Official Title Linking Age, Balance, Vestibular Function, and Falls

Purpose

The purpose of this study is to learn how aging in different sensory systems, including the vestibular system (that portion of the inner ear that measures both motion and orientation of the head), influences maintaining balance while standing and walking, and contributes to fall risk. 

Could this study be right for you?

• Must be able to stand
• No leg or foot amputations
• No lower limb braces
• Not currently feeling dizzy/lightheaded
• Not currently pregnant by self-report
  • Due to potentially nauseogenic nature of some motions and to protect fetus and mother, pregnant women will also be excluded from this study
• Weight <= 275 pounds
• No past or current history of:
  • Severe head trauma or traumatic brain injury
  • Any vestibular disorder (e.g., Meniere’s Disease, Vestibular Migraine, Unresolved BPPV/BPPN, Vestibular hypofunction, except that due to aging, PPPD) as assessed using clinical diagnostic tests described in proposal
  • History of seizures
  • Neurologic illness or conditions known to impact vestibular or balance function(e.g., stroke, neurodegenerative disorders, demyelinating illness)
  • Major psychiatric (e.g., panic disorder, psychosis, etc.) disorder
  • Any of the following eye diseases or conditions: amblyopia (or “lazy eye”) or history of amblyopia, diagnosis of age-related macular degeneration, retina dystrophy, glaucoma, cataracts, or any other eye condition that limits vision to worse than 20/40
  • Recent (<6 months) orthopedic injuries of the lower extremities (e.g., plantar fasciitis, ankle, knee or hip injury, back strain/herniated disc, …).
  • Upper extremity injuries requiring current sling immobilization
  • Recent surgery
  • Any other severe health problem (heart disease, pulmonary disease, cancer, etc.).
  • Vision in both eyes must be better than 20/40 with best correction
  • Outer and/or middle ear pathologies
  • Otologic pathologies or diagnoses (e.g. Meniere’s disease, otosclerosis, conductive or mixed hearing losses)
• Must be able to walk unassisted for 30 minutes
• No current use of ambulatory assistive devices
• Normal hearing bilaterally, air conduction pure-tone thresholds ≤ 25 dB HL at all octave frequencies between 250 and 8000 Hz
• Bilaterally, symmetric sensorineural hearing loss with four-frequency pure-tone average (500, 1000, 2000, 4000) less than 71 dB HL
• If interested, please go to go.osu.edu/vestibular to be screened for eligibility

Age Range

18 - 89 years

Contact Information

OSU Bevis Hall, 1080 Carmack Rd, Columbus, OH 43210

John Oas

oas01@osumc.edu

Official Title Fostering Agricultural Relationships and Meaning - Thriving on Kinship (FARM-TOK)

Purpose

The purpose of this study is to understand how well and how accepted a phone-based intervention for loneliness works for people in rural or farming/agricultural areas. The goal of this intervention is to reduce loneliness and improve mental well-being. 

Could this study be right for you?

Inclusion criteria 

• Understand English
• Reside in an agricultural area in Ohio 
• Experiencing loneliness or social isolation 

Exclusion Criteria 

• Limited mental competency/not able to give informed consent 
• Non-English Speaking 
• Diagnosis of neurological disorder or Bipolar I
• Current psychotic diagnosis
• Suicidal or homicidal intent indicating need for hospitalization or treatment (as determined by clinical interviewer)

Age Range

18 years and up

Contact Information

Taylor Sabbagh

taylor.sabbagh@osumc.edu

614-814-1545

Official Title The Foods and Oils to Repair Correct and Enhance Strength (FORCES) Study: Determining the effect of dietary oils on muscle function, strength and mass

Purpose

The purpose of the FORCES Study is to determine how dietary oils effect muscle function, strength and mass in older adults who feel their muscle function and strength has declined with age.

During this 27-week study participants will

•  Consume ~2.5 tsp of oil each day through foods

• Complete muscle function and strength testing

• Have their blood drawn

• Have their body weight and composition measured

• Have an MRI scan of your legs, if able

• Fill out questionnaires

• Collect a small amount of muscle tissue from the leg (muscle biopsy

Could this study be right for you?

Feel your muscle function, strength or mass as decreased with age

Do NOT have food allergies 

Are not taking any weight loss medications or following a weight loss program

Age Range

65 - 80 years

Contact Information

The Ohio State University Columbus Campus

Rachel Cole

belurylabstudies@osu.edu

614-247-8235

Official Title Learning Interactions Made for Everyone (LIME)

Purpose

This study will examine activities of caregivers and their preschool aged child over a 12-week period. Caregivers will track learning activities with their child over the 12-weeks. Some participants will be asked to engage in additional learning activities with their child. Researchers will conduct assessments with the child before and after the 12-week program, as well as brief follow-ups 3-, 6-, and 12- months after completion. The total duration of participation in this study is up to 24 hours. The study will identify strategies in home-based learning activities and inform development of interventions to improve school readiness among children.

Could this study be right for you?

Child is minimally verbal in English.

Caregiver understands enough English to understand intervention materials.

Child does not have a severe intellectual disability.

Caregiver and child reside in the greater Columbus area.

Age Range

42 - 57 months

Contact Information

Columbus, Ohio

Eileen Donnally

donnally.7@osu.edu

614-247-5897

Official Title Phase I Study of the Safety and Feasibility of a Ketogenic Dietary Intervention to Improve Response to Immunotherapy

Purpose

This study will look at if a ketogenic diet (KD) can help treatment work better in patients with metastatic melanoma or metastatic kidney cancer. People who take part in the study will be randomly assigned to either continue eating their usual diet or trying the KD diet for 24 weeks. Participants will have blood and stool samples collected during the study. They will also test their sugar by doing daily glucose fingers sticks. Participants may be paid up to $200 for taking part in the study.

Could this study be right for you?

1. Patients with metastatic melanoma receiving first-line treatment with immunotherapy or Patients with metastatic renal cell cancer receiving first line treatment with immunotherapy.
2. Willing to give three stool samples
3. Willing to participate in a ketogenic diet (KD)

Age Range

18 years and up

Contact Information

The Ohio State University

Helena Gastier

_JOC-NTresearch_@osumc.edu

614-257-3434

Official Title The Knowledge and Perceptions of Gen Zs Regarding the Dietary Guidelines for Americans

Purpose

1. Use ideas from Social Cognitive Theory to describe Gen Zs regarding the Dietary Guidelines for Americans (DGA) 2020 to 2025
2. Explain what Gen Z knows and believes regarding the MyPlate recommendations for healthy eating related to:

• Filling half their plate with fruit and vegetables
• Filling one-quarter of their plate with lean protein, and varying the sources of protein
• Filling one-quarter of their plate with grains, making half of the grains whole grains

3. To describe the associations between demographic variables (ethnicity, education, household income, and home environment) and Gen Zs perceptions and knowledge of the DGA

Could this study be right for you?

18 to 28 years old

Live in the US

English speaker

Have access to a device that supports Zoom

Age Range

18 - 28 years

Contact Information

United States

Livia Schorn or Rhea Umrani

umrani.2@buckeyemail.osu.edu; schorn.5@buckeyemail.osu.edu

614-814-0866

Official Title AMC-111 Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

Purpose

This clinical trial evaluates the usefulness of using a smartphone-based HIV-specific smoking cessation intervention at the time of lung cancer screening in helping people living with HIV quit smoking. Positively Smoke Free - Mobile may help patients with HIV quit smoking.

 

In this study, you will have lung cancer screening performed via a CT scan. You will also be enrolled into a self-guided smartphone-based HIV-specific smoking cessation intervention called “Positively Smoke Free - Mobile” lasting 42 days. After starting the intervention, you will be evaluated at 3, 6, and 12 months. 

Could this study be right for you?

Must have at least a 20 pack-year history of smoking (a way to measure how much a person has smoked over time, 1 pack-year is a pack per day for a year or 2 packs of cigarettes for half a year, etc.)

Must have not had a CT scan in the past 12 months

HIV positive, and must be receiving antiretroviral therapy and have a CD4 count of at least 200cells/uL within 6 months of enrolling in the study

Able to understand and provide informed consent

Possess a smart phone that can browse the web

Not receiving any other smoking cessation interventions currently or within the prior 30 days

Female volunteers cannot be pregnant, lactating, or breast-feeding

Age Range

45 - 80 years

Contact Information

Columbus, OH

Zachary Dohar

Zachary.Dohar@osumc.edu

614-814-0377

Official Title Dance-Based Avenues to Advance Nonpharmacologic Treatment of Chemotherapy Effects (DAANCE): A Multi-Center Trial

Purpose

This study will teach tango dance to try to help with neuropathy symptoms. Tango dancing classes will take place for 2 times a week for 8 weeks. You will be asked about symptoms such as numbness, tingling, fatigue, pain, and balance. There is a 6 month follow up period where we will ask you to tell us about your symptoms via an app. 

Could this study be right for you?

1. Breast cancer survivors stage I-IV
2. Exposure to chemotherapy with the last exposure being at least 3 months prior to study participation
3. Must be ambulatory

 

Age Range

40 years and up

Contact Information

Stephanie Spielman Comprehensive Breast Center

Jenna Cody

jenna.cody@osumc.edu

Official Title A randomized, double-blind, double-dummy, placebo-controlled, multicenter, Phase 3 study assessing the efficacy, safety, and tolerability of 2 doses of remibrutinib over a 68-week treatment period in adult patients with moderate to severe hidradenitis suppurativa

Purpose

This study is being done to see how well remibrutinib works for people who have hidradenitis suppurativa

 

Could this study be right for you?

• Subject must have a diagnosis of moderate to severe hidradenitis suppurativa (HS) for at least 6 months with lesions in 2 distinct areas
• Subject must be in good general health with no history of tuberculosis, HIV, or hepatitis B or C
• Subject must have no recent history (within 6 months) of significant medical conditions such as a heart attack or stroke
• Subject must not be taking anticoagulant medication (ex. warfarin) or dual anti-platelet therapy (ex. acetylsalicylic acid + clopidogrel)

Age Range

18 years and up

Contact Information

Elizabeth Begle

elizabeth.begle@osumc.edu

614-293-9306

Official Title AN OBSERVATIONAL, LONG-TERM SAFETY STUDY OF TZIELD® (TEPLIZUMAB-MZWV) IN PATIENTS WITH STAGE 2 TYPE 1 DIABETES

Purpose

The objective of the study is to test the safety and efficacy of TZIELD over the course of 10 years in patients with Stage 2, Type 1 Diabetes, as well as the prevention of Stage 3, Type 1 Diabetes. 

Could this study be right for you?

Inclusion Criteria:

TZIELD-Exposed Cohort
1. Patients in the US diagnosed with Stage 2 T1D who are planned to initiate TZIELD treatment according to the currently approved label or who have initiated TZIELD treatment within 6 months prior to enrollment:
− Day 1: 65 μg/m²
− Day 2: 125 μg/m²
− Day 3: 250 μg/m²
− Day 4: 500 μg/m²
− Days 5 through 14: 1,030 μg/m² per day
− Cumulative dose is approximately 11,240 μg/m²

2. Appropriate written informed consent/assent as applicable for the age of the patient

TZIELD-Unexposed Cohort
1. Patients in the US diagnosed with Stage 2 T1D but who are not treated with TZIELD
2. Appropriate written informed consent/assent as applicable for the age of the patient

Exclusion Criteria:
1. Patients who initiated TZIELD treatment more than 6 months prior to enrollment
2. Patients who had participated in a previous clinical trial for TZIELD
3. Patients in an ongoing clinical trial of an investigational product or who had ended participation within 6 months prior to study enrollment; patients participating in other observational studies may be enrolled.

Age Range

18 - 70 years

Contact Information

CarePoint East, CarePoint Dublin

Zack Lauderback

zackary.lauderback@osumc.edu

614-814-1055

Official Title Biomechanical Metrics of Movement Relative to Total Knee Arthroplasty

Purpose

This study aims to understand how a total knee replacement surgery (TKR) affects muscle function and movement in the lower body. It focuses on four key areas:

1. Examining how TKR changes the way muscles work in the lower body.

2. Exploring how these muscle changes relate to the forces people experience when walking and doing daily activities after surgery.

3. Connecting muscle function to how well patients feel and move after TKR.

4. Identifying different types of TKR patients based on their physical traits, movement patterns, and medical history to see how they compare.

Could this study be right for you?

• Must be scheduled to receive a total knee replacement within the next 2 months
• Have a body mass index (BMI) < 40
• Do not require the use of a cane or other assistive device when walking, climbing stairs, and getting up from a chair

Exclusion criteria varies; please contact Study Coordinator for more information

Age Range

18 years and up

Contact Information

Science Village (1381 Kinnear Rd Columbus, OH, 43212)

Kathryn Blessinger

blessinger.1@osu.edu

Official Title Effects of Acute and Chronic Ketone Ester Consumption on Exercise Tolerance and Cardiac Function in Subjects with Diabetes

Purpose

This placebo-controlled study is being done to evaluate the effects of a ketone ester drink on exercise performance and heart health in a group of subjects diagnosed with type 2 diabetes.

Could this study be right for you?

There are additional exclusion criteria, study staff will screen fully before enrollment.

Age Range

18 - 80 years

Contact Information

Center for Imaging Excellence, 2050 Kenny Road

Debbie Scandling

debbie.scandling@osumc.edu

614-688-5623