Research studies are looking for volunteers just like you. Both healthy volunteers and participants with specific health conditions are needed to help answer important questions impacting the health of our friends and family. Join us to improve the health of others.

Study Categories

  • A Study to Learn More about Sleep and Memory Changes in Youth

    Official Title
    Typical Sleep Brain Dynamics
    Purpose

    The Malerba Lab at the Research Institute at Nationwide Children's Hospital is looking for healthy volunteers ages 8 to 19 for a research study on the relation between sleep and memory in children and adolescents. Our goal is to learn how sleep brain activity and memory change throughout development. Children/adolescents will participate in an overnight study in the sleep lab; and play memory games both before and after the sleep night. The study will take about one evening to the next morning to complete and you may be compensated for your time. 

    Could this study be right for you?

    1. Participant and legal guardian are each able to complete measures in English

    2. Participant has no history of sleep study required for medical reasons

    3. Participant has no history of neurodevelopmental disorder, intellectual disability (defined as presence of Individualized Educational Plan or Section 504 Plan), or chronic illness affecting brain system development (defined as lasting six months and requiring ongoing treatment by a subspecialist, e.g., cancer, epilepsy)

    4. Participant has no history of severe mental illness or behavioral disorder requiring inpatient hospitalization of treatment;

    5. Participant does not have sensory or motor impairment precluding completion of study measures

    Age Range
    8 - 19 years
  • Healthy Diet Study

    Official Title
    A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fraction
    Purpose

    The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with heart failure and diabetes or pre-diabetes or metabolic syndrome.

     

    Could this study be right for you?
    • Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
    • NYHA class I – III for at least 3 months.
    • Ejection fraction ≥50% by biplane 2D, or 3D echo, or CMR
    • Echo findings of abnormal or indeterminant diastolic function or RHC data:  At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg.  pulmonary vascular resistance (PVR) < 3 Wood Units.
    • Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
    • Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
    • Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
    • Ability to participate in exercise treadmill testing.
    • Ability to sign written consent.

    Exclusions:

    •  Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
    •  Known allergy or sensitivity to gadolinium-based contrast agents.           
    • Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
    • Other metallic implants/aneurysm clips that are contraindicated in MRI.           
    • Claustrophobia
    • History of severe kidney disease of eGFR<30 ml/kg/1.73m2.

     

    Exclusion Criteria varies, please contact Study Coordinator. 

    Age Range
    18 - 80 years
  • PREVENTABLE

    Official Title
    PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults
    Purpose

    The purpose of PREVENTABLE is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability, or heart disease. The duration of the study will last 5 years. 

    Could this study be right for you?

    Inclusion Criteria:

    • Community-dwelling adults
    • Age ≥75 years
    • English or Spanish as primary language

     

    Exclusion Criteria:

    • Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
    • Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
    • Dementia (clinically evident or previously diagnosed)
    • Dependence in any Katz Basic Activities of Daily Living [ADL] (with the exception of urinary or bowel continence)
    • Severe hearing impairment (preventing phone follow up)
    • Unable to talk (preventing phone follow up)

    Exclusion Criteria varies, please contact Study Coordinator for more information. 

    Age Range
    75 years and up
  • Breathing Training Program for Breast Cancer Survivors with Obesity

    Official Title
    Reducing exercise intolerance through inspiratory muscle training in obese breast cancer survivors (IMOCS)
    Purpose

    The purpose of this study is to better understand why some survivors of breast cancer have difficulty exercising. We also want to learn if breathing exercises can make it easier to tolerate exercise. 

    Could this study be right for you?
    • Breast Cancer Survivor
    • Completed treatment within 6 months–5 years
    • Have obesity, defined as body mass index between 30-50 kg/m2
    • Can exercise independently
    Age Range
    18 years and up
  • The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience

    Official Title
    The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience
    Purpose

    The purpose of this study is to improve the sense of hope and build resilience through creating one’s Tree of Hope. This study is being done because we see that today’s environment is quite stressful and this can lead to people feeling less hopeful in their present and the future. 

     

    Could this study be right for you?
    • At least 18 years old 
    • Able to read and understand English 
    • Healthy people and patients will be eligible for this research study 
    • Participants will be eligible even if they are not seen at OSU for their care.
    • We will not abstract any data from electronic health records. Patients will complete a survey that asks them questions about their health conditions

    Exclusion Criteria

    • Any physical or mental condition that the principal investigator considers as impacting the ability of the patient to participate in the research study. Examples include visual or hearing impairment, arthritis, weakness or other medical problem that impairs their ability to write. 
    Age Range
    18 years and up
  • Contact Lens Study in Adults with Presbyopia

    Official Title
    Evaluation of Wear Experience with Dailies TOTAL1 Multifocal® Contact lenses in Presbyopic Adults That Have Dropped out of Contact Lens Wear
    Purpose

    The purpose of this study is to learn about the wear experience of adults who dropped out of contact lens wear once they became presbyopic. 

    Could this study be right for you?
    • Adults who have dropped out of contact lens wear 
    • Ability to attend 3 visits over the course of 5 weeks
    • Satisfy all other study eligibility and exclusion criteria
    Age Range
    38 years and up
  • A Study to Evaluate Baricitinib in Adult Patients with Severe or Very Severe Alopecia Areata

    Official Title
    A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients with Severe or Very Severe Alopecia Areata BRAVE-AA1
    Purpose

    The purpose of this study is to evaluate the efficacy of baricitinib.

    Could this study be right for you?
    • Subject must self-identify as Black or African American 
    • Subject's current episode of alopecia areata must be more than 6 months and no longer than 8 years
    • Subject must not have any spontaneous improvement 
    • Subject must be in good general health with no history of tuberculosis, heart disease, cancer, HIV, hepatitis B or C, or blood clots 
    • Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study 
    Age Range
    18 years and up
  • A Study to Evaluate Rocatinlimab in Adults with Atopic Dermatitis (Ezcema)

    Official Title
    A Phase 3, Randomized, 24-week, Placebo-controlled, Double-blind Study to Assess the Efficacy, Safety and Tolerability of Rocatinlimab (AMG 451) Monotherapy in Adult
    Subjects With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon)
    Purpose

    The purpose of this study is to evaluate the efficacy of rocatinlimab. 

    Could this study be right for you?
    • Subject must have a diagnosis of atopic dermatitis for a least 6 months prior to study visit
    • Subject must have tried a topical medication with little to no improvement
    • Subject must be in good general health with no history of tuberculosis, heart disease, cancer, HIV, hepatitis B or C, or blood clots 
    • Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study 
    Age Range
    18 years and up
  • A Study to Evaluate Povorcitinib in Adults with Hidradenitis Suppurativa (HS)

    Official Title
    A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Efficacy and Safety Study of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa
    Purpose

    The purpose of this study is to evaluate the efficacy of povorcitinib.

    Could this study be right for you?
    • Subject must have a diagnosis of hidradenitis suppurativa for at least 3 months prior to study visit 
    • Subject must have at least 5 active HS spots in 2 different body areas 
    • Subject must have tried an oral or injected medication for HS with little to no improvement 
    • Subject must be in good general health with no history of tuberculosis, heart disease, cancer, HIV, hepatitis B or C, or blood clots 
    • Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study 
    Age Range
    18 years and up
  • Impact of A Low Glycemic Index Diet on Blood Pressure and Blood Sugar in Individuals with Spinal Cord Injury

    Official Title
    Two Birds with One Stone: Impact of A Low Glycemic Index Diet on Postprandial Hypotension and Glucose Metabolism in Individuals with Spinal Cord Injury (FIP)
    Purpose

    The purpose of this study is to examine the effect of a short-term low glycemic index diet on blood pressure and blood sugar control after eating.

    Could this study be right for you?
    • Adults aged 18-65 years old
    • Chronic spinal cord injury
    • Level of injury between C4 and L2
    Age Range
    18 - 65 years
  • Brains, Emotion Regulation and Adolescent Moods (BEAM) Study

    Official Title
    Neurodevelopmental Mechanisms Underlying the Onset of Depression among At-Risk Youth: The Role of Dysregulation in the Negative Valence System
    Purpose

    The purpose of this study is to test whether changes in the way in which we react and respond to emotional or stressful information represent a risk factor for depression in kids of mothers with and without depression. Findings from the study have the potential to decrease the high rates of depression observed in children of depressed mothers.  

    Could this study be right for you?

    You may be eligible for this study if:

    • You are 18-65 years old and female.
    • You have a biological child who is between 9 and 14 years of age.
  • Understanding Patient Experiences of Gestational Diabetes

    Official Title
    A Multi-Actor Examination of Gestational Diabetes Mellitus (GDM)
    Purpose

    This study aims to examine the experience of people who have been diagnosed or are currently living with gestational diabetes, including how they manage and make sense of their diagnosis. 

    Could this study be right for you?
    • Aged 18 years or older
    • Must live in the state of Ohio
    • Must be currently pregnant and have been diagnosed with gestational diabetes OR must have been diagnosed with gestational diabetes during a recent pregnancy (within the last 12 months)
    Age Range
    18 years and up