Official Title ANB019-003: A Phase II, Randomized, Placebo-controlled, Double-blind, Multiple Dose Study to Evaluate the Efficacy and Safety of ANB019 in Subjects with Palmoplantar Pustulosis

Purpose

This study is being done to assess the effects of the experimental study drug (ANB019) in patients with PPP.

Could this study be right for you?

• Must have a clinical diagnosis of PPP for at least 6 months prior to screening
• Must have active pustules on palms and/or soles of feet
• BMI must be within the range of 18-36 kg/m2
• Subjects must be in otherwise good health
• Must not have any suspected autoimmune disorder or immune deficiency
• No major surgeries in the past 4 weeks
• No history of malignancy in the past 5 years
• No history of drug, alcohol, or other substance abuse

Age Range

18 and up

Official Title Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent

Purpose

The purpose of the study is to determine if the investigational study drug will rapidly reduce depression associated with thoughts of harming oneself when given in addition to standard antidepressant medication.

Your participation in this study will last for a minimum of 14 weeks and maximum of 58 weeks.

Could this study be right for you?

• Aged 18-65 years old
• Diagnosed with major depressive disorder (MDD) with a current major depressive episode
• Having current suicidal ideation with intent
• Already in the hospital or agree to be hospitalized voluntarily for the required period of time

Age Range

18 and up

Official Title Effects of Knee Brace Stiffness on Muscle Control following Total Knee Replacement

Purpose

The purpose of this study is to determine the effects of various knee braces on how you walk.

Participation in this study consists of 1 session lasting 2-3 hours. During testing, you will walk on a treadmill during several trials, each lasting 2-5 minutes. While walking, you will wear a knee brace, motion capture markers, and muscle activation sensors.

Could this study be right for you?

Knee Replacement participants:

• Men and women aged 45-89 years old
• Can walk for 45 minutes without stopping
• Received a TKR (total knee replacement) in the last 2 years

Healthy participants:

• Men and women aged 45-89 years old
• Can walk for 45 minutes without stopping
• No history of lower limb surgery

Exclusion criteria:

• Lower extremity surgeries (other than knee replacement)
• Spine pain
• Scoliosis
• Known pregnancy

Exclusion criteria varies, please contact Study Coordinator for more information.

Age Range

45 and up

Official Title Remote monitoring of retina vasculature in women with preeclampsia: novel biomarker for disease severity

Purpose

The overall goal is to evaluate whether pictures we take of the retina of the eye can be used to detect preeclampsia and its severity.

Your participation will be from your enrollment visit, until 2-4 months after delivery, which will be no more than 32 weeks.

Could this study be right for you?

Inclusion criteria for normal blood pressure healthy pregnant women:

• Women aged 18 years or older
• Pregnant females at enrollment being >= 24 0/7 of pregnancy
• Able and willing to provide consent and willing to conduct the postpartum follow-up
• Normal blood pressure at enrollment

Inclusion criteria for Preeclampsia Pregnancies with severe features:

• Women aged 18 years or older
• Pregnant female at enrollment between 24 0/7 and 33 6/7 of pregnancy
• Able and willing to provide consent and willing to conduct the postpartum follow-up
• All subjects must be Preeclampsia (dangerous high blood pressure in pregnancy) diagnosed.

Exclusion Criteria for both groups:

• Known chromosomal, genetic, major malformations, fetal demise.
• Past medical history of hypertension >5 years, pre-gestational diabetes, or known retinal disease
• Pregnant for twin, triplets or higher
• Participating in another intervention study that influences the outcomes in this study.

Age Range

18 and up

Official Title [American Lung Association (ALA)] Lung Health Cohort (LHC) Study

Purpose

The purpose of this study is to examine why some people have better lung function than others as young adults during the period of peak lung health (ages 25 to 35 years old). The long-term goal of this study is to come up with ideas about how to promote the best possible lung function in young adults.

Participation in this study will be 4.5 years.

Could this study be right for you?

Inclusion Criteria:

• Men and women aged 25-35 years old at time of examination
• Able to read and understand English or Spanish
• Have a social security number

Exclusion Criteria:

• Severe asthma or other chronic lung disease
• Diagnosed cardiovascular disease
• History of cancer other than non-melanoma skin cancer
• Currently pregnant

Age Range

25 and up

Official Title STATBI: School Transitions after Traumatic Brain Injury

Purpose

The purpose of this study is to understand the best ways to help students return to school after brain injury of any severity. This is important to study because finding the best ways to help students go back to school right after brain injury, and over time, can help improve student success and recovery.

Your participation in the study would take place when you/your child begins the study and then at 3 months, 6 months, 12 months, 2 years (if applicable) and 3 years (if applicable) after the study starts.

Could this study be right for you?

• Students aged 5 to 18 years old
• In kindergarten through 12th grade
• Must Speak English
• Traumatic Brain Injury (TBI) of any severity
• Parent/caregiver is willing to share medical and academic information with the research team (all study activities are virtual/remote)

Age Range

5 and up

Official Title The Ontogenesis of Categorization (Children age 4)

Purpose

The purpose of the study is to investigate the early development of attention, learning and memory; this is a multi-year study.

All sessions will take approximately 60-120 minutes to complete. This study will be conducted in our lab, and mandated OSU COVID safety protocol will be followed.

Could this study be right for you?

• Children who are 4 years old
• Have normal or corrected to normal vision

Age Range

4 and up

Official Title Cognitive Development (Children 4-9 yrs old)

Purpose

The purpose of this study is to understand how children sort new information using simple memory exercises with animated computer games.

All sessions will take approximately 25-45 minutes to complete. Participating children will play memory games on our touchscreens and computers. For on-campus sessions, mandated OSU COVID safety precautions will be followed.

Could this study be right for you?

• Children ages 4-9 years old

Age Range

4 and up

Official Title Creation of a pediatric healthy control repository for clinical diagnostic immunology test development and validation

Purpose

This study uses healthy children from newborns to 18 years old to help understand immune disorders. This study will compare healthy children and teens to children and teens with disorders of the immune system.

Volunteers will visit Nationwide Children's Hospital (NCH) for a blood draw either one time or not more than once every three months.

Could this study be right for you?

If your child is:

• Newborn to 18 years of age
• Healthy with no significant medical diagnoses
• Has no chronic medical conditions that can affect results of immunological studies
• Is not on any medication known to alter immune status or function
• Has not undergone recent surgery, chemotherapy, radiation or transplantation
• Has had no infections within the last 2 months

Official Title Cognition and Brain Circuitry

Purpose

The purpose of the study is to look at how our brain networks interact for different mental functions and how individual differences in brain structure and function determines individual differences in behavior. During this study, we use magnetic resonance imaging methods: functional magnetic resonance imaging (fMRI) and diffusion weighted imaging (DWI). Functional MRI (fMRI) and DWI are typical imaging methods that use a strong magnetic field and radio waves to make pictures of your body. The total length of the study will be between 3 and 4 hours, including up to 2 hours outside the MRI scanner and 2 hours in the scanner.

Could this study be right for you?

• Healthy adults between 18-40 years of age
• Have normal or corrected-to-normal vision

Age Range

18 and up

Official Title Death of a Child During the Pandemic: Experiences of Parents

Purpose

The purpose of this exploratory study with parents who have experienced the death of a minor child during the COVID-19 pandemic is to determine a) if it is worthwhile to recruit parents using an online platform; b) if it is suitable to be able to obtain the data of interest using an online platform; c) if parents find this type of recruitment and data collection strategy acceptable; and d) what the experiences of parents whose child died during the COVID-19 pandemic have been like.

Could this study be right for you?

The following are the eligibility criteria:

• Inclusion:
  • Parents whose child died between March 15, 2020 and present
  • 30 days post child death
  • Child age at death: Birth to 19 years
  • Speaks English
  • Any care setting (home, hospital, hospice care facility, long-term care)
  • Parents who are 18 years or older

Age Range

18 and up

Official Title Couple Dynamics Surrounding Contraceptive Sterilization

Purpose

This study aims to understand people’s experiences with contraceptive sterilization (such as tubal ligations or vasectomies).
The purpose of this study is to better understand how adults decide to use sterilization as
their main form of birth control. By examining sterilization decisions, this study will
provide a better understanding of how individuals describe and explain their decision
making process.

In this study we are interested in learning how people discuss these decisions with their partner, as
well as everyday interactions with their partner, other forms of birth control, and attitudes
about gender more generally.

Could this study be right for you?

• Ages 21-55
• Have used tubal ligation or vasectomy as primary contraception, WITHIN the last five (5) years

Participants will be asked to answer a series of questions regarding their experience with sterilization. Interviews will be digitally recorded by audiotape and will remain confidential. The duration of the interview will last approximately one hour to one hour and thirty minutes.

Age Range

21 and up