Official Title AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion

Purpose

The purpose of this research is to determine if the IMPEDE-FX RapidFill System is safe and helps to shrink abdominal aortic aneurysm (AAA - a bulge or swelling due to weakening of the walls of the aorta, which is the main blood vessel that carries blood from your heart to other parts of your body) sacs after an endovascular stent graft (a fabric tube supported by metal wire stents that reinforces a weakened aorta) has been placed. The IMPEDE-FX RapidFill System used in this study is classified as investigational, which means it has not been approved by the Food and Drug Administration (FDA).

Could this study be right for you?

Inclusion:

• A candidate for elective EVAR of an infrarenal fusiform aortic aneurysm ≥5.5 cm in diameter in men and ≥ 5.0 cm in women 
• Thrombus burden (percentage of the AAA sac occupied by thrombus) <50%, based on pre-procedure CTA
• Maximum Lumen diameter within the AAA sac of ≥40mm
• The predicted minimum number of IMPEDE-FX RapidFill Implants for the subject is ≤200

Exclusion:

• An inability to provide informed consent
• Enrolled in another clinical study that could interfere with the outcomes being studied in this trial
• Unable or unwilling to comply with study follow-up requirements

Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range

18 years and up

Official Title Sexual and gender diverse young adults' preferences for nicotine and tobacco product attributes

Purpose

We are inviting LGBTQ+ folks to share their opinions about product features (e.g., flavors, nicotine levels) and other factors (e.g., stress, social media, marketing) that make people want to try or continue to use tobacco products.

Could this study be right for you?

• Able to speak English fluently
• Identify as LGBTQ+
• Used nicotine/tobacco products in the past 30-days (cigarettes, cigars, cigarillos, e-cigarettes, etc.)
• Reside in the U.S.

Age Range

18 - 34 years

Official Title Operating Microscope versus Traditional Loupes during Regeneration Therapy for Peri-implantitis: A Randomized Controlled Trial with Ultrasonographic and Biomarkers Evaluation

Purpose

The purpose of this study is to compare the one-year outcomes of treating peri-implantitis with periodontal surgical means between the use of an Operating Microscope and dental loupes.

This study includes the comparisons of the changes of inflammation of the gums, the bacteria present, and wound healing at the surgical site between the two methods. The hypothesis is that the use of the operating microscope, compared to dental loupes, is associated with better bacteria removal, quicker inflammatory resolution, and improved wound healing, which will contribute to better outcomes.

This study is 15 months, but your actual appointment time in the study, outside of the surgery itself, will be 6 – 9 hours. This will be in 6 study visits of 60 – 90 minutes in length. 

Could this study be right for you?

Inclusion criteria: Participant has at least one implant indicated for peri-implant regenerative treatment.

Exclusion criteria: Participant has known systemic conditions and medication interactions that can affect healing of the surgical site.

Age Range

18 - 99 years

Official Title Examining the safety and clinical efficacy of psilocybin therapy for Veterans with PTSD: An open label proof-of-concept trial

Purpose

The study will demonstrate the safety and efficacy of psilocybin in treating post-traumatic stress disorder (PTSD) in veterans. Psilocybin-assisted therapy has shown great promise in treating anxiety symptoms that comprise post-traumatic stress disorder (PTSD).  Current therapeutic treatments for PTSD are difficult to tolerate and limited in efficacy, especially in the US military veteran population. This study will examine the safety and efficacy of two psilocybin sessions, combined with psychotherapy, among military veterans with severe, treatment resistant PTSD.

Could this study be right for you?

Inclusion criteria:

• Be a United States military veteran 
• 21 to 64 years old  
• Have at least a high-school level of education or equivalent (e.g. GED)
• Current diagnosis of PTSD
• Be medically stable as determined by screening for medical problems via a personal interview, a medical questionnaire, a physical examination, an electrocardiogram (ECG), and routine medical blood and urinalysis laboratory tests  

Exclusion criteria:  

• Women who are pregnant
• Cardiovascular conditions: coronary artery disease, stroke, angina, uncontrolled hypertension, a clinically significant ECG abnormality (e.g., atrial fibrillation), artificial heart valve, or TIA in the past year  
• High blood pressure
• History of seizures or epilepsy

Exclusion Criteria varies, please contact Study Coordinator.

 

Age Range

21 - 64 years

Official Title Patterns Of Survivors’ Recovery Trajectories in the ICECAP trial 􀂥POST-ICECAP􀂦

Purpose

The purpose of this study is to describe the physical, neuropsychological outcomes of adults who have experienced an outside of hospital cardiac arrest; and examine any associations between those outcomes and any clinical and/or rehabilitative interventions and/or social determinants of health.

Could this study be right for you?

• Experienced a coma after resuscitation from a cardiac arrest
• Received targeted/controlled body temperature management
• Survived to at least 1 month after experiencing a outside of hospital cardiac arrest

Age Range

18 years and up

Official Title AROMA-NT: Assessment of the Mechanisms of Action of Inhaled Essential Oils and Wearable TENS unit device on Nausea

Purpose

The purpose of this research study is to understand how a combination of two aromatic inhalers containing a blend of essential oils and a wearable TENS unit affects nausea and stress in those suffering from chronic nausea and anxiety.

Could this study be right for you?

• Able to understand English
• Nausea going on for longer than 6 months

Age Range

18 - 80 years

Official Title Preschooler's Language Use and Media (PLUM) Study

Purpose

This study is designed to investigate media’s role in language development during early childhood. The goal of the proposed work is to examine the relation between the quantity of children’s media use and their language development trajectories, as well as how characteristics of media use (i.e., parent-child joint engagement, interactive media features, and educational content) predict growth in language over time. 

Could this study be right for you?

• Children 3 to 3.5 years of age (36 to 42 months).

Age Range

36 - 42 months

Official Title Project Limb Rescue: A pilot study evaluating the feasibility of transcutaneous sensors for the detection of cancer-related lymphedema

Purpose

The goal of this study is to use new, adhesive-based sensors (pads that stick on your skin) to detect lymphedema, and to develop a way for patients to check for lymphedema at home.

This study will assist in distinguishing participants with lymphedema in comparison to participants without lymphedema at rest by using a combination of photoplethysmography (PPG) and bioimpedance (BI). Photoplethysmography is an optical technique that can be used to detect blood volume changes in tissue. Bioimpedance evaluates how tissue responds to an externally applied electrical current.

Could this study be right for you?

• History of cancer-related lymphedema, cancer in your arm, or the lymph nodes in the arm
• History of cancer therapy with surgery or radiation involving the axillary basin and upper arm that requires compression or pneumatic therapy
• Physically capable of performing a brief bike riding exercise for about seven minutes
• No metal implants
• Willingness to take off shoes and any metal jewelry
• Not currently pregnant
• Not currently incarcerated

Age Range

18 - 90 years

Official Title Decay of HIV-1 Reservoirs in Participants on Long-Term Antiretroviral Therapy: The ACTG HIV Reservoirs Cohort (AHRC) Study

Purpose

The purpose of this study is to examine longitudinal changes in HIV-1 reservoirs among participants with HIV-1 who are either currently receiving antiretroviral therapy (ART) or who received ART previously. Participants will undergo blood and hair sample collections for immunologic, virologic, and pharmacologic evaluations to study HIV-1 reservoirs in the body.

Could this study be right for you?

This study is currently only enrolling in Group 6 which includes participants who acquired HIV while taking long-acting cabotegravir (CAB).

Age Range

18 years and up

Official Title A Double-Blind, Randomized, Placebo-Controlled Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined with ART Initiation during Acute HIV Infection to Induce HIV Remission

Purpose

The purpose of this study is to evaluate the safety and efficacy of combination bNAbs in addition to ART initiated during acute HIV infection and to evaluate the impact on HIV viral reservoirs.

Could this study be right for you?

• Newly diagnosed HIV+ individuals who have not yet started antiretroviral therapy (ART)
• Willingness to start ART at enrollment
• Ability and willingness to participate in scheduled study visits and analytic treatment interruption (ATI)
• Weight <115kg

Age Range

18 - 70 years

Official Title A Randomized, Placebo-Controlled, Double-Blinded Trial of the Safety and Efficacy of Tecovirimat for the Treatment of Human Mpox Disease

Purpose

This study will evaluate the safety and efficacy of tecovirimat for the treatment of human monkeypox virus (HMPXV) disease.

Could this study be right for you?

• Lab-confirmed OR suspected HMPXV infection
• At least one active skin lesion, mouth lesion, or proctitis with or without visible ulcers
• HMPXV illness of <14 days duration prior to study entry

Age Range

18 years and up

Official Title Safety, Tolerability and Immunogenicity of Recombinant HIV Envelope Protein VRC-HIVRGP096-00-VP (Trimer 4571) vaccine, in HIV-1 Infected Adults on suppressive ART

Purpose

The goal of this research study is to see if an investigational vaccine called Trimer 4571 is safe and well tolerated. Additionally, researchers will see if it will help the immune system produce broadly neutralizing antibodies (bNAbs) against HIV. bNAbs are a type of antibody that can recognize and block many types of HIV from entering healthy cells. Trimer 4571 is a vaccine designed to stimulate the development of bnAbs against HIV.

Could this study be right for you?

• On ART for at least 24 months
• HIV RNA <50 for at least 24 months
• CD4 count ≥200
• Known to have started ART during acute HIV infection
• BMI <40kg/m2

Age Range

18 years and up