Search Studies
Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.
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Evaluating the Efficacy of a Psychedelic Investigational Drug for Patients who are Struggling with Symptoms of Depression and Anxiety due to Cancer or Other Life-Changing Medical Illness
Official Title A Randomized, Double-Blind, Parallel-Group, Dose-Controlled Study Evaluating the Safety and Efficacy of RE104 for Injection in the Treatment of Adjustment Disorder in Patients with Cancer and Other Medical IllnessesPurpose
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to cancer or other illnesses such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease (PD) or Idiopathic Pulmonary Fibrosis (IPF) as compared to active-placebo.
Could this study be right for you?
- Depression due to cancer, Parkinson’s, ALS, MS, or IPF
- Currently depressed
- Projected life expectancy of ≥6 months.
Age Range
18 - 80 years -
Evaluating the Safety and Efficacy of Icalcaprant in the Treatment of Subjects with Major Depressive Disorder (MDD)
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Major Depressive DisorderPurpose
Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as feelings of sadness, irritability, not being able to focus on activities, tiredness, changes in eating habits, and aches and pains.
This study will assess the changes in disease activity and adverse events of oral Icalcaprant in adult participants with major depressive disorder who are currently experiencing a major depressive episode (MDE).
Could this study be right for you?
- Diagnosed with MDD
- Current major depressive episode
- Willing to discontinue antidepressant treatments
Age Range
18 - 65 years -
Evaluating the Efficacy and Safety of Icalcaprant in Subjects with Bipolar Depression
Official Title A Phase 2, Multicenter, 6-Week, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Icalcaprant in Subjects with Bipolar DepressionPurpose
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population.This study will assess how safe and effective Icalcaprant is in treating adult participants with bipolar I or II disorder.
Could this study be right for you?
- Diagnosed with Bipolar Disorder I or II
- Currently in a depressive episode
- Currently receiving treatment of a mood stabilizer
Age Range
18 - 65 years -
Generalized Anxiety Disorder Study for Those Who Have Had an Inadequate Response to Antidepressants
Official Title A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Fixed-Dose Study to Evaluate the Efficacy, Safety, and Tolerability of ABBV-932 as an Adjunct to Antidepressant Therapies in the Treatment of Subjects With Generalized Anxiety Disorder Who Have Had an Inadequate Response to Antidepressant TherapiesPurpose
Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD. The purpose of this study is to assess how safe and effective ABBV-932 is when added to the antidepressant therapies in adult participants with GAD who have had an inadequate response ADTs.
Could this study be right for you?
- Adults 18-65
- Diagnosed with GAD
- No depressive episodes in at least 6 months
- Currently receiving treatment of either paroxetine, escitalopram, duloxetine, or venlafaxine ER
Age Range
18 - 65 years -
Research Study for Grave's Disease
Official Title A Phase 1, First-in-Human, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Intravenous and Subcutaneous Administration of MER511 in Adults With Graves’ DiseasePurpose
1. To find out how safe the study drug is and how well people with Graves’ disease can handle taking one or more doses.
2. To describe how the body absorbs, uses, and removes a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
3. To check whether the body creates an immune response after a single IV or subcutaneous dose, or several subcutaneous doses, of MER511 in people with Graves’ disease.
Could this study be right for you?
1. Grave's disease diagnosis
2. Taking methimazole or propylthiouracil
3. Weigh at least 110 lbs
4. Women of childbearing potential must agree to use contraceptive methods and avoid egg donation during the study; Men with partners of childbearing potential must agree to use a condom or abstinence and avoid sperm donation during the study
Age Range
18 - 55 years -
Men’s Health, Friendships and Relationships
Official Title Men Talking: How Do Men Discuss Health, Friendships, and Relationships?Purpose
The purpose of this study is to gain a better understanding of men’s friendships, relationships, and health-information seeking.
The study consists of a 60–90-minute interview at a location of the participant’s choosing.
Thank you for your time and assistance!
Could this study be right for you?
- 18 years and older
- assigned male at birth
- live in Columbus Metro Area
Age Range
18 years and up -
Kicking the Habit: A Research Study Testing the Buckeye Quit Stick
Official Title A Pilot/Feasibility Study of the Buckeye Quit Stick: A Novel Resource for Successful Tobacco CessationPurpose
The Buckeye Quit Stick is part of a research study to learn whether people are willing to use a handheld stick as a tool for the hand-mouth routine of smoking. It focuses on the hand-to-mouth habit by providing something to hold and use instead of a cigarette. The main goal of this study is to see if patients that plan to quit smoking will use this device and evaluate their experiences with the Buckeye Quit Stick.
Participants will also continue to receive national guidelines for smoking cessation support from the James Comprehensive Cancer Center Smoking Cessation Clinic. A participant is considered to have completed the research study when they complete all study visits or at approximately 6 months.Could this study be right for you?
- Must be 21 years of age or older
- Patient of the OSU Thoracic Clinics
- Suspected or confirmed lung cancer diagnosis
- Current self-reported smoker
Age Range
21 years and up -
Emotions, Stress, and Mental Health
Official Title Emotions and Stress StudyPurpose
We are conducting a study to learn about the ways that adults cope with different types of stress in daily life. If you choose to participate in this study, you will be asked to answer a few questions to determine if you are a good fit for the study.
If you are a good fit for the study, you will attend a virtual meeting with a researcher, complete 2 questionnaires about your emotions and coping strategies, and complete short surveys multiple times per day for one week. This virtual meeting and first questionnaire will take about 1 hour to complete. The short surveys will take about 2-5 minutes to complete. The last questionnaire will take about 30 minutes to complete. The final questionnaire will take no longer than an hour to complete.
This entire study will last up to 5.5 hours total.
Could this study be right for you?
Individuals who identify as Black or African American.
Age Range
18 years and up -
Contact Lens Performance during Long Days of Wear
Official Title Evaluation of Wear Experience with Dailies Total 1® for Astigmatism Contact Lenses on Long Lens-Wear DaysPurpose
For this study, we are investigating the performance of a daily disposable lens in individuals who have astigmatism and are willing to wear contacts for the majority of their day (~16 hours a day).
Could this study be right for you?
Eligibility:
- Adults ages 18-40 years old.
- Willing to wear soft, single vision contact lenses during long days (approximately 16 hours/day).
- Access to a smart device and willingness to complete surveys throughout the day on the survey days.
Age Range
18 - 40 years -
Preserving Manual Wheelchair User Shoulder Health
Official Title Quantifying Musculoskeletal Adaptations to Manual Wheelchair Use Across the LifespanPurpose
Manual wheelchair use places high physical demands on the arms and shoulders, which can lead to pain and injury, especially with aging. This study aims to understand how wheelchair use affects shoulder anatomy and movement to improve prevention, early detection, and treatment of upper extremity pain and injury in manual wheelchair users.
Participation includes two in-person research sessions, each lasting about 60 minutes, conducted at the Martha Morehouse Medical Pavilion:
- MRI session to examine shoulder anatomy (no radiation involved)
- Movement analysis session to assess muscle activity and arm function during everyday tasks such as wheelchair propulsion and reaching
Sessions may be completed on the same day or on different days within one week.
Total study participation is approximately 2 hours.
Could this study be right for you?
- Adults (>18 years old) who are primary manual wheelchair users
- Must be able to safely participate in MRI and movement analysis
- Individuals who are pregnant or have MRI-incompatible metal implants are not eligible
Age Range
18 - 110 years -
Chill Nic (Nicotine Pouch) Study
Official Title Examining the Role of Cooling Agents in Oral Nicotine PouchesPurpose
Adult cigarette smokers who live in Ohio are invited to participate in 5 study visits to understand how different nicotine pouches compare to one another as well as their usual brand of cigarette. Each visit lasts about 1 hour.
Participation involves visiting our lab, trying oral nicotine pouches, smoking your regular brand of cigarette, and filling out surveys.
Could this study be right for you?
- Must be a current cigarette user
- Must be 21 years old or older
- Must be willing to attend 5 study visits at OSU
Age Range
21 years and up -
How Do Ketone Supplements Affect Brain Function in Healthy Adults
Official Title Effects of Acute Ketone Supplementation on the Brain (KETO-BRAIN)Purpose
This study looks at how ketone drinks affect the brain in healthy adults. Ketones are natural substances your body makes when it breaks down fat for energy. Scientists think ketones might help protect the brain and improve how it works.
We want to learn if drinking a ketone supplement changes blood flow to the brain and affects brain chemicals that help with thinking and memory. This information could help us understand if ketone drinks might be helpful for brain health as people age.
If you join this study, you will:
- Come to the research center 3 times over about 1-2 weeks
- Drink either a ketone supplement or a comparison drink (you will not know which one)
- Have brain scans using an MRI machine (like a large medical camera)
- Take simple thinking tests on a computer
- Have finger stick blood tests to measure ketone and sugar levels
You will first come in for a consent visit that take about 1 hour. Then, you will return for two more visits that will take about 3 hours each. You will drink a special beverage twice a day for two days before each scan visit. The study uses MRI scans to safely take pictures of your brain without radiation. We will measure blood flow in your brain and certain brain chemicals before and after you drink the supplement.
This research may help scientists better understand how ketones work in the brain. This could lead to new ways to support brain health in the future.
Could this study be right for you?
Who Can Join:
- Body Mass Index (BMI) between 18.5 and 30
- Able to skip eating overnight before study visits
- Not following a keto diet
Who Cannot Join:
- People who do not speak English
- Currently using ketone supplements or following a keto diet
- Pregnant or breastfeeding
- Allergic to milk protein or lactose intolerant
- History of high blood pressure
- History of alcohol problems in the past 2 years
- History of illegal drug use
- Head injury that caused loss of consciousness
- Brain or nerve disease diagnosis
- Taking medications for mental health conditions
- Current smokers
- Anyone with metal in their body or other reasons they cannot have an MRI scan
Age Range
45 - 65 years