This research is studying a new drug, NLY01, in a large number of persons to learn about its effects in people with early-stage Parkinson’s disease (PD). Researchers want to know whether NLY01 helps lessen symptoms and signs of early PD, as well as slow the progression of the disease.

You will have a 2 in 3 chance of receiving NLY01 and a 1 in 3 chance of receiving a placebo, sterile salt water that looks like NLY01 but does not contain the study drug.

The total amount of time for you to be in the study will be approximately 45 to 54 weeks.

The main purpose of this study is to learn how well tavapadon (the study drug) works as a possible treatment for Parkinson’s disease and how safe the study drug is. The target dose range of tavapadon being studied is 5 to 15 mg once daily.

If you choose to participate in this study, you may receive the study drug, or you may receive placebo. A placebo is an inactive material, such as a sugar pill, that looks like the study drug but does not contain any active study drug. Researchers use a placebo to see if the study drug works better or is safer than taking nothing.
You will be in this study for approximately 35 weeks, which includes a screening visit and safety follow up, and you will need to come to the study center at least 11 times over this period.

The main reason for you to take part in this study is not to treat you for your condition but to help in answering the following research questions:
• Whether baricitinib is better than placebo in the treatment of patients with severe alopecia areata (AA)
• The safety of baricitinib and any side effects you may have when you take it.

Brexpiprazole is a medication being studied as a possible treatment for adjunctive treatment for Major Depressive Disorder (MDD). The reason for this study is to find out about the potential benefits and safety of Brexpiprazole.

The purpose of this study is to understand how Continuous Positive Airway Pressure (CPAP)
for mild to moderate sleep apnea may affect hypertensive disorders of pregnancy and other
complications of pregnancy such as gestational diabetes.

The purpose of this study is to examine the influence of nicotine form, concentration, and e-liquid flavor on youth vaping as well as the heart and lung effects associated with this behavior. You will be asked to attend 9 vaping sessions at The Ohio State University.

Your participation in this study will last up to 6 months.

The purpose of this research is to assess if receiving real-time visual feedback on your breathing pattern during a run has any influence on time to exhaustion.

The feedback will be provided through animations on a screen placed in front of the treadmill that open and close as the chest and abdomen expand and contract. Research has shown that you want the chest and abdomen to expand and contract at the same time to achieve the most efficient breathing possible, meaning you will want the animations to open and close at the same time.

The ultimate objective is to see if this feedback allowed the participant to last longer until reaching their exhaustion point.

This study is investigating if Long-Acting (LA) Injectable HIV-medications will be more successful for people who are non-adherent to their HIV medications than oral standard of care regimens. To be eligible to receive LA ART, participants will need to attain virologic suppression through adherence to an oral regimen first.

This study is being done to better understand relationship dynamics between children with ADHD, their siblings, and their parents. Our goal is to better understand how differences in family dynamics affect children with ADHD. Participants will be asked to fill out several self-report questionnaires and engage in a family conflict task. During several tasks, participants will have various physiological measures (e.g., heart rate, breathing rate, etc.) taken using electrodes placed on their body. Results of this study will be used to develop other studies and to inform future treatment and prevention programs.

The purpose of the study is to investigate how different parts of the brain are wired together and how they interact to form complex human behavior, and how our brain’s design makes each of us unique individuals. Different types of imaging methods - functional magnetic resonance imaging (fMRI ) and diffusion weighted imaging (DWI), imaging methods that use a strong magnetic field and radio waves to make pictures of your body, will be used to gather information from participants. No X-rays or other radiation is used in fMRI or DWI. Eye movements may be tracked as well, and you will be asked to respond to various conditions, questions, and stimuli.

To evaluate the efficacy and safety of study drug NBI-1065846, used as adjunctive treatment to oral antidepressant medication(s), compared with a placebo when treating symptoms of anhedonia.

The purpose of this trial is to determine whether a commercially available dietary supplement may decrease the severity of patients with early COVID-19