1% and atropine 0.01% eye solutions. These drugs are being tested to see if they slow the worsening of nearsightedness. Children who participate in this study will be asked to use their assigned study medication every night and willing to attend visits at The Ohio State University of Optometry 1 month after starting treatment. These visits will continue for 6 months until the duration of the study ends. This study will take place over a 4-year time period.

The purpose of this study is to evaluate whether group-art sessions can reduce stress, improve sleep quality, improve quality of life and decrease severity of digestive symptoms in participants who suffer from chronic digestive issues. Participants will meet virtually once per week for 1.5 hour sessions, via Zoom, and will be provided with art supplies.

The start date will be determined by the date the 1st session starts for a given group. Thus participants can be in the study for up to 14 weeks.

The purpose of this study is to evaluate the use of statins to possibly prevent Mild Cognitive Intervention (MCI) or dementia, along with the prevention of physical disability and cardiovascular disease in older adults. Your participation in this study will last up to 5 years.

The purpose of this study is to examine how men and women with and without dementia might perceive and respond to pain or discomfort.

Participants may complete various questionnaires by phone or video conferencing once a week for up to 8 weeks with an optional MRI screening.

The purpose of this study is to investigate the early development of attention, learning, and memory.

The duration of the study will last over 4 years.

Participation in this study includes 4, 90-minute-long visits to the lab per year. During these 90-minute-long visits, your child will play 2-3 computerized games, designed to assess different aspects of their cognitive ability.

Researchers want to examine the effects of movies on children aged 8 - 12 years. If your child joins this study, they will watch a 1-minute safety video at home and answer a short survey. At-home activities should take less than 20 minutes. Next, they will come to OSU campus for the lab part (parking is paid, mask wearing is required) with a same aged peer or sibling. There they will watch a movie clip for 20 minutes (rated PG) and afterwards be placed in a room containing toys and games that they can play with for another 20 minutes. The children will be videotaped so we can see what they do. Participation in the lab portion will take 50 – 60 minutes.

The purpose of this research study is to see if practicing mindful breathing daily can reduce stress, improve sleep
and possibly improve symptoms in patients with Gastroparesis.

Gastroparesis is a condition characterized by symptoms such as nausea, vomiting, feeling excessively full after eating a little bit, bloating and abdominal pain. One or more of these symptoms can be present in a given patient.

Your participation throughout the study will last 6 weeks.

This study is being done to see if the study drug, called BI 1358894, compared to a drug called quetiapine, may help people with Major Depressive Disorder (MDD) who do not progress when taking an antidepressant medication alone. This study will help to gain information for providing better or new possible treatments for people in the future.

This study will take place over a period of 13 weeks and have about 8 visits to the study center and 2 that will be done by phone.

The purpose of this study is to find out if taking one medication Diovan (valsartan) or a combination of two medications (valsartan and sacubatril) in one pill called Entresto, will improve prediabetes in Blacks /African Americans over the course of 6 months. We will also look for changes in blood pressure and blood vessel stiffness throughout the course of the study in order to better understand how these medications may impact prediabetes.

This study is being done to develop a Magnetic resonance imaging (MRI) test that provides better-quality whole-heart pictures. MRI is a non-invasive machine that collects detailed pictures inside your body. Healthy volunteers will be tested in the MRI scanner while being given a dose of a medicine called Ferumoxytol into an IV (intravenous catheter) that will be placed in your arm or hand. Ferumoxytol is a medicine usually used in patients with iron deficiencies and has recently been used as an alternative to other MRI contrast agents and has successfully been applied in adult and pediatric patient populations.