Official Title Assessing Responses to Exercise in the Heat in Trained Women

Purpose

The purpose of this research study is to conduct exercise in hot and neutral environments on women who are aerobically trained and resistance trained to characterize and compare responses across physiologic, perceptual, and neurocognitive domains. Our rationale for this investigation is that its completion would provide evidence as to how women of different fitness backgrounds respond to exercise in the heat and how that response is different from exercising in thermoneutral conditions to better describe how the female body tolerates exercise in the heat with implications for those in recreation, competitive sports, and occupation that expands to emergency and military services.

Could this study be right for you?

• Aerobically Trained: having a measured aerobic capacity in the 80th percentile according to age

• Resistance Trained: able to squat 120% and bench press 60% of their body weight.

• Unacclimatized: participants had not been consistently exposed to hot conditions (i.e., sauna, hot yoga, etc.) in the past 2 months.

Age Range

18 - 35

Official Title Evaluating the effect of a WearIng a TENS-device in NausEa Relief (The WINNER Study)

Purpose

The purpose of this study is to evaluate if this wearable device can help manage nausea in those who suffer from this problem chronically. 

If you choose to participate, then you will be given the study device to wear on your wrist for 12 weeks. In the weeks before and during this time, you will complete a series of daily and weekly questionnaires about your nausea symptoms, mood, sleep, and bowel habits.

Could this study be right for you?

• Nausea going on for more than 2 months
• 18 years or older
• Able to understand English
• Seen at OSU for their care
• Able to complete surveys online using either smartphone or computer

Age Range

18 and up

Official Title Orexin Receptor Antagonists as Modulators of Threat Sensitivity in individuals with Alcohol Use Disorder

Purpose

The purpose of this study is to see if BELSOMRA, an FDA approved medication that is prescribed to treat insomnia, changes the body’s response to stress. Participation in the study includes 3 or 5 in-person lab visits (depending on randomization), which include EEG and MRI. Nearly all visits are 1.5 hours long, with the exception of one that is 4-5 hours in duration. Visits are flexible and scheduled at your convenience. Participants take the medication (or placebo) for 4 weeks, during which participation is only composed of virtual surveys via a smartphone app.

The total length of participation in the study is 1.5-2 months depending on scheduling/availability.

Could this study be right for you?

Eligibility Criteria:

• 18-65 years old
• Generally medically and physically healthy
• Regular alcohol use

Exclusion Criteria:

• Diagnosis of bipolar disorder, schizophrenia, mania, or psychosis
• Currently pregnant or trying to become pregnant (female)
• Presence of ferrous-containing metal in the body
• Inability to tolerate enclosed spaces

Exclusion Criteria varies, please contact Study Coordinator for more information.

Age Range

18 - 65

Official Title Ontogenesis of Categorization; Linking development, mechanisms, and biology

Purpose

The purpose of this study is to investigate the early development of attention, learning, and memory during childhood. Participation in this study includes 4, 90-minute-long visits to the lab per year. During these visits, your child will play 2-3 fun, computerized games. These games are designed to assess various aspects of their cognitive ability. 

The duration of the study will last 4 years.

Could this study be right for you?

Eligibility Criteria: 

• African-American/Black children who are 4 years old 

Age Range

4 - 4

Official Title A Phase I Study to Assess the Safety, Tolerability and Preliminary Efficacy of AAV2-BDNF [Adeno-Associated Virus (AAV)-based, Vector-Mediated Delivery of Human Brain Derived Neurotrophic Factor] in Subjects with Early Alzheimer’s Disease and Mild Cognitive Impairment

Purpose

The primary aim of this study is to determine whether administration of the nervous system growth factor "Brain-Deruved Neurotrophic Factor" (BDNF) to eligible patients with Alzheimer's disease and Mild Cognitive Impairment is safe and tolerable. This study will be used to determine whether BDNF administration reduces neuronal loss and rebuilds synapses in the brain of patients with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). 

Could this study be right for you?

• Male and Females aged 50 years or older
• Diagnosis of dementia due to Alzheimer's Disease/Diagnosis of Mild Cognitive Impairment (MCI) due to Alzheimer’s Disease
• A caregiver is available who has frequent contact with the subject, agrees to observe for adverse events, and will accompany the subject to all clinic visits for the duration of the protocol
• CT or MRI scans within 24 months prior to screening without evidence of an infection, infarction, or other focal 

Inclusion Criteria varies, please contact Study Coordinator for more information.

The below Exclusion Criteria apply to both the AD and MCI groups.

• Any significant neurological disease other than suspected incipient disease
• History of schizophrenia 
• History of systemic cancer within the past 18 months (non-metastatic skin cancers are acceptable).
• Any significant systemic illness or unstable medical conditions which could lead to difficulty complying with the protocol
• Use of any investigational drugs within thirty days or five half-lives, whichever is longer, prior to screening.

Exclusion Criteria varies, please contact Study Coordinator for more information. 

Age Range

50 and up

Official Title An Intervention Study about Primary Care Algorithms for Early Identification of Young Women with von Willebrand Disease

Purpose

Researchers at Nationwide Children’s Hospital are seeking volunteers to be a part of a study looking at how to best screen for bleeding disorders in young women.

Participants will be asked to undergo a finger prick blood test and complete questionnaires. If their survey answers suggest they have heavy menses or abnormal bleeding, they will also be asked to have a blood draw on the same day.

Could this study be right for you?

• Are 9 to 21 years old
• Have had your first menstrual cycle

Age Range

9 - 21

Official Title FASED (Footstool in Alleviating Symptoms of Evacuation Disorder)

Purpose

The purpose of this research study is to see if using a footstool can make it easier to have bowel movements in patients who suffer from chronic constipation. The participants will be given a free footstool to use. They will be asked to keep a record of their bowel symptoms and answer some surveys about their symptoms on a phone or computer. 

You will be in the study for approximately 12 weeks. This includes 2 weeks before you start using the footstool, followed by 8 weeks where you will be using the footstool and up to 2 weeks to complete your initial and final surveys. 

Could this study be right for you?

• At least 18 years old
• Able to understand English
• Symptoms such as feeling incompletely empty after a bowel movement, needing to strain a lot when having a bowel movement or needing to use maneuvers such as rocking one's body back and forth or using their finger to remove stool.

Age Range

18 - 99

Official Title Mentoring to be Active: Peer Mentoring for Rural Appalachian Children to Reduce Overweight and Obesity

Purpose

The purpose of this study is to lower the rate of type 2 diabetes in rural Appalachia youth due to obesity and/or being overweight. Our long-term goal is to improve the health of underserved, high-risk youth.

This study will test the effectiveness of the Mentored Planning to be Active + Family on physical activity outcomes and health outcomes among rural Appalachian middle school aged youth suffering from either overweight or obesity.

We have local high school-aged teen mentors work closely with middle school youth to increase social support, self-efficacy, and self-regulation skills to sustain physical activity and improve health before the children enter high school.

The peer mentoring is followed by a 6-month family reinforcement program.

Some parents will provide child assessment data of perceived child physical activity behaviors and child health.

 

Could this study be right for you?

• Child has access to a computer or tablet device at home for virtual mentoring sessions/meetings
• Child suffers from overweight or obesity - does not need to be under the care of a health care professional for this condition
• Child and Parent able to participate read English at a 4th grade level. 
• Family not expected to move from rural Appalachia within the 18 months. 

Age Range

12 - 13

Official Title "What do physicians know about intellectual disability?" Getting information to design better medical training

Purpose

The purpose of this study is to explore the physicians’ knowledge of intellectual disabilities (ID) and their medical training and practice. The information resulting from this study will help to design adequate interventions and training programs for medical students and physicians aimed to improve their ID knowledge and the health care services provided to patients with ID. This is an observational cross-sectional study of physicians in the US using an anonymous online survey. The entire survey has 156 items and will require 15-20 minutes to complete.

Could this study be right for you?

• You are an American medical resident, an attending physician, or a medical educator in any type of medical specialization, and
• You have or do not have experience with patients with intellectual disabilities

Age Range

24 and up

Official Title Distracted Driving Study--A phone app to reduce cell phone usage among young drivers

Purpose

This is a study is being done to find out if a phone app reduces calling and texting while driving among young drivers.

Could this study be right for you?

• 18-20 years old
• Use an iPhone or Android smartphone
• Have a full driver’s license that allows unsupervised driving at all times
• Have a car that they are exclusive access to (primary driver, do not share the car)
• Car is insured for liability during crashes
• Driver uses the car more than 2 days a week on average
• Are a US citizen

Age Range

18 and up

Official Title A Double-blind, Placebo- and Active-controlled Evaluation of the Safety and Efficacy of Levomilnacipran ER in Pediatric Patients 7-17 Years With Major Depressive Disorder

Purpose

The purpose of this research study is to evaluate the drug Levomilnacipran extended-release to see how well the drug works, observe the side effects, and how well tolerated it is compared to placebo in pediatric patients with major depressive disorder.

Could this study be right for you?

Your child may be eligible if:

• be between 7 and 17 years of age
• give their assent (a simplified version of this consent form that your child will sign)
• have a diagnosis of Major Depressive Disorder
• meet all of the additional relevant inclusion criteria
• understand the study instructions, and be willing and able to follow these instructions

Exclusion Criteria:

• Your child will not be able to take part in the study if she is pregnant, nursing, or planning a pregnancy
• Your child will not be able to take part in this study if he/she takes any illegal substances

Age Range

7 and up

Official Title A multicenter, randomized, double-blind, parallel group, placebo-controlled study to assess safety, tolerability, pharmacokinetics and pharmacodynamics of BI 764198 administered orally once daily for 12 weeks in patients with focal segmental glomerulosclerosis.

Purpose

The overall objective is to investigate to investigate how safe, how well tolerated, and how effective R3R01 is in treating uncontrolled proteinuria in patients with Alport syndrome and steroid-resistant Focal Segmental Glomerulosclerosis. All eligible participants will be enrolled to receive R3R01 over a treatment period of 12 weeks. The study will consist of 3 periods, including a screening period of 3 weeks, a treatment period of 12 weeks, and a follow up of period of 12 weeks.

Could this study be right for you?

You may be eligible to participate if:

• You are aged 18 years or older
• Female patients and female partners of male patients willing to not become pregnant for the duration of the study
• Have not had an organ transplant and/or on a organ transplant list
• Have high protein in urine Alport Syndrome (AS) specific:
• Have X-linked AS and autosomal recessive AS
• Confirmed diagnosis of AS by genetic testing or kidney biopsy
• Do not have another kidney disease
• FSGS specific:
• Not older than 75 years of age
• Primary Focal segmental glomerulosclerosis (FSGS) (not caused by other condition) that is confirmed by kidney biopsy or documentation of genetic mutation
• Steroid-resistance: previous steroid treatment without remission

Age Range

18 and up