Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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Food and Fitness with Medicine
Official Title Food and Fitness with MedicinePurpose
We are conducting a new study to explore whether a supportive program that combines healthy eating, enjoyable physical activity, and practical resources can improve health in postmenopausal women living with heart, kidney, or metabolic conditions who are using weight‑management medications. As more women use these medications, researchers want to understand how they can be paired with supportive lifestyle changes like nourishing food and enjoyable movement to improve overall health.
As more women turn to these medications, there is an important need to understand how they work best alongside real‑world lifestyle supports. This study aims to answer that question.
Depending on your group, you may also take part in activities such as personalized nutrition counseling, cooking demonstrations, groceries or vouchers, structured fitness, and optional online or at‑home resources. The goal of this research is to understand what truly helps people build and maintain healthy habits over time. By participating, you can contribute to research that will help guide future care and improve health programs for women like you.
Could this study be right for you?
Eligibility criteria:
- Post-menopausal
- Have at least one of the following conditions: hypertension, type 2 diabetes, high triglycerides, metabolic syndrome, moderate CKD
- Plan to start a GLP-1 medication or have started a GLP-1 medication within the last 6 weeks
Age Range
45 - 79 years -
Using Mobile Technology to Improve Body Composition Assessment and Track Physical Activity in Adults with Down Syndrome
Official Title Improving Body Composition Assessment and Physical Activity Monitoring in Adults with Down Syndrome using Mobile Technology
Purpose
The purpose of this study is to learn how well wearable technologies, such as smartwatches and activity trackers, can measure body composition and physical activity in adults with Down syndrome. Adults with Down syndrome are at a higher risk for obesity and related health conditions, and current methods used to measure body composition and activity can be difficult or uncomfortable. This study aims to identify simpler and more comfortable ways to collect this information.
If you choose to participate, you will be asked to attend one in-person study visit at a research laboratory. During this visit, you will complete a series of body measurements and light physical activity tasks. These include providing a small urine sample to check hydration, having your height, weight, and body composition measured using several methods (including a scan where you lie still for several minutes), and completing strength and walking tests. You will also wear multiple activity tracking devices on different parts of your body while completing short walking activities.
Your total time involved in this study will be one visit lasting approximately a few hours.
Could this study be right for you?
- Adult diagnosed with Down Syndrome
- Weight <350 lbs
- No condition that impacts body composition assessments (e.g., pacemaker)
- Not pregnant or planning to become pregnant
Age Range
18 - 60 years -
Evaluating the Efficacy of a Psychedelic Investigational Drug for Patients who are Struggling with Symptoms of Depression and Anxiety due to Cancer or Other Life-Changing Medical Illness
Official Title A Randomized, Double-Blind, Parallel-Group, Dose-Controlled Study Evaluating the Safety and Efficacy of RE104 for Injection in the Treatment of Adjustment Disorder in Patients with Cancer and Other Medical IllnessesPurpose
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to cancer or other illnesses such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease (PD) or Idiopathic Pulmonary Fibrosis (IPF) as compared to active-placebo.
Could this study be right for you?
- Depression due to cancer, Parkinson’s, ALS, MS, or IPF
- Currently depressed
- Projected life expectancy of ≥6 months.
Age Range
18 - 80 years -
Evaluating the Safety and Efficacy of Icalcaprant in the Treatment of Subjects with Major Depressive Disorder (MDD)
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Major Depressive DisorderPurpose
Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as feelings of sadness, irritability, not being able to focus on activities, tiredness, changes in eating habits, and aches and pains.
This study will assess the changes in disease activity and adverse events of oral Icalcaprant in adult participants with major depressive disorder who are currently experiencing a major depressive episode (MDE).
Could this study be right for you?
- Diagnosed with MDD
- Current major depressive episode
- Willing to discontinue antidepressant treatments
Age Range
18 - 65 years -
Evaluating the Efficacy and Safety of Icalcaprant in Subjects with Bipolar Depression
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Bipolar DepressionPurpose
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population.This study will assess how safe and effective Icalcaprant is in treating adult participants with bipolar I or II disorder.
Could this study be right for you?
- Diagnosed with Bipolar Disorder I or II
- Currently in a depressive episode
- Currently receiving treatment of a mood stabilizer
Age Range
18 - 65 years -
Research Study for Grave's Disease
Official Title A Phase 1, First-in-Human, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Intravenous and Subcutaneous Administration of MER511 in Adults With Graves’ DiseasePurpose
1. To find out how safe the study drug is and how well people with Graves’ disease can handle taking one or more doses.
2. To describe how the body absorbs, uses, and removes a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
3. To check whether the body creates an immune response after a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
Could this study be right for you?
1. Grave's disease diagnosis
2. Taking methimazole or propylthiouracil
3. Weigh at least 110 lbs
4. Women of childbearing potential must agree to use contraceptive methods and avoid egg donation during the study; Men with partners of childbearing potential must agree to use a condom or abstinence and avoid sperm donation during the study
Age Range
18 - 55 years -
Men’s Health, Friendships and Relationships
Official Title Men Talking: How Do Men Discuss Health, Friendships, and Relationships?Purpose
The purpose of this study is to gain a better understanding of men’s friendships, relationships, and health-information seeking.
The study consists of a 60–90-minute interview at a location of the participant’s choosing.
Thank you for your time and assistance!
Could this study be right for you?
- 18 years and older
- assigned male at birth
- live in Columbus Metro Area
Age Range
18 years and up -
Kicking the Habit: A Research Study Testing the Buckeye Quit Stick
Official Title A Pilot/Feasibility Study of the Buckeye Quit Stick: A Novel Resource for Successful Tobacco CessationPurpose
The Buckeye Quit Stick is part of a research study to learn whether people are willing to use a handheld stick as a tool for the hand-mouth routine of smoking. It focuses on the hand-to-mouth habit by providing something to hold and use instead of a cigarette. The main goal of this study is to see if patients that plan to quit smoking will use this device and evaluate their experiences with the Buckeye Quit Stick.
Participants will also continue to receive national guidelines for smoking cessation support from the James Comprehensive Cancer Center Smoking Cessation Clinic. A participant is considered to have completed the research study when they complete all study visits or at approximately 6 months.Could this study be right for you?
- Must be 21 years of age or older
- Patient of the OSU Thoracic Clinics
- Suspected or confirmed lung cancer diagnosis
- Current self-reported smoker
Age Range
21 years and up -
Preserving Manual Wheelchair User Shoulder Health
Official Title Quantifying Musculoskeletal Adaptations to Manual Wheelchair Use Across the LifespanPurpose
Manual wheelchair use places high physical demands on the arms and shoulders, which can lead to pain and injury, especially with aging. This study aims to understand how wheelchair use affects shoulder anatomy and movement to improve prevention, early detection, and treatment of upper extremity pain and injury in manual wheelchair users.
Participation includes two in-person research sessions, each lasting about 60 minutes, conducted at the Martha Morehouse Medical Pavilion:
- MRI session to examine shoulder anatomy (no radiation involved)
- Movement analysis session to assess muscle activity and arm function during everyday tasks such as wheelchair propulsion and reaching
Sessions may be completed on the same day or on different days within one week.
Total study participation is approximately 2 hours.
Could this study be right for you?
- Adults (>18 years old) who are primary manual wheelchair users
- Must be able to safely participate in MRI and movement analysis
- Individuals who are pregnant or have MRI-incompatible metal implants are not eligible
Age Range
18 - 110 years -
CP-MOVES: Standing Intervention for Children with Motor Delays.
Official Title CP-MOVES: Complex rehabilitation technology enabled Physical activity for children with Motor delays Via telehealth in natural EnvironmentsPurpose
This study will examine physical activity, sleep, and quality of life in children with severe motor delays and their parents before and after an 8-week intervention using adaptive standers.
Parents with a child with severe motor delay will enroll with their child (up to 1 parent per child). Both parent and child will participate in one telehealth-supervised session per week and two unsupervised sessions per week. Both parent and child will wear activity trackers on the wrists and waist for 1 week before and 1 week after treatment in order to measure physical activity and sleep. Parents will also complete surveys on quality of life before and after treatment.
Could this study be right for you?
- Medical diagnosis causing motor delay
- Unable to stand independently
- A parent or primary caregiver able to enroll as a participant in the study
- Internet or cellular service to join telehealth sessions
- Live within 100 miles of Ohio State University or willing to travel to the lab for one visit
Age Range
1 - 6 years -
Living Well with Advanced Breast Cancer
Official Title Living Well with Advanced Breast CancerPurpose
The purpose of this study is to understand how patients with advanced breast cancer are using supportive care, what has helped them, what has been hard, and what kind of help they still need. Our goal is to learn from patients and caregivers about met and unmet survivorship care needs, including care that focuses on improving health and well-being of a person living with cancer.
Study participants would be asked to complete a brief survey on their demographics via phone or email. Participants will then complete a one-time interview with our study staff via zoom, phone call, or in person, depending on preference. During the interview, the study team will ask for feedback on patient and caregiver experience and needs regarding support services.
Total study participation is less than 2 hours and can be done remotely.
Could this study be right for you?
- Diagnosed with stage 4 metastatic breast cancer within the past 5 years
- A patient in the Medical Oncology Clinic at Stephanie Spielman Comprehensive Breast Center (SSCBC)
Age Range
18 - 110 years -
TBI and other Acquired Brain Injuries Study
Official Title Resource Mapping for Families of Children with Brain InjuryPurpose
The purpose of this study is to assess the family needs of children with a brain injury. We want to explore your experiences getting care, the barriers, and facilitators your family has faced in navigating and accessing services after hospital discharge, and your ongoing unmet needs.
Could this study be right for you?
- You are a primary care giver of a child that sustained a brain injury
- Your child was hospitalized for an overnight stay as a result of their brain injury
- Your child was 18 or younger when their brain injury occurred
- You speak English
Age Range
19 years and up