Official Title Breathing Reduces Enteric symptoms and Anxiety promoting Therapeutic Healing Experience (BREATHE) – A Randomized Clinical Trial in Patients with Symptoms of Gastroparesis

Purpose

The purpose of this research study is to see if practicing mindful breathing daily can reduce stress, improve sleep
and possibly improve symptoms in patients with Gastroparesis.

Gastroparesis is a condition characterized by symptoms such as nausea, vomiting, feeling excessively full after eating a little bit, bloating and abdominal pain. One or more of these symptoms can be present in a given patient.

Your participation throughout the study will last 6 weeks.

Could this study be right for you?

• At least 18 years of age
• Able to read and understand English
• Has symptoms of gastroparesis for at least 6 months (gastric emptying study is NOT required for inclusion)

Age Range

18 and up

Official Title Development and Testing of Ferumoxytol-enhanced MRI Protocol in Healthy Subjects

Purpose

This study is being done to develop a Magnetic resonance imaging (MRI) test that provides better-quality whole-heart pictures. MRI is a non-invasive machine that collects detailed pictures inside your body. Healthy volunteers will be tested in the MRI scanner while being given a dose of a medicine called Ferumoxytol into an IV (intravenous catheter) that will be placed in your arm or hand. Ferumoxytol is a medicine usually used in patients with iron deficiencies and has recently been used as an alternative to other MRI contrast agents and has successfully been applied in adult and pediatric patient populations.

Could this study be right for you?

Inclusion:

• Males and females ages 18 years and older
• No history of cardiovascular disease

Exclusion:

• Evidence of any physical, mental, and/or medical conditions that would make the proposed studies relatively more hazardous including:
• Reactions to MRI including metallic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, coronary artery stent, neurostimulator, any other medical metallic implant
• History of cardiovascular disease or uncontrolled high blood pressure
• Claustrophobia
• Inability to lie flat for up to 1 hour
• Weight exceeding 300 pounds
• Pregnancy

Age Range

18 and up

Official Title A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir® System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis (SPRAY-CB)

Purpose

The purpose of this study is to determine the safety and effectiveness of a device called the RejuvenAir® System, developed for patients with chronic bronchitis. The primary objective of this trial is to demonstrate the safety and effectiveness of the RejuvenAir® System for the treatment of adult subjects with a diagnosis of CB defined as COPD with classic 3 months of cough and sputum production for a minimum of 2 years who demonstrate ongoing symptoms of cough and significant mucus production. You will be in the study for approximately 36 months, including the screening period.

Could this study be right for you?

Inclusion Criteria:

1. Males and females 40-80 years of age
2. Must demonstrate daily cough and significant mucus production
3. Have had a diagnosis of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) for a minimum of two years. (CB is defined clinically as chronic productive cough for 3 months in each of 2 successive years in a patient in whom other causes of productive cough have been excluded)
4. Smoking history of at least 10 pack years
5. Non-smoking for a minimum of 2 months prior to consent and agrees to continue not smoking for the duration of the study

Exclusion Criteria:

1. Have had an acute pulmonary infection, exacerbation or pneumonia requiring medical treatment (with antibiotics and/or steroids) within 4 weeks prior of initially planned study bronchoscopy
2. Diagnosis of Asthma
3. You have had any type of transplant procedure
4. Use e-cigarettes, vaping or inhaled substances not prescribed by a physician RejuvenAir® System
5. You are pregnant, nursing, or planning to get pregnant during study

* This is not a complete list of either inclusion or exclusion criteria

Age Range

40 and up

Official Title Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy for Tremor Surgery

Purpose

The goal of this study is to understand if there are any changes to the connections between the cells in the brain before and after the ultrasound surgery for the treatment of Essential Tremor. This will be done by comparing patients who have had ultrasound surgery and Essential Tremor with healthy individuals. This study may help us to better target the tremor region in the brain during the ultrasound surgery.

Could this study be right for you?

• You must be between the ages of 40 and 85
• Willing to have MRI imaging of the brain

Age Range

40 and up

Official Title Evaluation of the efficacy of radiofrequency-based debridement vs. mechanical debridement for the treatment of articular cartilage lesions.

Purpose

The purpose of this study is to evaluate 2 different treatments, Mechanical Debridement (i.e., a mechanical shaver that removes areas of damaged tissue) and Radiofrequency Debridement (i.e., electrical energy that removes areas of damaged tissue), used to treat the chondral lesion in your knee.

Could this study be right for you?

You may be eligible for this study if you:

• Are 18 - 50 years of age
• Suspected chondral damage in the following locations where debridement is indicated:
  • Medial femoral condyle
  • Lateral femoral condyle
  • Trochlea
  • Patella
• 1 or more chondral lesion(s) as noted on MRI

Exclusion:

• Previous chondral treatment in the same compartment (prior debridement and lavage performed more than three months prior to baseline are acceptable)
• Pregnant and/or intending to become pregnant during this study period

Age Range

18 and up

Official Title A Multicenter, Randomized, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira™ Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD)

Purpose

The purpose of this research study is to evaluate the safety and efficacy of the Nuvaira System, which is made by Nuvaira, Inc., for Targeted Lung Denervation (TLD) Therapy.

The primary purpose of conducting this study is to see if TLD Therapy in addition to optimal medical care (daily breathing medications you have been prescribed by your doctor) is better at reducing a moderate or severe worsening of symptoms (known as an COPD flare-ups or exacerbations) and related hospitalizations than optimal medical care (daily breathing medications you have been prescribed by your doctor) alone.

Could this study be right for you?

Inclusion Criteria:

• Between 40 and 75 years of age
• Non-smoking for a minimum of 2 months prior to consent and agrees to not smoke for the duration of the study
• Diagnosis of COPD with 30% ≤ FEV1 <60% of predicted and FEV1/FVC <70% (post-bronchodilator)
• SpO2 of at least 89% on room air at the time of screening
• Has a documented history of having minimally been taking a regular respiratory maintenance medication for at least 12 months at the time of consent; medications will be reviewed by study team
• If you have participated in a formal pulmonary rehabilitation program recently, program completion should have occurred more than 3 months prior to consent; if in a maintenance program, you will agree to continue your current program through your 12-month follow-up visit;
• Additional criteria will be reviewed by the study team

Involvement in this study will last approximately 62 months.

Age Range

40 and up

Official Title ABT-CIP-10300: Abbott DBS Registry of Outcomes for Indications over Time (ADROIT)

Purpose

The purpose of this study is to collect information and evaluate outcomes for Abbott Deep Brain Stimulation (DBS) systems that are approved and sold in your country.

In order to evaluate how the DBS system performs, data will be collected before, during and after DBS implant when you visit the study doctor. The data collected will include information on your movements, feelings, daily activities, and DBS program settings.

The information gathered in this study will add to the understanding of treatment options for future patients receiving DBS.

Could this study be right for you?

Inclusion Criteria:

• You are scheduled for a new implant or IPG device replacement surgery with a market-released Abbott DBS system within 3 months

Exclusion Criteria:

• You are currently enrolled or plan to enroll in another study that may alter the results of this clinical investigation
• You have another disease, conditions, or other medical, social, or psychological conditions that could limit your ability to participate in the clinical investigation or to satisfy follow-up requirements

Official Title Comprehensive Protocol for Cognitive Development Research

Purpose

The purpose of this study is to better understand learning, memory and attention development from childhood to adulthood using eye-tracking techniques.

This study will include one lab visit which will take place on Ohio State's main campus and will last approximately 40-60 minutes.

Could this study be right for you?

Eligibility Criteria:

• Must be 18 and 35 years of age
• Have normal or corrected to normal vision

Age Range

18 and up

Official Title Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation

Purpose

A test for healthy adults from 19 - 75 years old to develop normal values for interpretation of immunological tests in adults with disorders of the immune system.

Voluntary participation involves blood draw at Nationwide Children's hospital. Qualified participants would be eligible to provide a sample every 2 months (not more than 6 times per year).

Could this study be right for you?

If you are:

• An adult 19 years of age or older
• Healthy with no significant medical diagnoses
• Have no chronic conditions that can affect results of immunological studies
• Not on any medication known to alter immune status or function
• Have not undergone recent surgery, chemotherapy, radiation or transplantation
• Non-smoker
• Body mass index (BMI) in healthy range
• No infections within last 2 months

Age Range

19 and up

Official Title ANB019-003: A Phase II, Randomized, Placebo-controlled, Double-blind, Multiple Dose Study to Evaluate the Efficacy and Safety of ANB019 in Subjects with Palmoplantar Pustulosis

Purpose

This study is being done to assess the effects of the experimental study drug (ANB019) in patients with PPP.

Could this study be right for you?

• Must have a clinical diagnosis of PPP for at least 6 months prior to screening
• Must have active pustules on palms and/or soles of feet
• BMI must be within the range of 18-36 kg/m2
• Subjects must be in otherwise good health
• Must not have any suspected autoimmune disorder or immune deficiency
• No major surgeries in the past 4 weeks
• No history of malignancy in the past 5 years
• No history of drug, alcohol, or other substance abuse

Age Range

18 and up

Official Title Effects of Knee Brace Stiffness on Muscle Control following Total Knee Replacement

Purpose

The purpose of this study is to determine the effects of various knee braces on how you walk.

Participation in this study consists of 1 session lasting 2-3 hours. During testing, you will walk on a treadmill during several trials, each lasting 2-5 minutes. While walking, you will wear a knee brace, motion capture markers, and muscle activation sensors.

Could this study be right for you?

Knee Replacement participants:

• Men and women aged 45-89 years old
• Can walk for 45 minutes without stopping
• Received a TKR (total knee replacement) in the last 2 years

Healthy participants:

• Men and women aged 45-89 years old
• Can walk for 45 minutes without stopping
• No history of lower limb surgery

Exclusion criteria:

• Lower extremity surgeries (other than knee replacement)
• Spine pain
• Scoliosis
• Known pregnancy

Exclusion criteria varies, please contact Study Coordinator for more information.

Age Range

45 and up

Official Title Remote monitoring of retina vasculature in women with preeclampsia: novel biomarker for disease severity

Purpose

The overall goal is to evaluate whether pictures we take of the retina of the eye can be used to detect preeclampsia and its severity.

Your participation will be from your enrollment visit, until 2-4 months after delivery, which will be no more than 32 weeks.

Could this study be right for you?

Inclusion criteria for normal blood pressure healthy pregnant women:

• Women aged 18 years or older
• Pregnant females at enrollment being >= 24 0/7 of pregnancy
• Able and willing to provide consent and willing to conduct the postpartum follow-up
• Normal blood pressure at enrollment

Inclusion criteria for Preeclampsia Pregnancies with severe features:

• Women aged 18 years or older
• Pregnant female at enrollment between 24 0/7 and 33 6/7 of pregnancy
• Able and willing to provide consent and willing to conduct the postpartum follow-up
• All subjects must be Preeclampsia (dangerous high blood pressure in pregnancy) diagnosed.

Exclusion Criteria for both groups:

• Known chromosomal, genetic, major malformations, fetal demise.
• Past medical history of hypertension >5 years, pre-gestational diabetes, or known retinal disease
• Pregnant for twin, triplets or higher
• Participating in another intervention study that influences the outcomes in this study.

Age Range

18 and up