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Official Title Effect of Fixation Training with Colored Light Targets on Traumatic Brain Injury-Associated Photophobia

Purpose

Researchers at The Ohio State University College of Optometry are seeking individuals with a recent history of head trauma who are experiencing light sensitivity. The goal of this study is to determine if daily 20 minute fixation training sessions using a colored (red or blue) light target affects symptoms of light sensitivity, or alters other measurements of the eyes and vision including pupil response.  

This study will involve attending five 1-2 hour study visits, occurring every 1.5 months for 6 months. Study visits will include answering questions about eye and health history, completing surveys, reading letters on an eye chart, having the pupils measured in response to flashes of light, measuring the side vision, measuring eye alignment and in some cases focusing ability. Outside of the study visits, participants will also complete daily 20 minute fixation training sessions for 6 months using a colored (red or blue) light target, completed at home between study visits.

Could this study be right for you?

• Must be 18 to 80 years old
• Experienced a head injury 3 or more months ago
• Current symptoms of light sensitivity
• Be healthy and have good eye health 

Age Range

18 - 80 years

Official Title Impulsivity Domains and Subjective Response

Purpose

The purpose of this study is to examine the degree to which different ways of thinking and decision making – measured using computer tasks and questionnaire – relate to how people feel after a dose of alcohol. By doing this study, we hope to learn about the relationships between decision making and responses to alcohol.

Could this study be right for you?

Inclusion criteria include:

1. Ages 21-25
2. Report drinking to an estimated BAC > 80mg% at least once in the past 30 days 
3. Report drinking at least twice weekly in the past 30 days 
4. English language Fluency

Exclusion criteria include:

1. Any serious medical problems (i.e., liver disease, cardiac abnormality, pancreatitis, diabetes, neurological problems, gastrointestinal disorders, abnormal kidney function)
2. Body weight < 110 or > 210 pounds
3. Current medical or psychiatric condition requiring medication for which alcohol consumption is contraindicated
4. Lifetime history of schizophrenia or other psychotic disorder
5. Substance Use Disorder other than alcohol

Exclusion Criteria varies, please contact Study Coordinator. 

Age Range

21 - 25 years

Official Title Typical Sleep Brain Dynamics

Purpose

The Malerba Lab at the Research Institute at Nationwide Children's Hospital is looking for healthy volunteers ages 8 to 19 for a research study on the relation between sleep and memory in children and adolescents. Our goal is to learn how sleep brain activity and memory change throughout development. Children/adolescents will participate in an overnight study in the sleep lab; and play memory games both before and after the sleep night. The study will take about one evening to the next morning to complete and you may be compensated for your time. 

Could this study be right for you?

1. Participant and legal guardian are each able to complete measures in English

2. Participant has no history of sleep study required for medical reasons

3. Participant has no history of neurodevelopmental disorder, intellectual disability (defined as presence of Individualized Educational Plan or Section 504 Plan), or chronic illness affecting brain system development (defined as lasting six months and requiring ongoing treatment by a subspecialist, e.g., cancer, epilepsy)

4. Participant has no history of severe mental illness or behavioral disorder requiring inpatient hospitalization of treatment;

5. Participant does not have sensory or motor impairment precluding completion of study measures

Age Range

8 - 19 years

Official Title A prospective randomized unblinded study of ketogenetic versus mixed diet on exercise tolerance in subjects with the metabolic phenotype of heart failure with preserved ejection fraction

Purpose

The purpose of this study is to compare the effects of a well-formulated ketogenic diet with a low-fat diet on exercise tolerance in patients with heart failure and diabetes or pre-diabetes or metabolic syndrome.

 

Could this study be right for you?

• Age ≥ 18 years old and ≤ 80 years old & willingness to be randomized to either diet.
• NYHA class I – III for at least 3 months.
• Ejection fraction ≥50% by biplane 2D, or 3D echo, or CMR
• Echo findings of abnormal or indeterminant diastolic function or RHC data:  At rest: mean pulmonary capillary wedge pressure (PCWP) > 15 mmHg.  pulmonary vascular resistance (PVR) < 3 Wood Units.
• Stable medical therapy for at least 3 months as determined by the treating physician (no new cardiac or diabetic medications within 3 months of enrollment or during enrollment and dosage should be stable for 1 month prior to enrollment).
• Dose of oral diuretics changes allowed but must be stable for 1 week prior to randomization.
• Body Mass Index (BMI) ≥ 25 and ≤ 50 or Type 2 Diabetes Mellitus or prediabetes (fasting glucose of 100 - 125 mg/dL or hemoglobin A1C 5.7-6.4%) or metabolic syndrome.
• Ability to participate in exercise treadmill testing.
• Ability to sign written consent.

Exclusions:

•  Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the study.
•  Known allergy or sensitivity to gadolinium-based contrast agents.           
• Implanted pacemaker, cardioverter defibrillator, Cardiac resynchronization therapy, left ventricular assist devices.
• Other metallic implants/aneurysm clips that are contraindicated in MRI.           
• Claustrophobia
• History of severe kidney disease of eGFR<30 ml/kg/1.73m2.

 

Exclusion Criteria varies, please contact Study Coordinator. 

Age Range

18 - 80 years

Official Title PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults

Purpose

The purpose of PREVENTABLE is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability, or heart disease. The duration of the study will last 5 years. 

Could this study be right for you?

Inclusion Criteria:

• Community-dwelling adults
• Age ≥75 years
• English or Spanish as primary language

 

Exclusion Criteria:

• Clinically evident cardiovascular disease defined as prior myocardial Infarction (MI), prior stroke, prior revascularization procedure, or a secondary prevention indication for a statin (clinician determined)
• Hospitalization for a primary diagnosis of heart failure in the prior 12 months (Note: History of heart failure in the absence of recent hospitalization or clinically evident cardiovascular disease is not an exclusion)
• Dementia (clinically evident or previously diagnosed)
• Dependence in any Katz Basic Activities of Daily Living [ADL] (with the exception of urinary or bowel continence)
• Severe hearing impairment (preventing phone follow up)
• Unable to talk (preventing phone follow up)

Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range

75 years and up

Official Title Reducing exercise intolerance through inspiratory muscle training in obese breast cancer survivors (IMOCS)

Purpose

The purpose of this study is to better understand why some survivors of breast cancer have difficulty exercising. We also want to learn if breathing exercises can make it easier to tolerate exercise. 

Could this study be right for you?

• Breast Cancer Survivor
• Completed treatment within 6 months–5 years
• Have obesity, defined as body mass index between 30-50 kg/m2
• Can exercise independently

Age Range

18 years and up

Official Title The Tree of Hope: A Method to Reduce Burnout, Improved Hope and Increase Resilience

Purpose

The purpose of this study is to improve the sense of hope and build resilience through creating one’s Tree of Hope. This study is being done because we see that today’s environment is quite stressful and this can lead to people feeling less hopeful in their present and the future. 

 

Could this study be right for you?

• At least 18 years old 
• Able to read and understand English 
• Healthy people and patients will be eligible for this research study 
• Participants will be eligible even if they are not seen at OSU for their care.
• We will not abstract any data from electronic health records. Patients will complete a survey that asks them questions about their health conditions

Exclusion Criteria

• Any physical or mental condition that the principal investigator considers as impacting the ability of the patient to participate in the research study. Examples include visual or hearing impairment, arthritis, weakness or other medical problem that impairs their ability to write. 

Age Range

18 years and up

Official Title A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients with Severe or Very Severe Alopecia Areata BRAVE-AA1

Purpose

The purpose of this study is to evaluate the efficacy of baricitinib.

Could this study be right for you?

• Subject must self-identify as Black or African American 
• Subject's current episode of alopecia areata must be more than 6 months and no longer than 8 years
• Subject must not have any spontaneous improvement 
• Subject must be in good general health with no history of tuberculosis, heart disease, cancer, HIV, hepatitis B or C, or blood clots 
• Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study 

Age Range

18 years and up

Official Title A Phase 3, Randomized, 24-week, Placebo-controlled, Double-blind Study to Assess the Efficacy, Safety and Tolerability of Rocatinlimab (AMG 451) Monotherapy in Adult
Subjects With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon)

Purpose

The purpose of this study is to evaluate the efficacy of rocatinlimab. 

Could this study be right for you?

• Subject must have a diagnosis of atopic dermatitis for a least 6 months prior to study visit
• Subject must have tried a topical medication with little to no improvement
• Subject must be in good general health with no history of tuberculosis, heart disease, cancer, HIV, hepatitis B or C, or blood clots 
• Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study 

Age Range

18 years and up

Official Title A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Efficacy and Safety Study of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa

Purpose

The purpose of this study is to evaluate the efficacy of povorcitinib.

Could this study be right for you?

• Subject must have a diagnosis of hidradenitis suppurativa for at least 3 months prior to study visit 
• Subject must have at least 5 active HS spots in 2 different body areas 
• Subject must have tried an oral or injected medication for HS with little to no improvement 
• Subject must be in good general health with no history of tuberculosis, heart disease, cancer, HIV, hepatitis B or C, or blood clots 
• Female subjects must not be pregnant, breastfeeding, or considering becoming pregnant for the duration of the study 

Age Range

18 years and up

Official Title Neurodevelopmental Mechanisms Underlying the Onset of Depression among At-Risk Youth: The Role of Dysregulation in the Negative Valence System

Purpose

The purpose of this study is to test whether changes in the way in which we react and respond to emotional or stressful information represent a risk factor for depression in kids of mothers with and without depression. Findings from the study have the potential to decrease the high rates of depression observed in children of depressed mothers.  

Could this study be right for you?

You may be eligible for this study if:

1. Are 18-65 years old and female.

2. Have a biological child who is between 9 and 14 years of age.

3. Have a history of major depressive disorder

Official Title Uncertainty and Firearms: Obtaining Secure Storage (UFOS)

Purpose

The purpose of this study is to examine whether fear of uncertainty plays a role in home safety practices among firearm owners who are currently or have recently served in the U.S. military.

Could this study be right for you?

• Currently serving in any Branch or Component of the U.S. military, or were discharged from the U.S. military within the past 90 days
• 18 years or older
• Own at least one firearm located in your home or vehicle
• Are able to speak and understand the English language
• Have an Apple or Android smartphone 

Age Range

18 - 99 years