Search Studies

Official Title Concurrent optical and magnetic stimulation (COMS) for treatment of refractory diabetic foot ulcer; a prospective randomized, sham-controlled, double-blinded, pivotal clinical trial

Purpose

The purpose of this study is to evaluate the safety and effectiveness of the treatment with the COMS One device in subjects with refractory diabetic foot ulcers (DFUs). 

The duration of this study will last up to 28 weeks. 

Could this study be right for you?

Inclusion

• Male and females aged 22 to 90 years old 
• Able to understand and sign the informed consent form (ICF) and comply with requirements set in the protocol including trial visits, trial treatment and dressing regimens and compliance with required offloading device (if applicable)
• Type 1 or Type 2 diabetes mellitus

Exclusion

• Known pregnancy or lactating
• Active skin cancer, a history of skin cancer or any other localized cancer, precancerous lesions or large moles in the areas to be treated
   

Inclusion and Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range

22 - 90 years

Official Title An open-label clinical trial evaluating the ExAblate Model 4000 Type-1 focused ultrasound unilateral thalamotomy for patients with treatment-refractory focal onset epilepsy and comorbid anxiety

Purpose

The purpose of the study is to learn more about whether an ultrasound treatment for epilepsy and anxiety is safe and effective.

Could this study be right for you?

• Age: 18-65 years old
• Treatment resistant Epilepsy (focal or partial-onset seizures)
• ≥ 3 seizures/month
• Moderate-to-severe Anxiety

 

 

Age Range

18 - 65 years

Official Title Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study: Dietary Fat Quality and Cognitive Impairment

Purpose

The purpose of the EFFECT Study is to determine how dietary fats influence cognitive (mental) function in adults.

 

During the 7-week study participants will

• Consume one study food per day for a total of 3 weeks
• Have their blood drawn
• Have their body weight and shape measured
• Complete cognitive tests
• Fill out questionnaires
• Complete diet and physical activity recalls

Could this study be right for you?

• Feel your memory or concentration is not as good as you'd like it to be
• Are overweight
• Do NOT have diabetes
• Do NOT have dementia or Alzheimer's
• Do NOT have food allergies 
• Are NOT pregnant or nursing an infant

Age Range

40 - 75 years

Official Title Strategies to Augment Ketosis- Variations in Ketone Metabolism

Purpose

This study is being done to see how individuals respond to a ketone ester (KE) across different age groups and health statuses. With the ketogenic diet becoming more popular, research on ketones (a molecule created when fat is broken down in the body) has grown as well. 

These findings will be used to help develop future research studies and help others to pick the right doses of ketone supplement.

Could this study be right for you?

• Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction 

• Have NOT experienced >10% weight loss in the last 6 months 

• Do NOT currently consume a low carbohydrate diet 

• Do NOT consume alcohol more than 3 drinks/daily or 14 drinks/weekly 

• Do NOT suffer from food allergies or gastrointestinal disorders 

Age Range

20 - 70 years

Official Title Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction (STAK-Sleep)

Purpose

To examine if drinking a ketone supplement, twice a day, can improve brain, digital shooting, and physical performance during short-term sleep restriction (4 nights, 50% of normal sleep).

Could this study be right for you?

• Healthy
• Age: 18 - 40 years old
• BMI: 20-35 kg/m2
• No diagnosed sleep disorders
• Not consuming a ketogenic diet

Age Range

18 - 40 years

Official Title Strategies to Augment Ketosis: Optimization of Ketone Delivery Strategies (STAK: OK'd)

Purpose

This study is intended to evaluate the effects of different dosing measurements for different ketone products in healthy male adults. After giving consent to this study you will schedule 9 testing sessions about 3 days apart. During these sessions you will come into the Physical Activity and Education Services (PAES) building in the morning, having had no food that day and take a study product. Various tests will be administered after ingestion. You will have blood draws to tell us more about your metabolic response to the product.

Could this study be right for you?

• Have a BMI >18 kg/m2 or ≤29 kg/m2
• Do NOT smoke or have diabetes, liver disease, kidney disease, cardiovascular disease, or any form of endocrine dysfunction
• Do NOT currently consume a low carbohydrate diet

 

Age Range

20 - 30 years

Official Title MapLight Study (IRIS Clinical Trial)

Purpose

The purpose of this study is to investigate a medication intended to improve social communication in adolescents and adults with ASD.

Could this study be right for you?

• Have an autism diagnosis or suspect you have an autism diagnosis
• Have a caregiver or study partner willing to enroll in the study with you

Age Range

18 - 45 years

Official Title Ketogenic Intervention in Depression (KIND)

Purpose

The overarching goal of this pilot study is to: (1) demonstrate that a well-formulated KD can be implemented in treatment program for major depression, and (2) test whether such a program results in reductions of symptoms of depression. 

Could this study be right for you?

Inclusion Criteria:

• OSU students (age 18-30 years at the time of enrollment) with confirmed major depressive disorder as determined by SCID-5 diagnosis at baseline testing.
• Currently engaged in counseling and or mediation treatment for depression
• Available for a 12-week period and indicate willingness and ability to eat KD foods as prescribed

Exclusion Criteria:

• Disordered eating, as evidenced by meeting criteria for Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Eating Disorder, Unspecified Eating Disorder, or Avoidant Restrictive Eating Disorder during the SCID-5 interview at baseline testing.
• Substantial imminent risk of suicide as assessed during the SCID-5 interview.
• Body mass index (BMI) < 20 kg/m2
• Habitual consumption of a structured low-carbohydrate diet in the last 6-months

Exclusion Criteria varies, please contact Study Coordinator.

 

Age Range

18 - 30 years

Official Title Understanding the Neurodevelopmental Effects of Youth Tackle Football Participation

Purpose

In this study we are aiming to identify risk factors for higher exposure to football-related neurotrauma in youth tackle football players and to determine the effects of football-related neurotrauma exposure on neurodevelopment in children with no previous tackle football participation.

For this specific posting, we are looking for boys ages 8-12 who are non-athletes or athletes who play non-contact sports to serve as control subjects for our fMRI study. 

Could this study be right for you?

We are looking for boys ages 8-12 who are either non-athletes or do not participate in any contact sports

• Boys must have no metal implanted in the body
• Have no prior history of head trauma
• Have no serious health or mental health diagnoses
• Must not have a fear of enclosed spaces

Age Range

8 - 12 years

Official Title Exploring the Connectivity and Functional Organization of the Infant Brain

Purpose

The purpose of the study is to investigate how the brain that we are each born with leads to our own unique behavior later in life, and the similarities and differences between maternal and child brains. We are studying infants prenatally and postnatally, following up with them as they grow and develop, and studying their mothers to understand how similar/different they are to their child.

Could this study be right for you?

• Infants under 3 years of age, and pregnant persons who are at least 20 weeks pregnant
• All participants must have no metal implanted in the body
• Have no significant health conditions or history of serious mental illness
• Not suffer froma (fear of enclosed spaces)
• Pregnancies must be without complication.

Age Range

Up to 40 years

Official Title PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life (PROMISE)

Purpose

The purpose of this study is to find out more about how health and exposures during pregnancy, such as having an infection, diet and growth may impact later risk of islet autoimmunity in the
child. We are also interested in finding out more about why having a father or sibling with type 1 diabetes increases risk of autoimmunity in the child than having a mother with type 1 diabetes.

Could this study be right for you?

Inclusion:
Pregnant women:
- who is between 8-24 weeks gestation with a singleton pregnancy
- have had type 1 diabetes for at least 12 months, or the father of the baby or a full sibling of the baby has type 1 diabetes
- is 18 years of age or older
- is willing to have blood collected and to complete questionnaires about prenatal exposures once per trimester during their pregnancy (up to 3 visits) and up to 12
weeks after they deliver their baby
- is willing to have their baby screened for genetic risk for type 1 diabetes, to complete online questionnaires, and to have their child followed for measurement
of islet autoimmunity according to the determined risk for type 1 diabetes, through 5-7 years of age.
o If low risk, two screenings: the first at 2 years of age and the second between 5-7 years of age
o If high risk, five screenings: every six months through 2 years of age, and one between 5-7 years of age

The father of the baby will also be asked to complete one visit during pregnancy but it is not mandatory.

Exclusion:
- Multiple Gestation pregnancy
- Mother unable to consent due to intellectual impairment
- Fetus with known medical issue that would affect study participation
- Surrogate / gestational mothers who are not biologically related to offspring they are carrying

Age Range

18 years and up

Official Title Associations between Race, Gut Microbiota-Metabolites, and Long-Term Symptom Toxicity in African Americans and Caucasian Americans Colorectal Cancer Survivors

Purpose

The purpose of this study is to learn about the associations of symptoms such as fatigue, depression, and gastrointestinal distress including constipation, abdominal pain, and diarrhea with stool microbiomes and metabolites in patients with colorectal cancer. We will compare the associations of symptoms with microbiomes among colorectal cancer patients and healthy patients. You will be asked to complete several surveys that ask questions about your dietary habits, your health history, your social demographics, and your symptoms. You will also be asked to collect a stool sample with an at-home stool sample collection kit that will be provided to you.

Could this study be right for you?

• Diagnosed with stage I-IV colorectal cancer (ICD-10 C18, C19 and C20) OR Healthy.
• 18+ years of age at time of diagnosis.
• Able to communicate in English and provide consent.
• African American OR White.
• Not currently in cancer treatment.
• No current ostomy.
• No chronic bowel disorders (e.g., irritable bowel syndrome).
• No diagnosis of functional GI disorders.
• No food allergies or dietary restrictions.
• No use of probiotics or antibiotics within the past two months prior to fecal collection.
• No significant cognitive or developmental delay that precedes cancer diagnosis (e.g., down syndrome, autism spectrum disorder).

Age Range

18 years and up