Official Title Living Well with Advanced Breast Cancer

Purpose

The purpose of this study is to understand how patients with advanced breast cancer are using supportive care, what has helped them, what has been hard, and what kind of help they still need. Our goal is to learn from patients and caregivers about met and unmet survivorship care needs, including care that focuses on improving health and well-being of a person living with cancer.

Study participants would be asked to complete a brief survey on their demographics via phone or email. Participants will then complete a one-time interview with our study staff via zoom, phone call, or in person, depending on preference. During the interview, the study team will ask for feedback on patient and caregiver experience and needs regarding support services.

Total study participation is less than 2 hours and can be done remotely.

Could this study be right for you?

• Diagnosed with stage 4 metastatic breast cancer within the past 5 years
• A patient in the Medical Oncology Clinic at Stephanie Spielman Comprehensive Breast Center (SSCBC)

 

Age Range

18 - 110 years

Contact Information

Columbus, OH

Breast Non-Therapeutic Research Team

_breastNTresearch_@osumc.edu

614-814-1284

Official Title Phase 2 Study of Low Dose Tamoxifen +/- High Dose Omega-3 Fatty Acids in Overweight Postmenopausal Women at Increased Risk for Breast Cancer

Purpose

This study wants to measure the effects of low dose tamoxifen and omega-3 fatty acids (may also be known as fish oil) on a woman's risk of developing breast cancer.

In this study, half of the participants will be asked to take low dose tamoxifen and the other half low dose tamoxifen with omega-3 fatty acids for about six months. Everyone taking part in the study will be watched carefully for any side effects, which may or may not happen. Tissue and blood collection will be a part of the study participation.

This study is looking for volunteers with an above average risk of developing breast cancer. We will enroll up to 66 participants at institutions across the country. The study lasts about eight months.

Could this study be right for you?

• Postmenopausal
• At increased risk of breast cancer, due to genetic mutation, family history, prior DCIS, LCIS, or atypical hyperplasia
• Overweight or obese (BMI ≥ 25 kg/m2)
• Do not have breast implants
• Seen in Stefanie Spielman Comprehensive Breast Cancer Center in Columbus, OH

Age Range

45 - 65 years

Contact Information

Columbus, OH

Breast Non-Therapeutic Research Team

_breastNTresearch_@osumc.edu

614-257-2045

Official Title Resource Mapping for Families of Children with Brain Injury

Purpose

The purpose of this study is to assess the family needs of children with a brain injury. We want to explore your experiences getting care, the barriers, and facilitators your family has faced in navigating and accessing services after hospital discharge, and your ongoing unmet needs.

Could this study be right for you?

• You are a primary care giver of a child that sustained a brain injury

• Your child was hospitalized for an overnight stay as a result of their brain injury
• Your child was 18 or younger when their brain injury occurred
• You speak English 

Age Range

19 years and up

Contact Information

Virtual

Archana Kaur

Archana.Kaur@nationwidechildrens.org

Official Title Longitudinal Modeling of Interpersonal Stress Induced Rumination to Understand Depression Risk in Adolescent Girls (MARIS)

Purpose

This study looks at how young girls think about and react to stress—both in their brains and in their daily lives—to see how these patterns might lead to or predict depression. It aims to understand whether certain ways of handling stress put some girls at higher risk for developing depressive symptoms.

If eligible, the child will complete assessments which include clinical interviews over Zoom, surveys, cognitive testing, and an MRI each year, for up to three years.

A parent/guardian is required to enroll in the study and will complete questionnaires and a clinical interview as well.

Could this study be right for you?

Inclusion Criteria:

• Female
• 10-14 years of age at enrollment
• Youth assent and parent consent

Exclusion Criteria:

• Psychotropic medication use in the past 4 months
• Metal braces or plans for braces in the next 2 years
• Developmental disorder
• History or diagnosis of depression, substance use disorder, bipolar disorder, psychosis or seizures
• Traumatic brain injury
• Claustrophobia

Age Range

10 - 14 years

Contact Information

The Ohio State University, Columbus, OH

Caty Escobar

mend2lab@osumc.edu

Official Title Phase IIA Trial of Acolbifene (20 mg) vs Low Dose Tamoxifen (5 mg) in Pre-menopausal Women at High Risk for Development of Breast Cancer

Purpose

This study wants to see if two medicines, acolbifene or a small dose of tamoxifen, can lower the chance of getting breast cancer in women who are at high risk before menopause.

Acolbifene and tamoxifen work by blocking estrogen, a hormone that can help cancer cells grow. By blocking estrogen, these medicines may lower the chance of breast cancer in women at high risk. The study lasts between 6 and 8 months.

If this study works, it could give us new ways to help prevent breast cancer.

Could this study be right for you?

• Pre-menopausal
• At increased risk of breast cancer, due to genetic mutation, family history, prior DCIS, LCIS, or atypical hyperplasia
• Seen in Stefanie Spielman Comprehensive Breast Cancer Center in Columbus, OH

Age Range

35 years and up

Contact Information

Columbus, OH

Breast Non-Therapeutic Research Team

_breastNTresearch_@osumc.edu

614-257-2045

Official Title OASIS - Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking

Purpose

This study will look at whether suvorexant can help treat alcohol use disorder, how it works, and who it works best for. Suvorexant is a medicine that blocks certain brain signals linked to wakefulness.

 

Your total participation time in this study will be approximately 9 weeks.

Could this study be right for you?

Inclusion Criteria: 

1. Age 18-65
2. Participant is able to give informed consent 
3. Engage in heavy alcohol use defined as drinking ≥14 standard drinks per week if male and ≥7 standard drinks per week if female. 

General - Exclusion Criteria

1. Clinically significant medical or neurological condition (e.g., liver disease, narcolepsy, complex sleep behaviors, severe hepatic impairment, COPD, severe obstructive sleep apnea) 
2. Current or past DSM-5 diagnosis of mania, schizophrenia, psychosis 
3. Past suicide attempt within 3 years or presence of moderate suicidal ideation
4. Engage in night-shift work 

 

 

Age Range

18 - 65 years

Contact Information

Institute for Behavior, Brain, and Immunology at the Ohio State University Wexner Medical Center

Annabel Fuller

annabel.fuller@osumc.edu

6143663523

Official Title Co-designing a Emotion Mapping Tool to Enhance Patient-Provider Communication

Purpose

The objective of this research is to co-design with former inpatients to gradually refine and reimagine an emotion mapping toolkit through co-design workshops hosted at The Ohio State University (OSU) campus. 

This research will ultimately inform future work aimed at enhancing patient engagement, emotional empowerment, and satisfaction through improved communication practices and the creation of actionable emotional data in healthcare settings.  

Your time involved with this study will be approximately 1 hour. 

 

Could this study be right for you?

• Former inpatient who had been hospitalized for 3 or more days within the last 6 months
• Able to attend in-person workshop at The Ohio State University Columbus Campus

Age Range

18 years and up

Contact Information

Columbus, Ohio

Valeska Tan

tan.1333@osu.edu

Official Title Phase II - Modular Convertible Child Safety Seat to Improve Usage

Purpose

We want to learn parents' and caregivers' opinions on a new design for a child car safety seat. You will be asked to install a rotating child seat and a regular child seat into a provided vehicle and tell us what you like and don't like about each one.

Could this study be right for you?

To qualify for the study, you must be:

1. Between the ages of 18 and 65
2. A parent or care provider to a child who is 0 to 4 years of age
3. Have installed a child safety seat in the last 2 years 
4. Able to lift and install a child car safety seat into a vehicle

Age Range

18 - 65 years

Contact Information

Columbus, Ohio

Julie Mansfield

julie.mansfield@osumc.edu

Official Title Improving Physical Ability and Cellular Senescence Elimination in HIV (IPACE-HIV)

Purpose

The purpose of this study is to evaluate the safety and tolerability of dasatinib and quercetin (D+Q) and efficacy of this regimen in improving physical function outcomes in people with HIV (PWH) who are frail or prefrail.

Could this study be right for you?

• People living with HIV ≥50 years diagnosed with HIV 10 or more years ago
• Currently on combination antiretroviral therapy
• Currently virologically suppressed
• Must meet FFP criteria & have 4-meter gait speed in the range of .5-1.2 m/sec

Age Range

50 years and up

Contact Information

McCampbell Hall

Jessica Marburger

Jessica.Marburger@osumc.edu

Official Title A randomized, double-blind, Phase 3 study to investigate efficacy and safety of teplizumab compared with placebo in participants 1 to 25 years of age with recently diagnosed Stage 3 Type 1 Diabetes (T1D)

Purpose

This study is testing a medicine called teplizumab to see if it can help people aged 18 to 25 who were recently diagnosed with Type 1 Diabetes (T1D). The goal is to find out if teplizumab can protect the cells in the body that make insulin, which helps control blood sugar.

People with T1D usually lose these insulin-producing cells over time, and this study wants to see if teplizumab can slow down or stop that process. Everyone in the study will continue using insulin as usual, but some will also get teplizumab (or a placebo, which has no medicine) through IV infusions.

Researchers hope this treatment will:

• Help the body keep making some of its own insulin

• Reduce the amount of insulin people need to take

• Improve blood sugar control

• Lower the risk of very low blood sugar levels

The study will last about 84 weeks (a little over a year and a half), and participants will have regular checkups and tests to see how well the medicine works and how safe it is.

Could this study be right for you?

• Must be diagnosed with Type 1 Diabetes in the past 2 months
• Must have had a positive test for at least one Type 1 Diabetes antibody
• For female participants of childbearing potential - must use a contraception method (or abstinence) 

Age Range

18 - 25 years

Contact Information

Ohio State University Wexner Medical Center

Lindsey Aldrich

lindsey.aldrich@osumc.edu

614-814-0772

Official Title A Multicenter, Randomized, Double-blind, Sham-controlled study for Assessing the Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals with Type II Diabetes (ReCET Study)

Purpose

To test the efficacy of a one-time non-surgical endoscopic procedure on improved glycemic control in patients with type 2 diabetes who are not on insulin. 

Could this study be right for you?

Participants are eligible to be included in the study if all of the following criteria apply:
1. 22-70 years of age, inclusive.
2. T2D diagnosis for at least 6 months.
3. HbA1c of 7.5-10.5%, inclusive, determined by central laboratory. If the individual is on four glucose-lowering medications, HbA1c should be between 7.5% and 9.0%.
4. BMI 27-40 kg/m2, inclusive.
5. On 2-4 non-insulin glucose lowering mediations or on monotherapy with either GLP-1, or GLP-1/GIP medications, with no changes in medication or dosing for at least 12 weeks prior to the baseline visit.
6. Individualized metabolic surgery (IMS) score ≤ 115.
7. Weight stability (defined as a < 5% change in body weight) for at least 12 weeks prior to the screening visit.
8. Agree not to donate blood during participation in the study.
9. Able to comply with study requirements and understand and sign the Informed Consent Form.
10. Women of childbearing potential must be not pregnant and using an acceptable method of contraception throughout the study.
11. Willing and able to comply with study visits and study tasks as required per protocol.

Age Range

22 - 70 years

Contact Information

OSU Outpatient Care East 543 Taylor Ave, Columbus, OH 43203

Thaina Gatti

thaina.gatti@osumc.edu

Official Title Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults with Obesity

Purpose

This study is testing whether taking vitamin C can improve gut health and reduce inflammation in adults with obesity. We want to learn if vitamin C helps strengthen the gut lining (“gut barrier”), improve digestion, and support overall health.

Could this study be right for you?

• Body weight: Have overweight or obesity (BMI 30 or higher)

• Location: Able to come to The Ohio State University campus in Columbus, Ohio for study visits

• Diet: Willing to follow a low vitamin C diet during the study

• Health status: Generally healthy, without major chronic diseases other than obesity

• Other: Non-smoker, not pregnant or breastfeeding, not currently taking high-dose vitamin C supplements

Age Range

18 - 55 years

Contact Information

Ohio State University study

Saba Belyani

belyani.1@osu.edu

6143305095